HUP0100865A3 - Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists, pharmaceutical compositions comprising thereof and their use - Google Patents

Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists, pharmaceutical compositions comprising thereof and their use

Info

Publication number: HUP0100865A3
Authority: HU; Hungary
Prior art keywords: meta; derivatives; pharmaceutical compositions; benzoic acid; acid compounds
Prior art date: 1998-03-04

Application number

HU0100865A

Other languages

English (en)

Hungarian (hu)

Original Assignee

G D Searle & Co Skokie

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-04

Filing date

1999-02-22

Publication date

2001-11-28

1999-02-22 Application filed by G D Searle & Co Skokie filed Critical G D Searle & Co Skokie

2001-08-28 Publication of HUP0100865A2 publication Critical patent/HUP0100865A2/hu

2001-11-28 Publication of HUP0100865A3 publication Critical patent/HUP0100865A3/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
- C07D239/12—Nitrogen atoms not forming part of a nitro radical
- C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Rheumatology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Oncology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HU0100865A 1998-03-04 1999-02-22 Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists, pharmaceutical compositions comprising thereof and their use HUP0100865A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3427098A	1998-03-04	1998-03-04
PCT/US1999/003281 WO1999044994A1 (en)	1998-03-04	1999-02-22	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists

Publications (2)

Publication Number	Publication Date
HUP0100865A2 HUP0100865A2 (hu)	2001-08-28
HUP0100865A3 true HUP0100865A3 (en)	2001-11-28

Family

ID=21875345

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU0100865A HUP0100865A3 (en)	1998-03-04	1999-02-22	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists, pharmaceutical compositions comprising thereof and their use

Country Status (29)

Country	Link
EP (1)	EP1060164A1 (et)
JP (1)	JP2002505323A (et)
KR (1)	KR20010041584A (et)
CN (1)	CN1214011C (et)
AP (1)	AP1244A (et)
AR (1)	AR018139A1 (et)
AU (1)	AU753230B2 (et)
BG (1)	BG104740A (et)
BR (1)	BR9908470A (et)
CA (1)	CA2322207A1 (et)
EA (1)	EA200000804A1 (et)
EE (1)	EE200000506A (et)
GE (1)	GEP20033118B (et)
HR (1)	HRP20000574A2 (et)
HU (1)	HUP0100865A3 (et)
ID (1)	ID25591A (et)
IL (1)	IL137653A0 (et)
IS (1)	IS5582A (et)
MY (1)	MY123908A (et)
NO (1)	NO315703B1 (et)
NZ (1)	NZ506598A (et)
OA (1)	OA11530A (et)
PL (1)	PL342726A1 (et)
SK (1)	SK13002000A3 (et)
TR (1)	TR200002542T2 (et)
UA (1)	UA71906C2 (et)
WO (1)	WO1999044994A1 (et)
YU (1)	YU52000A (et)
ZA (1)	ZA994406B (et)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9805655D0 (en)	1998-03-16	1998-05-13	Celltech Therapeutics Ltd	Chemical compounds
GB9814414D0 (en)	1998-07-03	1998-09-02	Celltech Therapeutics Ltd	Chemical compounds
GB9821061D0 (en)	1998-09-28	1998-11-18	Celltech Therapeutics Ltd	Chemical compounds
GB9826174D0 (en)	1998-11-30	1999-01-20	Celltech Therapeutics Ltd	Chemical compounds
US6518283B1 (en)	1999-05-28	2003-02-11	Celltech R&D Limited	Squaric acid derivatives
US6455539B2 (en)	1999-12-23	2002-09-24	Celltech R&D Limited	Squaric acid derivates
JP2003531141A (ja)	2000-04-17	2003-10-21	セルテックアールアンドディリミテッド	エナミン誘導体
US6545013B2 (en)	2000-05-30	2003-04-08	Celltech R&D Limited	2,7-naphthyridine derivatives
US6403608B1 (en)	2000-05-30	2002-06-11	Celltech R&D, Ltd.	3-Substituted isoquinolin-1-yl derivatives
US6921767B2 (en) *	2000-06-15	2005-07-26	Pharmacia Corporation	Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives
JP2004505110A (ja)	2000-08-02	2004-02-19	セルテック　アール　アンド　ディ　リミテッド	３位置換イソキノリン−１−イル誘導体
AU2003299600A1 (en) *	2002-12-20	2004-07-29	Pharmacia Corpration	The r-isomer of beta amino acid compounds as integrin receptor antagonists derivatives
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
BRPI0611814A2 (pt) *	2005-06-10	2008-12-09	Bipar Sciences Inc	moduladores parp e tratamento de cÂnceres
CN101687040A (zh)	2007-03-01	2010-03-31	马林克罗特公司	整合光活性的小分子及其用途
JP4792124B1 (ja) *	2010-11-15	2011-10-12	エフイートレード株式会社	車両用保護フィルムの型取り方法、及び、車両用保護フィルムの製造方法
US8716226B2 (en)	2012-07-18	2014-05-06	Saint Louis University	3,5 phenyl-substituted beta amino acid derivatives as integrin antagonists
IN2015DN00099A (et)	2012-07-18	2015-05-29	Univ Saint Louis
WO2015181676A1 (en)	2014-05-30	2015-12-03	Pfizer Inc.	Carbonitrile derivatives as selective androgen receptor modulators
WO2015187774A1 (en) *	2014-06-04	2015-12-10	Monsanto Technology Llc	3,6-dichlorosalicylic acid compounds and related synthetic processes
CN108779077A (zh)	2015-12-30	2018-11-09	圣路易斯大学	作为pan整合素拮抗剂的间位氮杂环氨基苯甲酸衍生物
CA3182964A1 (en)	2020-05-14	2021-11-18	Ube Corporation	1,4,5,6-tetrahydropyrimidin-2-amine derivative
WO2023275715A1 (en)	2021-06-30	2023-01-05	Pfizer Inc.	Metabolites of selective androgen receptor modulators
JPWO2023085396A1 (et)	2021-11-12	2023-05-19

