PE20110551A1 - Composicion farmaceutica solida que contiene un derivado de bencimidazol y un diuretico - Google Patents
Composicion farmaceutica solida que contiene un derivado de bencimidazol y un diureticoInfo
- Publication number
- PE20110551A1 PE20110551A1 PE2011000100A PE2011000100A PE20110551A1 PE 20110551 A1 PE20110551 A1 PE 20110551A1 PE 2011000100 A PE2011000100 A PE 2011000100A PE 2011000100 A PE2011000100 A PE 2011000100A PE 20110551 A1 PE20110551 A1 PE 20110551A1
- Authority
- PE
- Peru
- Prior art keywords
- diuretic
- methyl
- pharmaceutical composition
- solid pharmaceutical
- composition containing
- Prior art date
Links
- 239000002934 diuretic Substances 0.000 title abstract 2
- 230000001882 diuretic effect Effects 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000007787 solid Substances 0.000 title abstract 2
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- -1 CARBOXYL GROUP Chemical group 0.000 abstract 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 abstract 1
- JZUFKLXOESDKRF-UHFFFAOYSA-N Chlorothiazide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC2=C1NCNS2(=O)=O JZUFKLXOESDKRF-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229960001523 chlortalidone Drugs 0.000 abstract 1
- JIVPVXMEBJLZRO-UHFFFAOYSA-N chlorthalidone Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C2(O)C3=CC=CC=C3C(=O)N2)=C1 JIVPVXMEBJLZRO-UHFFFAOYSA-N 0.000 abstract 1
- 235000015165 citric acid Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 229960002003 hydrochlorothiazide Drugs 0.000 abstract 1
- 239000004310 lactic acid Substances 0.000 abstract 1
- 235000014655 lactic acid Nutrition 0.000 abstract 1
- VRVKOZSIJXBAJG-TYYBGVCCSA-M monosodium fumarate Chemical compound [Na+].OC(=O)\C=C\C([O-])=O VRVKOZSIJXBAJG-TYYBGVCCSA-M 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dispersion Chemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UNA COMPOSICION FARMACEUTICA SOLIDA QUE COMPRENDE: A) UN COMPUESTO DERIVADO DE BENCIMIDAZOL DE FORMULA (I) DONDE R1 ES HETEROCICLICO QUE CONTIENE N MONOCICLICO; R2 ES UN GRUPO CARBOXILO ESTERIFICADO; R3 ES ALQUILO INFERIOR; SIENDO UN COMPUESTO PREFERIDO LA SAL (5-METIL-2-OXO-1,3-DIOXOL-4-IL)METIL 2-ETOXI-1-{[2'-(5-OXO-4,5-DIHIDRO-1,2,4-OXADIAZOL-3-IL)BIFENIL-4-IL]METIL}-1H-BENCIMIDAZOL-7-CARBOXILATO DE POTASIO; B) UN AGENTE DE CONTROL DEL pH TAL COMO FUMARATO MONOSODICO, ACIDO TARTARICO, ACIDO CITRICO, ACIDO LACTICO, ACIDO SUCCINICO, ENTRE OTROS, CUYO pH ES DE 2 A 5 Y SE ENCUENTRA EN UNA PROPORCION DE 0,01-20% EN PESO DE LA COMPOSICION; Y C) UN DIURETICO TAL COMO CLORTALIDONA O HIDROCLOROTIAZIDA. DICHA COMPOSICION PRESENTA UNA ESTABILIDAD Y DISOLUCION MEJORADA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8520108P | 2008-07-31 | 2008-07-31 | |
| US8562708P | 2008-08-01 | 2008-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20110551A1 true PE20110551A1 (es) | 2011-09-02 |
Family
ID=41610805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2011000100A PE20110551A1 (es) | 2008-07-31 | 2009-07-29 | Composicion farmaceutica solida que contiene un derivado de bencimidazol y un diuretico |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US9169238B2 (es) |
| EP (1) | EP2310385B1 (es) |
| JP (1) | JP5635491B2 (es) |
| KR (1) | KR20110038145A (es) |
| CN (1) | CN102164918B (es) |
| AR (1) | AR072883A1 (es) |
| AU (1) | AU2009277455A1 (es) |
| BR (1) | BRPI0916847A2 (es) |
| CA (1) | CA2732018C (es) |
| CL (1) | CL2011000187A1 (es) |
| CO (1) | CO6341633A2 (es) |
| CR (1) | CR20110111A (es) |
| DO (1) | DOP2011000032A (es) |
| EA (1) | EA201170273A1 (es) |
| EC (1) | ECSP11010856A (es) |
| GE (1) | GEP20146062B (es) |
| IL (1) | IL210819A0 (es) |
| MA (1) | MA32553B1 (es) |
| MX (1) | MX2011001150A (es) |
| NZ (1) | NZ590948A (es) |
| PE (1) | PE20110551A1 (es) |
| PT (1) | PT2310385T (es) |
