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#!/usr/bin/perl -w
use strict;
use warnings;
my $sample_file = $ARGV[0];
my $sites = $ARGV[1];
my (@samples, %phenotypes);
open(PHENO, $sample_file) || die("Could not open $sample_file\n");
while (my $pheno_line = <PHENO>)
{
chomp $pheno_line;
my ($FID, $IID, $pheno) = split("\t", $pheno_line);
push(@samples, "$IID:1");
$phenotypes{"$IID:1"} = $pheno;
}
close PHENO;
# Sites increase in minor allele count (mac)
for (my $site_idx = 1; $site_idx <= $sites; $site_idx++)
{
my @sampled_samples;
my $mac = int(scalar(@samples) * ($site_idx/$sites));
# Reservoir sampler over all samples for each site
for (my $sample_idx = 0; $sample_idx < scalar(@samples); $sample_idx++)
{
if (scalar(@sampled_samples) < $mac)
{
push(@sampled_samples, $samples[$sample_idx]);
}
else
{
my $r = int(rand($sample_idx));
if ($r < $mac)
{
$sampled_samples[$r] = $samples[$sample_idx];
}
}
}
print join(" ", $site_idx, "5.033430 0.161246 100 0 100 0.151841 100 |", @sampled_samples) . "\n";
}
exit(0);
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