[go: up one dir, main page]

HU911186D0 - Process for producing ammonium salts of n-methyl-5,6,7,8-tetrahydropholic acid, for separation of (6rs) diastereomer mixtures and for producing (6r)- and (6s)-alcaline metal and alcaline earth metal salts - Google Patents

Process for producing ammonium salts of n-methyl-5,6,7,8-tetrahydropholic acid, for separation of (6rs) diastereomer mixtures and for producing (6r)- and (6s)-alcaline metal and alcaline earth metal salts

Info

Publication number
HU911186D0
HU911186D0 HU911186A HU118691A HU911186D0 HU 911186 D0 HU911186 D0 HU 911186D0 HU 911186 A HU911186 A HU 911186A HU 118691 A HU118691 A HU 118691A HU 911186 D0 HU911186 D0 HU 911186D0
Authority
HU
Hungary
Prior art keywords
alcaline
producing
salts
methyl
separation
Prior art date
Application number
HU911186A
Other languages
English (en)
Other versions
HUT60741A (en
Inventor
Fabrizio Marazza
Jean Jacques
Original Assignee
Sapec S A Fine Chemicals Barbe
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sapec S A Fine Chemicals Barbe filed Critical Sapec S A Fine Chemicals Barbe
Publication of HU911186D0 publication Critical patent/HU911186D0/hu
Publication of HUT60741A publication Critical patent/HUT60741A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HU911186A 1990-04-12 1991-04-11 Process for producing ammonium salts of n5-methyl-5,6,7,8-tetrahydrofolic acid, for separating (6rs)-diastereoisomer mixtures and for producing (6r)- and (6s)-alkali metal and alkali-earth metal salts HUT60741A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1255/90A CH680731A5 (hu) 1990-04-12 1990-04-12

Publications (2)

Publication Number Publication Date
HU911186D0 true HU911186D0 (en) 1991-10-28
HUT60741A HUT60741A (en) 1992-10-28

Family

ID=4206110

Family Applications (1)

Application Number Title Priority Date Filing Date
HU911186A HUT60741A (en) 1990-04-12 1991-04-11 Process for producing ammonium salts of n5-methyl-5,6,7,8-tetrahydrofolic acid, for separating (6rs)-diastereoisomer mixtures and for producing (6r)- and (6s)-alkali metal and alkali-earth metal salts

Country Status (14)

