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HK1223371B - Fused imidazole derivatives useful as ido inhibitors - Google Patents

Fused imidazole derivatives useful as ido inhibitors Download PDF

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Publication number
HK1223371B
HK1223371B HK16111731.3A HK16111731A HK1223371B HK 1223371 B HK1223371 B HK 1223371B HK 16111731 A HK16111731 A HK 16111731A HK 1223371 B HK1223371 B HK 1223371B
Authority
HK
Hong Kong
Prior art keywords
imidazo
isoindol
ethyl
hydroxy
cyclohexyl
Prior art date
Application number
HK16111731.3A
Other languages
English (en)
French (fr)
Chinese (zh)
Other versions
HK1223371A1 (en
Inventor
Mario Mautino
Sanjeev Kumar
Jesse Waldo
Firoz Jaipuri
Tanay Kesharwani
Xiaoxia Zhang
Original Assignee
Newlink Genetics Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Newlink Genetics Corporation filed Critical Newlink Genetics Corporation
Publication of HK1223371A1 publication Critical patent/HK1223371A1/en
Publication of HK1223371B publication Critical patent/HK1223371B/en

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Claims (14)

  1. Pharmazeutische Zusammensetzung, die eine Verbindung umfasst, die
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)ethanol;
    Ethyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)acetat;
    (E)-5-(2-Bromstyryl)-5H-imidazo[5,1-a]isoindol;
    2-(6-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanol;
    2-(6-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)ethyl-2-(((1R,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetat;
    tert-Butyl-(4-(2-(5H-imidazo[5,1-a]isoindol-5-yl)acetyl)phenyl)carbamat;
    1-(4-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    tert-Butyl-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)phenyl)carbamat;
    1-(4-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a] isoindol-5-yl)-l-(3-nitrophenyl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(3-nitrophenyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(2-nitrophenyl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(2-nitrophenyl)ethanol;
    tert-Butyl-(2-(2-(5H-imidazo[5,l-a]isoindol-5-yl)acetyl)phenyl)carbamat;
    tert-Butyl-(2-(1-hydroxy-2-(5H-imidazo[5,1-a] isoindol-5-yl)ethyl)phenyl)carbamat;
    1-(2-Aminophenyl)-2-(5H-imidazo[5,1-alisoindol-5-yl)ethanon;
    1-(2-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(2-Chlorphenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    1-(5H-Imidazo[5,1-a]isoindol-5-yl)-2-methylpropan-2-ol;
    1-(2-Chlorphenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(3-Chlorphenyl)-2-(5H-imidazo[5,l-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-phenylethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-phenylethanol;
    1-(2,4-Dimethylfuran-3-yl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(3-Chlorphenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    1-Cyclohexyl-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    1-Cyclohexyl-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(tetrahydro-2H-pyran-4-yl)ethanol;
    2-(7-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanol;
    (Z)-1-Cyc1ohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanonoxim;
    1-Cyclopentyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    tert-Butyl-4-(-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanamin;
    tert-Butyl-(3-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)phenyl)carbamat;
    1-(3-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    1-Cyclohexyl-2-(9-methoxy-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    5-(2-Cyclohexyl-2-hydroxyethyl)-5H-imidazo[5,1-a]isoindol-9-ol;
    2-(8-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanol;
    1-(Cyclohex-1-en-1-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-(8-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)ethanol;
    4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanon;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-methylencyclohexyl)ethanol;
    1-(Cyc1ohex-3-en-1-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4-(Hydroxymethyl)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)(thiophen-2-yl)methanon;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-methylencyclohexyl)ethanol-,
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-methylcyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(thiazol-4-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(thiazol-5-yl)ethanol;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2,2-dimethylpropan-1-on;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(furan-2-yl)ethanol;
    (1S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (1R)-1-Cyclohexyl-2-(5H-imidazo[5,1-a] isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-(iodmethylen)cyclohexyl)ethanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)propan-1-ol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)acetonitril;
    1-Cyclohexyl-3-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)propan-2-ol;
