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Connie Hayward mounts an expedition into the Himalayan Mountains looking for her brother, who has not returned from a previous trek trying to locate the Yeti, or "Abominable Snowman". Arriving at her brother's last-known camp Connie and her companions find only a strange old guide, Varga. They are soon attacked by gigantic Snowmen but are not half as surprised as when Vargas reveals his secret origin and the plans he has for Connie.

A mad scientist, who discovered the secret of eternal youth by draining of blood from a young woman, gets executed. His ancestor moves into the home, eventually discovering the scientist's body. He revives him, and the terror continues.

Experimenting in hypnotic regression to past lives, Dr. Edmund Redding of the Cowan Institute in Pasadena has discovered that Ann Taylor is a reincarnated Aztec woman. Via her recovered memories, she is able to lead Redding and his associates to a hidden chamber in the Great Pyramid of Yucatan, where they hope to find the lost treasure of the Aztecs. Instead, they find two mummified bodies - one of a modern man, quite dead, and the other of an ancient Aztec, quite alive. They are able to return safely to Pasadena with both finds, but a rival professor, Janney, kills Redding and steals the body of the modern man-mummy. This he subjects to a resurrection experiment, which works - only the mummy proves to be a werewolf. This creature breaks free of Janney's lab. Meanwhile, a hired thief sent by Janney to steal the other, living mummy, is overcome and that creature escapes also. Two supernatural menaces roam the city that night...