PE20020690A1 - Metodo y tratamiento y prevencion de los dolores de cabeza de migranas - Google Patents
Metodo y tratamiento y prevencion de los dolores de cabeza de migranasInfo
- Publication number
- PE20020690A1 PE20020690A1 PE2001001081A PE2001001081A PE20020690A1 PE 20020690 A1 PE20020690 A1 PE 20020690A1 PE 2001001081 A PE2001001081 A PE 2001001081A PE 2001001081 A PE2001001081 A PE 2001001081A PE 20020690 A1 PE20020690 A1 PE 20020690A1
- Authority
- PE
- Peru
- Prior art keywords
- cycloalkyl
- alkyl
- ch2cf3
- headaches
- prevention
- Prior art date
Links
- 206010019233 Headaches Diseases 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZISSAWUMDACLOM-UHFFFAOYSA-N triptane Chemical compound CC(C)C(C)(C)C ZISSAWUMDACLOM-UHFFFAOYSA-N 0.000 abstract 2
- -1 2-THIOPHENYL Chemical class 0.000 abstract 1
- RMRFFCXPLWYOOY-UHFFFAOYSA-N allyl radical Chemical class [CH2]C=C RMRFFCXPLWYOOY-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- OFKDAAIKGIBASY-VFGNJEKYSA-N ergotamine Chemical compound C([C@H]1C(=O)N2CCC[C@H]2[C@]2(O)O[C@@](C(N21)=O)(C)NC(=O)[C@H]1CN([C@H]2C(C3=CC=CC4=NC=C([C]34)C2)=C1)C)C1=CC=CC=C1 OFKDAAIKGIBASY-VFGNJEKYSA-N 0.000 abstract 1
- 229960004943 ergotamine Drugs 0.000 abstract 1
- XCGSFFUVFURLIX-UHFFFAOYSA-N ergotaminine Natural products C1=C(C=2C=CC=C3NC=C(C=23)C2)C2N(C)CC1C(=O)NC(C(N12)=O)(C)OC1(O)C1CCCN1C(=O)C2CC1=CC=CC=C1 XCGSFFUVFURLIX-UHFFFAOYSA-N 0.000 abstract 1
- 125000002827 triflate group Chemical group FC(S(=O)(=O)O*)(F)F 0.000 abstract 1
- ORGHESHFQPYLAO-UHFFFAOYSA-N vinyl radical Chemical compound C=[CH] ORGHESHFQPYLAO-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
SE REFIERE A UN METODO DE PREVENCION DE LA OCURRENCIA DE DOLORES DE CABEZA Y MIGRANA QUE COMPRENDE UN COMPUESTO DE FORMULA I DONDE R1 Y R2 SON H, OH, CN, CH2CN, 2-CF3, CH2CF3, CH2CHF2, HC=CF2, (CH2)2CF3, ETENILO, 2-PROPENILO, OSO2CH3, OSO2CF3, COR, O(CH2)xCF3, CONH2, SOxCH3, ENTRE OTROS; x ES 0-2; R3 ES H, CF3, CH2CF3, ALQUILO C1-C8, CICLOALQUILO C3-C8, CICLOALQUIL C4-C9-METILO, ALQUENILO C2-C8, ALQUINILO C2-C8, (CH2)m-R5; m ES 1-8; R5 ES CN, CF3, CH2CF3, ALQUILO C1-C8, CICLOALQUILO C3-C8, 2-TIOFENILO, NR6CONR6R7; R6 Y R7 SON H, ALQUILO C1-C8, CICLOALQUILO C3-C8, ALQUENILO C2-C8; n ES 1-2; R4 Y R SON H, CF3, CH2CF3, ALQUILO C1-C8, CICLOALQUILO C3-C8, CICLOALQUIL C4-C9-METILO; SIENDO UN COMPUESTO PREFERIDO S-(-)-3-[3-(METILSULFONIL)FENIL]-1-PROPIL-PIPERIDINA; UTILIZANDOSE DE 0,5mg A 2mg; TAMBIEN SE REFIERE AL USO CON UN ANALGESICO, ANTIINFLAMATORIO, ERGOTAMINA, TRIPTAN
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24596700P | 2000-11-03 | 2000-11-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20020690A1 true PE20020690A1 (es) | 2002-08-23 |
Family
ID=22928823
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001001081A PE20020690A1 (es) | 2000-11-03 | 2001-10-31 | Metodo y tratamiento y prevencion de los dolores de cabeza de migranas |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6589965B2 (es) |
| EP (1) | EP1335721A4 (es) |
| JP (1) | JP2004518636A (es) |
| AU (1) | AU2002232457A1 (es) |
| CA (1) | CA2426894A1 (es) |
| PE (1) | PE20020690A1 (es) |
| WO (1) | WO2002036071A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| US20050065094A1 (en) | 2003-09-05 | 2005-03-24 | Boehringer Ingelheim International Gmbh | Use of telmisartan for the prevention and treatment of vascular headache |
| KR101336991B1 (ko) * | 2007-05-16 | 2013-12-16 | 삼성전자주식회사 | 교차점 래치 및 그의 동작 방법 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1989006645A1 (en) * | 1988-01-15 | 1989-07-27 | Abbott Laboratories | 1-aminomethyl-1,2,3,4-tetrahydronaphthalenes |
