HU904906D0 - Process for producing alpha-1-aspartil-1-phenylalanine-methyl-esther-hydrochloride utilizing separated n-formyl-1-aspartil-anhydride - Google Patents

Process for producing alpha-1-aspartil-1-phenylalanine-methyl-esther-hydrochloride utilizing separated n-formyl-1-aspartil-anhydride

Info

Publication number: HU904906D0
Authority: HU; Hungary
Prior art keywords: aspartil; phenylalanine; esther; formyl; anhydride
Prior art date: 1988-07-14

Application number

HU904906A

Other languages

English (en)

Other versions

HUT59658A (en

HU210688B (en

Inventor

John B Hill

Yefim Gelman

Original Assignee

Nutrasweet Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-07-14

Filing date

1990-08-06

Publication date

1991-01-28

1988-07-14 Priority to US07/219,613 priority Critical patent/US4946988A/en

1990-07-11 Priority to JP2511850A priority patent/JP2609368B2/ja

1990-07-11 Priority to KR1019910700149A priority patent/KR0185409B1/ko

1990-07-11 Priority to PCT/US1990/003899 priority patent/WO1992000950A1/en

1990-07-11 Priority to AU61820/90A priority patent/AU648747B2/en

1990-07-11 Priority to BR909007648A priority patent/BR9007648A/pt

1990-07-13 Priority to CA002021180A priority patent/CA2021180C/en

1990-07-19 Priority to ZA905687A priority patent/ZA905687B/xx

1990-07-20 Priority to DK90113895.8T priority patent/DK0466963T3/da

1990-07-20 Priority to ES90113895T priority patent/ES2079402T3/es

1990-07-20 Priority to EP90113895A priority patent/EP0466963B1/en

1990-07-20 Priority to AT90113895T priority patent/ATE130010T1/de

1990-07-30 Priority to DD343152A priority patent/DD300232A5/de

1990-08-06 Priority to RO145705A priority patent/RO108865B1/ro

1990-08-06 Priority to HU904906A priority patent/HU210688B/hu

1990-08-06 Application filed by Nutrasweet Co filed Critical Nutrasweet Co

1990-08-06 Priority to CN90106906A priority patent/CN1035183C/zh

1990-08-06 Priority to CS903874A priority patent/CZ283231B6/cs

1991-01-28 Publication of HU904906D0 publication Critical patent/HU904906D0/hu

1992-06-29 Publication of HUT59658A publication Critical patent/HUT59658A/hu

1995-06-28 Publication of HU210688B publication Critical patent/HU210688B/hu

1995-11-09 Priority to GR950403024T priority patent/GR3018046T3/el

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06104—Dipeptides with the first amino acid being acidic
- C07K5/06113—Asp- or Asn-amino acid
- C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
- C07K5/0613—Aspartame

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Seasonings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

HU904906A 1988-07-14 1990-08-06 Process for the preparation of alpha-l-aspartyl-l-phenylalanine-methyl-ester hydrochloride by use of isolated n-formyl-l-aspartic anhydride HU210688B (en)

Priority Applications (18)

Application Number	Priority Date	Filing Date	Title
US07/219,613 US4946988A (en)	1988-07-14	1988-07-14	Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
JP2511850A JP2609368B2 (ja)	1988-07-14	1990-07-11	単離したＮ―ホルミル―Ｌ―アスパラギン酸無水物を使用するα―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステル塩酸塩の製造方法
KR1019910700149A KR0185409B1 (ko)	1988-07-14	1990-07-11	순수분리된 n-포밀-l-아스파라틱 무수물을 사용하여 알파-l-아스파르틸-l-페닐알라닌 메틸에스테르 염산 제조공정
PCT/US1990/003899 WO1992000950A1 (en)	1988-07-14	1990-07-11	A process for the preparation of alpha-l-aspartyl-l-phenylalanine methyl ester hydrochloride by use of isolated n-formyl l-aspartic anhydride
AU61820/90A AU648747B2 (en)	1988-07-14	1990-07-11	A process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
BR909007648A BR9007648A (pt)	1988-07-14	1990-07-11	Processos para preparar hidrocloreto de -apm,e anidrido n-formil-l-aspartico
CA002021180A CA2021180C (en)	1988-07-14	1990-07-13	Process for the preparation of .alpha.-l-aspartyl-l-phenylalanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride
ZA905687A ZA905687B (en)	1988-07-14	1990-07-19	Process for the preparation of alpha-l-aspartyl-l-phenyl-alanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride
ES90113895T ES2079402T3 (es)	1988-07-14	1990-07-20	Un proceso para la preparacion de hidrocloruro de ester metilico de alfa-l-aspartil-l-fenilalanina mediante el uso de anhidrido n-formil-aspartico aislado.
DK90113895.8T DK0466963T3 (da)	1988-07-14	1990-07-20	Fremgangsmåde til fremstilling af alfa-L-aspartyl-L-phenyl-alaninmethylester, hydroclorid ved anvend else af isoleret N-formyl-asparaginsyreanhydrid
EP90113895A EP0466963B1 (en)	1988-07-14	1990-07-20	A process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl-aspartic anhydride
AT90113895T ATE130010T1 (de)	1988-07-14	1990-07-20	Verfahren zur herstellung des alpha-l-aspartyl-l- phenylalaninmethylesters mittels isolierten n- formyl-aspartylanhydrids.
DD343152A DD300232A5 (de)	1988-07-14	1990-07-30	Verfahren zur Herstellung von Alpha-L-Aspartylphenylananin-Methylester-Hydrochlorid durch Verwendung isolierter N-Formyl-L-Asparagin-Anhydride
HU904906A HU210688B (en)	1988-07-14	1990-08-06	Process for the preparation of alpha-l-aspartyl-l-phenylalanine-methyl-ester hydrochloride by use of isolated n-formyl-l-aspartic anhydride
RO145705A RO108865B1 (ro)	1988-07-14	1990-08-06	Procedeu pentru prepararea clorhidratului esterului metilic al alfa-l-aspartil-l-fenilalaninei
CN90106906A CN1035183C (zh)	1988-07-14	1990-08-06	制备α-L-天冬氨酰-L-苯丙氨酸甲酯盐酸盐的方法
CS903874A CZ283231B6 (cs)	1988-07-14	1990-08-06	Způsob přípravy hydrochloridu methylesteru alfa-L-asparagyl-L fenylalaninu
GR950403024T GR3018046T3 (en)	1988-07-14	1995-11-09	A process for the preparation of alpha-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl-aspartic anhydride.

