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PE20000003A1 - Conjugados mejorados de interferon-polimero - Google Patents

Conjugados mejorados de interferon-polimero

Info

Publication number
PE20000003A1
PE20000003A1 PE1998001237A PE00123798A PE20000003A1 PE 20000003 A1 PE20000003 A1 PE 20000003A1 PE 1998001237 A PE1998001237 A PE 1998001237A PE 00123798 A PE00123798 A PE 00123798A PE 20000003 A1 PE20000003 A1 PE 20000003A1
Authority
PE
Peru
Prior art keywords
interferon
polymer
conjugated
alpha
lis
Prior art date
Application number
PE1998001237A
Other languages
English (en)
Inventor
Myung-Ok Park-Cho
Carl W Gilbert
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25540857&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20000003(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Corp filed Critical Schering Corp
Publication of PE20000003A1 publication Critical patent/PE20000003A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE REFIERE A UNA COMPOSICION QUE COMPRENDE UNA MEZCLA DE AL MENOS 3 ISOMEROS POSICIONALES DE POLIMEROS DE INTERFERON ALFA CONJUGADO CON UN POLIMERO; DONDE DESDE 30% A 60% DE ISOMEROS ES UN INTERFERON ALFA 2b COVALENTEMENTE CONJUGADO EN EL RESIDUO HISTIDINA (His 34) CON UN POLIMERO NO ANTIGENICO; DESDE 7% A 20% DE ISOMEROS POSICIONALES DE INTERFERON ALFA CONJUGADO EN EL RESIDUO Cis 1 CON UN POLIMERO NO ANTIGENICO; DESDE 7% A 15% DE UN ISOMERO POSICIONAL DEL INTERFERON ALFA CONJUGADO EN EL RESIDUO Lis 121 CON UN POLIMERO NO ANTIGENICO. LOS ISOMEROS POSICIONALES SON DE PREFERENCIA CisI, Lis31, His34, Lis49, Lis83, Lis121, Lis 131, Lis 134. EL POLIMERO ES POLIETILENGLICOL, MONOMETOXI-POLIETILENGLICOL (mPEG), POLIPROPILENGLICOL, DEXTRANO, POLIVINILPIRROLIDONAS, POLIACRILAMIDAS, ALCOHOLES POLIVINILICOS, POLIMEROS A BASE DE CARBOHIDRATO, DE PESO MOLECULAR DESDE 200 HASTA 35OOO. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION QUE COMPRENDE PONER EN CONTACTO UN INTERFERON ALFA CON UN EXCESO MOLAR DE UN POLIMERO NO ANTIGENICO DE PESO MOLECULAR DE 200 A 35000 ACTIVADO CON CARBONATO DE SUCCINIMIDILO A pH 7
PE1998001237A 1997-12-19 1998-12-16 Conjugados mejorados de interferon-polimero PE20000003A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/994,622 US5951974A (en) 1993-11-10 1997-12-19 Interferon polymer conjugates

Publications (1)

Publication Number Publication Date
PE20000003A1 true PE20000003A1 (es) 2000-01-17

Family

ID=25540857

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1998001237A PE20000003A1 (es) 1997-12-19 1998-12-16 Conjugados mejorados de interferon-polimero

Country Status (23)

Country Link
US (2) US5951974A (es)
EP (1) EP1039922B1 (es)
JP (2) JP3747070B2 (es)
KR (1) KR100607388B1 (es)
AR (1) AR017435A1 (es)
AT (1) ATE218883T1 (es)
AU (1) AU739359B2 (es)
CA (1) CA2268433C (es)
CO (1) CO4870741A1 (es)
DE (1) DE69806055T2 (es)
DK (1) DK1039922T3 (es)
ES (1) ES2178297T3 (es)
HU (1) HU224696B1 (es)
IL (2) IL136290A0 (es)
MY (1) MY119581A (es)
NZ (1) NZ504735A (es)
PE (1) PE20000003A1 (es)
PT (1) PT1039922E (es)
SG (1) SG71179A1 (es)
SI (1) SI1039922T1 (es)
TW (1) TW570802B (es)
WO (1) WO1999032139A1 (es)
ZA (1) ZA9811590B (es)

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CO4870741A1 (es) 1999-12-27
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AR017435A1 (es) 2001-09-05
PT1039922E (pt) 2002-10-31
SI1039922T1 (en) 2002-10-31
ZA9811590B (en) 1999-06-18
JP2005015464A (ja) 2005-01-20
EP1039922A1 (en) 2000-10-04
KR100607388B1 (ko) 2006-08-02
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AU1916799A (en) 1999-07-12
ES2178297T3 (es) 2002-12-16
US5951974A (en) 1999-09-14
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ATE218883T1 (de) 2002-06-15
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HUP0101532A2 (hu) 2001-08-28
WO1999032139A1 (en) 1999-07-01
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