[go: up one dir, main page]

UA91521C2 - Композиции, содержащие липазу, протеазу и амилазу, предназначенные для лечения недостаточности поджелудочной железы - Google Patents

Композиции, содержащие липазу, протеазу и амилазу, предназначенные для лечения недостаточности поджелудочной железы

Info

Publication number
UA91521C2
UA91521C2 UAA200705128A UAA200705128A UA91521C2 UA 91521 C2 UA91521 C2 UA 91521C2 UA A200705128 A UAA200705128 A UA A200705128A UA A200705128 A UAA200705128 A UA A200705128A UA 91521 C2 UA91521 C2 UA 91521C2
Authority
UA
Ukraine
Prior art keywords
pancreatic insufficiency
amylase
protease
compositions containing
treating pancreatic
Prior art date
Application number
UAA200705128A
Other languages
English (en)
Ukrainian (uk)
Inventor
Алексей Л. Марголин
Бхами К. Шеной
Фредерик Т. Мюррей
Энтони Кристофер Ли Стивенс
Original Assignee
Элтус Фармасьютикалз Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Элтус Фармасьютикалз Инк. filed Critical Элтус Фармасьютикалз Инк.
Publication of UA91521C2 publication Critical patent/UA91521C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/54—Mixtures of enzymes or proenzymes covered by more than a single one of groups A61K38/44 - A61K38/46 or A61K38/51 - A61K38/53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)

Abstract

Изобретение относится к композициям, предназначенным для лечения состояний, которые включают недостаточность поджелудочной железы. Композиции по данному изобретению включают липазу, протеазу и амилазу в определенном соотношении и обеспечивают благоприятные результаты у пациентов, как, например, пациентов, которые страдают от недостаточности поджелудочной железы.
UAA200705128A 2004-10-14 2005-10-14 Композиции, содержащие липазу, протеазу и амилазу, предназначенные для лечения недостаточности поджелудочной железы UA91521C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61876404P 2004-10-14 2004-10-14

Publications (1)

Publication Number Publication Date
UA91521C2 true UA91521C2 (ru) 2010-08-10

Family

ID=35840531

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200705128A UA91521C2 (ru) 2004-10-14 2005-10-14 Композиции, содержащие липазу, протеазу и амилазу, предназначенные для лечения недостаточности поджелудочной железы

Country Status (23)

