PT2380874T - Compostos orgânicos - Google Patents

Compostos orgânicos

Info

Publication number: PT2380874T
Authority: PT; Portugal
Prior art keywords: alkyl; cycloalkyl; atom; organic compounds; proviso
Prior art date: 2007-03-20

Application number

PT110058633T

Other languages

English (en)

Portuguese (pt)

Inventor

Riedl Rosemarie

Heilmayer Werner

Badegruber Rudolf

Strickmann Dirk

Novak Rodger

Ferencic Matthias

Rama Chandra Murty Bulusu Atchyuta

Original Assignee

Nabriva Therapeutics Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-20

Filing date

2008-03-19

Publication date

2017-04-03

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38668870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT2380874(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-03-19 Application filed by Nabriva Therapeutics Ag filed Critical Nabriva Therapeutics Ag

2017-04-03 Publication of PT2380874T publication Critical patent/PT2380874T/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/61—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/72—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 spiro-condensed with carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/93—Spiro compounds
- C07C2603/95—Spiro compounds containing "not free" spiro atoms
- C07C2603/98—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members
- C07C2603/99—Spiro compounds containing "not free" spiro atoms containing at least one ring with more than six ring members containing eight-membered rings

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Emergency Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Dermatology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Peptides Or Proteins (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

PT110058633T 2007-03-20 2008-03-19 Compostos orgânicos PT2380874T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP07450053A EP1972618A1 (en)	2007-03-20	2007-03-20	Pleuromutilin derivatives for the treatment of diseases mediated by microbes

Publications (1)

Publication Number	Publication Date
PT2380874T true PT2380874T (pt)	2017-04-03

Family

ID=38668870

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
PT08714294T PT2137143E (pt)	2007-03-20	2008-03-19	Derivados de pleuromutilina para o tratamento de doenças mediadas por micróbios
PT110058633T PT2380874T (pt)	2007-03-20	2008-03-19	Compostos orgânicos

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
PT08714294T PT2137143E (pt)	2007-03-20	2008-03-19	Derivados de pleuromutilina para o tratamento de doenças mediadas por micróbios

Country Status (31)

Country	Link
US (12)	US20090118366A1 (uk)
EP (3)	EP1972618A1 (uk)
JP (2)	JP5479114B2 (uk)
KR (1)	KR101478593B1 (uk)
CN (2)	CN104211624B (uk)
AT (1)	ATE523486T1 (uk)
AU (1)	AU2008229609B2 (uk)
BR (1)	BRPI0809023B8 (uk)
CA (1)	CA2678795C (uk)
CY (2)	CY1117482T1 (uk)
DK (2)	DK2137143T3 (uk)
EA (1)	EA018707B1 (uk)
ES (2)	ES2620459T3 (uk)
FI (1)	FIC20200038I1 (uk)
HR (1)	HRP20110869T1 (uk)
HU (1)	HUS2100001I1 (uk)
IL (1)	IL200440A (uk)
LT (1)	LTC2137143I2 (uk)
MA (1)	MA31314B1 (uk)
MY (1)	MY148916A (uk)
NL (1)	NL301086I2 (uk)
NO (1)	NO2021002I1 (uk)
NZ (1)	NZ579011A (uk)
PL (1)	PL2137143T3 (uk)
PT (2)	PT2137143E (uk)
SI (1)	SI2137143T1 (uk)
TN (1)	TN2009000347A1 (uk)
TW (1)	TWI406657B (uk)
UA (1)	UA97836C2 (uk)
WO (1)	WO2008113089A1 (uk)
ZA (1)	ZA200905590B (uk)

Families Citing this family (29)