| TW (1) | TW201008915A (es) |
| UY (1) | UY32017A (es) |
| WO (1) | WO2010013835A2 (es) |
| ZA (1) | ZA201100871B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201014850A (en) | 2008-09-25 | 2010-04-16 | Takeda Pharmaceutical | Solid pharmaceutical composition |
| WO2010075347A2 (en) * | 2008-12-23 | 2010-07-01 | Takeda Pharmaceutical Company Limited | Methods of treating hypertension with at least one angiotensin ii receptor blocker and chlorthalidone |
| CN102351853B (zh) * | 2011-08-29 | 2014-03-12 | 石药集团欧意药业有限公司 | 一种阿齐沙坦酯化合物、制备方法及其药物组合物 |
| US20140056973A1 (en) * | 2012-08-22 | 2014-02-27 | Xenoport, Inc. | Oral Dosage Forms Having a High Loading of a Methyl Hydrogen Fumarate Prodrug |
| JP6935301B2 (ja) * | 2016-11-18 | 2021-09-15 | 花王株式会社 | モノハロゲノアミン製造用被覆粒子群 |
| IN202021028444A (es) * | 2020-07-03 | 2022-01-28 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4444769A (en) * | 1982-07-27 | 1984-04-24 | Mylan Pharmaceuticals, Inc. | Antihypertensive diuretic combination composition and associated method |
| IL102183A (en) * | 1991-06-27 | 1999-11-30 | Takeda Chemical Industries Ltd | Biphenyl substituted heterocyclic compounds their production and pharmaceutical compositions comprising them |
| JP3057471B2 (ja) * | 1993-06-07 | 2000-06-26 | 武田薬品工業株式会社 | アンジオテンシンｉｉ介在性諸疾患の予防または治療剤 |
| US5721263A (en) * | 1993-06-07 | 1998-02-24 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition for angiotensin II-mediated diseases |
| CA2125251C (en) * | 1993-06-07 | 2005-04-26 | Yoshiyuki Inada | A pharmaceutical composition for angiotensin ii-mediated diseases |
| AU2001232348A1 (en) | 2000-02-21 | 2001-08-27 | Takeda Chemical Industries Ltd. | Sustained release preparations of physiologically active compound hardly solublein water and production process and use of the same |
| JP2001294524A (ja) | 2000-04-12 | 2001-10-23 | Taisho Pharmaceut Co Ltd | アセトアミノフェン配合内服固形製剤 |
| FR2812876B1 (fr) * | 2000-08-08 | 2002-09-27 | Galderma Res & Dev | Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques |
| JP4365106B2 (ja) * | 2001-05-25 | 2009-11-18 | エスエス製薬株式会社 | 医薬配合剤 |
| CA2468827A1 (en) | 2001-12-03 | 2003-06-12 | Takeda Chemical Industries, Ltd. | Insulin resistance improving agents |
| DE10244681A1 (de) | 2002-09-24 | 2004-04-08 | Boehringer Ingelheim International Gmbh | Neue feste Telmisartan enthaltende pharmazeutische Formulierungen und deren Herstellung |
| WO2005014043A1 (en) | 2003-07-16 | 2005-02-17 | Boehringer Ingelheim International Gmbh | Chlorthalidone combinations |
| US7157584B2 (en) * | 2004-02-25 | 2007-01-02 | Takeda Pharmaceutical Company Limited | Benzimidazole derivative and use thereof |
| US7625940B2 (en) * | 2005-07-01 | 2009-12-01 | Accu-Break Technologies, Inc. | Method of treating hypertension with a very low dose of chlorthalidone |
| CN100558359C (zh) | 2004-09-06 | 2009-11-11 | 兴和株式会社 | 肾小球病治疗剂 |
| US20070049636A1 (en) * | 2005-08-26 | 2007-03-01 | Joerg Rosenberg | Pharmaceutical compositions |
| US20060159747A1 (en) * | 2004-12-17 | 2006-07-20 | Boehringer Ingelheim International Gmbh | Telmisartan and hydrochlorothiazide combination therapy |
| EP1827424A1 (en) * | 2004-12-17 | 2007-09-05 | Boehringer Ingelheim International GmbH | Combination therapy comprising telmisartan and hydrochlorothiazide |
| EP1863801B1 (en) | 2005-03-30 | 2010-09-29 | Takeda Pharmaceutical Company Limited | Benzimidazole derivative and use thereof |
| JP2008540573A (ja) | 2005-05-13 | 2008-11-20 | マイクロビア インコーポレーテッド | ４−ビアリーリル−１−フェニラゼチジン−２−オン類 |
| US20090208584A1 (en) * | 2005-06-09 | 2009-08-20 | Tomohiro Yoshinari | Solid preparation |
| EA016728B1 (ru) | 2006-08-10 | 2012-07-30 | Такеда Фармасьютикал Компани Лимитед | Фармацевтическая композиция |
| WO2008045006A1 (en) | 2006-10-11 | 2008-04-17 | Fako Ilaclari A. S. | Formulations of candesartan |
