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Raised by an uncle in New York after the mob killed his parents, Thomas is sent to live with his aunt and uncle in Italy. He is drawn to his mysterious, young aunt. Soon Thomas learns the truth and receives a generous inheritance.

In a future world where Earth's ozone layer has been completely destroyed, a brilliant but obsessed scientist, Hank Symes uses illegally obtained biological materials for an experiment that he hopes will save the world. In the course of his work, a terrible accident occurs, transforming him into a fantastic otherworldly lifeform and changing his house into a huge living entity which threatens all who enter.