Applications Claiming Priority (6)

Application Number	Priority Date	Filing Date	Title
US07/219,613 US4946988A (en)	1988-07-14	1988-07-14	Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
CA002021180A CA2021180C (en)	1988-07-14	1990-07-13	Process for the preparation of .alpha.-l-aspartyl-l-phenylalanine methyl ester hydrochloride by use of isolated n-formyl-aspartic anhydride
DD343152A DD300232A5 (de)	1988-07-14	1990-07-30	Verfahren zur Herstellung von Alpha-L-Aspartylphenylananin-Methylester-Hydrochlorid durch Verwendung isolierter N-Formyl-L-Asparagin-Anhydride
CS903874A CZ283231B6 (cs)	1988-07-14	1990-08-06	Způsob přípravy hydrochloridu methylesteru alfa-L-asparagyl-L fenylalaninu
RO145705A RO108865B1 (ro)	1988-07-14	1990-08-06	Procedeu pentru prepararea clorhidratului esterului metilic al alfa-l-aspartil-l-fenilalaninei
HU904906A HU210688B (en)	1988-07-14	1990-08-06	Process for the preparation of alpha-l-aspartyl-l-phenylalanine-methyl-ester hydrochloride by use of isolated n-formyl-l-aspartic anhydride

Publications (3)

Publication Number	Publication Date
HU904906D0 true HU904906D0 (en)	1991-01-28
HUT59658A HUT59658A (en)	1992-06-29
HU210688B HU210688B (en)	1995-06-28

Family

ID=27543426

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HU904906A HU210688B (en)	1988-07-14	1990-08-06	Process for the preparation of alpha-l-aspartyl-l-phenylalanine-methyl-ester hydrochloride by use of isolated n-formyl-l-aspartic anhydride

Country Status (18)

