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RU2001111880A - COMPOSITIONS FOR ORAL ADMINISTRATION CONTAINING LUFENURON AND NITENPIRA FOR THE STRUGGLE AGAINST Fleas - Google Patents

COMPOSITIONS FOR ORAL ADMINISTRATION CONTAINING LUFENURON AND NITENPIRA FOR THE STRUGGLE AGAINST Fleas

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Publication number
RU2001111880A
RU2001111880A RU2001111880/15A RU2001111880A RU2001111880A RU 2001111880 A RU2001111880 A RU 2001111880A RU 2001111880/15 A RU2001111880/15 A RU 2001111880/15A RU 2001111880 A RU2001111880 A RU 2001111880A RU 2001111880 A RU2001111880 A RU 2001111880A
Authority
RU
Russia
Prior art keywords
hydrogen
alkyl
halogen
formula
fully halogenated
Prior art date
Application number
RU2001111880/15A
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Russian (ru)
Other versions
RU2233590C2 (en
Inventor
Оливье ТИНЕМБАРТ
Мишель ФРАНК
Жан СТЕФФАН
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2001111880A publication Critical patent/RU2001111880A/en
Application granted granted Critical
Publication of RU2233590C2 publication Critical patent/RU2233590C2/en

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Claims (7)

1. Ветеринарная композиция для борьбы с блохами, содержащая эффективное в отношении блох количество комбинации соединения формулы (I)1. Veterinary composition for combating fleas, containing an effective against fleas amount of a combination of a compound of formula (I)
Figure 00000001
Figure 00000001
 где R1 обозначает водород, С1-С6алкил или С3-С7циклоалкил;where R 1 represents hydrogen, C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl; R2 обозначает водород, С1-С6алкил или С3-С7циклоалкил;R 2 is hydrogen, C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl; R3 обозначает водород или С1-С6алкил;R 3 is hydrogen or C 1 -C 6 alkyl; А обозначает гетероциклил, который является незамещенным или замещен одним или несколькими одинаковыми или различными атомами галогена,And denotes heterocyclyl, which is unsubstituted or substituted by one or more identical or different halogen atoms, и соединения формулы (II)and compounds of formula (II)
Figure 00000002
Figure 00000002
 где Х обозначает галоген;where X is halogen; X1 обозначает водород или галоген;X 1 is hydrogen or halogen; Х2 обозначает водород или галоген;X 2 is hydrogen or halogen; Y обозначает частично или полностью галогенированный С1-С6алкил или полностью галогенированный С1-С6алкил, цепь которого включает атом кислорода, или частично или полностью галогенированный С2-С6алкенил;Y denotes partially or fully halogenated C 1 -C 6 alkyl or fully halogenated C 1 -C 6 alkyl, the chain of which includes an oxygen atom, or partially or fully halogenated C 2 -C 6 alkenyl; Y1 обозначает водород или галоген;Y 1 is hydrogen or halogen; Y2 обозначает водород или галоген;Y 2 represents hydrogen or halogen; Y3 обозначает водород или галоген;Y 3 is hydrogen or halogen; Z1 обозначает водород или С1-С3алкил;Z 1 is hydrogen or C 1 -C 3 alkyl; Z2 обозначает водород или С1-С3алкил,Z 2 is hydrogen or C 1 -C 3 alkyl, и физиологически приемлемый эксципиент для композиции.and a physiologically acceptable excipient for the composition. 2. Способ борьбы с блохами на домашних животных, предусматривающий системное введение комбинации по п.1 домашнему животному в количестве, которое является эффективным в отношении блох.2. A method for controlling fleas in domestic animals, comprising systemically administering the combination of claim 1 to a pet in an amount that is effective against fleas. 3. Способ по п.2, где комбинацию вводят пероральным путем.3. The method according to claim 2, where the combination is administered orally. 