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PE20110071A1 - Anticuerpos anti-mcp-1, composiciones y metodos - Google Patents

Anticuerpos anti-mcp-1, composiciones y metodos

Info

Publication number
PE20110071A1
PE20110071A1 PE2010000028A PE2010000028A PE20110071A1 PE 20110071 A1 PE20110071 A1 PE 20110071A1 PE 2010000028 A PE2010000028 A PE 2010000028A PE 2010000028 A PE2010000028 A PE 2010000028A PE 20110071 A1 PE20110071 A1 PE 20110071A1
Authority
PE
Peru
Prior art keywords
prevention
mcp
antibodies
compositions
methods
Prior art date
Application number
PE2010000028A
Other languages
English (en)
Inventor
Raymond Sweet
Ping Tsui
Michael Bardroff
Anuk Das
Original Assignee
Centocor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centocor Inc filed Critical Centocor Inc
Publication of PE20110071A1 publication Critical patent/PE20110071A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

SE REFIERE A UN ANTICUERPO MONOCLONAL HUMANO QUE COMPRENDE: A) UNA SECUENCIA VARIABLE DE CADENA PESADA SEC. ID. Nº 27; B) UNA SECUENCIA DE CADENA LIVIANA SEC. ID. Nº 28. DICHO ANTICUERPO SE UNE A LA PROTEINA QUIMIOATRACTIVA MONOCICLICA HUMANA (MCP-1) INVOLUCRADA EN LA TRANSMIGRACION PERIVASCULAR Y EN LA ACUMULACION DE LEUCOCITOS EN LOS TEJIDOS DANADOS, POR LO QUE DICHO ANTICUERPO PUEDE UTILIZARSE PARA AYUDAR A PREVENIR LA INCIDENCIA DE ENFERMEDADES INMUNITARIAS, CARDIOVASCULARES, DESORDENES NEUROLOGICOS O INFECCIONES RELACIONADOS CON MCP-1
PE2010000028A 2005-05-19 2006-05-18 Anticuerpos anti-mcp-1, composiciones y metodos PE20110071A1 (es)

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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5379692B2 (ja) 2006-11-09 2013-12-25 プロビオドルグ エージー 潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての３−ヒドロキシ−１，５−ジヒドロ−ピロール−２−オン誘導体
EP2091948B1 (en) 2006-11-30 2012-04-18 Probiodrug AG Novel inhibitors of glutaminyl cyclase
EP2117540A1 (en) 2007-03-01 2009-11-18 Probiodrug AG New use of glutaminyl cyclase inhibitors
WO2008128985A1 (en) 2007-04-18 2008-10-30 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
AU2008269954A1 (en) * 2007-06-29 2009-01-08 Centocor Ortho Biotech Inc. Anti- MCP-1 antibodies, compositions, methods and uses
JP5819194B2 (ja) 2008-08-20 2015-11-18 プロビオドルグ エージー ピログルタミン酸化単球走化性タンパク質−１（ＭＣＰ−１Ｎ１ｐＥ）に対する抗体
WO2011029920A1 (en) 2009-09-11 2011-03-17 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
WO2011107530A2 (en) 2010-03-03 2011-09-09 Probiodrug Ag Novel inhibitors
ES2481823T3 (es) 2010-03-10 2014-07-31 Probiodrug Ag Inhibidores heterocíclicos de glutaminil ciclasa (QC, EC 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
IN2014DN09951A (es) * 2012-05-22 2015-08-14 Shire Human Genetic Therapies
EP2727944A1 (en) * 2012-10-30 2014-05-07 Universitätsklinikum Regensburg Depletion of CCR2-positive monocytes for the treatment of inflammatory conditions in the gastrointestinal system
WO2015126898A1 (en) 2014-02-18 2015-08-27 Dignity Health Lkb1 related diagnostics and treatments of cancer
ES2764840T3 (es) 2015-01-28 2020-06-04 Univ Bordeaux Uso de plerixafor para tratar y/o prevenir exacerbaciones agudas de la enfermedad pulmonar obstructiva crónica
US20200306283A1 (en) 2016-06-22 2020-10-01 William Warren HARLESS Cancer treatment and metastasis inhibition using an anti-cancer stem cell agent in combination with a neu1 sialidase inhibitor or a cytokine inhibitor after primary cancer treatment
EP3461819B1 (en) 2017-09-29 2020-05-27 Probiodrug AG Inhibitors of glutaminyl cyclase
CN114072173A (zh) 2019-04-17 2022-02-18 国立大学法人广岛大学 以联合施用il-6抑制剂和ccr2抑制剂为特征的泌尿系统癌症治疗剂
MX2022007479A (es) 2019-12-18 2022-06-29 Hoffmann La Roche Anticuerpos anti-ccl2 biespecificos.
CN112358547A (zh) * 2020-09-30 2021-02-12 浙江大学 抗人cxcl-2单克隆抗体3-d3及其编码基因和应用
CN114990073A (zh) * 2022-05-27 2022-09-02 河南农业大学 一种抗猪ccl2蛋白的单克隆抗体及其制备方法和应用

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986005807A1 (en) 1985-04-01 1986-10-09 Celltech Limited Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
EP0368684B2 (en) 1988-11-11 2004-09-29 Medical Research Council Cloning immunoglobulin variable domain sequences.
US5266491A (en) 1989-03-14 1993-11-30 Mochida Pharmaceutical Co., Ltd. DNA fragment and expression plasmid containing the DNA fragment
US5427908A (en) 1990-05-01 1995-06-27 Affymax Technologies N.V. Recombinant library screening methods
WO1991018980A1 (en) 1990-06-01 1991-12-12 Cetus Corporation Compositions and methods for identifying biologically active molecules
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
WO1992005258A1 (en) 1990-09-20 1992-04-02 La Trobe University Gene encoding barley enzyme
US5270170A (en) 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
DE4436420C5 (de) 1994-10-12 2009-04-02 Daimler Ag Mittelkonsole für ein Kraftfahrzeug
US6019968A (en) 1995-04-14 2000-02-01 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
KR100589926B1 (ko) 1997-09-29 2006-06-15 넥타르 테라퓨틱스 천공된 미립자 및 사용 방법
GB0016138D0 (en) * 2000-06-30 2000-08-23 Novartis Ag Organic compounds
EP1408873B1 (en) 2001-06-27 2016-03-09 Salviac Limited A catheter
EP1461300B1 (en) * 2001-11-30 2011-07-27 Biogen Idec MA Inc. Antibodies against monocyte chemotactic proteins
UA87979C2 (ru) * 2002-08-19 2009-09-10 Астразенека Аб Человеческое моноклональное антитело, которое нейтрализует моноцитарный хемоатрактантный белок (мср-1)
CA2497804A1 (en) * 2002-09-12 2004-03-25 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Human anti-human mcp-1 antibody and fragment of said antibody
US20060122377A1 (en) 2004-02-19 2006-06-08 Genentech, Inc. CDR-repaired antibodies
US7371825B2 (en) * 2004-06-30 2008-05-13 Centocor, Inc. Anti-MCP-1 antibodies, compositions, methods and uses

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PA8675801A1 (es) 2006-12-07
EP1888114B1 (en) 2013-09-18
EA014229B1 (ru) 2010-10-29
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CA2609349C (en) 2012-10-30
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PE20061444A1 (es) 2007-01-15
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IL187459A0 (en) 2008-03-20
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