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Gamaliel and Morris are two colorful characters, best friends since childhood, one Mexican and one gringo who engage together in people trafficking but who deep down have a good heart. After years of not seeing each other, they reunite and decide to join forces to create a transnational corporation: Run Coyote Run, a "touristic adventure" travel agency, as they like to call it, specialized in smuggling people illegally to the US.

Rosario (Palma) becomes a prostitute after losing her father and discovering her boyfriend had a liaison with another woman. In Veracruz, Rosario lives above a sordid cabaret "selling her love to the men coming from the sea." One night, sailor Alberto (Soler) rescues Rosario from the dirty hands of a drunk man. They get along and go to Rosario's room. After making love, they begin to talk and Rosario discovers they're siblings...