    1-Cyclohexyl-3-(5H-imidazo[5,1-a]isoindol-5-yl)propan-2-ol;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    1-(4,4-Difluorcyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4,4-Difluorcyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-methyl-1H-imidazol-5-yl)ethanol;
    1-(4-(Cyclopropylmethylen)cyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-(propan-2-yliden)cyclohexyl)ethanol;
    (E)-5-(2-Cyclohexylvinyl)-5H-imidazo[5,l-a]isoindol;
    2-(9-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-methylcyclohexyl)ethanol;
    1-(Cyclohex-3-en-1-yl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (S)-1-Cyclohexyl-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (R)-1-Cyclohexyl-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (R)-1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (S)-1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-(SH-imidazo[5,1-a]isoindol-5-yliden)ethanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylacetat;
    1-(4-(2-(Benzyloxy)ethyliden)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(1-(Benzylsulfonyl)piperidin-4-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(pyrimidin-5-yl)ethanon;
    2-(3,4-Difluorphenyl)-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    Cyclohexyl(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)methanon;
    Methyl-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexancarbox ylat;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylphenylcarbamat;
    4-(1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethoxy)-4-oxobuttersäure;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylbenzoat;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(2-(methylsulfonamido)ethyl)cyclohexancarboxamid;
    (2S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl-2-amino-3-methylbutanoat;
    1-Cyclohexyl-2-(5H-imidazo[5,l-a]isoindol-5-yl)ethyldihydrogenphosphat;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexancarbonsäure;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(pyridin-4-yl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(spiro[2.5]octan-6-yl)ethanol;
    2-(4-Fluorphenyl)-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    (2S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl-2-aminopropanoat;
    1-(4-(2-Hydroxyethyliden)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (2S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylpyrrolidin-2-carboxylat;
    (2S)-5-(1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-1-methyl-2-aminopentandioat;
    1-(4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    (3-Fluor-2-hydroxyphenyl)(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)methanon;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    (4-Fluorphenyl)(4-(1-hydroxy-2-(5H-imidazo[5,1-a] isoindol-5-yl)ethyl)piperidin-1-yl)methanon;
    (2S)-2-Amino-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-3-phenylpropan-1-on;
    (4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)((S)-pyrrolidin-2-yl)methanon;
    (1R,4s)-4-(2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)-cyclohexylbenzoat;
    (1R,4s)-4-(2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)-cyclohexanol;
    1-(3-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)azetidin-1-yl)-2-phenylethanon;
    3-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylazetidin-1-carboxamid;
    tert-Butyl-3-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)azetidin-1-carboxylat;
    1-(Azetidin-3-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    tert-Butyl-4-((S)-1-hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    tert-Butyl-4-((R)-1-hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    tert-Butyl-4-((R)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    tert-Butyl-4-((S)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)pipendm-1-carboxylat;
    1-((1s,4s)-4-(Benzyloxy)cyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(pyridin-3-yl)ethanol;
    (1r,4r)-4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    4-((S)-1-Hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    4-((R)-1-Hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin- 1-carboxamid;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    1-(4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isomdol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    (1R,4s)-4-((S)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4s)-4-((R)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4s)-4-((R)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-l-hydroxyethyl)cyclohexanol;
    (1R,4s)-4-((S)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4r)-4-((S)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4r)-4-((S)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1R,4r)-4-((R)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1R,4r)-4-((R)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    1-(4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethanon;
