Made to make your life simpler with packages, by installing and loading a list of packages, whether they are on CRAN, Bioconductor or github. For github, if you do not have the full path, with the maintainer name in it (e.g. "achateigner/topReviGO"), it will be able to load it but not to install it.

This package performs linear regression with respect to a data-driven convex loss function that is chosen to minimize the asymptotic covariance of the resulting M-estimator. The convex loss function is estimated in 5 steps: (1) form an initial OLS (ordinary least squares) or LAD (least absolute deviation) estimate of the regression coefficients; (2) use the resulting residuals to obtain a kernel estimator of the error density; (3) estimate the score function of the errors by differentiating the logarithm of the kernel density estimate; (4) compute the L2 projection of the estimated score function onto the set of decreasing functions; (5) take a negative antiderivative of the projected score function estimate. Newton's method (with Hessian modification) is then used to minimize the convex empirical risk function. Further details of the method are given in Feng et al. (2024) <doi:10.48550/arXiv.2403.16688>.

This package provides a testing framework for testing the multivariate point null hypothesis. A testing framework described in Elder et al. (2022) <arXiv:2203.01897> to test the multivariate point null hypothesis. After the user selects a parameter of interest and defines the assumed data generating mechanism, this information should be encoded in functions for the parameter estimator and its corresponding influence curve. Some parameter and data generating mechanism combinations have codings in this package, and are explained in detail in the article.

DEPRECATED. Do not start building new projects based on this package. (The (in-house) APD file format was initially developed to store Affymetrix probe-level data, e.g. normalized CEL intensities. Chip types can be added to APD file and similar to methods in the affxparser package, this package provides methods to read APDs organized by units (probesets). In addition, the probe elements can be arranged optimally such that the elements are guaranteed to be read in order when, for instance, data is read unit by unit. This speeds up the read substantially. This package is supporting the Aroma framework and should not be used elsewhere.).

This package creates interactive Venn diagrams using the amCharts5 library for JavaScript'. They can be used directly from the R console, from RStudio', in shiny applications, and in rmarkdown documents.

This package provides a framework for intuitive, multi-source gene and protein annotation, with a focus on integrating functional genomics with disease and drug data for translational insights. Methods used include g:Profiler (Raudvere et al. (2019) <doi:10.1093/nar/gkz369>), biomaRt (Durinck et al. (2009) <doi:10.1038/nprot.2009.97>), and the Open Targets Platform (Koscielny et al. (2017) <doi:10.1093/nar/gkw1055>).

The empirical cumulative average deviation function introduced by the author is utilized to develop both Ad- and Ud-plots. The Ad-plot can identify symmetry, skewness, and outliers of the data distribution, including anomalies. The Ud-plot created by slightly modifying Ad-plot is exceptional in assessing normality, outperforming normal QQ-plot, normal PP-plot, and their derivations. The d-value that quantifies the degree of proximity between the Ud-plot and the graph of the estimated normal density function helps guide to make decisions on confirmation of normality. Full description of this methodology can be found in the article by Wijesuriya (2025) <doi:10.1080/03610926.2024.2440583>.

For researchers to quickly and comprehensively acquire disease genes, so as to understand the mechanism of disease, we developed this program to acquire disease-related genes. The data is integrated from three public databases. The three databases are eDGAR', DrugBank and MalaCards'. The eDGAR is a comprehensive database, containing data on the relationship between disease and genes. DrugBank contains information on 13443 drugs and 5157 targets. MalaCards integrates human disease information, including disease-related genes.

Scraping content from archived web pages stored in the Internet Archive (<https://archive.org>) using a systematic workflow. Get an overview of the mementos available from the respective homepage, retrieve the Urls and links of the page and finally scrape the content. The final output is stored in tibbles, which can be then easily used for further analysis.

This package provides a modeling package compiling applicability domain methods in R. It combines different methods to measure the amount of extrapolation new samples can have from the training set. See <doi:10.4018/IJQSPR.2016010102> for an overview of applicability domains.

