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WO2000060350A3 - Optical glucose sensor apparatus and method for the optical detektion of glucose - Google Patents

Optical glucose sensor apparatus and method for the optical detektion of glucose Download PDF

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Publication number
WO2000060350A3
WO2000060350A3 PCT/US2000/008710 US0008710W WO0060350A3 WO 2000060350 A3 WO2000060350 A3 WO 2000060350A3 US 0008710 W US0008710 W US 0008710W WO 0060350 A3 WO0060350 A3 WO 0060350A3
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WO
WIPO (PCT)
Prior art keywords
glucose
solution
optical
magnetic field
concentration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2000/008710
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French (fr)
Other versions
WO2000060350A2 (en
Inventor
Martin D Fox
Sunghoon Jang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Connecticut
Original Assignee
University of Connecticut
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Filing date
Publication date
Application filed by University of Connecticut filed Critical University of Connecticut
Priority to AU40631/00A priority Critical patent/AU4063100A/en
Publication of WO2000060350A2 publication Critical patent/WO2000060350A2/en
Publication of WO2000060350A3 publication Critical patent/WO2000060350A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/14558—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using optical sensors, e.g. spectral photometrical oximeters by polarisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/21—Polarisation-affecting properties

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

A non-invasive apparatus and method of optically sensing the glucose concentration of a solution is provided. The optical glucose sensor is based on the fact that glucose solutions have a magnetic optical rotatory effect (MORE) such that when a magnetic field is set up in a glucose solution there is a rotation of the polarization vector of the incident light that is proportional to the path length, magnetic field strength, and the concentration of glucose in the solution. The optical glucose sensor includes a laser that passes a beam of polarized light through the glucose solution (i.e. aqueous humor or an eye) while a coil sets up a magnetic field (B) in the solution. A photomultiplier tube provides an output signal indicative of the rotation of the polarization vector of incident light. The beam of light is also modulated by a Faraday rotator, which is controlled by a lock-in amplifier that closes a feed back loop. The output of the lock-in amplifier generates a signal indicative of the glucose concentration in the solution, which may be displayed on an oscilloscope or provided to a processor, which displays a readout indicative of the glucose concentration.
PCT/US2000/008710 1999-04-01 2000-03-31 Optical glucose sensor apparatus and method for the optical detektion of glucose Ceased WO2000060350A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU40631/00A AU4063100A (en) 1999-04-01 2000-03-31 Optical glucose sensor apparatus and method

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28305199A 1999-04-01 1999-04-01
US09/283,051 1999-04-01

Publications (2)

Publication Number Publication Date
WO2000060350A2 WO2000060350A2 (en) 2000-10-12
WO2000060350A3 true WO2000060350A3 (en) 2001-08-02

Family

ID=23084275

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2000/008710 Ceased WO2000060350A2 (en) 1999-04-01 2000-03-31 Optical glucose sensor apparatus and method for the optical detektion of glucose

Country Status (2)

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AU (1) AU4063100A (en)
WO (1) WO2000060350A2 (en)

Cited By (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6958039B2 (en) 2003-05-02 2005-10-25 Oculir, Inc. Method and instruments for non-invasive analyte measurement
US6968222B2 (en) 2003-05-02 2005-11-22 Oculir, Inc. Methods and device for non-invasive analyte measurement
US6975892B2 (en) 2003-10-21 2005-12-13 Oculir, Inc. Methods for non-invasive analyte measurement from the conjunctiva
US8937540B2 (en) 2007-04-14 2015-01-20 Abbott Diabetes Care Inc. Method and apparatus for providing dynamic multi-stage signal amplification in a medical device
US8993331B2 (en) 2009-08-31 2015-03-31 Abbott Diabetes Care Inc. Analyte monitoring system and methods for managing power and noise
US9000929B2 (en) 2007-05-08 2015-04-07 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US9035767B2 (en) 2007-05-08 2015-05-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US9095290B2 (en) 2007-03-01 2015-08-04 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US9177456B2 (en) 2007-05-08 2015-11-03 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US9226701B2 (en) 2009-04-28 2016-01-05 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
US9314195B2 (en) 2009-08-31 2016-04-19 Abbott Diabetes Care Inc. Analyte signal processing device and methods
US9323898B2 (en) 2005-11-04 2016-04-26 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US9465420B2 (en) 2011-10-31 2016-10-11 Abbott Diabetes Care Inc. Electronic devices having integrated reset systems and methods thereof
US9532737B2 (en) 2011-02-28 2017-01-03 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
US9574914B2 (en) 2007-05-08 2017-02-21 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US12482558B2 (en) 2019-12-02 2025-11-25 Abbott Diabetes Care Inc. Medical devices and methods

