JPH04266816A - Bathing agent - Google Patents

Abstract

PURPOSE:To economically advantageously obtain a bathing agent having excellently therapeutic effects on symptoms such as the stiffness of the shoulders, neuralgia, lumbago, sprain or fracture of bone besides bathing effects by using pericarp prepared as a byproduct during processing fruit such as Citrus iyo hort. into juice. CONSTITUTION:Pericarp of Citrus iyo hort. or a relative plant thereof, especially Citrus iyo hort., which is prepared as a by-product during processing into juice, partially used as fertilizer, etc., but has been mostly abandoned, is dried into 2.5-12.5% water content to improve shelf stability. In order to prevent change of qualities of collected pericarp, the pericarp is preserved by avoiding direct sunlight and high temperature and high humidity and is preferably dried at least within 24 hours, especially within 8 hours after collecting the pericarp. The dried pericarp thus obtained or raw pericarp is cut into a size of square of preferably 0.5-2.0 cm side to give a bathing agent.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a bath preparation that is placed in hot water during bathing.

0002

[Prior Art] Conventionally, the herbal medicines Citrus iyo (scientific name: Citrus iyo HORT e) have been used as bath additives.
x TANAKA) was never used as a bath additive. On the other hand, Iyokan production has been rapidly increasing in recent years. Although some of the pericarp produced as a by-product in the process of processing iyokan into juice and other products is used as fertilizer, most of it is discarded.

0003

[Problems to be Solved by the Invention] Therefore, an excellent method of using the peel of Iyokan has been sought. The present inventors discovered the previously unknown value of the peel of Iyokan as a bath agent, and completed the present invention.

0004

[Means for Solving the Problems] In other words, in the present invention, a bath agent has been created that uses the pericarp of Iyokan or its related plants as the main raw material.

[0005] Scientific name: Citrus
This refers to iyo HORT ex TANAKA, and the current registered varieties include Iyokan, Miyauchi Iyokan,
There are Otani Iyokan and Katsuyama Iyokan.

[0006] Plants closely related to Iyokan refer to plants that are morphologically of the same origin as the Daidai area, and therefore, the pericarp of a plant created by breeding new plants by crossing plants from the Daidai area can also be used in the present invention. obtain. This is because it can be easily inferred from the morphology that the pericarp of a plant related to Iyokan has the same components as the pericarp of Iyokan.

[0007] The results of examining the morphology of the pericarp of each of the above-mentioned four registered varieties of Iyokan are shown below. For observation of the morphology, dried fruit skins were soaked in water and sectioned (thickness: approx. 20 mm) using a freezing method using a milrotome.
μm), decolorized with antiformin to make it transparent, and then examined using a microscope. In addition, the samples were stained with safranin or hematoxylin as necessary for observation.

[0008] Numbers 1 to 29 indicate each observation item, that is, 1 to 7 are items regarding ``macroscopic observation of the outer skin'', 1) color of the surface 2) apex of the round shape with pointed ends. 3) Fruit equatorial diameter 4) Thickness of the pericarp (exocarp) 5) Thickness of the pericarp (exocarp + endocarp) 6) Irregularities on the outer surface above the oil chamber 7) Pericarp within a unit area The numbers 8 to 11 indicate the "surface view of the epidermis"; 8) Shape of the epidermis on the apex of the oil sac 9) Number of epidermal cells on the apex of the oil sac within 50 μm 10 ) The arrangement of the epidermal cells on the apex of the oil chamber 11) The length of the stomatal accessory cells is shown respectively, 12 to 18 are matters regarding "observation of the cross section of the pericarp", and 13 to 18 are further A matter regarding "oil chamber lumen radial cross section",
12) Shape of flabedo 13) Length of oil chamber (vertical) 14) Length of oil chamber (horizontal) 15) Oil chamber (vertical)/oil chamber (horizontal) 16) Shape of secretory cells 17) Surrounding oil chamber Cell morphology 18) The length of the cells surrounding the oil chamber at the bottom is shown, and 19 to 22 are matters regarding "single crystal of calcium oxalate", 19) Crystals on the outside of flabedo 20) The lengths of the cells on the inside of flabedo Crystals 21) Crystals in albedo 22) Crystals in vascular bundles are shown, and 23 to 26 are matters regarding "hesperidin crystals", 23) Crystals on the outside of flabedo 24) Crystals on the inside of flabedo 25) Crystals in the albedo 26) Crystals in the vascular bundle are shown respectively, 27 to 2
Item 9 is about the "conduit", and shows 27) form and abundance, 28) internal form, 29) color of volatile oil.

[0009] Vs, Vc, Vp, Vg and Pfc respectively represent a spiral duct, a striated duct, a striated duct, an annular duct and a single perforation. Also, the numbers in parentheses indicate average values.