Country Link
US (1) US7718169B2 (ru)
EP (2) EP1809320B1 (ru)
JP (1) JP4908420B2 (ru)
KR (1) KR101333664B1 (ru)
CN (1) CN101068565B (ru)
AT (1) ATE474592T1 (ru)
AU (1) AU2005295754B2 (ru)
BR (1) BRPI0516515B1 (ru)
CA (1) CA2584069C (ru)
CY (2) CY1110838T1 (ru)
DE (1) DE602005022471D1 (ru)
DK (2) DK2198880T3 (ru)
ES (2) ES2352086T3 (ru)
HR (1) HRP20161684T1 (ru)
HU (1) HUE031245T2 (ru)
LT (1) LT2198880T (ru)
MX (1) MX2007004534A (ru)
PL (2) PL1809320T3 (ru)
PT (2) PT1809320E (ru)
RU (1) RU2385736C2 (ru)
SI (2) SI1809320T1 (ru)
UA (1) UA91521C2 (ru)
WO (1) WO2006044529A1 (ru)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6632429B1 (en) 1999-12-17 2003-10-14 Joan M. Fallon Methods for treating pervasive development disorders
US20010046493A1 (en) * 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
US20070053895A1 (en) * 2000-08-14 2007-03-08 Fallon Joan M Method of treating and diagnosing parkinsons disease and related dysautonomic disorders
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US8030002B2 (en) 2000-11-16 2011-10-04 Curemark Llc Methods for diagnosing pervasive development disorders, dysautonomia and other neurological conditions
JP5032300B2 (ja) 2004-03-22 2012-09-26 アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング 界面活性剤を含有している、リパーゼを含有する生成物の、とりわけパンクレアチンの経口医薬組成物
EP1771194A2 (en) * 2004-07-07 2007-04-11 Biodevelops Pharma Entwicklung GmbH Use of a deubiquitinating compound for enhancing the expression of membrane proteins on the cell surface
US20060198838A1 (en) * 2004-09-28 2006-09-07 Fallon Joan M Combination enzyme for cystic fibrosis
EP2278002B1 (en) 2005-07-29 2017-07-12 Abbott Laboratories GmbH Pancreatin with reduced viral content
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US20080058282A1 (en) 2005-08-30 2008-03-06 Fallon Joan M Use of lactulose in the treatment of autism
US20070116695A1 (en) * 2005-09-21 2007-05-24 Fallon Joan M Pharmaceutical preparations for attention deficit disorder, attention deficit hyperactivity disorder and other associated disorders
WO2007053619A2 (en) 2005-11-01 2007-05-10 Bio-Cat, Inc. A composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrous as well as people suffering from pancreatic lipase insufficiency
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
BRPI0721103A2 (pt) 2006-12-21 2014-03-04 Novozymes As Lipase, método de determinação do desempenho da digestão in vitro de uma lipase em comparação com uma lipase de referência, uso de uma lipase ou de uma mistura de lipases, composição farmacêutica, e, método para o tratamento de doença
US20080199448A1 (en) * 2007-02-16 2008-08-21 Ross Mairi R Enzyme composition for improving food digestion
US8246950B2 (en) 2007-02-20 2012-08-21 Aptalis Pharma Limited Stable digestive enzyme compositions
RU2445952C2 (ru) * 2007-02-20 2012-03-27 Юранд Фармасьютикалз Лимитед Стабильные композиции пищеварительных ферментов
WO2009109856A2 (en) 2008-03-07 2009-09-11 Axcan Pharma Inc. Method for detecting infectious parvovirus in pharmaceutical preparations
US8658163B2 (en) 2008-03-13 2014-02-25 Curemark Llc Compositions and use thereof for treating symptoms of preeclampsia
US8084025B2 (en) * 2008-04-18 2011-12-27 Curemark Llc Method for the treatment of the symptoms of drug and alcohol addiction
US20090324730A1 (en) * 2008-06-26 2009-12-31 Fallon Joan M Methods and compositions for the treatment of symptoms of complex regional pain syndrome
US9320780B2 (en) 2008-06-26 2016-04-26 Curemark Llc Methods and compositions for the treatment of symptoms of Williams Syndrome