Country Link
US (2) US5194611A (hu)
EP (1) EP0455013B1 (hu)
JP (1) JP2525965B2 (hu)
AT (1) ATE124043T1 (hu)
AU (1) AU635831B2 (hu)
CA (1) CA2040397A1 (hu)
CH (1) CH680731A5 (hu)
DE (1) DE59105758D1 (hu)
ES (1) ES2075247T3 (hu)
FI (1) FI911763L (hu)
HU (1) HUT60741A (hu)
IE (1) IE911224A1 (hu)
IL (1) IL97826A0 (hu)
MX (1) MX25305A (hu)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0432441T3 (da) * 1989-12-11 1996-07-29 American Cyanamid Co Fremgangsmåde til fremstilling af optisk rene diastereoisomere af tetrahydrofolatforbindelser
CH680731A5 (hu) * 1990-04-12 1992-10-30 Sapec Fine Chemicals
CH681303A5 (hu) * 1991-01-16 1993-02-26 Eprova Ag
CH684270A5 (de) * 1991-10-04 1994-08-15 Sapec Fine Chemicals Verfahren zur Herstellung von Erdalkalimetallsalzen von (6R)-N(10)-Formyl-5,6,7,8-tetrahydrofolsäure.
CH683261A5 (it) * 1991-10-10 1994-02-15 Applied Pharma Res Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali.
DE4136921A1 (de) * 1991-11-11 1993-05-13 Knoll Ag Verfahren zur trennung von 5-methyl-tetrahydrofolsaeure
CH683262A5 (it) * 1992-01-22 1994-02-15 Applied Pharma Res Procedimento per la separazione dei diastereomeri del sale di calcio dell'acido (6(R,S)-N-formiltetraidrofolico).
US5599931A (en) * 1992-02-20 1997-02-04 Bracco S.P.A. Process for separating stereoisomers of folinic acid
IT1254635B (it) * 1992-02-20 1995-09-28 Bracco Spa Processo per la separazione degli stereoisomeri dell'acido folinico
CH684644A5 (de) * 1992-07-13 1994-11-15 Eprova Ag 5,10-Methylentetrahydrofolsäure-Cyclodextrin-Einschlussverbindungen.
US5698693A (en) * 1992-11-16 1997-12-16 The United States Of America As Represented By The Department Of Health And Human Services Process of separating the diastereomers of (6R,6S) -5,6,7,8-tetrahydrofolic acid derivatives
CH686672A5 (de) * 1992-12-01 1996-05-31 Cerbios Pharma Sa Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure.
CH686369A5 (de) * 1994-05-09 1996-03-15 Eprova Ag Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure.
US5710271A (en) * 1994-06-08 1998-01-20 Dibra S.P.A. Process for the preparation and separation of diastereomeric salts of folinic acid
IT1270185B (it) * 1994-06-08 1997-04-29 Bracco Spa Processo per l'ottenimento e la separazione dei sali diastereoisomeri dell'acido folinico
CH693905A5 (de) 1999-04-15 2004-04-15 Eprova Ag Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
US6989386B2 (en) * 2002-04-30 2006-01-24 Dana-Farber Cancer Institute Pharmaceutically active ornithine derivatives, ammonium salts thereof and methods of making same
US20050032807A1 (en) * 2003-08-06 2005-02-10 Rosenwald Lindsay A. Methods of treating inflammatory diseases with ammonium salts of ornitihine derivatives
DE10349501A1 (de) 2003-10-23 2005-05-25 Bayer Cropscience Ag Synergistische fungizide Wirkstoffkombinationen
CH698729B1 (de) * 2007-05-30 2009-10-15 Cerbios Pharma Sa Stabile, kristalline (6S)-N(5)-Methyl-5, 6,7,8-tetrahydrofolsäure.
PL2254890T3 (pl) * 2008-02-20 2015-10-30 Gnosis Spa Sposób diastereoizomerycznego rozdzielania kwasu 5-metylotetrahydrofoliowego
JP7395556B2 (ja) 2018-07-06 2023-12-11 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング ５－メチル－（６ｓ）－テトラヒドロ葉酸及びアミノ酸エチルエステルの結晶塩
EP3646873A1 (en) 2018-10-31 2020-05-06 Aprofol AG Folate salts
KR102651030B1 (ko) * 2021-06-08 2024-03-26 세메스 주식회사 반송 유닛, 물품 반송 시스템 및 반송 유닛의 제어 방법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2688018A (en) * 1952-06-28 1954-08-31 American Cyanamid Co Method of preparing alkaline earth metal salts of 1-leucovorin
DE2063027A1 (de) * 1969-12-26 1971-07-01 Yamanouchi Pharmaceutical Co Ltd , Tokio Salz einer basischen Aminosäure der 5 6,7,8 Tetrahydrofolsaure
US5124452A (en) * 1978-07-10 1992-06-23 Bioresearch S.P.A. Process for producing d,1-5-methyltetrahydrofolic acid and its salts
US5223500A (en) * 1977-02-22 1993-06-29 Bioresearch S.P.A. Stable pharmaceutical composition of alkaline or alkaline earth 5-methyl tetrahydrofolate
GB1572137A (en) * 1977-02-22 1980-07-23 Bioresearch Sas Del Dr Livio C Stable compositions for therapeutic use based on d,1-5-methyltetrahydrofolic acid and its salts
GB8621268D0 (en) * 1986-09-03 1986-10-08 Univ Strathclyde Separation of substances
CH673459A5 (hu) * 1987-05-15 1990-03-15 Eprova Ag
DE3773390D1 (de) * 1987-12-07 1991-10-31 Holger Blum Stabilisierte waessrige folsaeurezubereitung.
DE3821875C1 (hu) * 1988-06-29 1990-02-15 Eprova Ag, Forschungsinstitut, Schaffhausen, Ch
CH676981A5 (hu) * 1988-11-11 1991-03-28 Eprova Ag
FR2643081B1 (fr) * 1989-02-14 1991-06-07 Panmedica Sa Folates de magnesium, procede de preparation et compositions pharmaceutiques
US5173488A (en) * 1989-08-21 1992-12-22 American Cyanamid Company Stable injectable pharmaceutical formulation for folic acid and leucovorin salts and method
FR2659330B1 (fr) * 1990-03-09 1994-02-11 Sapec Sa Composes diastereoisomeres derivant de l'acide tetrahydrofolique, procede de preparation et utilisation dans la synthese de diastereomeres 6s et 6r de folates reduits.
CH680731A5 (hu) * 1990-04-12 1992-10-30 Sapec Fine Chemicals

