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HK1231095B - Method for improving solubility of protein and peptide by using immunoglobulin fc fragment linkage - Google Patents

Method for improving solubility of protein and peptide by using immunoglobulin fc fragment linkage Download PDF

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Publication number
HK1231095B
HK1231095B HK17104780.7A HK17104780A HK1231095B HK 1231095 B HK1231095 B HK 1231095B HK 17104780 A HK17104780 A HK 17104780A HK 1231095 B HK1231095 B HK 1231095B
Authority
HK
Hong Kong
Prior art keywords
peptide
immunoglobulin
fragment
insulin
physiologically active
Prior art date
Application number
HK17104780.7A
Other languages
English (en)
French (fr)
Chinese (zh)
Other versions
HK1231095A1 (en
Inventor
Kyu Lim Hyung
Soo Lee Jong
Jin Kim Dae
Min Bae Sung
Youb Jung Sung
Chang Kwon Se
Original Assignee
韩美药品株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 韩美药品株式会社 filed Critical 韩美药品株式会社
Publication of HK1231095A1 publication Critical patent/HK1231095A1/en
Publication of HK1231095B publication Critical patent/HK1231095B/en

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Claims (1)

  1. Verwendung eines pegylierten Immunglobulin-Fc-Fragments in einem Verfahren zum Verbessern der Löslichkeit eines physiologisch aktiven Proteins oder Peptids in wässriger Lösung, die einen pH-Wert von 5,0 bis 7,0 aufweist, verglichen mit dem physiologisch aktiven Protein oder Peptid ohne pegyliertes Immunglobulin-Fc-Fragment, wobei das Verfahren das Konjugieren des pegylierten Immunglobulin-Fc-Fragments an das physiologisch aktive Protein oder Peptid umfasst, wobei das physiologisch aktive Protein oder Peptid Exendin-4, Imidazoacetyl- (CA-) exendin-4 oder Insulin ist.
HK17104780.7A 2014-03-31 2015-03-31 Method for improving solubility of protein and peptide by using immunoglobulin fc fragment linkage HK1231095B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR10-2014-0038032 2014-03-31

Publications (2)

Publication Number Publication Date
HK1231095A1 HK1231095A1 (en) 2017-12-15
HK1231095B true HK1231095B (en) 2022-01-21

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