| ATE201669T1 (de) * | 1991-04-17 | 2001-06-15 | Upjohn Co | Substituierte (s)-3-phenylpiperidin derivate, deren herstellung und deren verwendung als dopamin autorezeptor antagonisten |
| SE9904724D0 (sv) * | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
-
2001
- 2001-10-31 PE PE2001001081A patent/PE20020690A1/es not_active Application Discontinuation
- 2001-11-01 JP JP2002538883A patent/JP2004518636A/ja not_active Withdrawn
- 2001-11-01 WO PCT/US2001/045384 patent/WO2002036071A2/en not_active Ceased
- 2001-11-01 AU AU2002232457A patent/AU2002232457A1/en not_active Abandoned
- 2001-11-01 CA CA002426894A patent/CA2426894A1/en not_active Abandoned
- 2001-11-01 US US09/999,251 patent/US6589965B2/en not_active Expired - Fee Related
- 2001-11-01 EP EP01991982A patent/EP1335721A4/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2426894A1 (en) | 2002-05-10 |
| WO2002036071A3 (en) | 2002-07-25 |
| EP1335721A4 (en) | 2005-09-14 |
| EP1335721A2 (en) | 2003-08-20 |
| US6589965B2 (en) | 2003-07-08 |
| US20020091140A1 (en) | 2002-07-11 |
| WO2002036071A2 (en) | 2002-05-10 |
| JP2004518636A (ja) | 2004-06-24 |
| AU2002232457A1 (en) | 2002-05-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200400063A1 (ru) | Антитела к опг лиганду | |
| ES2118250T3 (es) | Combinaciones germicidas de substancias activas. | |
| ES2149350T3 (es) | Compuestos y liposomas farmaceuticamente activos y metodos para su utilizacion. | |
| DK0639186T3 (da) | Taxolderivater | |
| KR950010888A (ko) | 평활근세포 증식 및 재발협착증을 억제하는 방법 | |
| ES2163665T3 (es) | Fenilimidazolidinas y su utilizacion como agente anti-androgeno. | |
| PE20021091A1 (es) | Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion | |
| ES2053094T3 (es) | Agentes ansioliticos y antidepresivos bis-aza-biciclicos. | |
| ES2158284T3 (es) | Metil-fenil-oxazolidinonas quirales. | |
| EA199900421A1 (ru) | Бензонафтиридины в качестве бронхиальных терапевтических средств | |
| CO5140075A1 (es) | Agentes terapeuticos para el tratamiento de la enfermedad de parkinson, adhd y microadenomas | |
| HUP0002330A2 (hu) | Azetidinilpropilpiperidin-származékok, ezek intermedierjei és tachikinin antagonistaként történő alkalmazásuk | |
| NO20072255L (no) | Sammensetning omfattende acetaminofen, koffein og valgfritt aspirin sammen med et alkalisk middel for forbedret absorpsjon | |
| SV2002000244A (es) | Metodos y compuestos para inhibir mrp1 ref.x-13353 | |
| CO4950553A1 (es) | Compuestos de 7-tetrahidroisoquinolinas y procedimiento para su preparacion | |
| JPS5382419A (en) | Blade cleaning device | |
| EA200000042A1 (ru) | Способ лечения диабета росиглитазоном и инсулином | |
| BG101104A (en) | New benzamide derivative, its preparation and use in pharmacuetical compositions | |
| PE20020690A1 (es) | Metodo y tratamiento y prevencion de los dolores de cabeza de migranas | |
| EA199901116A1 (ru) | Композиция, включающая 5-[4-[2-(n-метил-n-2-пиридил)-амино)этокси]бензил]тиазолидин-2,4-дион | |
| DE60121048D1 (de) | PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE | |
| CO5271679A1 (es) | Inhibidores de proteasa 7-14 miembros | |
| AR001259A1 (es) | Proceso para preparar 1,2-bencisotiazolin-3-onas | |
| EA200500878A1 (ru) | Кальцилитические соединения | |
| ES553560A0 (es) | Procedimiento para la obtencion de 5-amino-1-fenilpirazoles sustituidos |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |