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WO2006113050A3 - Reagents for the detection of protein phosphorylation in carcinoma signaling pathways - Google Patents

Reagents for the detection of protein phosphorylation in carcinoma signaling pathways Download PDF

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Publication number
WO2006113050A3
WO2006113050A3 PCT/US2006/010868 US2006010868W WO2006113050A3 WO 2006113050 A3 WO2006113050 A3 WO 2006113050A3 US 2006010868 W US2006010868 W US 2006010868W WO 2006113050 A3 WO2006113050 A3 WO 2006113050A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
reagents
phosphorylation
sites
detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2006/010868
Other languages
French (fr)
Other versions
WO2006113050A8 (en
WO2006113050A4 (en
WO2006113050A2 (en
Inventor
Ailan Guo
Klarisa Rikova
Albrecht Moritz
Yu Li
Charles Farnsworth
Kimberly Lee
Roberto Polakiewicz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cell Signaling Technology Inc
Original Assignee
Cell Signaling Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cell Signaling Technology Inc filed Critical Cell Signaling Technology Inc
Priority to EP06739581A priority Critical patent/EP1872134A4/en
Publication of WO2006113050A2 publication Critical patent/WO2006113050A2/en
Anticipated expiration legal-status Critical
Publication of WO2006113050A8 publication Critical patent/WO2006113050A8/en
Publication of WO2006113050A3 publication Critical patent/WO2006113050A3/en
Publication of WO2006113050A4 publication Critical patent/WO2006113050A4/en
Priority to US12/985,879 priority patent/US20110105732A1/en
Ceased legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57496—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving intracellular compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention discloses (214) novel phosphorylation sites identified in signal transduction proteins and pathways underlying human carcinoma, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeleton proteins, GTP Signaling proteins, Kinases, Metabolism proteins, Phosphatases/Phospho- diesterases/ Proteases, Receptor proteins, RNA Processing proteins, Transcription proteins, Translation proteins, Transporter proteins, and Ubitquitin proteins, as well as other protein types.
PCT/US2006/010868 2005-04-12 2006-03-24 Reagents for the detection of protein phosphorylation in carcinoma signaling pathways Ceased WO2006113050A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP06739581A EP1872134A4 (en) 2005-04-12 2006-03-24 REAGENTS FOR DETECTION OF PHOSPHORYLATION OF PROTEINS IN THE CARCINOMA SIGNALING PATHWAY
US12/985,879 US20110105732A1 (en) 2005-04-12 2011-01-06 Reagents for the Detection of Protein Phosphorylation in Carcinoma Signaling Pathways

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67044705P 2005-04-12 2005-04-12
US60/670,447 2005-04-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US67044705P Continuation 2005-04-12 2005-04-12

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/974,480 Continuation US20090099340A1 (en) 2005-04-12 2007-10-12 Reagents for the detection of protein phosphorylation in carcinoma signaling pathways

Publications (4)

Publication Number Publication Date
WO2006113050A2 WO2006113050A2 (en) 2006-10-26
WO2006113050A8 WO2006113050A8 (en) 2007-12-27
WO2006113050A3 true WO2006113050A3 (en) 2008-12-24
WO2006113050A4 WO2006113050A4 (en) 2009-03-26

Family

ID=37115632

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/010868 Ceased WO2006113050A2 (en) 2005-04-12 2006-03-24 Reagents for the detection of protein phosphorylation in carcinoma signaling pathways

Country Status (2)

Country Link
EP (1) EP1872134A4 (en)
WO (1) WO2006113050A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8242083B2 (en) * 2008-06-23 2012-08-14 Perkinelmer Health Sciences, Inc. Kinase substrates
CN111116734A (en) * 2019-12-23 2020-05-08 维塔恩(广州)医药有限公司 Tumor-associated gene c-kit mutation-associated antigen short peptide and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0640102B1 (en) * 1992-04-10 2006-08-09 Dana-Farber Cancer Institute, Inc. Activation-state-specific phosphoprotein immunodetection
WO2002081638A2 (en) * 2001-04-06 2002-10-17 Origene Technologies, Inc Prostate cancer expression profiles
US7335467B2 (en) * 2001-05-15 2008-02-26 Ludwig Institute For Cancer Research Breast cancer antigens

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of EP1872134A4 *
TABUCHI ET AL.: "Cask participates in alternative tripartite complexes in which mint1 completes for binding with Caskin 1, a novel Cask binding protein", J. NEUROSCIENCE, vol. 22, no. 11, 1 June 2002 (2002-06-01), pages 4264 - 4273, XP008125216 *

Also Published As

Publication number Publication date
WO2006113050A8 (en) 2007-12-27
EP1872134A2 (en) 2008-01-02
WO2006113050A4 (en) 2009-03-26
WO2006113050A2 (en) 2006-10-26
EP1872134A4 (en) 2010-09-01

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