PE20090045A1 - Docetaxel cristalino anhidro estable y metodo para la preparacion del mismo - Google Patents
Docetaxel cristalino anhidro estable y metodo para la preparacion del mismoInfo
- Publication number
- PE20090045A1 PE20090045A1 PE2008000630A PE2008000630A PE20090045A1 PE 20090045 A1 PE20090045 A1 PE 20090045A1 PE 2008000630 A PE2008000630 A PE 2008000630A PE 2008000630 A PE2008000630 A PE 2008000630A PE 20090045 A1 PE20090045 A1 PE 20090045A1
- Authority
- PE
- Peru
- Prior art keywords
- preparation
- docetaxel
- crystalline
- anhydro
- stable
- Prior art date
Links
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 title abstract 3
- 229960003668 docetaxel Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 3
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 abstract 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 abstract 2
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical class C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 abstract 1
- 238000002441 X-ray diffraction Methods 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000012296 anti-solvent Substances 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- WGLUMOCWFMKWIL-UHFFFAOYSA-N dichloromethane;methanol Chemical compound OC.ClCCl WGLUMOCWFMKWIL-UHFFFAOYSA-N 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 150000002576 ketones Chemical class 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000001228 spectrum Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
Abstract
SE REFIERE A UNA FORMA CRISTALINA ANHIDRA DE DOCETAXEL DE FORMULA (I) DONDE Ph ES FENILO; Ac ES ACETILO; Bz ES BENZOILO; Boc ES T-BUTOXICARBONILO, EN DONDE LA FORMA CRISTALINA TIENE UN ESPECTRO DE DIFRACCION DE RAYOS X QUE MUESTRA PICOS EXPRESADOS EN GRADOS 2 DE 4.88, 9.22, 9.72, 10.38, 11.30, 11.88, 13.34, 14.56, 15.14, 16.62, 17.28, 17.66, 19.02, 19.62, 19.86, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION DE LA FORMA CRISTALINA QUE COMPRENDE: i) DISOLVER DOCETAXEL EN UN SOLVENTE ORGANICO TAL COMO CETONA, MEZCLA DE DICLOROMETANO-METANOL, ENTRE OTROS; ii) ANADIR UN ANTISOLVENTE TAL COMO PENTANO, HEXANO Y HEPTANO A LA SOLUCION RESULTANTE; Y iii) RECUPERAR LOS CRISTALES RESULTANTES MEDIANTE FILTRACION. DICHA FORMA CRISTALINA ANHIDRA ES UN ANTITUMORAL
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020070035065A KR100878455B1 (ko) | 2007-04-10 | 2007-04-10 | 안정한 무수결정형 도세탁셀 및 이의 제조방법 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090045A1 true PE20090045A1 (es) | 2009-03-22 |
Family
ID=39831157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008000630A PE20090045A1 (es) | 2007-04-10 | 2008-04-09 | Docetaxel cristalino anhidro estable y metodo para la preparacion del mismo |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20100099897A1 (es) |
| EP (1) | EP2155709A4 (es) |
| JP (1) | JP2010523647A (es) |
| KR (1) | KR100878455B1 (es) |
| CN (1) | CN101652356A (es) |
| AR (1) | AR065928A1 (es) |
| CL (1) | CL2008000980A1 (es) |
| PE (1) | PE20090045A1 (es) |
| TW (1) | TW200906813A (es) |
| WO (1) | WO2008123751A1 (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1891143B1 (en) | 2005-06-06 | 2012-01-11 | The University Of British Columbia | Polymer-based serum albumin substitute |
| KR101149600B1 (ko) * | 2009-12-31 | 2012-05-29 | 주식회사 삼양제넥스바이오 | 고순도 무수결정형 도세탁셀 제조방법 |
| US9186410B2 (en) | 2010-03-01 | 2015-11-17 | The University Of British Columbia | Derivatized hyperbranched polyglycerols |