    1-(4-((R)-1-Hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    N-((1s,4s)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)benzamid;
    1-(4-((S)-1-Hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1-(phenylcarbamoyl)piperidin-4-yl)ethylphenylcarbamat;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-((1r,4R)-4-hydroxycyclohexyl)piperidin-1-carboxamid;
    4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-1-carboxamid;
    4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-((1r,4S)-4-hydroxycyclohexyl)piperidin-1-carboxamid;
    1-((1r,4r)-4-(Benzyloxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-(B enzyloxy)cyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(pyridin-4-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(pyridin-2-yl)ethanol;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-1-carboxamid;
    N-Cyclohexyl-4-((R)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    N-((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)benzamid;
    N-Cyclopentyl-4-((R)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-(trifluormethyl)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(trifluormethyl)cyclohexyl)ethanol;
    1-(4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(4-(trifluormethyl)phenyl)ethanon;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(4-(trifluormethyl)phenyl)piperidin-1-carboxamid;
    (4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)(1H-imidazol-1 -yl)methanon;
    1-(5H-Imidazo[5,1-a]isoindol-5-yl)-3-methylbutan-2-ol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(tetrahydro-2H-pyran-3-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(piperidin-3-yl)ethanol;
    1-Cyclohexyl-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-3-(5H-imidazo[5,1-a]isoindol-5-yl)propan-1-ol;
    1-Cyclohexyl-2-(9-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)phenyl)-2-(tetrahydro-2H-pyran-4-yl)acetamid;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1H-imidazol-2-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1H-imidazol-4-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(thiazol-2-yl)ethanol;
    (5S)-5-(2-Cyclohexyl-2-hydroxyethyl)-5H-imidazo[5,1-a]isoindol-6-ol;
    1-(2-Aminocyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-(1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)acetamid;
    N-(2-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)acetamid;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)-N-methylethanamin;
    2-((1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)amino)ethansulfonamid;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-methylpiperidin-4-yl)ethanol;
    1-(4-Aminocyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)acetamid;
    1-(4-(Aminomethyl)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexancarboxamid;
    1-(3-Aminocyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyridin-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyridin-3-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5, 1-a] isoindol-5-yl)- 1 -((1r,4r)-4-(pyridin-4-ylmethoxy)cyclohexyl)ethanol;
    1-((1r,4r)-4-((2-Aminopyridin-4-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a] isoindol- 5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyrazin-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyrimidin-5-ylmethoxy)cyclohexyl)ethanol;
    1-((1r,4r)-4-((6-Aminopyridin-2-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((6-Aminopyridin-3-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((3-Aminopyridin-2-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((2-Aminopyrimidin-5-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((4-Aminopyrimidin-5-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((5-Aminopyridin-2-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    4-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)-N,N-dimethylbenzamid;
    3-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)-N,N-dimethylbenzamid;
    2-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)-N,N-dimethylbenzamid;
    4-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    3-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    2-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    4-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzamid;
    3-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5, 1 -a] isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzamid;
    2-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzamid;
    Methyl-4-((((1r,4r)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzoat;
    Methyl-3-((((1r,4r)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzoat;
    Methyl-2-((((1r,4r)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzoat;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-methoxycyclohexyl)ethanol;
    1-((1r,4r)-4-Ethoxycyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-isopropoxycyclohexyl)ethanol;
    1-((1r,4r)-4-(Cyclopropylmethoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-(Cyclopentylmethoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(thiophen-2-ylmethoxy)cyclohexyl)ethanol;
