Non Functioning Testicles (NFTs)

Testicular failure occurs when the testicles cannot produce sperm or male hormones, such as testosterone.

Causes
Testicular failure is uncommon. Causes include:

Certain medicines, including glucocorticoids, ketoconazole, chemotherapy, and opioid pain medicines
Diseases that affect the testicle, including hemochromatosis, mumps, orchitis, testicular cancer, testicular torsion, and varicocele
Injury or trauma to the testicles
Obesity
Genetic diseases, such as Klinefelter syndrome or Prader-Willi syndrome
Other diseases, such as cystic fibrosis
The following can increase the risk of testicular failure:

Activities that cause constant, low-level injury to the scrotum, such as riding a motorcycle or bicycle
Frequent and heavy use of marijuana
Undescended testicles at birth

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