Analysis of means (ANOM) as used in technometrical computing. The package takes results from multiple comparisons with the grand mean (obtained with multcomp', SimComp', nparcomp', or MCPAN') or corresponding simultaneous confidence intervals as input and produces ANOM decision charts that illustrate which group means deviate significantly from the grand mean.

This package provides a set of Study Data Tabulation Model (SDTM) datasets from the Clinical Data Interchange Standards Consortium (CDISC) pilot project used for testing and developing Analysis Data Model (ADaM) derivations inside the admiral package.

Fit Generalized Additive Models (GAM) using mgcv with parsnip'/'tidymodels via additive <doi:10.5281/zenodo.4784245>. tidymodels is a collection of packages for machine learning; see Kuhn and Wickham (2020) <https://www.tidymodels.org>). The technical details of mgcv are described in Wood (2017) <doi:10.1201/9781315370279>.

This package implements a multiple testing approach to the choice of a threshold gamma on the p-values using the Average Power Function (APF) and Bayes False Discovery Rate (FDR) robust estimation. Function apf_fdr() estimates both quantities from either raw data or p-values. Function apf_plot() produces smooth graphs and tables of the relevant results. Details of the methods can be found in Quatto P, Margaritella N, et al. (2019) <doi:10.1177/0962280219844288>.

Allows access to selected services that are part of the Google Adwords API <https://developers.google.com/adwords/api/docs/guides/start>. Google Adwords is an online advertising service by Google', that delivers Ads to users. This package offers a authentication process using OAUTH2'. Currently, there are two methods of data of accessing the API, depending on the type of request. One method uses SOAP requests which require building an XML structure and then sent to the API. These are used for the ManagedCustomerService and the TargetingIdeaService'. The second method is by building AWQL queries for the reporting side of the Google Adwords API.

Epidemiological population dynamics models traditionally define a pathogen's virulence as the increase in the per capita rate of mortality of infected hosts due to infection. This package provides functions allowing virulence to be estimated by maximum likelihood techniques. The approach is based on the analysis of relative survival comparing survival in matching cohorts of infected vs. uninfected hosts (Agnew 2019) <doi:10.1101/530709>.

This package performs Bayesian prediction of complex computer codes when fast approximations are available. It uses a hierarchical version of the Gaussian process, originally proposed by Kennedy and O'Hagan (2000), Biometrika 87(1):1.

API for using episensr', Basic sensitivity analysis of the observed relative risks adjusting for unmeasured confounding and misclassification of the exposure/outcome, or both. See <https://cran.r-project.org/package=episensr>.

Supplies a set of functions to query air travel data for user- specified years and airports. Datasets include on-time flights, airlines, airports, planes, and weather.

Fits a linear-binomial model using a modified Newton-type algorithm for solving the maximum likelihood estimation problem under linear box constraints. Similar methods are described in Wagenpfeil, Schöpe and Bekhit (2025, ISBN:9783111341972) "Estimation of adjusted relative risks in log-binomial regression using the BSW algorithm". In: Mau, Mukhin, Wang and Xu (Eds.), Biokybernetika. De Gruyter, Berlin, pp. 665â 676.

Download Alphavantage financial data <https://www.alphavantage.co/documentation/> to reduced data.table objects. Includes support functions to extract and simplify complex data returned from API calls.

This package provides a stacking solution for modeling imbalanced and severely skewed data. It automates the process of building homogeneous or heterogeneous stacked ensemble models by selecting "best" models according to different criteria. In doing so, it strategically searches for and selects diverse, high-performing base-learners to construct ensemble models optimized for skewed data. This package is particularly useful for addressing class imbalance in datasets, ensuring robust and effective model outcomes through advanced ensemble strategies which aim to stabilize the model, reduce its overfitting, and further improve its generalizability.

Allows access to the data found in the species list featured in the renowned List of the Birds of Peru Plenge, M. A. (2023) <https://sites.google.com/site/boletinunop/checklist>. This publication stands as one of Peru's most comprehensive reviews of bird diversity. The dataset incorporates detailed species accounts and has been meticulously structured for effortless utilization within the R environment.

Storing very large data objects on a local drive, while still making it possible to manipulate the data in an efficient manner.