Search Results for "next-generation dna sequencing"
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Showing 242 open source projects for "next-generation dna sequencing"
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MongoDB Atlas runs apps anywhereMongoDB Atlas gives you the freedom to build and run modern applications anywhere—across AWS, Azure, and Google Cloud. With global availability in over 115 regions, Atlas lets you deploy close to your users, meet compliance needs, and scale with confidence across any geography.
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Yeastar: Business Phone System and Unified CommunicationsUser-friendly, optimized, and scalable, the Yeastar P-Series Phone System redefines business connectivity by bringing together calling, meetings, omnichannel messaging, and integrations in one simple platform—removing the limitations of distance, platforms, and systems.
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DeepVariant
DeepVariant is an analysis pipeline that uses a deep neural networks
DeepVariant is an analysis pipeline that uses a deep neural network to call genetic variants from next-generation DNA sequencing data. DeepVariant is a deep learning-based variant caller that takes aligned reads (in BAM or CRAM format), produces pileup image tensors from them, classifies each tensor using a convolutional neural network, and finally reports the results in a standard VCF or gVCF file. DeepTrio is a deep learning-based trio variant caller built on top of DeepVariant. ... -
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popoolation
estimate natural variation and positive selection
PoPoolation is a pipeline for analysing pooled next generation sequencing data. Currently PoPoolation allows to calculate Tajima’s Pi, Watterson’s Theta and Tajima’s D with a sliding window approach for chromosomes or for set of genes. One of the main challenges in population genomics is to identify regions of intererest on a genome wide scale. We believe that PoPoolation will greatly aid this task by allowing a fast and user friendly analysis of NGS data from DNA pools. ... -
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pydna
Clone with Python! Data structures for double stranded DNA
Clone with Python! Data structures for double stranded DNA & simulation of homologous recombination, Gibson assembly, cut & paste cloning. Planning genetic constructs with many parts and assembly steps, such as recombinant metabolic pathways, are often difficult to properly document as is evident from the poor state of documentation in the scientific literature. The pydna python package provide a human-readable formal description of cloning and genetic assembly strategies in Python which... -
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Oasis
Inference script for Oasis 500M
Open-Oasis provides inference code and released weights for Oasis 500M, an interactive world model that generates gameplay frames conditioned on user keyboard input. Instead of rendering a pre-built game world, the system produces the next visual state via a diffusion-transformer approach, effectively “imagining” the world response to your actions in real time. The project focuses on enabling action-conditional frame generation so developers can experiment with interactive, model-generated... -
Attack Surface Management | Criminal IP ASMCriminal IP’s Attack Surface Management (ASM) is a threat-intelligence–driven platform that continuously discovers, inventories, and monitors every internet-connected asset associated with an organization, including shadow and forgotten resources, so teams see their true external footprint from an attacker’s perspective. The solution combines automated asset discovery with OSINT techniques, AI enrichment and advanced threat intelligence to surface exposed hosts, domains, cloud services, IoT endpoints and other Internet-facing vectors, capture evidence (screenshots and metadata), and correlate findings to known exploitability and attacker tradecraft. ASM prioritizes exposures by business context and risk, highlights vulnerable components and misconfigurations, and provides real-time alerts and dashboards to speed investigation and remediation.
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Subread
High-performance read alignment, quantification and mutation discovery
The Subread software package is a tool kit for processing next-gen sequencing data. It includes Subread aligner, Subjunc exon-exon junction detector and featureCounts read summarization program. Subread aligner can be used to align both gDNA-seq and RNA-seq reads. Subjunc aligner was specified designed for the detection of exon-exon junction. For the mapping of RNA-seq reads, Subread performs local alignments and Subjunc performs global alignments.">
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JuiceFS
JuiceFS is a distributed POSIX file system built on top of Redis
...Whether it's a public cloud, private cloud, or hybrid cloud, JuiceFS is available on any cloud of your choice and delivers flexibility, availability, scalability and strong consistency for your data-intensive applications. Purposely built to serve big data scenarios such as self-driving model training, recommendation engine, and Next-generation Gene Sequencing, JuiceFS specializes in high performance and easier management of tens of billion of files management. We bring JuiceFS to developers with the hope that it will be easy to use, reliable, high-performance, and solve all your file storage problems in a cloud environment. -
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AWS ParallelCluster Cookbook
The Chef cookbook used to build and bootstrap AWS ParallelCluster
...AWS ParallelCluster facilitates both quick start proof of concepts (POCs) and production deployments. You can build higher-level workflows, such as a Genomics portal that automates the entire DNA sequencing workflow, on top of AWS ParallelCluster. Node.js is required by AWS CDK library used by ParallelCluster. -
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hg38 version of the pipelines for whole exome sequencing: exome_test38.sh wole transcription sequencing: rna_test38.sh somatic calling: somatic38.sh SV detect: svdetect38.sh, meerkat38.sh cnv: svdetectcnv38.sh, contra38.sh, cnvkit38.sh *** Mutect2 instead of haptotypecaller is used to call variants in DNA-seq.
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This Shiny app provides a user-friendly interface for performing Weighted Gene Co-expression Network Analysis (WGCNA) on RNA-seq/Microarray and DNA methylation (Array/Sequencing) data. It allows for data upload, parameter customization, visualization of results, and exporting of analysis outputs. Online webserver https://shinywgcna.serve.scilifelab.se/app/shinywgcna PLEASE NOTE Datasets with larger dimensions (e.g., 1000x100) may fail on the server,because it is only running on 1GB RAM allocation. ...
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Contract Management Software | ConcordConcord serves small and mid-sized businesses and Fortune 500 companies. This robust, web-based platform is used by human resource, sales, procurement, and legal teams, and virtually anyone who deals with contracts.
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AWS ParallelCluster Node
Python package installed on the Amazon EC2 instances
...AWS ParallelCluster facilitates both quick start proof of concepts (POCs) and production deployments. You can build higher-level workflows, such as a Genomics portal that automates the entire DNA sequencing workflow, on top of AWS ParallelCluster. -
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123FASTQ
An intuitive and efficient tool for preprocessing Illumina FASTQ reads
123FASTQ performs all the pre-processes of Illumina next-generation sequencing reads (FASTQ files) easier than ever. Download the quick user manual for the latest version: https://dl.adbioinformatics.net/NGSNeeds/myTools/123Fastq_v1.3_Manual.pdf Authors: Milad Eidi, Samaneh Abdolalizadeh, Mohammad Hossein Nassirpour Supervisors: Javad Zahiri, PhD University of California San Diego Masoud Garshasbi, PhD Tarbiat Modares University, Tehran, Iran If you use 123FASTQ, please cite this preprint: 123FASTQ: an intuitive and efficient tool for preprocessing Illumina FASTQ reads https://www.biorxiv.org/content/10.1101/2024.03.08.584032v1 ########################################################## Take care of the details and ensure you use the latest version. ... -
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NGSEP
NGSEP (Next Generation Sequencing Experience Platform)
NGSEP is an integrated framework for analysis of short and long DNA high throughput sequencing reads. The current version provides functionalities for both de-novo and reference guided analysis of sequencing data, including genome assembly, read mapping, variants detection and genotyping and de-novo analysis of data generated from reduced representation protocols. NGSEP also provides modules for analysis of genomic variation databases (VCF files), including functional annotation, filtering, format conversion, comparison, clustering, imputation, introgression analysis and different kinds of statistics. ...">
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Bowtie, an ultrafast, memory-efficient short read aligner for short DNA sequences (reads) from next-gen sequencers. Please cite: Langmead B, et al. Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol 10:R25.
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Learn AI Engineering
Learn AI and LLMs from scratch using free resources
...It mixes courses, articles, code labs, and videos, emphasizing materials that teach both concepts and hands-on implementation. The curation recognizes modern AI realities, including data pipelines, evaluation, prompt engineering, retrieval-augmented generation, and cost/performance trade-offs. It’s equally useful for refreshers—dipping into a specific module before a project—as it is for a full, self-directed curriculum. By centralizing the best references in one place, the repo reduces the overhead of finding, filtering, and sequencing resources, letting you focus on learning and building. -
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MicroRNAs (miRNAs) are of significance in tuning and buffering gene expression. Despite abundant analysis tools have been developed in the last two decades, plant miRNA identification from next-generation sequencing (NGS) data remains challenging. Here present a user-friendly pure Java-based software package, SRICATs, which enable researchers to perform all steps of plant miRNA analysis based on convolutional neural network methods. SRICATs outperforms currently popular software tools on the test data from five plant species: Oryza sativa, Arabidopsis thaliana, Sorghum bicolor, Chlamydomonas reinhardtii and Physcomitrella patens.
