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WO2014022807A3 - Compositions and methods of using the compositions for plaque softening - Google Patents

Compositions and methods of using the compositions for plaque softening Download PDF

Info

Publication number
WO2014022807A3
WO2014022807A3 PCT/US2013/053489 US2013053489W WO2014022807A3 WO 2014022807 A3 WO2014022807 A3 WO 2014022807A3 US 2013053489 W US2013053489 W US 2013053489W WO 2014022807 A3 WO2014022807 A3 WO 2014022807A3
Authority
WO
WIPO (PCT)
Prior art keywords
compositions
methods
disclosed
plaque
softening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2013/053489
Other languages
French (fr)
Other versions
WO2014022807A2 (en
Inventor
Barbara R. Haberer
Therese J. DOWNEY
Ronald E. Utecht
Jeffrey E. ELBERT
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alumend LLC
Original Assignee
Alumend LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alumend LLC filed Critical Alumend LLC
Publication of WO2014022807A2 publication Critical patent/WO2014022807A2/en
Publication of WO2014022807A3 publication Critical patent/WO2014022807A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Disclosed herein is a compound for use in a composition applied to a blood vessel, wherein the compound softens and/or disrupts the crystalline matrix of calcified plaque. Methods of treatment comprising applying the disclosed composition are also disclosed. Plaque-softening compounds are also disclosed.
PCT/US2013/053489 2012-08-03 2013-08-02 Compositions and methods of using the compositions for plaque softening Ceased WO2014022807A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261679365P 2012-08-03 2012-08-03
US61/679,365 2012-08-03
US201361793170P 2013-03-15 2013-03-15
US61/793,170 2013-03-15

Publications (2)

Publication Number Publication Date
WO2014022807A2 WO2014022807A2 (en) 2014-02-06
WO2014022807A3 true WO2014022807A3 (en) 2014-05-30

Family

ID=50028673

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2013/053489 Ceased WO2014022807A2 (en) 2012-08-03 2013-08-02 Compositions and methods of using the compositions for plaque softening

Country Status (1)

Country Link
WO (1) WO2014022807A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105541855B (en) * 2015-11-25 2018-08-07 内蒙古自治区科学技术研究院有限责任公司东部分院 A kind of 1,8- naphthalimide compounds being bonded with spiro-pyrans and preparation method and application
EP3662034B1 (en) 2017-08-03 2023-04-26 ChampionX USA Inc. Thiol adducts for corrosion inhibition
CN115469032B (en) * 2022-09-16 2024-09-06 江苏嘉逸医药有限公司 Method for measuring arginine perindopril Li Yigou body by high performance liquid chromatography
CN120441637B (en) * 2025-07-11 2025-10-21 鼎科医疗技术（苏州）有限公司 Photosensitive material with vascular repair function, preparation method thereof and balloon dilation catheter

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410505B1 (en) * 1999-06-28 2002-06-25 Microbiomed Corp. Dimeric non-azo naphthalimides and uses for the same
US20040180391A1 (en) * 2002-10-11 2004-09-16 Miklos Gratzl Sliver type autonomous biosensors
US20060069068A1 (en) * 2004-07-15 2006-03-30 Nanobac Pharmaceuticals, Inc. Methods and compositions for the treatment of diseases characterized by pathological calcification
US20060182751A1 (en) * 2004-12-01 2006-08-17 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
US20090181927A1 (en) * 2003-11-05 2009-07-16 Photobiomed Corporation Bonding tissues and cross-linking proteins with naphthalimide compounds
US7666980B2 (en) * 2006-07-20 2010-02-23 Chisso Corporation Calcium-binding photoprotein, gene encoding the same, and use thereof
US20100144869A1 (en) * 2006-07-17 2010-06-10 Abraham Nudelman Conjugates Comprising a gaba-or glycine compound, pharmaceutical compositions and combinations thereof as well as their use in treating cns disorders
US20100168428A1 (en) * 2007-02-26 2010-07-01 Massachusetts Institute Of Technology Environmentally sensitive fluorophores
WO2011130537A2 (en) * 2010-04-14 2011-10-20 Northwestern University Pharmaceutical compositions and methods for digesting atherosclerotic plaques
US20120039980A1 (en) * 2004-04-28 2012-02-16 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410505B1 (en) * 1999-06-28 2002-06-25 Microbiomed Corp. Dimeric non-azo naphthalimides and uses for the same
US20040180391A1 (en) * 2002-10-11 2004-09-16 Miklos Gratzl Sliver type autonomous biosensors
US20090181927A1 (en) * 2003-11-05 2009-07-16 Photobiomed Corporation Bonding tissues and cross-linking proteins with naphthalimide compounds
US20120039980A1 (en) * 2004-04-28 2012-02-16 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US20060069068A1 (en) * 2004-07-15 2006-03-30 Nanobac Pharmaceuticals, Inc. Methods and compositions for the treatment of diseases characterized by pathological calcification
US20060182751A1 (en) * 2004-12-01 2006-08-17 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
US20100144869A1 (en) * 2006-07-17 2010-06-10 Abraham Nudelman Conjugates Comprising a gaba-or glycine compound, pharmaceutical compositions and combinations thereof as well as their use in treating cns disorders
US7666980B2 (en) * 2006-07-20 2010-02-23 Chisso Corporation Calcium-binding photoprotein, gene encoding the same, and use thereof
US20100168428A1 (en) * 2007-02-26 2010-07-01 Massachusetts Institute Of Technology Environmentally sensitive fluorophores
WO2011130537A2 (en) * 2010-04-14 2011-10-20 Northwestern University Pharmaceutical compositions and methods for digesting atherosclerotic plaques

Also Published As

Publication number Publication date
WO2014022807A2 (en) 2014-02-06

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