4. Способ по п.2, где соединение формулы (I) и соединение формулы (II) вводят в виде отдельных дозируемых форм, но одновременно друг с другом.4. The method according to claim 2, where the compound of formula (I) and the compound of formula (II) are administered as separate dosage forms, but simultaneously with each other. 5. Способ по п.2, где сначала вводят соединение формулы (I), затем производят обработку соединением формулы (II).5. The method according to claim 2, where the compound of formula (I) is first introduced, then the compound of formula (II) is treated. 6. Применение комбинации соединения формулы (I)6. The use of a combination of the compounds of formula (I)
Figure 00000003
Figure 00000003
 где R1 обозначает водород, С1-С6алкил или С3-С7циклоалкил;where R 1 represents hydrogen, C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl; R2 обозначает водород, C1-С6алкил или С3-С7циклоалкил;R 2 is hydrogen, C 1 -C 6 alkyl or C 3 -C 7 cycloalkyl; R3 обозначает водород или С1-С6алкил;R 3 is hydrogen or C 1 -C 6 alkyl; А обозначает гетероциклил, который является незамещенным или замещен одним или несколькими одинаковыми или различными атомами галогена,And denotes heterocyclyl, which is unsubstituted or substituted by one or more identical or different halogen atoms, и соединения формулы (II)and compounds of formula (II)
Figure 00000004
Figure 00000004
 где X обозначает галоген;where X is halogen; Х1 обозначает водород или галоген;X 1 is hydrogen or halogen; Х2 обозначает водород или галоген;X 2 is hydrogen or halogen; Y обозначает частично или полностью галогенированный С1-С6алкил или полностью галогенированный C1-С6алкил, цепь которого включает атом кислорода, или частично или полностью галогенированный С2-С6алкенил;Y denotes partially or fully halogenated C 1 -C 6 alkyl or fully halogenated C 1 -C 6 alkyl, the chain of which includes an oxygen atom, or partially or fully halogenated C 2 -C 6 alkenyl; Y1 обозначает водород или галоген;Y 1 is hydrogen or halogen; Y2 обозначает водород или галоген;Y 2 represents hydrogen or halogen; Y3 обозначает водород или галоген;Y 3 is hydrogen or halogen; Z1 обозначает водород или С1-С3алкил;Z 1 is hydrogen or C 1 -C 3 alkyl; Z2 обозначает водород или С1-С3алкил,Z 2 is hydrogen or C 1 -C 3 alkyl, для приготовления ветеринарной композиции, предназначенной для борьбы с блохами на домашних животных.for the preparation of a veterinary composition intended for controlling fleas in domestic animals. 7. Применение ветеринарной композиции по п.1 или содержащейся в ней комбинации действующих веществ для борьбы с блохами на домашних животных.7. The use of the veterinary composition according to claim 1 or the combination of active substances contained therein for controlling fleas in domestic animals.
RU2001111880/15A 1998-10-09 1999-10-07 Veterinary combination and method for flea control RU2233590C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH204198 1998-10-09
CH2041/98 1998-10-09

Publications (2)

Publication Number Publication Date
RU2001111880A true RU2001111880A (en) 2004-04-20
RU2233590C2 RU2233590C2 (en) 2004-08-10

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RU2001111880/15A RU2233590C2 (en) 1998-10-09 1999-10-07 Veterinary combination and method for flea control

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US (2) US20020058683A1 (en)
EP (1) EP1119256B1 (en)
JP (1) JP2002527362A (en)
KR (1) KR20010075604A (en)
CN (1) CN1323161A (en)
AT (1) ATE241908T1 (en)
AU (1) AU757825B2 (en)
BR (1) BR9914365A (en)
CA (1) CA2345132A1 (en)
DE (1) DE69908626T2 (en)
DK (1) DK1119256T3 (en)
ES (1) ES2201775T3 (en)
NZ (1) NZ510846A (en)
PT (1) PT1119256E (en)
RU (1) RU2233590C2 (en)
WO (1) WO2000021371A1 (en)
ZA (1) ZA200102715B (en)

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