UA81292C2 - Hiv replication inhibiting pyrimidines and triazines - Google Patents

Hiv replication inhibiting pyrimidines and triazines Download PDF

Info

Publication number: UA81292C2
Authority: UA; Ukraine
Prior art keywords: cyano; alkyl; halogen; optionally substituted; сно
Prior art date: 2003-06-02

Application number

UAA200508361A

Other languages

English (en)

Ukrainian (uk)

Inventor

Jan Heeres

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-02

Filing date

2004-02-20

Publication date

2007-12-25

2004-02-20 Application filed filed Critical

2004-02-20 Priority claimed from PCT/EP2004/050177 external-priority patent/WO2004074262A1/en

2007-12-25 Publication of UA81292C2 publication Critical patent/UA81292C2/uk

Links

230000010076 replication Effects 0.000 title abstract description 9
150000003918 triazines Chemical class 0.000 title description 8
230000002401 inhibitory effect Effects 0.000 title description 4
150000003230 pyrimidines Chemical class 0.000 title description 2
150000003839 salts Chemical class 0.000 claims abstract description 32
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
150000001875 compounds Chemical class 0.000 claims description 242
125000004093 cyano group Chemical group *C#N 0.000 claims description 171
-1 hydroxy, mercapto Chemical class 0.000 claims description 130
150000002367 halogens Chemical class 0.000 claims description 119
229910052736 halogen Inorganic materials 0.000 claims description 118
125000000217 alkyl group Chemical group 0.000 claims description 112
229910052739 hydrogen Inorganic materials 0.000 claims description 73
239000001257 hydrogen Substances 0.000 claims description 73
125000001424 substituent group Chemical group 0.000 claims description 71
229920006395 saturated elastomer Polymers 0.000 claims description 62
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 54
125000002619 bicyclic group Chemical group 0.000 claims description 50
125000002950 monocyclic group Chemical group 0.000 claims description 49
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 47
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 42
125000003118 aryl group Chemical group 0.000 claims description 31
125000003545 alkoxy group Chemical group 0.000 claims description 29
125000004448 alkyl carbonyl group Chemical group 0.000 claims description 28
150000002431 hydrogen Chemical class 0.000 claims description 28
125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 27
125000000623 heterocyclic group Chemical group 0.000 claims description 27
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 21
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 19
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 17
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 17
125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 14
125000002837 carbocyclic group Chemical group 0.000 claims description 14
125000003277 amino group Chemical group 0.000 claims description 12
XTFIVUDBNACUBN-UHFFFAOYSA-N 1,3,5-trinitro-1,3,5-triazinane Chemical compound [O-][N+](=O)N1CN([N+]([O-])=O)CN([N+]([O-])=O)C1 XTFIVUDBNACUBN-UHFFFAOYSA-N 0.000 claims description 10
239000012634 fragment Substances 0.000 claims description 10
125000000753 cycloalkyl group Chemical group 0.000 claims description 9
229910052799 carbon Inorganic materials 0.000 claims description 8
125000005843 halogen group Chemical group 0.000 claims description 8
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230000000996 additive effect Effects 0.000 claims description 3
AEMOLEFTQBMNLQ-SYJWYVCOSA-N (2s,3s,4s,5s,6r)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound O[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@@H]1O AEMOLEFTQBMNLQ-SYJWYVCOSA-N 0.000 claims description 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 2
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
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HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 5
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UAA200508361A 2003-06-02 2004-02-20 Hiv replication inhibiting pyrimidines and triazines UA81292C2 (en)

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US47501203P	2003-06-02	2003-06-02
PCT/EP2004/050177 WO2004074262A1 (en)	2003-02-20	2004-02-20	Hiv replication inhibiting pyrimidines and triazines

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UA81292C2 true UA81292C2 (en)	2007-12-25

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UAA200508325A UA81654C2 (ru)	2003-06-02	2004-02-20	Пиримидины и триазины, которые ингибируют репликацию вич

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UA (2)	UA81292C2 (ru)

2004
- 2004-02-20 UA UAA200508361A patent/UA81292C2/uk unknown
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