EP2318035B1 (en) * 2008-07-01 2019-06-12 Curemark, Llc Methods and compositions for the treatment of symptoms of neurological and mental health disorders
US10776453B2 (en) * 2008-08-04 2020-09-15 Galenagen, Llc Systems and methods employing remote data gathering and monitoring for diagnosing, staging, and treatment of Parkinsons disease, movement and neurological disorders, and chronic pain
EP2328609A1 (en) * 2008-08-26 2011-06-08 Cystic Fibrosis Foundation Therapeutics, Inc. Rapidly disintegrating tablets comprising lipase, amylase, and protease
EP2165717A1 (de) 2008-08-27 2010-03-24 Nordmark Arzneimittel GmbH & Co.KG Verfahren zur Verringerung der viralen und mikrobiellen Belastung feststoffhaltiger biologischer Extrakte
EP2328566A1 (en) * 2008-09-30 2011-06-08 DSM IP Assets B.V. Enzyme composition and application thereof in the treatment of pancreatic insufficiency
US20100092447A1 (en) 2008-10-03 2010-04-15 Fallon Joan M Methods and compositions for the treatment of symptoms of prion diseases
WO2010080830A1 (en) 2009-01-06 2010-07-15 Curemark Llc Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces
BRPI1007379B8 (pt) 2009-01-06 2022-07-19 Curemark Llc composições farmacêuticas para o tratamento ou prevenção de infecções orais por e. coli
AU2015252099B2 (en) * 2009-01-06 2017-08-10 Galenagen, Llc Compositions and methods for the treatment or prevention of staphylococcus aureus infections and for the eradication or reduction of staphylococcus aureus on surfaces
EP2391382B1 (de) * 2009-01-29 2014-06-04 Nordmark Arzneimittel GmbH & Co.KG Pharmazeutisches präparat enthaltend lipase bakteriellen ursprungs
US9056050B2 (en) 2009-04-13 2015-06-16 Curemark Llc Enzyme delivery systems and methods of preparation and use
WO2010130622A1 (en) * 2009-05-11 2010-11-18 Dsm Ip Assets B.V. Enzyme composition for the treatment of prancreatic insufficiency
EP2295039B2 (de) 2009-08-28 2022-10-26 Nordmark Pharma GmbH Verfahren zur Herstellung von Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und hiernach hergestellte Pankreatin-Pellets
US8784884B2 (en) * 2009-09-17 2014-07-22 Stephen Perrett Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency
AU2016216662B2 (en) * 2009-09-17 2017-09-07 Allergan Therapeutics LLC Pancreatic enzyme compositions and methods for treating pancreatitis and pancreatic insufficiency
US9511125B2 (en) 2009-10-21 2016-12-06 Curemark Llc Methods and compositions for the treatment of influenza
CA2783342A1 (en) * 2009-12-08 2011-06-16 Depomed, Inc. Gastric retentive pharmaceutical compositions for extended release of polypeptides
RU2429291C1 (ru) * 2009-12-28 2011-09-20 Российская Федерация, от имени которой выступает Министерство образования и науки Российской Федерации (Минобрнауки России) Пищеварительное средство на основе ферментов микробного происхождения
JP2011162491A (ja) * 2010-02-10 2011-08-25 Ezaki Glico Co Ltd 乾燥麹抽出物及びこれを用いた口腔用組成物
SE535296C2 (sv) 2010-09-08 2012-06-19 Anara Ab Mognad av mag-tarmkanalen
CN108187033A (zh) 2010-10-01 2018-06-22 阿普塔利斯制药有限公司 肠溶包衣的低强度胰脂肪酶制剂
FR2966734B1 (fr) 2010-10-29 2014-07-18 Max Rombi Composition comprenant au moins une enzyme proteolytique pour son utilisation pour empecher la synthese des triglycerides
EP2489349B1 (de) 2011-02-17 2014-05-28 Nordmark Arzneimittel GmbH & Co.KG Pankreatin-Pellets, insbesondere Pankreatin-Mikropellets, und Verfahren zu deren Herstellung
BR112013027034A8 (pt) 2011-04-21 2018-01-02 Curemark Llc "compostos para o tratamento de transtornos neuropsiquiátricos."
