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WO1998036061A3 - Reducing fibrosis and/or scarring by inhibiting interleukin-6 receptor-mediated activity - Google Patents

Reducing fibrosis and/or scarring by inhibiting interleukin-6 receptor-mediated activity Download PDF

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Publication number
WO1998036061A3
WO1998036061A3 PCT/GB1998/000319 GB9800319W WO9836061A3 WO 1998036061 A3 WO1998036061 A3 WO 1998036061A3 GB 9800319 W GB9800319 W GB 9800319W WO 9836061 A3 WO9836061 A3 WO 9836061A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
interleukin
scarring
mediated activity
inhibiting interleukin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/GB1998/000319
Other languages
French (fr)
Other versions
WO1998036061A2 (en
Inventor
Mark William James Ferguson
Sharon O'kane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Manchester
Original Assignee
Victoria University of Manchester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Victoria University of Manchester filed Critical Victoria University of Manchester
Priority to AU62203/98A priority Critical patent/AU6220398A/en
Publication of WO1998036061A2 publication Critical patent/WO1998036061A2/en
Publication of WO1998036061A3 publication Critical patent/WO1998036061A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Environmental Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present application relates to the use of agents which inhibit Interleukin-6 receptor mediated activity for the treatment of wounds and/or fibrotic disorders such that fibrosis and/or scarring are reduced or prevented. Preferred agents for use in such treatments include Interleukin-6 neutralising antibodies, Interleukin-6 Receptor antagonists and inhibitors of Interleukin-6 Receptor signal transduction.
PCT/GB1998/000319 1997-02-13 1998-02-13 Reducing fibrosis and/or scarring by inhibiting interleukin-6 receptor-mediated activity Ceased WO1998036061A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU62203/98A AU6220398A (en) 1997-02-13 1998-02-13 Reducing fibrosis and/or scarring by inhibiting interleukin-6 receptor-mediated activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9702944.1 1997-02-13
GBGB9702944.1A GB9702944D0 (en) 1997-02-13 1997-02-13 Reducing fibrosis

Publications (2)

Publication Number Publication Date
WO1998036061A2 WO1998036061A2 (en) 1998-08-20
WO1998036061A3 true WO1998036061A3 (en) 1998-11-12

Family

ID=10807559

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1998/000319 Ceased WO1998036061A2 (en) 1997-02-13 1998-02-13 Reducing fibrosis and/or scarring by inhibiting interleukin-6 receptor-mediated activity

Country Status (3)

Country Link
AU (1) AU6220398A (en)
GB (1) GB9702944D0 (en)
WO (1) WO1998036061A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945558B2 (en) 2005-10-21 2015-02-03 Chugai Seiyaku Kabushiki Kaisha Methods for treating myocardial infarction comprising administering an IL-6 inhibitor

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GB9818278D0 (en) * 1998-08-22 1998-10-14 Smith & Nephew Compositions
EP1129190B2 (en) 1998-11-13 2017-01-11 Immunex Corporation Human tslp dna and polypeptides
DK1717316T3 (en) * 2000-06-30 2008-12-08 Zymogenetics Inc Allelic variant of interferon-like protein Zcyto21
US7288633B2 (en) 2001-07-23 2007-10-30 Immunex Corporation Modified human thymic stromal lymphopoietin
AU2003290682A1 (en) * 2002-11-15 2004-06-15 Centocor, Inc. Anti-angiogenic uses of il-6 antagonists
CA2539061A1 (en) * 2003-09-22 2005-03-31 Biovation Gmbh & Co. Kg Use of an antagonist of il-6 for treating il-6-mediated diseases
US20060171943A1 (en) * 2005-02-01 2006-08-03 Amgen Inc. Compositions and methods of treating fibrotic disorders
RU2446826C2 (en) 2005-10-14 2012-04-10 Фукуока Юниверсити Agents for suppressing transplanted island damage following island transplantation
AR057582A1 (en) 2005-11-15 2007-12-05 Nat Hospital Organization AGENTS TO DELETE INDUCTION OF CYTOTOXIC T LYMPHOCYTES
CA2637917C (en) 2006-01-27 2015-11-24 Keio University Therapeutic agents for diseases involving choroidal neovascularization
US9260516B2 (en) 2006-04-07 2016-02-16 Osaka University Method for promoting muscle regeneration by administering an antibody to the IL-6 receptor
CA2657763C (en) 2006-08-03 2016-05-31 Vaccinex Inc. Anti-il-6 monoclonal antibodies and uses thereof
EP2123302B1 (en) 2007-01-23 2015-12-09 Shinshu University Il-6 inhibitors to treat chronic rejection
US7982016B2 (en) 2007-09-10 2011-07-19 Amgen Inc. Antigen binding proteins capable of binding thymic stromal lymphopoietin
KR101665729B1 (en) 2008-06-05 2016-10-12 국립연구개발법인 고쿠리츠간켄큐센터 Neuroinvasion inhibitor
DK2578231T3 (en) 2010-05-28 2022-12-12 Chugai Pharmaceutical Co Ltd ANTI-TUMOR T-CELL RESPONSE AMPLIFIER
WO2013106702A1 (en) 2012-01-13 2013-07-18 President And Fellows Of Harvard College Halofuginol derivatives and their use in cosmetic and pharmaceutical compositions
GB201522186D0 (en) 2015-12-16 2016-01-27 Singapore Health Services Pte Ltd And Nat University Of Singapore The Treatment of fibrosis
EP3555131B1 (en) 2016-12-16 2024-07-31 Singapore Health Services Pte Ltd Il-11 antibodies
GB201621439D0 (en) 2016-12-16 2017-02-01 Singapore Health Services Pte Ltd And Nat Univ Of Singapore IL-11Ra Antibodies
WO2018203545A1 (en) 2017-05-02 2018-11-08 国立研究開発法人国立精神・神経医療研究センター Method for predicting and evaluating therapeutic effect in diseases related to il-6 and neutrophils
CN111372599A (en) * 2017-07-19 2020-07-03 奥克兰联合服务有限公司 Cytokine regulation
US11692037B2 (en) 2017-10-20 2023-07-04 Hyogo College Of Medicine Anti-IL-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion
WO2019237125A1 (en) 2018-06-08 2019-12-12 The General Hospital Corporation Inhibitors of prolyl-trna-synthetase
EP3914621A1 (en) 2019-01-21 2021-12-01 Singapore Health Services Pte. Ltd. Treatment of hepatotoxicity
AU2022339767A1 (en) 2021-08-30 2024-04-11 Lassen Therapeutics, Inc. Anti-il-11rα antibodies
CN117338907A (en) * 2022-06-29 2024-01-05 华东师范大学 Application of IL-17D in scar prevention and treatment