| WO2008068217A2 (en) | 2006-12-04 | 2008-06-12 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition comprising a coated hmg-coa reductase inhibitor and an inhibitor of the renin-angiotensin system |
| AU2008235790B2 (en) | 2007-03-28 | 2013-06-06 | Takeda Pharmaceutical Company Limited | Solid pharmaceutical composition comprising a benzimidazole-7-carboxylate derivative and a pH control agent |
| US20090048317A1 (en) | 2007-08-01 | 2009-02-19 | Michael Fox | Formulations of candesartan |
| EP2203158A4 (en) | 2007-10-30 | 2012-12-26 | Reddys Lab Ltd Dr | PHARMACEUTICAL FORMULATIONS WITH TELMISARTAN AND HYDROCHLORTHIAZIDE |
| WO2010075347A2 (en) | 2008-12-23 | 2010-07-01 | Takeda Pharmaceutical Company Limited | Methods of treating hypertension with at least one angiotensin ii receptor blocker and chlorthalidone |
-
2009
- 2009-07-29 AU AU2009277455A patent/AU2009277455A1/en not_active Abandoned
- 2009-07-29 NZ NZ590948A patent/NZ590948A/en not_active IP Right Cessation
- 2009-07-29 EA EA201170273A patent/EA201170273A1/ru unknown
- 2009-07-29 CA CA2732018A patent/CA2732018C/en active Active
- 2009-07-29 BR BRPI0916847A patent/BRPI0916847A2/pt not_active IP Right Cessation
- 2009-07-29 CN CN200980138066.4A patent/CN102164918B/zh active Active
- 2009-07-29 US US12/737,612 patent/US9169238B2/en active Active
- 2009-07-29 AR ARP090102885A patent/AR072883A1/es not_active Application Discontinuation
- 2009-07-29 TW TW098125491A patent/TW201008915A/zh unknown
- 2009-07-29 PT PT97880173T patent/PT2310385T/pt unknown
- 2009-07-29 WO PCT/JP2009/063833 patent/WO2010013835A2/en not_active Ceased
- 2009-07-29 JP JP2011503295A patent/JP5635491B2/ja active Active
- 2009-07-29 KR KR1020117003910A patent/KR20110038145A/ko not_active Withdrawn
- 2009-07-29 UY UY0001032017A patent/UY32017A/es not_active Application Discontinuation
- 2009-07-29 PE PE2011000100A patent/PE20110551A1/es not_active Application Discontinuation
- 2009-07-29 MX MX2011001150A patent/MX2011001150A/es unknown
- 2009-07-29 GE GEAP200912119A patent/GEP20146062B/en unknown
- 2009-07-29 EP EP09788017.3A patent/EP2310385B1/en active Active
-
2011
- 2011-01-23 IL IL210819A patent/IL210819A0/en unknown
- 2011-01-28 CL CL2011000187A patent/CL2011000187A1/es unknown
- 2011-01-28 DO DO2011000032A patent/DOP2011000032A/es unknown
- 2011-02-02 ZA ZA2011/00871A patent/ZA201100871B/en unknown
- 2011-02-11 MA MA33604A patent/MA32553B1/fr unknown
- 2011-02-28 CR CR20110111A patent/CR20110111A/es not_active Application Discontinuation
- 2011-02-28 CO CO11023785A patent/CO6341633A2/es not_active Application Discontinuation
- 2011-02-28 EC EC2011010856A patent/ECSP11010856A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2310385A2 (en) | 2011-04-20 |
| CR20110111A (es) | 2011-04-28 |
| IL210819A0 (en) | 2011-04-28 |
| US20110123615A1 (en) | 2011-05-26 |
| AR072883A1 (es) | 2010-09-29 |
| NZ590948A (en) | 2012-06-29 |
| KR20110038145A (ko) | 2011-04-13 |
| UY32017A (es) | 2010-02-26 |
| US9169238B2 (en) | 2015-10-27 |
| ECSP11010856A (es) | 2011-03-31 |
| MX2011001150A (es) | 2011-03-29 |
| DOP2011000032A (es) | 2011-02-28 |
| ZA201100871B (en) | 2012-05-30 |
| CO6341633A2 (es) | 2011-11-21 |
| EP2310385B1 (en) | 2017-06-07 |
| CL2011000187A1 (es) | 2011-06-24 |
| EA201170273A1 (ru) | 2011-08-30 |
| JP5635491B2 (ja) | 2014-12-03 |
| CA2732018C (en) | 2017-07-04 |
| MA32553B1 (fr) | 2011-08-01 |
| WO2010013835A2 (en) | 2010-02-04 |
| CN102164918B (zh) | 2014-05-07 |
| WO2010013835A3 (en) | 2010-06-10 |
| PT2310385T (pt) | 2017-09-11 |
| AU2009277455A1 (en) | 2010-02-04 |
| BRPI0916847A2 (pt) | 2016-02-10 |
| JP2011529444A (ja) | 2011-12-08 |
| CA2732018A1 (en) | 2010-02-04 |
| GEP20146062B (en) | 2014-03-25 |
| TW201008915A (en) | 2010-03-01 |
| CN102164918A (zh) | 2011-08-24 |
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