Also Published As

Publication number Publication date
CA2040397A1 (en) 1991-10-13
ES2075247T3 (es) 1995-10-01
FI911763A7 (fi) 1991-10-13
IE911224A1 (en) 1991-10-23
FI911763L (fi) 1991-10-13
HUT60741A (en) 1992-10-28
FI911763A0 (fi) 1991-04-11
EP0455013B1 (de) 1995-06-21
DE59105758D1 (de) 1995-07-27
US5382581A (en) 1995-01-17
IL97826A0 (en) 1992-06-21
ATE124043T1 (de) 1995-07-15
JPH0725876A (ja) 1995-01-27
AU7429791A (en) 1991-11-14
US5194611A (en) 1993-03-16
JP2525965B2 (ja) 1996-08-21
MX25305A (es) 1993-12-01
EP0455013A1 (de) 1991-11-06
CH680731A5 (hu) 1992-10-30
AU635831B2 (en) 1993-04-01

Similar Documents

Publication Publication Date Title
HU911186D0 (en) Process for producing ammonium salts of n-methyl-5,6,7,8-tetrahydropholic acid, for separation of (6rs) diastereomer mixtures and for producing (6r)- and (6s)-alcaline metal and alcaline earth metal salts
GR3026322T3 (en) Process for the preparation of pure polylactide.
HU903799D0 (en) Process for producing ascorbic acid
GB1536945A (en) Machine for forming cup-shaped articles
DE3573601D1 (en) Sulfate of 5,6,7,8-tetrahydro-l-erythro-biopterin and process for preparing the same
GB2002361B (en) Process for the production of 1,2,4-triazin-5-one derivatives
HUT47114A (en) Process for producing podophyllotoxin and podophyllotoxin derivatives
NZ236370A (en) Preparation of substantially pure 6r or 6s diastereoisomers of a derivative of 5,6(r or s),7,8-tetrahydrofolic acid using enzymatic formylation
PT78775A (en) Process for preparing 7-piperidino-1,2,3,5-tetrahydroimidazo<2,1-b>quinazolin-2-one and of pharmaceutical compositions containing the same
GR62157B (en) Preparation process of 1,2,5-triazine-2,6-dione
EG14958A (en) Process for the preparation of 1-amino-1,3,5-triazine-2,4(1h,3h)-diones
EP0055933A3 (en) 6-(2-aryl-2-(1,1-dioxopenicillanoyloxy-methoxycarbonyl)acetamido) penicillanic acids
DE3378823D1 (en) Process for the preparation of 2,4,5,6-tetrachloropyrimidine
EP0290862A3 (en) Process for the preparation of 2,4-diazabicycloû2.2.2¨ octanes
DE3160133D1 (en) 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines, process for their preparation and pharmaceutical compositions containing them
IL62969A0 (en) Preparation of 4-amino-6-tert.butyl-3-mercapto-1,2,4-triazin-5-one
DE3267898D1 (en) Process for the preparation of n,n'-disubstituted 3-amino-propanamides
ZA739126B (en) Process and intermediates for preparation of 2-aryl-6-carboxy-1,2,4-triazine-3,5(2h,4h)-diones
PT75251A (en) Process for the preparation of 6-<3,6-dihydro-1(2h)-pyridyl>-pyrimidine-3-oxides
ZA8410109B (en) Process for the preparation of substituted quinazoline-2,4(1h,3h)-diones
ZA821162B (en) Process for the preparation of 1-amino-1,3,5-triazine-2,4(1h,3h)-diones
PT67605B (en) Process for the preparation of 2,9-dioxatricyclo <4,3,1,03,7>-decanes
HUT57224A (en) Process for producing nojivimycin and nojivimycin-derivatives
CA997343A (en) Process for the preparation of 4-mercapto-1h-pyrazolo (3,4-d) pyrimidine
GR3022125T3 (en) Process for the preparation of 1,3-dialkyl-5-hydroxyoxindoles and of their ether derivatives

Legal Events

Date Code Title Description
DFC9 Refusal of application