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US8617015B2 (en)	2005-09-27	2013-12-31	Wick Werks, LLC	Bicycle chain rings
US8092329B2 (en)	2005-08-31	2012-01-10	Wick Werks, LLC	Bicycle chain rings with ramps
EP1808431A1 (en) *	2006-01-16	2007-07-18	Nabriva Therapeutics Forschungs GmbH	Mutilin derivatives and their use as pharmaceutical
EP1972618A1 (en)	2007-03-20	2008-09-24	Nabriva Therapeutics AG	Pleuromutilin derivatives for the treatment of diseases mediated by microbes
EP2159220A1 (en) *	2008-09-02	2010-03-03	Nabriva Therapeutics AG	Organic compounds
US20100184987A1 (en) *	2008-11-13	2010-07-22	Teva Pharmaceutical Industries Ltd.	Preparation of Retapamulin via its Pleuromutilin-thiol precursor
EP2399904A1 (en)	2010-05-26	2011-12-28	Nabriva Therapeutics AG	Process for the preparation of pleuromutilins
EP2390245A1 (en) *	2010-05-26	2011-11-30	Nabriva Therapeutics AG	Enantiomerically pure amines
EP2433926A1 (en) *	2010-09-09	2012-03-28	Nabriva Therapeutics AG	Pleuromutilin derivatives for use in the treatment of diseases mediated by microbes
EP2731933B1 (de)	2011-07-15	2015-09-30	Bayer Intellectual Property GmbH	2,3-diphenyl-valeronitrilderivate, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren
CN103265487A (zh) *	2013-06-05	2013-08-28	北京理工大学	截短侧耳素扩环衍生物及其制备方法和用途
CN104803911B (zh) *	2014-01-23	2018-01-05	中国科学院上海药物研究所	一类截短侧耳素化合物、其药物组合物、合成方法与用途
ES2553929B1 (es) *	2014-06-11	2016-09-26	Antonio Javier MORENO CASTRO	Dispositivo de modificación/destrucción selectiva de tejidos orgánicos
UA121240C2 (uk)	2015-06-17	2020-04-27	Набріва Терапютикс Гмбх	Ін'єкційна фармацевтична композиція лефамуліну
DK3106148T3 (en)	2015-06-18	2018-05-07	Mithra Pharmaceuticals S A	Orodispersible dosing unit containing an estetrol component
SMT202200102T1 (it)	2015-06-18	2022-05-12	Estetra Srl	Unità di dosaggio orodispersibile contenente un componente di estetrolo
TWI762573B (zh)	2017-02-10	2022-05-01	奧地利商納畢瓦治療有限責任公司	截短側耳素之純化
TWI801561B (zh)	2018-04-19	2023-05-11	比利時商依思特拉私人有限責任公司	化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar)	2018-04-19	2019-10-19	Estetra Sprl	مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
CN111170911A (zh) *	2019-09-29	2020-05-19	安帝康（无锡）生物科技有限公司	用于治疗细菌感染性疾病的截短侧耳素类化合物
CN111170893B (zh) *	2020-01-19	2022-04-26	郑州依米花手性药物研究有限公司	Lefamulin的中间体化合物及其在Lefamulin制备中的应用
TWI893101B (zh)	2020-04-16	2025-08-11	比利時商埃斯特拉有限責任公司	具有降低之副作用之避孕組成物
EP4135682A1 (en) *	2020-04-17	2023-02-22	Nabriva Therapeutics GMBH	Therapeutic use of pleuromutilins
WO2021209173A1 (en)	2020-04-17	2021-10-21	Nabriva Therapeutics GmbH	Novel therapeutic use of pleuromutilins
WO2021209596A1 (en)	2020-04-17	2021-10-21	Nabriva Therapeutics GmbH	Therapeutic use of pleuromutilins
US20240208989A1 (en) *	2021-04-16	2024-06-27	Nabriva Therapeutics GmbH	Novel 12-epi-mutilin compounds and uses thereof
EP4475834A1 (en)	2022-02-09	2024-12-18	Nabriva Therapeutics GMBH	Lefamulin and its derivatives for use in the treatment of a spiral shaped bacteria
EP4338732A1 (en)	2022-09-16	2024-03-20	Nabriva Therapeutics GMBH	Lefamulin and its derivatives for use in the treatment of tularemia
WO2025081213A1 (en)	2023-10-21	2025-04-24	Ariva Med Gmbh	NOVEL USES OF 12-EPI-MUTILIN COMPOUNDs