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6853854B1 (en) 1998-09-18 2005-02-08 Q Step Technologies, Llc Noninvasive measurement system
US6650915B2 (en) 2001-09-13 2003-11-18 Fovioptics, Inc. Non-invasive measurement of blood analytes using photodynamics
DE10210436A1 (en) * 2002-03-09 2003-10-02 Michael Licht Determining the concentration of an analyte comprises irradiating a sample with polarized light through a magnetic field and measuring reflected/scattered light absorption as a function of polarization angle
US6895264B2 (en) 2002-08-26 2005-05-17 Fovioptics Inc. Non-invasive psychophysical measurement of glucose using photodynamics
US8066639B2 (en) 2003-06-10 2011-11-29 Abbott Diabetes Care Inc. Glucose measuring device for use in personal area network
GB2407378B (en) 2003-10-24 2006-09-06 Lein Applied Diagnostics Ltd Ocular property measuring apparatus and method therefor
GB2409033C (en) 2003-12-12 2006-05-24 Lein Applied Diagnostics Ltd Extended focal region measuring apparatus and method
CA2556331A1 (en) 2004-02-17 2005-09-29 Therasense, Inc. Method and system for providing data communication in continuous glucose monitoring and management system
US9788771B2 (en) 2006-10-23 2017-10-17 Abbott Diabetes Care Inc. Variable speed sensor insertion devices and methods of use
US8226891B2 (en) 2006-03-31 2012-07-24 Abbott Diabetes Care Inc. Analyte monitoring devices and methods therefor
CA2690742C (en) 2007-06-21 2018-05-15 Abbott Diabetes Care Inc. Health management devices and methods
GB2451443B (en) 2007-07-30 2012-12-26 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
GB2457302B (en) 2008-02-11 2013-04-10 Lein Applied Diagnostics Ltd Measurement apparatus and method therefor
US9402544B2 (en) 2009-02-03 2016-08-02 Abbott Diabetes Care Inc. Analyte sensor and apparatus for insertion of the sensor
WO2010138856A1 (en) 2009-05-29 2010-12-02 Abbott Diabetes Care Inc. Medical device antenna systems having external antenna configurations
AU2010286917B2 (en) 2009-08-31 2016-03-10 Abbott Diabetes Care Inc. Medical devices and methods
CN101852721B (en) * 2010-05-18 2012-06-27 南京邮电大学 Device for detecting concentration of transparent mixed solution with two solutes
US9636041B2 (en) * 2011-01-28 2017-05-02 Bar Ilan University Method and system for non-invasively monitoring biological or biochemical parameters of individual
WO2012101644A2 (en) 2011-01-28 2012-08-02 Bar Ilan University Method and system for non-invasively monitoring biological or biochemical parameters of individual
EP3677182B1 (en) 2011-11-07 2022-05-04 Abbott Diabetes Care Inc. Analyte monitoring device and methods
CN104736042B (en) 2012-08-01 2017-09-12 巴伊兰大学 Method and system for non-invasively monitoring a biological or biochemical parameter of an individual
US9968306B2 (en) 2012-09-17 2018-05-15 Abbott Diabetes Care Inc. Methods and apparatuses for providing adverse condition notification with enhanced wireless communication range in analyte monitoring systems
US8743355B2 (en) 2012-10-16 2014-06-03 K Sciences Gp, Llc Simple sugar concentration sensor and method
US10067054B2 (en) 2012-10-16 2018-09-04 K Sciences Gp, Llc Simple sugar concentration sensor and method
JP6332166B2 (en) * 2014-03-20 2018-05-30 富士ゼロックス株式会社 Optically active substance concentration calculation system and program
US9459201B2 (en) 2014-09-29 2016-10-04 Zyomed Corp. Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing
US11426100B1 (en) 2015-12-08 2022-08-30 Socrates Health Solutions, Inc. Blood glucose trend meter
US9554738B1 (en) 2016-03-30 2017-01-31 Zyomed Corp. Spectroscopic tomography systems and methods for noninvasive detection and measurement of analytes using collision computing
CN115444410B (en) 2017-01-23 2025-08-15 雅培糖尿病护理公司 Applicator and assembly for insertion into an in vivo analyte sensor
WO2020095296A1 (en) 2018-11-11 2020-05-14 Biobeat Technologies Ltd Wearable apparatus and method for monitoring medical properties
US10813578B1 (en) 2019-12-26 2020-10-27 Biobeat Technologies Ltd. Sensor device for optical measurement of biological properties
JP2023540275A (en) 2020-08-31 2023-09-22 アボット ダイアベティス ケア インコーポレイテッド Systems, devices, and methods for analyte sensor insertion

