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In a quiet southern town, several lives are changed forever when an isolated mute with a dark secret is admitted to a mental institution.

A year after their father's death, four brothers decide it's time to quit their dead-end jobs and start a family business: a funeral home. Soon after securing a business loan from a shady, drug-addicted acquaintance, they find out that they actually borrowed this guy's theft debt--to the mafia. With a call from the Mafia's boss, the guys not only learn that their loaner has been killed, but that they must come up with double the money they borrowed in two weeks time. The brothers turn to theft, conning, and anything else they can do to get the money, but they just aren't good at it. As the end of the two weeks nears, the family is forced to turn to desperate measures and a bizarre road trip.

Thirty years after the Second Great Depression of 2015, one man's decision to cease his daily "Life Pill" intake sends shock waves through his imprisoned village, introducing a dangerous new drug - emotion.