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008474A2 (en) * 1990-11-20 1992-05-29 The National Heart & Lung Institute Treatment of lung diseases
EP0617126A2 (en) * 1993-02-17 1994-09-28 Ajinomoto Co., Inc. Polypeptide capable of inhibiting the binding bewteen human IL-6 and its receptor
WO1994025036A1 (en) * 1993-04-30 1994-11-10 Chugai Seiyaku Kabushiki Kaisha Expression inhibitor containing antisense oligonucleotide derivative against human interleukin-6 receptor
WO1996012503A1 (en) * 1994-10-21 1996-05-02 Chugai Seiyaku Kabushiki Kaisha Remedy for diseases caused by il-6 production
WO1996018648A1 (en) * 1994-12-14 1996-06-20 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Superagonists and antagonists of h il-6, and 3d modelling method for their selection
WO1997048728A1 (en) * 1996-06-20 1997-12-24 Koster, Henk, Wilhelmus Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992008474A2 (en) * 1990-11-20 1992-05-29 The National Heart & Lung Institute Treatment of lung diseases
EP0617126A2 (en) * 1993-02-17 1994-09-28 Ajinomoto Co., Inc. Polypeptide capable of inhibiting the binding bewteen human IL-6 and its receptor
WO1994025036A1 (en) * 1993-04-30 1994-11-10 Chugai Seiyaku Kabushiki Kaisha Expression inhibitor containing antisense oligonucleotide derivative against human interleukin-6 receptor
WO1996012503A1 (en) * 1994-10-21 1996-05-02 Chugai Seiyaku Kabushiki Kaisha Remedy for diseases caused by il-6 production
WO1996018648A1 (en) * 1994-12-14 1996-06-20 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Superagonists and antagonists of h il-6, and 3d modelling method for their selection
WO1997048728A1 (en) * 1996-06-20 1997-12-24 Koster, Henk, Wilhelmus Il-6 and il-6-receptor derived peptides having il-6 antagonistic or agonistic activity

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
R. SAVINO ET AL.: "Generation of interleukin-6 receptor antagonists by molecular-modeling guided mutagenesis of residues important for gp130 activation.", THE EMBO JOURNAL, vol. 13, no. 6, 15 March 1994 (1994-03-15), Oxford, GB, pages 1357 - 1367, XP000565719 *
T. TAGA ET AL.: "Functional inhibition of hematopoietic and neurotrophic cytokines by blocking the interleukin 6 signal transducer gp130.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE USA, vol. 89, no. 22, November 1992 (1992-11-01), Washinton, DC, USA, pages 10998 - 11001, XP002075302 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945558B2 (en) 2005-10-21 2015-02-03 Chugai Seiyaku Kabushiki Kaisha Methods for treating myocardial infarction comprising administering an IL-6 inhibitor

Also Published As

Publication number Publication date
AU6220398A (en) 1998-09-08
GB9702944D0 (en) 1997-04-02
WO1998036061A2 (en) 1998-08-20

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