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WO2003035695A2 - Agents that activate or inhibit toll-like receptor 9 - Google Patents

Agents that activate or inhibit toll-like receptor 9 Download PDF

Info

Publication number
WO2003035695A2
WO2003035695A2 PCT/US2002/023645 US0223645W WO03035695A2 WO 2003035695 A2 WO2003035695 A2 WO 2003035695A2 US 0223645 W US0223645 W US 0223645W WO 03035695 A2 WO03035695 A2 WO 03035695A2
Authority
WO
WIPO (PCT)
Prior art keywords
tlr9
molecule
binds
antibody
cpg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2002/023645
Other languages
French (fr)
Other versions
WO2003035695A3 (en
Inventor
Ling-Ling An
Herren Wu
Michael S. C. Fung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanox Inc
Original Assignee
Tanox Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanox Inc filed Critical Tanox Inc
Priority to EP02795487A priority Critical patent/EP1412390A2/en
Priority to AU2002360243A priority patent/AU2002360243A1/en
Publication of WO2003035695A2 publication Critical patent/WO2003035695A2/en
Publication of WO2003035695A3 publication Critical patent/WO2003035695A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants

Definitions

  • the present invention is related to the identification of an epitope on the toll-like receptor, TLR9, responsible for interaction with the CpG motif.
  • An organism's immunity includes all of the mechanisms it uses for protection against foreign environmental agents, e.g., microorganisms, foods, chemicals, drugs, or pollens. In vertebrates, immunity may be either innate or acquired (adaptive).