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WO2001066065A3 - Systems and methods for fluid transport through dermal barriers - Google Patents

Systems and methods for fluid transport through dermal barriers Download PDF

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Publication number
WO2001066065A3
WO2001066065A3 PCT/US2001/007170 US0107170W WO0166065A3 WO 2001066065 A3 WO2001066065 A3 WO 2001066065A3 US 0107170 W US0107170 W US 0107170W WO 0166065 A3 WO0166065 A3 WO 0166065A3
Authority
WO
WIPO (PCT)
Prior art keywords
microneedles
microneedle
systems
methods
fluid transport
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2001/007170
Other languages
French (fr)
Other versions
WO2001066065A2 (en
Inventor
Yehoshua Yeshurun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanopass Ltd
Original Assignee
Nanopass Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL13499700A external-priority patent/IL134997A0/en
Priority claimed from US09/589,369 external-priority patent/US6558361B1/en
Application filed by Nanopass Ltd filed Critical Nanopass Ltd
Priority to AU2001245472A priority Critical patent/AU2001245472A1/en
Priority to EP01918390A priority patent/EP1276426A4/en
Publication of WO2001066065A2 publication Critical patent/WO2001066065A2/en
Publication of WO2001066065A3 publication Critical patent/WO2001066065A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00111—Tips, pillars, i.e. raised structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150015—Source of blood
    • A61B5/150022—Source of blood for capillary blood or interstitial fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150213—Venting means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150221—Valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150229—Pumps for assisting the blood sampling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150206—Construction or design features not otherwise provided for; manufacturing or production; packages; sterilisation of piercing element, piercing device or sampling device
    • A61B5/150274—Manufacture or production processes or steps for blood sampling devices
    • A61B5/150282—Manufacture or production processes or steps for blood sampling devices for piercing elements, e.g. blade, lancet, canula, needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150389—Hollow piercing elements, e.g. canulas, needles, for piercing the skin
    • A61B5/150396—Specific tip design, e.g. for improved penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150412—Pointed piercing elements, e.g. needles, lancets for piercing the skin
    • A61B5/150427—Specific tip design, e.g. for improved penetration characteristics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150374—Details of piercing elements or protective means for preventing accidental injuries by such piercing elements
    • A61B5/150381—Design of piercing elements
    • A61B5/150503—Single-ended needles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150007—Details
    • A61B5/150847—Communication to or from blood sampling device
    • A61B5/150854—Communication to or from blood sampling device long distance, e.g. between patient's home and doctor's office
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/150977—Arrays of piercing elements for simultaneous piercing
    • A61B5/150984—Microneedles or microblades
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/15—Devices for taking samples of blood
    • A61B5/157—Devices characterised by integrated means for measuring characteristics of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0053—Methods for producing microneedles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81B—MICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00—Specific applications of microelectromechanical systems
    • B81B2201/05—Microfluidics
    • B81B2201/055—Microneedles

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Manufacturing & Machinery (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Anesthesiology (AREA)
  • Optics & Photonics (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A device (10) for the transport of fluids through a biological barrier includes a number of microneedles (16) projecting from the front face (14) of a substrate (12). A conduit (18) is associated with each of the microneedles (16) to provide a flow path for transport of fluid through a hole in the biological barrier formed by the corresponding microneedle (16). Each of the microneedles (16) is configured to provide a penetrating tip (20), and each conduit (18) terminates at an opening (22) which is proximal with respect to the microneedle tip (20). Also described are microneedle-based devices with integrated MEMS pumping configurations for withdrawal and/or delivery of fluids, and remote healthcare systems based on such devices.
PCT/US2001/007170 2000-03-09 2001-03-07 Systems and methods for fluid transport through dermal barriers Ceased WO2001066065A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001245472A AU2001245472A1 (en) 2000-03-09 2001-03-07 Systems and methods for the transport of fluids through a biological barrier andproduction techniques for such systems
EP01918390A EP1276426A4 (en) 2000-03-09 2001-03-07 Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IL134997 2000-03-09
IL13499700A IL134997A0 (en) 2000-03-09 2000-03-09 Health care system based on micro device
US58936800A 2000-06-08 2000-06-08
US09/589,369 US6558361B1 (en) 2000-03-09 2000-06-08 Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US09/589,368 2000-06-08
US09/589,369 2000-06-08