[0010] Iyokan fruit peel form 1) Deep yellow-red color 2) Approximately 7 cm 3) Approximately 8.7 cm 4) 2-3.8 mm (2.6) 5) 6.5-17.0 mm (10.6) 6) Concave+
Convex + 7) Difficult to count due to complex unevenness 8) A mix of 4- to hexagonal oblong cells, equal-shaped cells, etc. 9) 5-9 (6.8) 10) Long cells aligned in the tangential direction There are several layers of cells, following the usual epidermal cells11) 25-39 μm (32.2) 12) The upper 3-4 layers are oblong inside and have many isodiametric yellow-red pigment masses13) 1060-2040 μm (1682) 14)
520-980 μm (768) 15) 1.39-3.
65 (2.27) 16) The bottom of the oil chamber is large and has an equal diameter lumen, and the part that touches the cells surrounding the oil chamber is horizontally elongated17)
4-5 layer AB part Relatively large and wide CD part The part in contact with the oil chamber lumen is large E part Large and continuous 18) (98) 140 μm 19) ++ 9-31 μm 20) + 9-31 μm 21) ++ 20 ~57μm 22) +++ 10-20μm (14) 23) ± 24) + 25) ++ 26) - 27) vs>vc>vp>vg 28) PFC and net pattern 29) Yellow

[0011] Form of the peel of Miyauchi Iyokan 1) Deep yellow-red color 2) Approximately 7 cm 3) Approximately 9.5 cm 4) 1.6 to 3.5 mm (2.6) 5) 6.0 to 14.0 mm (9) .2)6) Concave+
Convex + 7) Difficult to count due to complex unevenness 8) A mixture of 4- to octagonal oblong cells and equal-shaped cells. There are many isomorphic cells9) 3-7 (4.2) 10) There are 1-2 isomorphic cells (18-30 μm) in the center, and 6 cells (18-30 μm) on the apex of the oil chamber. ~
Surrounding 8 cells, 3 to 5 layers of horizontally elongated cells (major axis 20 to 30 μm, short axis 6 to 8 μm) connect in a radial pattern on the outside, and continue to normal epidermal cells11) 26 to 48 μm (33.9) 12) The upper 3-4 layers have many isodiametric yellow-red pigment masses in the horizontally elongated interior13) 1340-2480 μm (1970)14)
750~1250μm (1079)15) 1.50~
2.25 (1.83) 16) The bottom of the oil chamber is large and has an equal diameter lumen, and the part that touches the cells surrounding the oil chamber is horizontally elongated 17)
4th to 5th layer AB part Relatively large and wide CD part The part in contact with the oil chamber lumen is large E part Continuing in large size 18) 100 to 160 μm (132) 19) ++
9~31μm 20) + 15~30μm21) ++
20-45μm 22) +++ 10-20μm 23) ± 24) + 25) ++ 26) - 27) vs>vc>vp>vg 28) There are also PFC and net pattern 29) Yellow

[0012] Morphology of the peel of Otani Iyokan 1) Deep yellow-red color 2) Approximately 7.5 cm 3) Approximately 9 cm 4) 0.8 to 2.5 mm (1.5) 5) 9.0 to 12.0 mm (10 .5)6) Concave+
Convex - Smooth surface 7) Difficult to count due to complexity 8) Pentagonal cells Mixed with long cells with many pentagons, equal shapes, etc. 9) 5-8 (6.2) 10) 5-8 1 rectangular isomorphic cell (20-30 μm)
0 to 15 cells are combined, and 1 to 2 layers of vertically elongated cells (major axis 25 to 38 μm, short axis 8 to 12 μm) are connected radially on the outside and continue to normal epidermal cells11) 24 to 34 μm (30.1) 12) The upper 3 to 4 layers have many isodiametric yellow-red pigment masses in the horizontally elongated interior13) 720 to 1580 μm (1127)14) 4
00-1100μm (792)15) 1.10-1.
80 (1.44) 16) The bottom of the oil chamber is large and has an equal diameter lumen, and the part that touches the cells surrounding the oil chamber is horizontally elongated 17)
4-5 layer AB section Relatively large and wide CD section The part in contact with the oil chamber lumen is the large E section Large and continuous 18) Up to 170 μm19) ++ 10-30 μm 20) + 10-30 μm21) ± 22) ± 23) ± 24) + 25) - 26) - 27) vs>vc>vp>vg 28) PFC and net pattern 29) Yellow

[0013] Form of the peel of Katsuyama Iyokan 1) Deep yellow-red color 2) Approximately 7.5 cm 3) Approximately 10 cm 4) 0.5 to 4.0 mm (1.7) 5) 6.0 to 14.0 mm (10 .3)6) Concave+
Convex + 7) Difficult to count due to complex unevenness 8) A mixture of 4- to hexagonal long cells, equal-shaped cells, etc. 9) 3-7 (5.0) 10) The center is 5- to 8-gon isomorphic cells (30-46 μ
6 to 8 m) are combined, and the outside is surrounded by 2 to 4 layers of vertically or horizontally elongated cells (6 to 18 μm), which continue to normal epidermal cells11) 24 to 52 μm (38.5) 12) Upper part Approximately 3 to 4 layers have many isodiametric yellow-red pigment masses in the horizontally elongated interior13) 800 to 1640 μm (1224)14) 4
00-1020 μm (643) 15) 1.43-2.
55 (1.98) 16) The bottom of the oil chamber is large and has an equal diameter lumen and the part that touches the cells surrounding the oil chamber is horizontally long17)
2nd to 4th layer AB section Relatively large and wide CD section The part in contact with the oil chamber lumen is large E section Large and continuous 18) Up to 170μm19) ++ 10 to 30μm 20) + 10 to 30μm21) ± 22) ± 23) ± 24) + 25) +++ 26) + 27) vs>vc>vp>vg 28) There are also pfc and net pattern 29) Yellow

As shown above, in the internal structure of the pericarp of Iyokan, Miyauchi Iyokan, Otani Iyokan, and Katsuyama Iyokan, differences were observed in the epidermal cells on the apex of the oil chamber. In other words, normal Iyokan and Katsuyama Iyokan are surrounded by a mixture of vertically and horizontally elongated cells radially surrounding several cells of equal diameter, but in Miyauchi Iyokan, cells are radially elongated and horizontally centered around several cells of equal diameter. surrounds. Furthermore, Otani Iyokan differs in that several cells of equal diameter are surrounded by radially elongated cells, and the four types can be distinguished from each other in this point.