ES2558756T3 (es) 2011-08-08 2016-02-08 Aptalis Pharma Limited Método para la prueba de disolución de composiciones sólidas que contienen enzimas digestivas
US8268305B1 (en) 2011-09-23 2012-09-18 Bio-Cat, Inc. Method and compositions to reduce serum levels of triacylglycerides in human beings using a fungal lipase
NZ629943A (en) * 2012-02-17 2016-06-24 Alcresta Inc Methods, compositions, and devices for supplying dietary fatty acid needs
US10350278B2 (en) 2012-05-30 2019-07-16 Curemark, Llc Methods of treating Celiac disease
KR102198633B1 (ko) 2012-09-19 2021-01-05 그레스포 에이비 뇌기능 향상용 조성물
MX2015012078A (es) 2013-03-15 2016-04-15 Allergan Pharmaceuticals Internat Ltd Composicion que contiene enzimas digestivas y nutrientes adecuados para la administracion enteral.
US9861681B2 (en) 2013-04-18 2018-01-09 The United States of America as represented by the Secretary of the Army, on behalf of the United States Army Medical Research Institute of Infectious Diseases Therapeutic compositions for neutralizing type I interferons, and methods of use
US10184121B2 (en) 2013-06-28 2019-01-22 Allergan Pharmaceuticals International Limited Methods for removing viral contaminants from pancreatic extracts
JP2016527247A (ja) 2013-07-22 2016-09-08 アラガン ファーマシューティカルズ インターナショナル リミテッド 高力価パンクレアチン医薬組成物
WO2015069677A1 (en) 2013-11-05 2015-05-14 Aptalis Pharma Ltd. High potency pancreatin pharmaceutical compositions
EP3030257B1 (en) 2013-08-09 2020-02-19 Allergan Pharmaceuticals International Limited Digestive enzyme composition suitable for enteral administration
JP2014193909A (ja) * 2014-06-04 2014-10-09 Nordmark Arzneimittel Gmbh & Co Kg 医薬調製物
GB201501081D0 (en) 2015-01-22 2015-03-11 Cilian Ag Use of enzymes with a wide pH activity range as medicaments for promoting digestion
EP3267197B1 (en) * 2015-03-02 2020-09-16 Toray Industries, Inc. Method and kit for the detection of pancreatic dysfunction
DE102015114859A1 (de) * 2015-09-04 2017-03-09 Nordmark Arzneimittel Gmbh & Co. Kg Verwendung einer pharmazeutischen Zusammensetzung, enthaltend mindestens ein Verdauungsenzym, bei der künstlichen Ernährung
US10258590B2 (en) 2015-10-14 2019-04-16 Alcresta Therapeutics, Inc. Enteral feeding device and related methods of use
DE102017104472A1 (de) * 2017-03-03 2018-09-06 Nordmark Arzneimittel Gmbh & Co. Kg Schmelztablette enthaltend Burlulipase und daraus hergestellte pharmazeutische Zusammensetzung
WO2018191233A1 (en) 2017-04-10 2018-10-18 Curemark, Llc Compositions for treating addiction
US11045396B2 (en) 2017-08-17 2021-06-29 Alcresta Therapeutics, Inc. Devices and methods for the supplementation of a nutritional formula
FR3079146B1 (fr) 2018-03-23 2020-04-17 Karim Ioualalen Formulation gastroprotectrice de complexes d’enzymes permettant de restaurer la fonction digestive.
US11547745B1 (en) * 2018-08-23 2023-01-10 Vets Plus, Inc. Compositions and methods for treating pancreatic enzyme deficiencies in mammals
CA3152763A1 (en) 2019-08-30 2021-03-04 Codexis, Inc. Engineered lipase variants
WO2021202363A1 (en) * 2020-03-30 2021-10-07 Wall Jai Combined animal-derived and synthetically produced pancreatic enzyme replacement therapy
US11541009B2 (en) 2020-09-10 2023-01-03 Curemark, Llc Methods of prophylaxis of coronavirus infection and treatment of coronaviruses
WO2023056469A2 (en) * 2021-09-30 2023-04-06 Synspira Therapeutics, Inc. Engineered lipase enzymes, manufacture and use thereof
WO2025054130A1 (en) 2023-09-05 2025-03-13 The Regents Of The University Of California Enzymes for oxidizing beta-hydroxybutyrate (bhb), test strips, and sensors of using the same