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US4130709A (en) *	1977-12-08	1978-12-19	Eli Lilly And Company	Pleuromutilin glycoside derivatives
DE4023848C2 (de)	1990-07-27	1994-04-21	Huels Chemische Werke Ag	Verfahren zur Herstellung von 3-C¶1¶- bis C¶6¶-Alkoxycarbonylcyclohexanpropionsäureestern
GB9918037D0 (en) *	1999-07-30	1999-09-29	Biochemie Gmbh	Organic compounds
GB0017031D0 (en) *	2000-07-11	2000-08-30	Biochemie Gmbh	Antimicrobials
GB0207495D0 (en)	2002-03-28	2002-05-08	Biochemie Gmbh	Organic compounds
GB0209262D0 (en)	2002-04-23	2002-06-05	Biochemie Gmbh	Organic compounds
RU2005105576A (ru) *	2002-07-24	2005-10-10	Сандоз АГ (CH)	Производные плевромутилина в качестве противомикроюных средств
GB0513058D0 (en) *	2005-06-27	2005-08-03	Sandoz Ag	Organic compounds
WO2007000004A1 (en) *	2005-06-27	2007-01-04	Nabriva Therapeutics Forschungs Gmbh	Pleuromutilin derivatives containing a hydroxyamino- or acyloxyaminocycloalkyl group
GB0515995D0 (en) *	2005-08-03	2005-09-07	Sandoz Ag	Organic compounds
EP1972618A1 (en)	2007-03-20	2008-09-24	Nabriva Therapeutics AG	Pleuromutilin derivatives for the treatment of diseases mediated by microbes

2007
- 2007-03-20 EP EP07450053A patent/EP1972618A1/en not_active Withdrawn
- 2007-07-25 US US11/828,224 patent/US20090118366A1/en not_active Abandoned
2008
- 2008-03-19 HR HR20110869T patent/HRP20110869T1/hr unknown
- 2008-03-19 NZ NZ579011A patent/NZ579011A/en unknown
- 2008-03-19 SI SI200830451T patent/SI2137143T1/sl unknown
- 2008-03-19 AU AU2008229609A patent/AU2008229609B2/en active Active
- 2008-03-19 CN CN201410406131.XA patent/CN104211624B/zh active Active
- 2008-03-19 CA CA2678795A patent/CA2678795C/en active Active
- 2008-03-19 WO PCT/AT2008/000097 patent/WO2008113089A1/en not_active Ceased
- 2008-03-19 BR BRPI0809023A patent/BRPI0809023B8/pt active IP Right Grant
- 2008-03-19 PT PT08714294T patent/PT2137143E/pt unknown
- 2008-03-19 PT PT110058633T patent/PT2380874T/pt unknown
- 2008-03-19 PL PL08714294T patent/PL2137143T3/pl unknown
- 2008-03-19 ES ES11005863.3T patent/ES2620459T3/es active Active
- 2008-03-19 ES ES08714294T patent/ES2375503T3/es active Active
- 2008-03-19 CN CN200880007780.5A patent/CN101668738B/zh active Active
- 2008-03-19 KR KR1020097018920A patent/KR101478593B1/ko active Active
- 2008-03-19 ZA ZA200905590A patent/ZA200905590B/xx unknown
- 2008-03-19 EP EP08714294A patent/EP2137143B1/en active Active
- 2008-03-19 MY MYPI20093722A patent/MY148916A/en unknown
- 2008-03-19 DK DK08714294.9T patent/DK2137143T3/da active
- 2008-03-19 US US12/531,839 patent/US8071643B2/en active Active
- 2008-03-19 EP EP11005863.3A patent/EP2380874B1/en active Active
- 2008-03-19 EA EA200970868A patent/EA018707B1/ru unknown
- 2008-03-19 UA UAA200910582A patent/UA97836C2/uk unknown
- 2008-03-19 AT AT08714294T patent/ATE523486T1/de active
- 2008-03-19 JP JP2009553863A patent/JP5479114B2/ja active Active
- 2008-03-19 DK DK11005863.3T patent/DK2380874T3/en active
- 2008-03-20 TW TW097109871A patent/TWI406657B/zh active
2009
- 2009-08-17 IL IL200440A patent/IL200440A/en active IP Right Grant
- 2009-08-19 TN TNP2009000347A patent/TN2009000347A1/fr unknown
- 2009-10-15 MA MA32283A patent/MA31314B1/fr unknown
2011
- 2011-10-04 US US13/252,732 patent/US8153689B2/en active Active
- 2011-12-02 CY CY20111101198T patent/CY1117482T1/el unknown
2012
- 2012-04-03 US US13/438,160 patent/US20130040954A1/en not_active Abandoned
2014
- 2014-02-12 JP JP2014024500A patent/JP5893651B2/ja active Active
- 2014-05-21 US US14/283,734 patent/US20140256731A1/en not_active Abandoned
2017
- 2017-04-06 US US15/480,756 patent/US20170266194A1/en not_active Abandoned
2018
- 2018-06-29 US US16/023,880 patent/US20180303842A1/en not_active Abandoned
2019
- 2019-02-15 US US16/277,143 patent/US20190175603A1/en not_active Abandoned
- 2019-10-04 US US16/593,449 patent/US20200030335A1/en not_active Abandoned
2020
- 2020-05-22 US US16/881,117 patent/US20200281933A1/en not_active Abandoned
- 2020-09-16 CY CY2020032C patent/CY2020032I1/el unknown
- 2020-10-01 FI FIC20200038C patent/FIC20200038I1/fi unknown
- 2020-10-22 LT LTPA2020531C patent/LTC2137143I2/lt unknown
- 2020-12-30 US US17/138,097 patent/US20210113571A1/en not_active Abandoned
2021
- 2021-01-04 NL NL301086C patent/NL301086I2/nl unknown
- 2021-01-12 HU HUS2100001C patent/HUS2100001I1/hu unknown
- 2021-01-15 NO NO2021002C patent/NO2021002I1/no unknown
2022
- 2022-03-23 US US17/702,304 patent/US20220218713A1/en not_active Abandoned