Country	Link
US (1)	US4946988A (hu)
EP (1)	EP0466963B1 (hu)
JP (1)	JP2609368B2 (hu)
KR (1)	KR0185409B1 (hu)
CN (1)	CN1035183C (hu)
AT (1)	ATE130010T1 (hu)
AU (1)	AU648747B2 (hu)
BR (1)	BR9007648A (hu)
CA (1)	CA2021180C (hu)
CZ (1)	CZ283231B6 (hu)
DD (1)	DD300232A5 (hu)
DK (1)	DK0466963T3 (hu)
ES (1)	ES2079402T3 (hu)
GR (1)	GR3018046T3 (hu)
HU (1)	HU210688B (hu)
RO (1)	RO108865B1 (hu)
WO (1)	WO1992000950A1 (hu)
ZA (1)	ZA905687B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BR9007646A (pt) *	1988-02-12	1992-09-15	Nutrasweet Co	Processo em recipiente unico de preparacao de hidrocloreto de -apm,processo de copulacao de anidrido n-formil-l-aspartico com l-fenilalanina e processo de preparacao de isomeros de / -n-formil-l-aspartil-l-fenilalanina
US5053532A (en) *	1988-02-12	1991-10-01	The Nutra Sweet Company	One-pot process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride
US4946988A (en) *	1988-07-14	1990-08-07	The Nutrasweet Company	Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride
HU212897B (en) *	1990-03-12	1996-12-30	Nutrasweet Co	Process for increasing the alpha/beta isomer ratio in asphartame coupling reaction
AU2001263267A1 (en) *	2000-05-18	2001-11-26	The Nutrasweet Company	Synthesis of n-(n-(3,3-dimethylbutyl)-l-alpha-aspartyl)-l-phenylalanine 1-methylester using l-alpha-aspartyl-l-phenylalanine 1-methyl ester precursors
US9101160B2 (en)	2005-11-23	2015-08-11	The Coca-Cola Company	Condiments with high-potency sweetener
US8017168B2 (en)	2006-11-02	2011-09-13	The Coca-Cola Company	High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith
CN103130870B (zh) *	2011-11-30	2015-03-18	江苏维多股份有限公司	α-L-天冬氨酸-L-苯丙氨酸甲酯盐酸盐的制备方法
CN102584938B (zh) *	2012-03-02	2014-02-19	孟州市华兴生物化工有限责任公司	一种阿斯巴甜的结晶方法
CN104628819B (zh) *	2014-10-23	2019-05-21	常茂生物化学工程股份有限公司	一种偶合反应生成阿斯巴甜的工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5232371B2 (hu) *	1972-07-20	1977-08-20
US3933781A (en) *	1973-11-05	1976-01-20	Monsanto Company	Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
JPS5113737A (en) *	1974-07-23	1976-02-03	Ajinomoto Kk	Arufua ll asuparuchiru ll fueniruaraninteikyuarukiruesuteruno seizoho
FR2295015A1 (fr) *	1974-12-18	1976-07-16	Ajinomoto Kk	Procede de preparation d'esters alkyliques inferieurs d'a-l-aspartyl l-phenylalanine
JPH07636B2 (ja) *	1984-12-17	1995-01-11	三井東圧化学株式会社	Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法
JPH0680075B2 (ja) *	1985-12-24	1994-10-12	味の素株式会社	Ｎ―ホルミル―α―Ｌ―アスパルチル―Ｌ―フェニルアラニンメチルエステルの製造法
US4946988A (en) *	1988-07-14	1990-08-07	The Nutrasweet Company	Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester hydrochloride by use of isolated N-formyl L-aspartic anhydride

1988
- 1988-07-14 US US07/219,613 patent/US4946988A/en not_active Expired - Lifetime
1990
- 1990-07-11 JP JP2511850A patent/JP2609368B2/ja not_active Expired - Lifetime
- 1990-07-11 AU AU61820/90A patent/AU648747B2/en not_active Ceased
- 1990-07-11 BR BR909007648A patent/BR9007648A/pt not_active Application Discontinuation
- 1990-07-11 KR KR1019910700149A patent/KR0185409B1/ko not_active Expired - Fee Related
- 1990-07-11 WO PCT/US1990/003899 patent/WO1992000950A1/en not_active Ceased
- 1990-07-13 CA CA002021180A patent/CA2021180C/en not_active Expired - Fee Related
- 1990-07-19 ZA ZA905687A patent/ZA905687B/xx unknown
- 1990-07-20 AT AT90113895T patent/ATE130010T1/de not_active IP Right Cessation
- 1990-07-20 ES ES90113895T patent/ES2079402T3/es not_active Expired - Lifetime
- 1990-07-20 DK DK90113895.8T patent/DK0466963T3/da active
- 1990-07-20 EP EP90113895A patent/EP0466963B1/en not_active Expired - Lifetime
- 1990-07-30 DD DD343152A patent/DD300232A5/de unknown
- 1990-08-06 HU HU904906A patent/HU210688B/hu not_active IP Right Cessation
- 1990-08-06 CZ CS903874A patent/CZ283231B6/cs not_active IP Right Cessation
- 1990-08-06 CN CN90106906A patent/CN1035183C/zh not_active Expired - Fee Related
- 1990-08-06 RO RO145705A patent/RO108865B1/ro unknown
1995
- 1995-11-09 GR GR950403024T patent/GR3018046T3/el unknown

Also Published As

Publication number	Publication date
DK0466963T3 (da)	1996-02-05
ZA905687B (en)	1991-07-31
AU648747B2 (en)	1994-05-05
ES2079402T3 (es)	1996-01-16
CA2021180A1 (en)	1992-01-14
CN1058783A (zh)	1992-02-19
DD300232A5 (de)	1992-05-27
JP2609368B2 (ja)	1997-05-14
HUT59658A (en)	1992-06-29
EP0466963B1 (en)	1995-11-08
BR9007648A (pt)	1992-09-15
CN1035183C (zh)	1997-06-18
WO1992000950A1 (en)	1992-01-23
ATE130010T1 (de)	1995-11-15
RO108865B1 (ro)	1994-09-30
KR920702341A (ko)	1992-09-03
JPH05500364A (ja)	1993-01-28
EP0466963A1 (en)	1992-01-22
GR3018046T3 (en)	1996-02-29
US4946988A (en)	1990-08-07
AU6182090A (en)	1992-02-04
CA2021180C (en)	1998-06-23
CZ283231B6 (cs)	1998-02-18
HU210688B (en)	1995-06-28
KR0185409B1 (ko)	1999-06-01
CS387490A3 (en)	1992-02-19

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Legal Events

Date	Code	Title	Description
2002-05-28	HMM4	Cancellation of final prot. due to non-payment of fee