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FullSSR
SSR detection and primer designing software
Traditional methods for isolation of microsatellites (SSRs) are often expensive and time consuming. Nowadays is easier and cheaper to obtain genomic data from next generation sequencing. Then, at least two software need to be applied in order to obtain SSR primers of SSR flanking sequences for PCR assays. Here we propose new software that allows the user to work with several sequences for PCR primer design in one step. -
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XLibraryDisplay
A sequence analysis tool for protein engineering
XLibraryDisplay is an intuitive sequence analysis program optimized for protein engineering. It is ideal for all directed evolution platforms including phage, ribosome, and yeast display. Analysis can be quickly done on hundreds to thousands of sequences. Best suited for Sanger sequencing. Requirements: Microsoft Windows XP, 7, 8, or 10 and Excel 2007, 2010, 2013, or 2016 Described in Stafford et al JCIM 2014: http://pubs.acs.org/doi/abs/10.1021/ci500362s -
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...Easy353: A tool to get Angiosperms353 genes for phylogenomic research. Molecular Biology and Evolution 39(12): msac261. Xie PL, Guo YL, Teng Y, Zhou WB, Yu Y. 2024. GeneMiner: A tool for extracting phylogenetic markers from next-generation sequencing data. Molecular Ecology Resources e139.
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SolexaQA is a software to calculate quality statistics and visual representations of data quality for second-generation sequencing data.
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ViReMa
Viral Recombination Mapper
ViReMa (Viral Recombination Mapper) detects and reports recombination or fusion events in virus genomes using deep sequencing datasets. Feb 2014 - Our paper (Open Access) is available at Nucleic Acids Research: "Discovery of functional genomic motifs in viruses with ViReMa–a Virus Recombination Mapper–for analysis of next-generation sequencing data" http://nar.oxfordjournals.org/content/42/2/e11 This is an on-going project and updates will be regularly posted. ... -
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Gemi
PCR primers / probes design from multiple & degenerate sequences
...https://sites.google.com/view/hsa23/ Gemi, an automated, fast, and easy-to-use bioinformatics tool with a user-friendly interface to design primers and probes for polymerase chain reaction (PCR). Gemi accepts multiple aligned and long DNA and RNA sequences with degenerate nucleotide (non-A/C/G/T bases). Gemi can be used for quantitative, real-time and conventional PCR (qPCR, rt-PCR, etc.), and Sanger sequencing. Gemi can parse large dataset of sequences efficiently. Python codes can be supported upon request. Article: Gemi: PCR primers prediction from multiple alignments Comparative and functional genomics 2012;2012:783138 DOI: https://doi.org/10.1155/2012/783138 PMID: https://www.ncbi.nlm.nih.gov/pubmed/23316117 PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3535827/ -
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123VCF
An Intuitive and Efficient Tool for VCF file filtration
123VCF has been developed to make the filtration step of VCF files efficient and more importantly easy to understand. It can be used in the most important step of whole exome/genome sequencing data analysis in the research and also clinical settings. User manual: https://dl.adbioinformatics.net/123VCF/123VCF_Manual.ver2.pdf If you use 123VCF, please cite its paper: Eidi, M., Abdolalizadeh, S., Moeini, S. et al. 123VCF: an intuitive and efficient tool for filtering VCF files. BMC... -
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TerraCognita
Reads from existing public and private cloud providers
Imports your current Cloud infrastructure to an Infrastructure As Code Terraform configuration (HCL) or/and to a Terraform State. At Cycloid, Infrastructure As Code is in the company's DNA since the beginning. To help our new customers adopt this best practice, we decided to build Terracognita to convert an existing infrastructure on Cloud Infrastructure into Terraform code in an automated way, relying on Terraform providers built by the community. We focused on AWS, GCP and Azure but Alibaba, Vmware and Openstack will be the next to be integrated. ... -
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Seqs Extractor is a useful tool, and can reduce ambiguities in analyses which uses BLAST command ine, commonly in the next generation sequencing, Transcriptomics, Proteomics, etc and help extract BLASTed sequences and sequences that contains microsatellites. Seqs Extrator also turns the BLAST command line more friendly.
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ESTScan is a program that can detect coding regions in DNA/RNA sequences, even if they are of low quality (e.g. EST sequences). ESTScan will also detect and correct sequencing errors that lead to frameshifts.