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UA90259C2 - CRYSTALLINE FORMS OF [9S-(9,10,12)]-5,16-BIS[(ETHYLTHIO)METHYL]-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-fg:3',2',1'-kl]PYRROLO[3,4-i][1,6]BENZODIA-ZOCINE-10-CARBOXYLIC ACID METHYL ESTER (VARIANTS), SOLID FORM OF [9S-(9,10,12)]-5,16-BIS[(ETHYLTHIO)METHYL]-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-fg:3',2',1'-kl]PYRROLO[3,4-i][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID METHYL ESTER (VARIANTS), METHOD FOR THE TREATMENT OF NEURODEGENERATIVE DISEASE AND PARKINSON'S DISEASE - Google Patents

CRYSTALLINE FORMS OF [9S-(9,10,12)]-5,16-BIS[(ETHYLTHIO)METHYL]-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-fg:3',2',1'-kl]PYRROLO[3,4-i][1,6]BENZODIA-ZOCINE-10-CARBOXYLIC ACID METHYL ESTER (VARIANTS), SOLID FORM OF [9S-(9,10,12)]-5,16-BIS[(ETHYLTHIO)METHYL]-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-fg:3',2',1'-kl]PYRROLO[3,4-i][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID METHYL ESTER (VARIANTS), METHOD FOR THE TREATMENT OF NEURODEGENERATIVE DISEASE AND PARKINSON'S DISEASE

Info

Publication number
UA90259C2
UA90259C2 UAA200609568A UAA200609568A UA90259C2 UA 90259 C2 UA90259 C2 UA 90259C2 UA A200609568 A UAA200609568 A UA A200609568A UA A200609568 A UAA200609568 A UA A200609568A UA 90259 C2 UA90259 C2 UA 90259C2
Authority
UA
Ukraine
Prior art keywords
methyl
diindolo
ethylthio
pyrrolo
hexahydro
Prior art date
Application number
UAA200609568A
Other languages
Russian (ru)
Inventor
Майкл Харольд Рок
Де Диего Хейди Лопес
Ким Лассе Христенсен
Оле Нильсен
Аннерс Буур
Марк Хауэлз
Original Assignee
Х.Луннбек А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х.Луннбек А/С filed Critical Х.Луннбек А/С
Publication of UA90259C2 publication Critical patent/UA90259C2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Described are crystalline forms of the pharmaceutical compound "[9S-(9,10,12)]-5,16-is[(ethylthio)methyl]-2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester", as well as methods for their use and preparation.
UAA200609568A 2004-02-27 2005-02-24 CRYSTALLINE FORMS OF [9S-(9,10,12)]-5,16-BIS[(ETHYLTHIO)METHYL]-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-fg:3',2',1'-kl]PYRROLO[3,4-i][1,6]BENZODIA-ZOCINE-10-CARBOXYLIC ACID METHYL ESTER (VARIANTS), SOLID FORM OF [9S-(9,10,12)]-5,16-BIS[(ETHYLTHIO)METHYL]-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-fg:3',2',1'-kl]PYRROLO[3,4-i][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID METHYL ESTER (VARIANTS), METHOD FOR THE TREATMENT OF NEURODEGENERATIVE DISEASE AND PARKINSON'S DISEASE UA90259C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DKPA200400326 2004-02-27

Publications (1)

Publication Number Publication Date
UA90259C2 true UA90259C2 (en) 2010-04-26

Family

ID=36607170

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200609568A UA90259C2 (en) 2004-02-27 2005-02-24 CRYSTALLINE FORMS OF [9S-(9,10,12)]-5,16-BIS[(ETHYLTHIO)METHYL]-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-fg:3',2',1'-kl]PYRROLO[3,4-i][1,6]BENZODIA-ZOCINE-10-CARBOXYLIC ACID METHYL ESTER (VARIANTS), SOLID FORM OF [9S-(9,10,12)]-5,16-BIS[(ETHYLTHIO)METHYL]-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-fg:3',2',1'-kl]PYRROLO[3,4-i][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID METHYL ESTER (VARIANTS), METHOD FOR THE TREATMENT OF NEURODEGENERATIVE DISEASE AND PARKINSON'S DISEASE

Country Status (9)

Country Link
KR (1) KR20070012644A (en)
CN (1) CN100591685C (en)
AR (1) AR047821A1 (en)
CA (1) CA2762878C (en)
EA (1) EA200601566A1 (en)
ES (1) ES2397342T3 (en)
TW (1) TW200530254A (en)
UA (1) UA90259C2 (en)
ZA (1) ZA200606556B (en)

Also Published As

Publication number Publication date
KR20070012644A (en) 2007-01-26
CN100591685C (en) 2010-02-24
ES2397342T3 (en) 2013-03-06
CA2762878A1 (en) 2005-09-09
HK1102087A1 (en) 2007-11-02
EA200601566A1 (en) 2006-12-29
CN1922196A (en) 2007-02-28
AR047821A1 (en) 2006-02-22
CA2762878C (en) 2014-08-19
TW200530254A (en) 2005-09-16
ZA200606556B (en) 2008-02-27

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