Publications (2)

Publication Number Publication Date
WO2001066065A2 WO2001066065A2 (en) 2001-09-13
WO2001066065A3 true WO2001066065A3 (en) 2002-01-31

Family

ID=27271924

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/007170 Ceased WO2001066065A2 (en) 2000-03-09 2001-03-07 Systems and methods for fluid transport through dermal barriers

Country Status (3)

Country Link
EP (1) EP1276426A4 (en)
AU (1) AU2001245472A1 (en)
WO (1) WO2001066065A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8192787B2 (en) 2004-08-16 2012-06-05 Innoture Limited Method of producing a microneedle or microimplant

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020095134A1 (en) * 1999-10-14 2002-07-18 Pettis Ronald J. Method for altering drug pharmacokinetics based on medical delivery platform
GB0030929D0 (en) * 2000-12-19 2001-01-31 Inverness Medical Ltd Analyte measurement
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
EP1490147A2 (en) 2002-03-04 2004-12-29 Nano Pass Technologies Ltd. Devices and methods for transporting fluid across a biological barrier
JP4500851B2 (en) 2004-03-12 2010-07-14 エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ Method and mold for use in manufacturing microneedles with side holes
WO2007130718A2 (en) * 2006-01-31 2007-11-15 Kralick Francis A Implantable micro-system for treatment of hydrocephalus
US8206334B2 (en) 2006-01-31 2012-06-26 Kralick Francis A Implantable micro-system for treatment of hydrocephalus
JP2009545368A (en) * 2006-08-01 2009-12-24 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ Ultrasonic enhanced micro needle
EP1967581B1 (en) * 2007-03-08 2016-08-17 Imec CMOS compatible method for manufacturing microneedle structures
EP2338557A1 (en) 2009-12-23 2011-06-29 Debiotech S.A. Soluble microneedle
EP2343550B1 (en) 2009-12-30 2013-11-06 Imec Improved microneedle
WO2019058329A1 (en) * 2017-09-22 2019-03-28 Sabic Global Technologies B.V. Methods and systems of producing microneedle arrays
EP4142857A4 (en) 2020-04-28 2024-07-10 Ticona LLC MICRONEEDLE ARRANGEMENT
US11690739B1 (en) 2020-08-25 2023-07-04 Francis A. Kralick Implantable device for treatment of hydrocephalus
US11717660B2 (en) 2021-07-29 2023-08-08 Nanopass Technologies Ltd. Silicon microneedle structure and production method
CN116870350A (en) * 2023-07-27 2023-10-13 南方科技大学 Quartz microneedles and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250023A (en) * 1989-10-27 1993-10-05 Korean Research Institute on Chemical Technology Transdermal administration method of protein or peptide drug and its administration device thereof
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US6077251A (en) * 1997-10-30 2000-06-20 Ting; Windsor Medicinal agent administration system
US6090790A (en) * 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) * 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
FR2535602B1 (en) * 1982-11-05 1986-06-13 Stallergenes Lab SCARIFIER DEVICE
CA2016900A1 (en) * 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
EP0796128B1 (en) * 1994-12-09 1999-03-10 Novartis AG Transdermal system
DE19525607A1 (en) * 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneal drug delivery system
JP3942640B2 (en) * 1996-07-03 2007-07-11 アルテア セラピューティクス コーポレイション Multiple mechanical microperforations of skin or mucous membrane
GB9817662D0 (en) * 1998-08-13 1998-10-07 Crocker Peter J Substance delivery

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250023A (en) * 1989-10-27 1993-10-05 Korean Research Institute on Chemical Technology Transdermal administration method of protein or peptide drug and its administration device thereof
US6090790A (en) * 1989-12-14 2000-07-18 Eriksson; Elof Gene delivery by microneedle injection
US5591139A (en) * 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US6077251A (en) * 1997-10-30 2000-06-20 Ting; Windsor Medicinal agent administration system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1276426A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8192787B2 (en) 2004-08-16 2012-06-05 Innoture Limited Method of producing a microneedle or microimplant

Also Published As

Publication number Publication date
EP1276426A2 (en) 2003-01-22
EP1276426A4 (en) 2008-03-19
WO2001066065A2 (en) 2001-09-13
AU2001245472A1 (en) 2001-09-17

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