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EP2137143A1 (en)	2009-12-30
ES2620459T3 (es)	2017-06-28
CA2678795A1 (en)	2008-09-25
US8071643B2 (en)	2011-12-06
DK2137143T3 (da)	2012-01-02
CN101668738A (zh)	2010-03-10
EP2137143B1 (en)	2011-09-07
JP5893651B2 (ja)	2016-03-23
IL200440A0 (en)	2010-04-29
PL2137143T3 (pl)	2012-02-29
KR20090123882A (ko)	2009-12-02
UA97836C2 (uk)	2012-03-26
US20170266194A1 (en)	2017-09-21
US20200281933A1 (en)	2020-09-10
CY2020032I2 (el)	2020-11-25
BRPI0809023A2 (pt)	2014-09-23
BRPI0809023B8 (pt)	2021-05-25
TN2009000347A1 (fr)	2010-12-31
BRPI0809023B1 (pt)	2020-12-01
AU2008229609B2 (en)	2012-03-29
CN104211624B (zh)	2017-12-15
TW200904402A (en)	2009-02-01
US20130040954A1 (en)	2013-02-14
CY2020032I1 (el)	2020-11-25
HK1140185A1 (en)	2010-10-08
HUS2100001I1 (hu)	2021-03-01
LTPA2020531I1 (lt)	2020-11-10
JP2014159416A (ja)	2014-09-04
AU2008229609A1 (en)	2008-09-25
US20090118366A1 (en)	2009-05-07
KR101478593B1 (ko)	2015-01-02
NL301086I2 (nl)	2021-01-28
NO2021002I1 (no)	2021-01-15
US20210113571A1 (en)	2021-04-22
US8153689B2 (en)	2012-04-10
FIC20200038I1 (fi)	2020-10-01
ES2375503T3 (es)	2012-03-01
MA31314B1 (fr)	2010-04-01
HRP20110869T1 (hr)	2011-12-31
US20200030335A1 (en)	2020-01-30
EA200970868A1 (ru)	2010-02-26
US20100035987A1 (en)	2010-02-11
CA2678795C (en)	2014-11-18
ZA200905590B (en)	2010-10-27
US20120029072A1 (en)	2012-02-02
MY148916A (en)	2013-06-14
US20140256731A1 (en)	2014-09-11
EP2380874A3 (en)	2011-12-07
IL200440A (en)	2013-09-30
US20190175603A1 (en)	2019-06-13
ATE523486T1 (de)	2011-09-15
EP2380874B1 (en)	2016-12-28
NZ579011A (en)	2011-03-31
DK2380874T3 (en)	2017-03-27
EP2380874A2 (en)	2011-10-26
LTC2137143I2 (lt)	2023-10-10
EA018707B1 (ru)	2013-10-30
CN101668738B (zh)	2014-10-15
US20220218713A1 (en)	2022-07-14
TWI406657B (zh)	2013-09-01
JP2010522143A (ja)	2010-07-01
PT2137143E (pt)	2011-12-22
CN104211624A (zh)	2014-12-17
US20180303842A1 (en)	2018-10-25
JP5479114B2 (ja)	2014-04-23
SI2137143T1 (sl)	2012-01-31
EP1972618A1 (en)	2008-09-24
CY1117482T1 (el)	2017-04-26
WO2008113089A1 (en)	2008-09-25

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BR112012027373A2 (pt)	2015-09-15	composição pesticida e seu uso
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TN2010000062A1 (en)	2011-09-26	Pyrrolidin -2-one derivatives as androgen receptor modulator
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