[0015] The pericarp of Iyocan, which is the main raw material for the bath preparation of the present invention, can be obtained from the fruit at any stage, or as the fruit matures, the amount of essential oil contained in the pericarp increases. It is best to use the peel of mature fruits.

[0016] Also, the pericarp collected from the fruit may be used as a bath preparation by soaking it raw in a bathtub, but in order to make a bath preparation with good shelf life, the pericarp is dried.

When drying the pericarp, it is best to dry the pericarp immediately after collecting it from the Iyokan fruit to prevent deterioration of the pericarp (rotting, mold growth, etc.). Drying is preferably carried out within at least 24 hours, more preferably within 8 hours after collection. In addition, to prevent deterioration, the collected peel should be stored away from direct sunlight, high temperature and humidity before drying.

[0018] When drying the pericarp of Iyokan to improve its shelf life, the moisture content should be 2.5% or more and 12.5%.
It is best to dry it below. This is because if the water content is dried to less than 2.5%, the essential oils and other components contained in the skin of Iyokan will scatter, reducing its effectiveness as a bath additive. The content is 12.
This is because if the amount exceeds 5%, the storage stability will deteriorate.

[0019] The dried pericarp or the raw pericarp may be used as a bath additive by placing it in a bathtub as is, but if the pericarp is cut into pieces and used, the total cross-sectional area of the pericarp for a given amount of pericarp becomes larger. , is more preferable because the components contained in the pericarp of Iyokan are more likely to come out in the hot water.

The size of the cut peel is preferably about 0.5 cm to 2.0 cm on each side, for example. This is because if the fruit is shredded into powder, many of the components contained in the peel, such as essential oils, will scatter and be lost. This is because the total cross-sectional area of the pericarp is small, so the components of the pericarp of Iyokan cannot be efficiently released into the hot water.

[0021] In addition, herbal medicines such as Angelica, Peony, Kouka, and Sojutsu, which have been conventionally used as ingredients for bath preparations, may be used together with the pericarp of Iyokan. Approximately 0.5~2c
Since the m square sizes are approximately the same, it is easy to uniformly mix these herbal medicines and the pericarp of Iyokan, which is convenient for production.

[0022] Next, the pericarp or cut pericarp is placed in a bag made of cloth or paper, such as a non-woven fabric bag, through which the pericarp does not pass through but the components contained in the pericarp do not pass through, and the bag is sealed. It is best to put the bag in the bathtub. Then, the peel does not come out from the bag, and only the components of the peel come out into the bath, so the bag can be removed and thrown away after use, making cleaning the bathtub easier.

Regarding the usage amount of the bath additive according to the present invention,
Since there are some individual differences in the perception of the effect of a bath agent, such as the effect of a warm bath, any amount can be used depending on the amount of hot water that each person perceives to be effective.

[0024] The bath preparation of the present invention may contain other herbal medicines or ingredients as mentioned above in addition to the pericarp of Iyokan or its related plants. It may also contain ingredients that are recognized as ingredients for bath preparations.

[0025]

[Function] The bathing agent according to the present invention exhibits effects as a bathing agent, such as a warm bath effect, due to the action of the pericarp of Iyokan or its related plants. The mechanism by which the peel of Iyokan or its related plants exerts its effect as a bath agent is not clear, but one of the main factors is that the peel of Iyokan or its related plants contains a large amount of essential oil. Conceivable. However, even if you extract the essential oil from the peel of Iyokan and put only this essential oil in the bathtub, the essential oil will float to the top of the water and will not mix with the water. Therefore, it is necessary to use the peel of Iyokan. In addition to the essential oil, the effects of other ingredients contained in the peel of Iyokan and/or
Alternatively, there is a possibility that the effect as a bath additive is caused by interactions between other components and essential oils.

[0026]

[Example] Next, a specific example of the bathing agent according to the present invention and the results of investigating the effects as a bathing agent such as warm bath effect using this specific example will be explained in detail.

Manufacture of bath additives according to the present invention [0027] Fruits that were colored after mid-December were selected and harvested from Iyokan trees grown in Ehime Prefecture. The harvested Iyokan fruits were stored in a storage warehouse under constant conditions of a temperature of 5 to 10°C and a humidity of 80 to 85% to ripen. The Iyokan fruits stored in this warehouse were taken out for processing at any time from around mid-December to around May of the following year.

[0028] The Iyokan fruit taken out from the storage warehouse was cut in half and the skin was peeled to collect the Iyokan pericarp. The collected Iyokan pericarp was immediately subjected to the following drying process. That is, the collected Iyokan pericarp was placed on a mesh shelf in a dryer. A plurality of these net shelves are provided in parallel in the horizontal direction. The temperature between these multiple net shelves is 50~
Iyokan pericarp was dried by circulating hot air at 60°C for 12 to 24 hours, and its moisture content was adjusted to an average of 9.4%. Next, this dried pericarp was cut into approximately square pieces of about 1 cm on each side to obtain the bath preparation of this example.

Next, the properties of the dried pericarp of Iyokan (hereinafter referred to as "this product") produced by the above method (the general rules for crude drugs of the Japanese Pharmacopoeia (hereinafter referred to as "Japanese Pharmacopoeia") apply mutatis mutandis) are as follows. It seemed like it. Properties: This product is an irregularly shaped piece of pericarp, approximately 4 mm thick. The outer surface is yellow-red to dark yellow-brown, with many small depressions caused by oil chambers, and the inner surface is white to light gray-yellow-brown, and is light and brittle. It also has a peculiar aroma and a bitter, slightly pungent taste.

[0030] Furthermore, various tests were conducted on this product in accordance with the Japanese Pharmacopoeia General Test Methods (hereinafter referred to as the present test methods). The results will be explained below.

Purity test (1) Take 1.0 g of this heavy metal product, and
The test was conducted using the following method. 3ml of lead standard solution is used as comparison solution.
When added, the result was less than 30 ppm. (2) Arsenic When 0.4g of this product was taken and tested according to the arsenic test section of this test method (Method 3, Apparatus B), the result was 0.4g.
It was 5 ppm or less.

Loss on Drying Main Test Method Crude Drug Test Method When the loss on drying was tested, it was 13.0% or less (drying time was 6 hours).

[0033] Ash content main test method Crude drug test method According to the ash content section, when the test was carried out using 2 g of the analytical sample, the ash content was 4.0% or less.

Dilute ethanol extract After drying this product at 105°C for 4 hours, approximately 2.3 g of it was accurately weighed, and the following was carried out according to the following test method: Crude drug test method, extract content (1) dilute ethanol extract quantitative method. When conducting the test, the amount of dilute ethanol extract was more than 30.0%.

Essential oil content: Take 50.0 g of this product as a powder, add 10 times the amount of water, and perform the test using the essential oil determination method of the herbal medicine test method below, when the amount is 0.2 ml or more. there were. However, the test was conducted by adding 1 ml of silicone resin onto the sample in the flask in advance.

[0036] Since there is no description in the Japanese Bureau of Confirmation Tests for this product, the present inventors defined the following two tests to confirm this product.

Confirmation test 1 Add 10 ml of methanol to 0.5 g of powder of this product, heat on a water bath for 2 minutes, filter, and add 0.1 g of ribbon-shaped magnesium and 1 ml of hydrochloric acid to 5 ml of the filtrate and leave to stand. The liquid takes on a reddish-purple color.

Confirmation Test 2 When a small amount of the powder of this product is placed on a slide glass, heated with chloral hydrate, and then sealed in a glycerin/water mixture (1:1) and viewed under a microscope, the result is a square, trapezoid, diamond, or diamond shape A single crystal of calcium oxalate with a polyhedral shape resembling two overlapped crystals was observed, and the length of this crystal was 3 to 45 μm.

Next, regarding the bathing agent of this example produced by the method described above, its effect as a bathing agent, that is, the warm bathing effect,
The following experiment was conducted to investigate the effect on the feeling of use. In each experiment, a conventional bath additive, Nippon Chimpi (obtained from Matsusada Herbal Medicine, Nagoya, date of manufacture: January 31, 1989, lot number 504035), was used for comparison.

Warm Bath Effect In order to investigate whether the bath agent of this example has a warm bath effect, experiments were conducted using the following two methods (measurement of oral temperature change and measurement of skin surface temperature change).

Measurement of oral temperature changes: 20 g of the bath additive of this example or 20 g of Japanese Pharmacological Chimpi cut into approximately 1 cm squares was sealed in a non-woven bag, and these were placed in the bathtub (
The water volume was 100 to 150 liters and the water temperature was approximately 40°C), and these were used as Iyokan-yu and Chimpi-yu, respectively. Ages 11 to 6
Iyokan-to was administered to 21 healthy men and women up to the age of 8.
Chimpi-yu and Sarayu without bath additives (control)
Before taking a bath, take a 10 minute bath and immediately after getting out of the bath (
Immediately after bathing, 0 minutes), 10 minutes after getting out of the bath, 20 minutes after getting out of the bath,
The oral temperature was measured 30 minutes later and 40 minutes later using a general household thermometer. In addition, there are individual differences in human body temperature, and individual differences are also recognized in the oral temperature before bathing, so in this experiment, each person's oral temperature before bathing was used as the standard.
Find the change in oral temperature at each measurement time for each person,
This was used as an index of the hot bath effect. After bathing, each subject immediately dressed and rested. Table 1 shows the results of this experiment.
and shown in FIG.

[0042]

[Table 1] Oral temperature change
(
Unit is °C) ──────────────────
──────────────────
Immediately after bathing 10 minutes later 20
Minutes later 30 minutes later 40 minutes later ──────
──────────────────────────
──── Iyokan-yu 0.74±0.11 0
．． 44±0.10 0.22±0.09 0.15
±0.07 0.09±0.09 Chimpiyu
0.72±0.11 0.40±0.10 0.
20±0.08 0.10±0.11 0.09±
0.08 Sarayu 0.59±0.12
0.23±0.08 0.04±0.15 -0.
03±0.15 -0.10±0.07 ─────
──────────────────────────
────

[0043] The values in Table 1 indicate the average value and standard deviation value of 21 subjects, and the numerical unit is °C. Figure 1
is a graph of the results in Table 1, where the vertical axis shows the change in oral temperature (℃), the horizontal axis shows the elapsed time (minutes) immediately after bathing (0 minutes), and 1 indicates the Iyokan-to bath. , 2 shows the results for chinpi-to, and 3 shows the results for sara-to.

[0044] As shown in Table 1 or Figure 1, the oral temperature increases when taking a bath in all three hot springs, but it drops rapidly after 10 minutes of bathing, and after that it drops more slowly as time passes. A trend was observed. However, with Sarayu, there was a tendency for the oral temperature to become lower than before bathing, that is, the water became colder, after 20 to 30 minutes immediately after bathing, whereas in the case of Chimpiyu or Iyokanto, Compared to the Sarayu bath, the temperature was 0.13°C or 0.15°C immediately after bathing, and 0.19°C higher in both cases after 40 minutes. These results demonstrate that Iyokan-yu, like Chimpi-yu, is easier to warm up and harder to cool down than Sara-yu. Based on the above, when Iyokan was compared with the conventional bath additive Chinpi, its body temperature raising effect was considered to be about the same.

Measurement of Skin Surface Temperature Change 5 g of the bath additive of this example or 5 g of Japanese Pharmacopoe Chimpi cut into approximately 1 cm squares was sealed in a non-woven bag and placed in hot water (30 liters of hot water, temperature 40°C). Therefore, it was designated as Iyokan-to or Chinpi-yu, respectively. The following experiment was conducted on four healthy men and women between the ages of 11 and 68. After soaking one forearm and hand in the above-mentioned Iyokan-to, Chinpi-to, or Sarayu without bath additives for 5 minutes, remove it. Immediately after lifting
5 minutes and 10 minutes after lifting, the average value of the skin surface temperature of a certain area (7 cm x 7 cm) in the approximate center of the palm was measured using a thermograph (infrared temperature measuring device Thermo Tracer 6T62 manufactured by Nichiden Sanei Co., Ltd.). . This thermography is a method of projecting the distribution of skin surface temperature on an infrared film using different colors, and is suitable for measuring the body temperature raising effect of bath additives. In addition, since there are individual differences in the skin surface temperature of each person before bathing, in this experiment, the average value of the skin surface temperature of the same part of each subject was measured using the same method before soaking in the hot water. Using this value as a reference, the change in skin surface temperature at each measurement time was determined for each person, and this was used as an index of the hot bath effect. The results of this experiment are shown in Table 2 and FIG. 2.

[0046]

[Table 2] Temperature changes on the skin surface ────────────────────────
───
Immediately after bathing 5 minutes later 10 minutes later ──
────────────────────────
Iyokan-yu (℃) 4.95±0.52 2.0
0±0.41 1.80±0.58 Chimpiyu
(℃) 4.80±0.74 1.80±0.55
1.75±0.37 Sarayu (℃)
4.20±0.29 1.75±0.13 0.5
5±0.13 ──────────────────
─────────

In Table 2, immediately after bathing (0
(minutes) means immediately after removing the arm from the bath, 5 minutes, 10 minutes.
The results after 5 minutes and 10 minutes after the arm was removed from the hot water, respectively. Furthermore, each value in Table 2 represents the average value and standard deviation of the four subjects.

[0048] Figure 2 is a graph of the results in Table 2, where the vertical axis represents the temperature change on the skin surface, and the horizontal axis represents the temperature change immediately after bathing.
minutes and indicates the elapsed time (minutes) thereafter. Further, each number in FIG. 2 has the same meaning as in FIG. 1.

As shown in Table 2 or FIG. 2, in the case of Iyokan-to and Chinpi-to, the skin surface temperature dropped rapidly after 5 minutes, but then gradually dropped. On the other hand, a rapid drop in temperature was observed in Sarayu even after 5 minutes. In Iyokan-to and Chinpi-yu, the skin surface temperature changes 10 minutes after bathing were 1.80°C and 1.75°C, respectively, which were higher than 0.55°C in Sara-yu. The above results demonstrate that Iyokan-to has the same warming effect as Chimpi-to.

Effects on sense of use (for unspecified general public) Iyokan-to and Chinpi-to prepared using the same method and conditions as in the above-mentioned ``Measurement of oral temperature changes'' were applied to patients aged 11 to 68 years old. 74 specific ordinary people (37 men)
The subjects (37 females) were bathed for 10 minutes, and after bathing, they were immediately clothed and allowed to rest. About 1 hour after taking a bath, a questionnaire survey was conducted regarding various items related to the feeling of using the bath additives.

[0051] In this questionnaire, the degree of effectiveness for each item was rated on a seven-point scale (very good (+3), quite good (+3)).
+2), slightly better (+), no change (±), slightly worse (
-), quite bad (-2), and very bad (-3), and each person was asked to select one of these for each item. The results are shown in Table 3 for Chimpi-to and Table 4 for Iyokan-to.

[0052] Very good (+3), quite good (+
The percentage of the total number of answers of 2) and Fairly Good (+) relative to the total number of answers (74) was determined, and this was taken as the effective percentage.

0053: On the contrary, somewhat bad (-), quite bad (-2)
The ratio of the sum of the number of answers of "very bad" and "very bad (-3)" to the total number of answers was calculated, and this was taken as the invalid percentage.