| JP5824511B2 (ja) | 2010-05-03 | 2015-11-25 | テイコク ファーマ ユーエスエー インコーポレーテッド | 非水タキサンプロエマルジョン配合物ならびにそれを調製および使用する方法 |
| US8842114B1 (en) | 2011-04-29 | 2014-09-23 | Nvidia Corporation | System, method, and computer program product for adjusting a depth of displayed objects within a region of a display |
| JO3685B1 (ar) | 2012-10-01 | 2020-08-27 | Teikoku Pharma Usa Inc | صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها |
| CN107683134B (zh) | 2015-05-15 | 2021-02-23 | 珠海贝海生物技术有限公司 | 多西他赛及人血清白蛋白复合物 |
| CN110062622B (zh) | 2016-10-27 | 2022-10-14 | 珠海贝海生物技术有限公司 | 多西他赛和人血清白蛋白的中性pH组合物 |
| CN115297857B (zh) | 2020-02-04 | 2024-07-19 | 珠海贝海生物技术有限公司 | 多西他赛制剂 |
| US20250152551A1 (en) | 2022-02-25 | 2025-05-15 | Zhuhai Beihai Biotech Co., Ltd. | Docetaxel compositions and methods |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2722191B1 (fr) | 1994-07-08 | 1996-08-23 | Rhone Poulenc Rorer Sa | Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle |
| EP1497275A4 (en) * | 2002-04-05 | 2006-04-12 | Natural Pharmaceuticals Inc | SELECTIVE ACYLATION OF SECONDARY HYDROXYL GROUPS |
| US6838569B2 (en) * | 2002-12-16 | 2005-01-04 | Dabur India Limited | Process for preparation of paclitaxel trihydrate and docetaxel trihydrate |
| WO2005061474A1 (en) * | 2003-12-12 | 2005-07-07 | Quiral Química Do Brasil | Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions |
| FR2864340B1 (fr) * | 2003-12-19 | 2006-03-24 | Commissariat Energie Atomique | Microcomposant comportant une microcavite hermetique et procede de fabrication d'un tel microcomposant |
| CN100420681C (zh) | 2005-04-29 | 2008-09-24 | 上海奥锐特国际贸易有限公司 | 多烯紫杉醇三水物的制备方法 |
| KR20070088784A (ko) * | 2005-10-12 | 2007-08-29 | 시코르, 인크. | 도세탁셀의 결정형 및 이의 제조 방법 |
| KR100995390B1 (ko) * | 2006-01-02 | 2010-11-19 | 주식회사 삼양제넥스 | 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법 |
| BRPI0600194A (pt) * | 2006-01-30 | 2007-10-23 | Quiral Quimica Do Brasil S A | composições farmacêuticas contendo docetaxel e um inibidor de degradação e processo de obtenção das mesmas |
| CN101534642A (zh) * | 2006-10-20 | 2009-09-16 | 神隆药业新加坡私人有限公司 | 用于制备结晶无水多西紫杉醇的方法 |
-
2007
- 2007-04-10 KR KR1020070035065A patent/KR100878455B1/ko not_active Expired - Fee Related
-
2008
- 2008-04-03 AR ARP080101384A patent/AR065928A1/es not_active Application Discontinuation
- 2008-04-04 CL CL200800980A patent/CL2008000980A1/es unknown
- 2008-04-09 PE PE2008000630A patent/PE20090045A1/es not_active Application Discontinuation
- 2008-04-09 TW TW097112817A patent/TW200906813A/zh unknown
- 2008-04-10 EP EP08741259A patent/EP2155709A4/en not_active Withdrawn
- 2008-04-10 CN CN200880011306A patent/CN101652356A/zh active Pending
- 2008-04-10 JP JP2010502936A patent/JP2010523647A/ja not_active Withdrawn
- 2008-04-10 US US12/532,887 patent/US20100099897A1/en not_active Abandoned
- 2008-04-10 WO PCT/KR2008/002014 patent/WO2008123751A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008123751A1 (en) | 2008-10-16 |
| KR100878455B1 (ko) | 2009-01-13 |
| JP2010523647A (ja) | 2010-07-15 |
| AR065928A1 (es) | 2009-07-08 |
| KR20080091945A (ko) | 2008-10-15 |
| EP2155709A4 (en) | 2010-09-15 |
| EP2155709A1 (en) | 2010-02-24 |
| CL2008000980A1 (es) | 2008-08-22 |
| US20100099897A1 (en) | 2010-04-22 |
| TW200906813A (en) | 2009-02-16 |
| CN101652356A (zh) | 2010-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD | Application declared void or lapsed |