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CZ293323B6 (cs) *	1995-08-30	2004-04-14	G. D. Searle & Co.	Meta-guanidinové, močovinové, thiomočovinové nebo azacyklické deriváty aminobenzoové kyseliny jako antagonisty integrinů

1999
- 1999-02-11 ZA ZA9904406A patent/ZA994406B/xx unknown
- 1999-02-22 YU YU52000A patent/YU52000A/sh unknown
- 1999-02-22 TR TR2000/02542T patent/TR200002542T2/xx unknown
- 1999-02-22 EP EP99937927A patent/EP1060164A1/en active Pending
- 1999-02-22 GE GEAP19995537A patent/GEP20033118B/en unknown
- 1999-02-22 BR BR9908470-8A patent/BR9908470A/pt not_active Application Discontinuation
- 1999-02-22 HU HU0100865A patent/HUP0100865A3/hu unknown
- 1999-02-22 JP JP2000534538A patent/JP2002505323A/ja active Pending
- 1999-02-22 AU AU32947/99A patent/AU753230B2/en not_active Ceased
- 1999-02-22 SK SK1300-2000A patent/SK13002000A3/sk unknown
- 1999-02-22 CA CA002322207A patent/CA2322207A1/en not_active Abandoned
- 1999-02-22 EA EA200000804A patent/EA200000804A1/ru unknown
- 1999-02-22 OA OA1200000238A patent/OA11530A/en unknown
- 1999-02-22 EE EEP200000506A patent/EE200000506A/et unknown
- 1999-02-22 IL IL13765399A patent/IL137653A0/xx unknown
- 1999-02-22 PL PL99342726A patent/PL342726A1/xx unknown
- 1999-02-22 UA UA2000095148A patent/UA71906C2/uk unknown
- 1999-02-22 CN CNB998035815A patent/CN1214011C/zh not_active Expired - Fee Related
- 1999-02-22 AP APAP/P/2000/001893A patent/AP1244A/en active
- 1999-02-22 NZ NZ506598A patent/NZ506598A/en unknown
- 1999-02-22 WO PCT/US1999/003281 patent/WO1999044994A1/en not_active Ceased
- 1999-02-22 KR KR1020007009774A patent/KR20010041584A/ko not_active Ceased
- 1999-02-22 HR HR20000574A patent/HRP20000574A2/hr not_active Application Discontinuation
- 1999-02-22 ID IDW20001695A patent/ID25591A/id unknown
- 1999-03-02 AR ARP990100880A patent/AR018139A1/es unknown
- 1999-03-03 MY MYPI99000772A patent/MY123908A/en unknown
2000
- 2000-08-04 IS IS5582A patent/IS5582A/is unknown
- 2000-08-30 NO NO20004316A patent/NO315703B1/no not_active IP Right Cessation
- 2000-09-01 BG BG104740A patent/BG104740A/xx unknown