[0054]

[Table 3] Feelings of using bath additives (Chinpi-to) ──────────────────────
──────────── Answer items
+3 +2 (effective%) + ± -
-2 (invalid%) -3 No answer ────
──────────────────────────
────── Yuzawari 7
0 (33.3%) 18 46 0
0 (0%) 0 3 My skin is smooth 0 13 (64.9%) 35
24 0 0 (0%) 0
2 Warmness at the tips of hands and feet 0 13 (50
．． 0%) 24 32 0 0 (0%)
0 5 Warmth in the core of the body
4 6 (37.8%) 18 39
0 0 (0%) 0 7
Difficulty cooling water 6 10 (71.6%)
37 18 0 0 (0%)
0 3 Muscle relaxation 0
4 (39.2%) 25 36 0
0 (0%) 0 9 Ease of joint movement 0 0 (27.0%)
20 45 0 0 (0%)
0 9 My body becomes lighter 0
0 (27.0%) 20 40 0 0
(0%) 0 14 ──────
──────────────────────────
────

[0055]

[Table 4] Feelings of using bath additives (Iyokan-to) ────────────────────────
──────────── Answer items
+3 +2 (effective%) + ± −
-2 (invalid%) -3 No answer ────
──────────────────────────
────── Yuzawari 3
10 (45.9%) 21 34 0
0 (0%) 0 6 My skin is smooth 4 9 (63.5%) 34
19 0 0 (0%) 0
8 Warmness at the tips of hands and feet 6 7 (50
．． 0%) 24 31 0 0 (0%)
0 6 Warmth in the core of the body
3 18 (50.0%) 16 28
0 0 (0%) 0 9
Difficulty cooling water 9 7 (62.2%)
30 19 0 0 (0%)
0 9 Muscle relaxation 0
10 (33.8%) 15 38 0
0 (0%) 0 11 Ease of joint movement 0 9 (25.7%)
10 43 0 0 (0%)
0 12 My body becomes lighter 3
6 (25.7%) 10 37 0 0
(0%) 0 18 ──────
──────────────────────────
────

[0056] Among the items investigated as shown in Tables 3 and 4, ``feeling of hot water'', ``skin feels smooth'',
Both Chimpi-to and Iyokan-to had an effectiveness rate of 30% or more for ``warming the tips of hands and feet,'' ``difficulty getting cold in the bath,'' and ``relaxing muscles.'' Especially "Yuzawari" and "
Regarding the item of ``warming the core of the body,'' Iyokan-to was more than 10% more effective than Chimpi-to.

On the other hand, compared to Iyokan-yu, Chimpi-yu was 9 points each in terms of ``difficulty getting cold'' and ``muscle relaxation''.
．． Although the 4% and 5.4% effective % values were high, for other items the effective % values for both baths were almost the same.

[0058] The number of "very good" responses was 28 and 17 for Iyokan-to and Chinpi-to, respectively, with Iyokan-to having a higher level of perceived effectiveness. Furthermore, the percentage of ineffectiveness was 0% for all items for both Chinpi-to and Iyokan-to.

Effects related to sensitivity to cold, etc. (for unspecified general public) In addition to the items listed in Tables 3 and 4, in addition to the items listed in Tables 3 and 4, effects related to sensitivity to cold, ``stiff shoulders,'' ``body fatigue, malaise,'' etc. '', ``low back pain'', and ``neuralgia'' were similarly surveyed. The results are shown in Table 5 for Chimpi-to and Table 6 for Iyokan-to.

[0060]

[Table 5] Chinpiyu ────────────────────────
──────────── Very
Effect Somewhat Effective I don't know Originally unanswered Effective
Yes Effective No No No symptoms
────────────────────────
────────── Cold sensitivity 4
3 13 0
22 27
5 Stiff shoulders 0 6
18 6 28
9 7 body
0 3 16
0 30 1
9 6 Fatigue, sluggishness, lower back pain 0 4
9 3 30
19 9 Neuralgia
0 0 0
3 19 42
10 ──────────────
──────────────────────

006
1]

[Table 6] Iyokan-yu ────────────────────────
──────────── Very
Effect Somewhat Effective I don't know Originally unanswered Effective
Yes Effective No No No symptoms
────────────────────────
────────── Cold sensitivity 7
0 15 0
16 22
14 Stiff shoulders 4 3
21 6 21
13 6 body
0 7 9
0 29 2
1 8 Fatigue, sluggishness, lower back pain 0 4
9 3 32
15 11 Neuralgia
0 0 0
7 19 39
9 ──────────────
──────────────────────

006
2] As shown in Tables 5 and 6, “Very effective”
If the total percentage of "effective" and "somewhat effective" accounts for the overall percentage, the effective percentage for Iyokanto is 29.7% for "sensitivity to cold" and 37.8% for "stiff shoulders." Met. Therefore, it has been proven that Iyokan-to is effective for cold sensitivity and stiff shoulders.

[0063] Effects related to neuralgia, etc. (for people with subjective symptoms) Regarding the above-mentioned "effects related to sensitivity to cold, etc.", the subjects of the questionnaire survey were unspecified general people. Fatigue, sluggishness, low back pain
Regarding the item ``,'' and ``neuralgia,'' many respondents answered ``I have never had this symptom.'' It was also found that some of those who answered "I don't know" did not have these symptoms. Therefore, in order to more accurately investigate the effects of Iyokanto on the above items, we limited the subjects for each of the above items to those who had subjective symptoms for each survey item.
The following experiment was conducted.

[0064] The Iyokan-to used in this experiment was prepared in the same manner and under the same conditions as those used in the above-mentioned ``Effect on sensation of use'' and ``Measurement of intraoral temperature change.'' Subjects were allowed to bathe in Iyokan-to for 10 minutes every day for one week, and a questionnaire survey was conducted to determine whether it was effective when compared to Sara-yu. The results are shown in Table 7.

[0065]

[Table 7] Effects of Iyokanto (for people with subjective symptoms) ──────────────────────
────────────
Very effective Effective Somewhat effective No effect Unanswered ────────────────
──────────────────── Neuralgia
2
3 1 6
3 Stiff shoulders
3 5
9 8 4 Rheumatism 0 0
1 1
0 back pain
2 3 6
6 3 Sprain
0 1
2 0
0 ──────────────────────
────────────────

As shown in Table 7, among the 15 people suffering from neuralgia, the responses were ``Very effective,''``Effective,'' and ``Somewhat effective.''
If the percentage of those who answered (total of 6 people) is the effective percentage, then
This effective percentage was 50%, proving that Iyokanto is effective against neuralgia.

Next, regarding rheumatism, clear results could not be obtained because the number of subjects was small at 2. However, 2
One of the respondents answered that it was ``somewhat effective,'' suggesting that Iyokan-to may also be effective for rheumatism.

[0068] Regarding stiff shoulders, the effectiveness percentage was 51% in the above-mentioned survey targeting the unspecified general public, whereas in this experiment targeting only people complaining of stiff shoulders, the effectiveness percentage was 51%. 68%, proving that Iyokan-to has an excellent effect on stiff shoulders.

Furthermore, regarding lower back pain, in the aforementioned survey of unspecified ordinary people, the effective percentage was 27%, whereas in this experiment, which targeted only those who complained of lower back pain (20 people), the effective percentage was 27%. 65%, proving that Iyokanto has an excellent effect on lower back pain.

[0070] Furthermore, when this experiment was conducted on three people who had newly suffered a sprain, all three people recognized the therapeutic effect of Iyokan-to. More specifically, Iyokan-to has the effect of quickly relieving the pain of a sprain; in one case, it took about a week for the pain of a sprain to go away after taking a bath in Sarayu; In some cases, the pain was alleviated within 3 days.

Effect on bone fractures In order to investigate the effect of Iyokanto on bone fractures, the following experiment was conducted on three dogs with bone fractures. The dog with the fracture was treated (pinning), and 7 days later, the dog's limbs were bathed in Iyokan-yu (28°C) for 20 minutes each day. This Iyokan-yu was prepared by adding 5 g of the bath additive of this example to 20 liters of hot water.

Adult dog (weight 2.5 kg) with a fracture in the right forelimb
After 5 days of bathing in Iyokan-to, the patient's limping and walking improved. In addition, for an adult dog (weight 5.3 kg) with a fracture in the right hind leg, we recommend bathing with Iyokan-to for 7 days.
After going for a few days, my limping gait improved. As a control, an adult dog with a left hindlimb fracture (weight 12.4
Kg) was bathed in Sarayu under the same conditions, but in this case, the limp gait improved after 14 days of bathing.

[0073] From the above results, it was found that dogs bathed in Iyokan-to healed their fractures more quickly than dogs bathed in Sara-yu. Therefore, it was proven that Iyokan-to prepared using the bath preparation of this example has a fracture treatment effect.

[0074] The Japanese Pharmacopoeia, which is known as a conventional bath agent,
The only known effect of Chimpi is the hot bath effect (warming the body). On the other hand, the bath preparation using Iyokan pericarp of this example has a remarkable therapeutic effect on symptoms such as "stiff shoulders,""neuralgia,""lower back pain,""sprain," or "fracture," in addition to the hot bath effect. Therefore, the bath preparation of this example can be used to treat these symptoms.

[0075] Furthermore, the bath preparation of this example is manufactured using the pericarp, which is a by-product when processing Iyocan fruit into juice or the like, so that it is inexpensive and economically advantageous.

Next, a specific example of a bath preparation prepared by mixing other herbal medicines with the bath preparation of this example (hereinafter referred to as a mixed bath preparation) will be described. This mixed bathing agent is also a bathing agent according to the present invention.

Table 8 shows the components and amounts (g) of each component in 100 g of the mixed bath agent.

[0078]

[Table 8]

[0079] Iyokan in Table 8 refers to the dried product of Iyokan fruit peel produced by the above-mentioned production method, and is referred to as "this product" before.
The substance has been clarified by the Japanese Bureau's test method and the inventors' confirmation test.

[0080] In Table 8, all of the names ``Nankyu'', ``Acanthus'', ``Koka'', ``Sojutsu'', and ``Peony'' are those listed in the Japanese Bureau.

Further, in Table 8, as the flavoring agent, a natural fragrance of Iyokan extracted from the skin of Iyokan by a conventional method was used. Other flavoring agents that are commonly used in bath preparations can also be used.

[0082] As other components of the mixed bath preparation, a small amount of a coloring agent arbitrarily selected from those listed in Attached Table 1 and Attached Table 2, which can be used in medicines etc. as specified by the Ordinance of the Ministry of Health and Welfare, is used. It's okay.

[0083] Manufacture of mixed bath preparation: Take the seven ingredients listed in Table 8 in the amounts listed in Table 8, and put 100 g of the mixture in a non-woven fabric bag (5
5 sachets each containing 20 g were produced. Add this 1 package (20g) to the bathtub (water volume: 150g).
~200 liters).

Mixed bath preparation prepared as above (hereinafter referred to as "
Various tests were conducted on the sample (referred to as "Sample") in accordance with the Japanese Bureau's general test methods. The results are shown below.

However, the confirmation test was carried out by the method described below by the present inventors. The reagents and test solutions used in this test were those specified in the Japanese Pharmacopoeia General Test Methods, unless otherwise specified.

[0086] Take 20 g of a confirmation test sample, powder it using an appropriate method, place a small amount on a slide glass, heat treat it with chloral hydrate, enclose it in a glycerin/water mixture (1:1), and microscopically examine it. The characteristic parts of each are recognized below. 1. Calcium oxalate single crystal Single crystals of calcium oxalate are recognized as square, trapezoidal, rhomboid, or polyhedral shapes such as two overlapping diamonds. The length of the liquid crystal is 3 to 45 μm. 2. Spiral-patterned conduit diameter (15-25 μm) accompanied by a nebula net pattern.Considering the diameter of the conduit, a conduit with a rough spiral pattern resembling a net pattern is observed. 3. Spindle-shaped skin parenchyma cells length (103-135 μm), diameter (22-27 μm)
In this case, cells with extremely fine diagonal parallel patterns that intersect with each other are observed in the fine cells. 4. Kouka pollen grains are deep yellow, circular to oval in shape, and germination holes are observed with a diameter (40-50 μm). Spherical granular protrusions are sparsely observed on the outer wall. 5. Contains bunched needle crystals in an oily mass in colorless parenchyma cells. The needle-like crystals are observed to be distributed randomly in length (4 to 15 μm). 6. The tip of the calcium oxalate crystal collected in peony is a crystal with a diameter (10 to 32 μm) formed by agglomeration of blunt polygonal calcium oxalate. Often, crystalline cell rows are also observed in the parenchyma cells.

Loss on drying test When a test sample is accurately weighed and tested in accordance with the Japan Pharmacopoeia General Test Method, Crude Drug Test Method, about 5 g of the sample is tested, the loss is 2.
．． It is 5% or more and 12.5% or less. (5g, 105℃,
6 hours)

[0088] Approximately 3 g of an ash sample is accurately weighed, and the ash content is 2.4% or more and 7.4% or less when tested in accordance with the Japanese Pharmacopoeia General Testing Methods, Crude Drugs Testing Method, Ash content section.

The acid-insoluble ash content of the sample is 4% or more and 7.4% or less when tested according to the ash content section of the Japan Pharmacopoeia General Testing Methods, Crude Drug Testing Methods.

[0090] After drying the dilute ethanol extract test sample at 105°C for 4 hours, accurately weigh approximately 2.3 g of it, and then use it to determine the exact amount of the test sample, according to the Japanese Pharmacopoeia General Testing Methods, Crude Drugs Testing Methods, Extract Content (1) When conducting a test using dilute ethanol extract. , the amount of dilute ethanol extract is 17.5% or more and 47.0% or less.

After drying the water extract test sample at 105°C for 4 hours, approximately 2.3 g of it was accurately weighed, and the following is the Japanese Pharmacopoeia General Testing Methods, Crude Drug Testing Method, Water Extract Content (2) Water Extract Determination Method. When conducting the test according to the above section, the amount of water extract is 12.5% or more and 42.5% or less.

[0092] Take 50.0 g of essential oil content sample, add 10 times the amount of water, and perform the following test according to the Japanese Pharmacopoeia General Testing Methods, Crude Drug Testing, Essential Oil Content section, and the essential oil content must be 0.1 or more and 0.7. (ml/5
0.0g) or less.

Purity test (1) A heavy metal sample is made into a powder, 1.0 g of it is weighed out, and a test is conducted according to the Japan Bureau of General Testing Methods, Heavy Metal Testing Method, Method 3. Add 3.0 ml of lead standard solution to the comparison solution. The result is 30 pages
pm or less.

(2) Make the arsenic sample into a powder, weigh out 0.4 g, prepare a test solution according to Method 3 of the Arsenic Test Method of the Japanese Pharmacopoeia General Test Methods, and prepare the test solution using Apparatus B.
The test shall be conducted using a method using The result is 0.5pp
m or less.

[0095] Since this mixed bath preparation contains other herbal medicines other than Iyokan peel, in addition to the above-mentioned warming bath effect of Iyokan peel, it can also be used to treat heat rash, eczema, bruises, stiff shoulders, sprains, etc.
It is effective against neuralgia, chilblains, hemorrhoids, sensitivity to cold, lower back pain, recovery from fatigue, cracks, chapped skin, sensitivity to cold before and after childbirth, and acne.

[0096]Furthermore, the flavoring agent hides most of the herbal odor caused by other herbal medicines, and the scent soothes the mood of the user. When a coloring agent is mixed in, the hot water becomes more colorful, making it more pleasant to use.

[0097]

[Effects of the Invention] According to the bath preparation of the present invention, the pericarp of Iyokan is effectively used, and waste during processing of Iyokan can be prevented, contributing to the utilization of resources.

[Brief explanation of the drawing]

FIG. 1 is a diagram showing the hot bath effects of chinpi-to and iyokan-to.

FIG. 2 is a diagram showing the hot bath effects of chinpi-to and iyokan-to.

[Explanation of symbols]

1 Iyokan-yu 2 Chimpi-yu 3. Sarayu

Claims (1)

[Claims] Claim 1: A bath preparation whose main ingredient is the pericarp of Iyokan or its related plants.