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5017559B2 (ru) 1972-09-20 1975-06-21
JPS5428820Y2 (ru) * 1974-06-14 1979-09-14
GB1509866A (en) * 1975-06-10 1978-05-04 Johnson & Johnson Enteric coated digestive enzyme compositions
US4659667A (en) * 1985-02-26 1987-04-21 Miles Laboratories, Inc. Process to recover crystalline enzymes and crystalline enzymes produced thereby
DK154572C (da) * 1985-08-07 1989-04-24 Novo Industri As Enzymatisk detergentadditiv, detergent og fremgangsmaade til vask af tekstiler
JP3079276B2 (ja) * 1988-02-28 2000-08-21 天野製薬株式会社 組換え体ｄｎａ、それを含むシュードモナス属菌及びそれを用いたリパーゼの製造法
DE3808695A1 (de) * 1988-03-16 1989-10-05 Henkel Kgaa Fluessiges waschmittel
DE69004301T2 (de) 1989-03-08 1994-03-24 Simon Lodewijk Scharpe Mischung zur Behandlung der von exokrinen Insuffizienz der Bauchspeicheldrüse und die Verwendung der genannten Mischung.
ES2044718T3 (es) 1989-12-21 1994-01-01 Novo Nordisk As Preparacion que contiene enzimas y detergente que contiene dicha preparacion.
DK173590D0 (da) * 1990-06-06 1990-07-19 Novo Nordisk As Rekombinante terapeutiske lipaser
US5618710A (en) * 1990-08-03 1997-04-08 Vertex Pharmaceuticals, Inc. Crosslinked enzyme crystals
SK283185B6 (sk) 1990-08-03 2003-03-04 Vertex Pharmaceuticals Incorporated Zosietené kryštály proteínov, zariadenie ich obsahujúce a ich použitie
US5892013A (en) * 1990-09-13 1999-04-06 Novo Nordisk A/S Lipase variants
WO1993000924A1 (de) * 1991-07-01 1993-01-21 Basf Aktiengesellschaft Verwendung von lipasen zur herstellung von arzneimitteln
FI942907L (fi) * 1991-12-20 1994-06-17 Novo Nordisk As Menetelmä lipaasin valmistamiseksi
NZ253748A (en) * 1992-06-30 1997-06-24 Cortecs Ltd Use of enzymes especially proteolytic enzymes in the management or treatment of diarrhoea
DK154292D0 (da) * 1992-12-23 1992-12-23 Novo Nordisk As Nyt enzym
DK39693D0 (da) * 1993-04-02 1993-04-02 Novo Nordisk As Enzym
GB9403344D0 (en) * 1994-02-22 1994-04-13 Cortecs Ltd Medical application of bromelain
DE4408152A1 (de) * 1994-03-11 1995-09-14 Studiengesellschaft Kohle Mbh Immobilisierte Lipasen in hydrophoben Sol-Gel-Materialien
JP3851656B2 (ja) * 1994-05-04 2006-11-29 ジェネンコア インターナショナル インコーポレーテッド 改善された界面活性剤耐性を有するリパーゼ
EP0828509B1 (en) * 1995-05-31 2005-01-26 Medzyme N.V. Composition to improve digestibility and utilisation of nutrients
US5932212A (en) * 1996-05-24 1999-08-03 Altus Biologics, Inc. Crosslinked protein crystal formulations and their use as catalysts in organic solvents
US5750104A (en) * 1996-05-29 1998-05-12 Digestive Care Inc. High buffer-containing enteric coating digestive enzyme bile acid compositions and method of treating digestive disorders therewith
US6140475A (en) * 1997-04-11 2000-10-31 Altus Biologics Inc. Controlled dissolution crosslinked protein crystals
ES2306477T3 (es) 1997-09-05 2008-11-01 Altus Pharmaceuticals Inc. Cristales de glicoproteina reticulados por carbohidratos.
US6013680A (en) * 1997-10-21 2000-01-11 Amano Pharmaceutical Co., Ltd. Digestive enzyme-containing medicament
US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
WO1999055310A1 (en) 1998-04-27 1999-11-04 Altus Biologics Inc. Stabilized protein crystals, formulations containing them and methods of making them
US6156552A (en) * 1998-02-18 2000-12-05 Novo Nordisk A/S Lipase variants
US6042823A (en) * 1998-07-02 2000-03-28 Amano Pharmaceuticals Co., Ltd. Enzyme composition and use thereof
US20010046493A1 (en) * 2000-02-24 2001-11-29 Alex Margolin Lipase-containing composition and methods of use thereof
AR032392A1 (es) * 2001-01-19 2003-11-05 Solvay Pharm Gmbh Mezcla de enzimas, preparado farmaceutico y utilizacion de dicho preparado.

Also Published As

Publication number Publication date
US20060121017A1 (en) 2006-06-08
EP2198880B1 (en) 2016-11-23
PL2198880T3 (pl) 2017-04-28
MX2007004534A (es) 2007-11-08
CY1118597T1 (el) 2017-07-12
ES2614157T3 (es) 2017-05-29
PL1809320T3 (pl) 2011-11-30
CN101068565B (zh) 2010-11-17
BRPI0516515B1 (pt) 2018-05-29
RU2385736C2 (ru) 2010-04-10
AU2005295754A1 (en) 2006-04-27
AU2005295754A2 (en) 2010-09-02
EP1809320A1 (en) 2007-07-25
EP1809320B1 (en) 2010-07-21
ES2352086T3 (es) 2011-02-15
US7718169B2 (en) 2010-05-18
DE602005022471D1 (de) 2010-09-02
HUE031245T2 (en) 2017-06-28
AU2005295754B2 (en) 2010-09-09
KR101333664B1 (ko) 2013-11-28
DK1809320T3 (da) 2010-11-15
BRPI0516515A (pt) 2008-09-16
CA2584069A1 (en) 2006-04-27
LT2198880T (lt) 2017-02-27
EP2198880A1 (en) 2010-06-23
CA2584069C (en) 2017-02-07
PT1809320E (pt) 2010-10-25
KR20070074622A (ko) 2007-07-12
HK1109068A1 (en) 2008-05-30
JP4908420B2 (ja) 2012-04-04
WO2006044529A1 (en) 2006-04-27
CY1110838T1 (el) 2015-06-10
PT2198880T (pt) 2017-01-04
SI1809320T1 (sl) 2010-11-30
HRP20161684T1 (hr) 2017-02-24
CN101068565A (zh) 2007-11-07
DK2198880T3 (en) 2017-01-23
ATE474592T1 (de) 2010-08-15
JP2008516965A (ja) 2008-05-22
RU2007117728A (ru) 2008-11-20
SI2198880T1 (sl) 2017-02-28

Similar Documents

Publication Publication Date Title
UA91521C2 (ru) Композиции, содержащие липазу, протеазу и амилазу, предназначенные для лечения недостаточности поджелудочной железы
HUS2100051I1 (hu) Kompozíciók és eljárások sejtproliferációs rendellenességek kezelésére
MX342128B (es) Compuestos farmaceuticos.
MXPA06014510A (es) Composiciones y metodos para tratar trastornos inflamatorios.
MX2010009456A (es) Composicion detergente que comprende lipasa.
MX2010007564A (es) Composiciones de limpieza y/o tratamiento.
DE60330161D1 (de) Rifalazil zur behandlung von infektionen mit clostridium difficile
MX2022009759A (es) El uso de 1-(4-ciano-3-trifluorometil-fenil)-3-[7-(4-ciano-3-trifl uorometil-fenil)-6-tioxo-5-p-tolilo-5,7-diazaespiro[3.4]oct-8-ili deno]-tiourea.
TW200714283A (en) Method and composition for treating peripheral vascular diseases
IL190796A0 (en) Compositions and their uses for gene therapy of bone conditions
WO2006024018A3 (en) Compositions for treating nociceptive pain
SG164368A1 (en) Treatment of cancer
IL181629A0 (en) Compositions and methods for the diagnosis and tretment of tumor
IS2882B (is) Samsetning epóþílonhliðstæðna og virkra efna til efnameðferðar til þess að meðhöndla frumufjölgunarsjúkdóma
PH12012501372B1 (en) Proteasome inhibitors and methods of using the same
EP1670450A4 (en) PHARMACEUTICAL COMPOSITIONS AND METHOD OF USING LEVODOPA AND CARBIDOPA
MX2012001346A (es) Polipeptidos del factor ix modificados y usos de los mismos.
MX2009012920A (es) Compuestos heptaciclicos y usos farmaceuticos de los mismos para la prevencion y tratamiento de diabetes y sindrome metabolico.
MY177001A (en) Phenothiazine compounds for treating mild cognitive impairment
TW200714277A (en) Methods and compositions for altering cell fuction
IN2012DN00592A (ru)
TW200716088A (en) Formulations and methods for treating amyloidosis
WO2006069253A3 (en) Trefoil factors and methods of treating proliferation disorders using same
MY180681A (en) Compositions and methods for treatment of aortic fibrosis
ATE519504T1 (de) Chromatin-remodellierende substanzen zur erhöhung der expression von pdx-1 und förderung der zelldifferenzierung