Also Published As

Publication number	Publication date
SK13002000A3 (sk)	2001-07-10
EA200000804A1 (ru)	2001-04-23
CN1214011C (zh)	2005-08-10
YU52000A (sh)	2003-02-28
AR018139A1 (es)	2001-10-31
MY123908A (en)	2006-06-30
HRP20000574A2 (en)	2001-08-31
CN1291978A (zh)	2001-04-18
NZ506598A (en)	2003-07-25
NO20004316L (no)	2000-11-06
CA2322207A1 (en)	1999-09-10
GEP20033118B (en)	2003-11-25
IL137653A0 (en)	2001-10-31
TR200002542T2 (tr)	2001-05-21
OA11530A (en)	2004-05-17
JP2002505323A (ja)	2002-02-19
AP1244A (en)	2004-02-04
NO315703B1 (no)	2003-10-13
IS5582A (is)	2000-08-04
AU3294799A (en)	1999-09-20
ID25591A (id)	2000-10-19
EE200000506A (et)	2002-04-15
NO20004316D0 (no)	2000-08-30
AU753230B2 (en)	2002-10-10
PL342726A1 (en)	2001-07-02
UA71906C2 (en)	2005-01-17
KR20010041584A (ko)	2001-05-25
WO1999044994A1 (en)	1999-09-10
ZA994406B (en)	2000-02-11
HUP0100865A2 (hu)	2001-08-28
EP1060164A1 (en)	2000-12-20
BG104740A (en)	2001-02-28
BR9908470A (pt)	2000-12-05
AP2000001893A0 (en)	2000-09-30

Publication	Publication Date	Title
HUP0100865A3 (en)	2001-11-28	Meta-azacyclic amino benzoic acid compounds and derivatives thereof being integrin antagonists, pharmaceutical compositions comprising thereof and their use
HUP0302969A3 (en)	2005-05-30	Npyy5 antagonists, pharmaceutical compositions containing them and their use
HUP0102766A3 (en)	2002-11-28	Aminomethylcarboxylic acid derivatives, their pharmaceutical use and pharmaceutical compositions comprising them
HUP0204413A3 (en)	2003-07-28	Quinazoline compounds, their preparation, their use and pharmaceutical compositions containing them
IL155196A0 (en)	2003-11-23	Benzamide derivatives and pharmaceutical compositions containing the same
HUP0200714A3 (en)	2003-01-28	Pharmaceutical compounds, pharmaceutical compositions containing them and their use
HUP0105133A3 (en)	2002-09-30	Quinoline derivatives and quinazoline derivatives, pharmaceutical compositions containing them and their use
HUP0103851A3 (en)	2002-05-28	Factor viia inhibitors, process for their preparation, their use and pharmaceutical compositions comprising thereof
HUP0105003A2 (en)	2002-06-29	2-oxy-4h-3,1-benzoxazin-4-one derivatives, their use and pharmaceutical compositions containing them
IL150449A0 (en)	2002-12-01	Aniline derivatives and pharmaceutical compositions containing the same
HUP0203325A3 (en)	2003-12-29	Bicyclic amino acids, pharmaceutical compositions containing them and their use
HUP0203939A3 (en)	2004-12-28	Pharmaceutical compounds and compositions containing them and their use
HUP0401567A3 (en)	2005-06-28	Novel 4,5-dyhydro-1h-pyrazole derivatives having cb1-antagonistic activity, their use and pharmaceutical compositions containing them
IL138969A0 (en)	2001-11-25	Anthranilic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
HUP0200155A3 (en)	2005-04-28	Thioamide derivatives, pharmaceutical compositions containing them and their use
HUP0204081A3 (en)	2003-07-28	4-pyrimidinyl-n-acyl-l-phenylalanines, pharmaceutical compositions containing them and their use
HUP0400558A3 (en)	2010-03-29	Substituted benzene derivatives or salts thereof and pharmaceutical compositions containing them
HUP0102579A3 (en)	2002-02-28	Peptide antiangiogenic drugs, pharmaceutical compositions comprising thereof and their use
HUP0101333A3 (en)	2002-12-28	Diazepan derivatives and their salts, pharmaceutical compositions containing the same
HUP0200996A3 (en)	2003-01-28	Amine derivatives, pharmaceutical compositions containing them and their use
HUP0203194A3 (en)	2004-01-28	Phenylpiperazines, pharmaceutical compositions containing them and their use
HUP0102255A3 (en)	2001-12-28	Vla-4 inhibitor omepupa-v, pharmaceutical compositions comprising thereof and their use
HUP0202781A3 (en)	2003-10-28	Betha-carboline particulate form, pharmaceutical compositions containing it, their preparations and their use
HUP0203735A3 (en)	2005-03-29	4-pyridinyl-n-acyl-l-phenylalanines, pharmaceutical compositions containing them and their use
HUP0203645A3 (en)	2004-01-28	Phenylpiperazinyl derivatives, pharmaceutical compositions containing them and their use