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5448992A (en) * 1992-12-10 1995-09-12 Sunshine Medical Instruments, Inc. Method and apparatus for non-invasive phase sensitive measurement of blood glucose concentration
US5685300A (en) * 1994-04-01 1997-11-11 Kuenstner; J. Todd Noninvasive and in-vitro measurement of glucose and cholesterol by nuclear magnetic resonance spectroscopy
US5788632A (en) * 1996-03-19 1998-08-04 Abbott Laboratories Apparatus and process for the non-invasive measurement of optically active compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5448992A (en) * 1992-12-10 1995-09-12 Sunshine Medical Instruments, Inc. Method and apparatus for non-invasive phase sensitive measurement of blood glucose concentration
US5685300A (en) * 1994-04-01 1997-11-11 Kuenstner; J. Todd Noninvasive and in-vitro measurement of glucose and cholesterol by nuclear magnetic resonance spectroscopy
US5788632A (en) * 1996-03-19 1998-08-04 Abbott Laboratories Apparatus and process for the non-invasive measurement of optically active compounds

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BROWNE A F ET AL: "MICRODEGREE POLARIMETRIC MEASUREMENT OF GLUCOSE CONCENTRATIONS FOR BIOTECHNOLOGY APLLICATIONS", DURHAM, NEW HAMPSHIRE, MAY 21 - 22, 1997,NEW YORK, IEEE,US, vol. CONF. 23, 21 May 1997 (1997-05-21), pages 9 - 10, XP000738103, ISBN: 0-7803-3849-9 *
JANG S ET AL: "OPTICAL GLUCOSE SENSOR USING A SINGLE FARADAY ROTATOR", DURHAM, NEW HAMPSHIRE, MAY 21 - 22, 1997,NEW YORK, IEEE,US, vol. CONF. 23, 21 May 1997 (1997-05-21), pages 11 - 12, XP000738104, ISBN: 0-7803-3849-9 *
JANG S. AND FOX M.: "Optical sensor using the magnetic optical rotatory effect of glucose", IEEE LEOS NEWSLETTERS, vol. 12, no. 2, April 1998 (1998-04-01), pages 28 - 30, XP002159449 *
JANG SUNGHOON AND FOX MARTIN D: "Double Lock-in Concept for MORE Clucose Detection", WEST HARTFORD, CT, APRIL 8 - 9, 1999,NEW YORK, NY: IEEE,US, 8 April 1999 (1999-04-08), pages 122 - 124, XP002155401, ISBN: 0-7803-5487-7 *

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6968222B2 (en) 2003-05-02 2005-11-22 Oculir, Inc. Methods and device for non-invasive analyte measurement
US6958039B2 (en) 2003-05-02 2005-10-25 Oculir, Inc. Method and instruments for non-invasive analyte measurement
US6975892B2 (en) 2003-10-21 2005-12-13 Oculir, Inc. Methods for non-invasive analyte measurement from the conjunctiva
US9323898B2 (en) 2005-11-04 2016-04-26 Abbott Diabetes Care Inc. Method and system for providing basal profile modification in analyte monitoring and management systems
US9095290B2 (en) 2007-03-01 2015-08-04 Abbott Diabetes Care Inc. Method and apparatus for providing rolling data in communication systems
US8937540B2 (en) 2007-04-14 2015-01-20 Abbott Diabetes Care Inc. Method and apparatus for providing dynamic multi-stage signal amplification in a medical device
US9402584B2 (en) 2007-04-14 2016-08-02 Abbott Diabetes Care Inc. Method and apparatus for providing dynamic multi-stage signal amplification in a medical device
US9177456B2 (en) 2007-05-08 2015-11-03 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US9035767B2 (en) 2007-05-08 2015-05-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US9314198B2 (en) 2007-05-08 2016-04-19 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US9000929B2 (en) 2007-05-08 2015-04-07 Abbott Diabetes Care Inc. Analyte monitoring system and methods
US9574914B2 (en) 2007-05-08 2017-02-21 Abbott Diabetes Care Inc. Method and device for determining elapsed sensor life
US9226701B2 (en) 2009-04-28 2016-01-05 Abbott Diabetes Care Inc. Error detection in critical repeating data in a wireless sensor system
US9314195B2 (en) 2009-08-31 2016-04-19 Abbott Diabetes Care Inc. Analyte signal processing device and methods
US8993331B2 (en) 2009-08-31 2015-03-31 Abbott Diabetes Care Inc. Analyte monitoring system and methods for managing power and noise
US9532737B2 (en) 2011-02-28 2017-01-03 Abbott Diabetes Care Inc. Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
US9465420B2 (en) 2011-10-31 2016-10-11 Abbott Diabetes Care Inc. Electronic devices having integrated reset systems and methods thereof
US12482558B2 (en) 2019-12-02 2025-11-25 Abbott Diabetes Care Inc. Medical devices and methods

Also Published As

Publication number Publication date
WO2000060350A2 (en) 2000-10-12
AU4063100A (en) 2000-10-23

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