    1-((1r,4r)-4-((1H-Indol-3-yl)oxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((1H-Indol-5-yl)oxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-((tetrahydro-2H-pyran-4-yl)methoxy)cyclohexyl)ethanol;
    4-(((4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(oxazol-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(thiazol-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1-(1-imino-2-phenylethyl)piperidin-4-yl)ethanol;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboximidamid;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(pyridin-4-yl)piperidin-1-carboximidamid;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-1-carboximidamid;
    N-(4-Cyanphenyl)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    N-(tert-Butyl)-4-(1-hydroxy-2-(5H-imidazo [5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    N-(tert-Butyl)-4-(1-hydroxy-2-(5H-imidazo[5,1-a] isoindol-5-yl)ethyl)piperidin- 1-sulfonamid;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(3-hydroxyphenyl)ethanon;
    2-(1-(Azetidin-1-carbonyl)piperidin-4-yl)-2-hydroxy-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    2-Cyclopentyl-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(2-methylthiazol-5-yl)ethanon;
    N-Cyclohexyl-N-hydroxy-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    N-(4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)phenyl)methansulfonamid;
    N-Cyclopropyl-N-hydroxy-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    3,3-Difluor-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)butan-1-on;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)pipendin-1-yl)-2-(p-tolyl)ethanon;
    1-(1-(4-Aminopyrimidin-2-yl)piperidin-4-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(1-(2-Aminopyrimidin-4-yl)piperidin-4-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-Cyclopropyl-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    2-Cyclopropyl-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyliden)acetonitril;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(4-(trifluormethyl)thiazol-2-yl)piperidin-1-carboxamid;
    4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzamid;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(4-(methylsulfonyl)phenyl)ethanon;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-((1r,4r)-4-methylcyclohexyl)piperidin-1-carboxamid;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-3,3-dimethylbutan-1-on;
    4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzolsulfonamid;
    N-(tert-Butyl)-4-(2-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzolsulfonamid;
    4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzoesäure;
    1-(4-(Difluormethylen)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(2,2,2-trifluorethyliden)cyclohexyl)ethanol;
    N-Benzyl-4-(2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexancarboxamid;
    4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)-N-phenylcyclohexancarboxamid;
    N-(4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexyl)benzamid;
    1-(4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexyl)-3-phenylharnstoff;
    N-(4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexyl)-2-phenylacetamid;
    oder ein pharmazeutisch verträgliches Salz davon ist.
  2. Zusammensetzung nach Anspruch 1, worin die Verbindung 4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid oder ein pharmazeutisch verträgliches Salz davon ist.
  3. Zusammensetzung nach Anspruch 1, worin die Verbindung 1-(4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon oder ein pharmazeutisch verträgliches Salz davon ist.
  4. Zusammensetzung nach Anspruch 1, worin die Verbindung 1-(4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon oder ein pharmazeutisch verträgliches Salz davon ist.
  5. Zusammensetzung nach Anspruch 1, worin die Verbindung (S)-1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol oder ein pharmazeutisch verträgliches Salz davon ist.
  6. Zusammensetzung nach Anspruch 1, worin die Verbindung (1R,4r)-4-((R)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol oder ein pharmazeutisch verträgliches Salz davon ist.
  7. Verbindung der Formel
    oder ein pharmazeutisch verträgliches Salz davon zur Verwendung bei der Behandlung von Erkrankungen und Störungen, die durch Indolamin-2,3-dioxygenase vermittelt werden, worin Bindung α eine Einfach- oder Doppelbindung ist;
    n 0, 1, 2, 3 oder 4 ist;
    jeder R1 unabhängig Halogenatom, Cyangruppe, Nitrogruppe, C1-6Alkylruppe, C1-6Haloalkylgruppe, -OR, -N(R)2, -SR, -C(O)OR, -C(O)N(R)2, -C(O)R, -S(O)R, -S(O)OR, -S(O)N(R)2, -S(O)2R, -S(O)2OR, -S(O)2N(R)2, -OC(O)R, -OC(O)OR, -OC(O)N(R)2, -N(R)C(O)R, -N(R)C(O)OR oder -N(R)C(O)N(R)2 ist;
    R2 -C1-4Alkyl-RA oder -C2-4Alkenyl-R3 ist, wenn Bindung α eine Einfachbindung ist; und
    R2 =C(H)RA ist, wenn Bindung α eine Doppelbindung ist;
    worin
    RA -CN, -C(O)R3, -C(O)OR3, -C(O)N(R3)(RC), -C(ORB)(R3)(RC), -C(NHRB)(R3)(RC) oder -C(=N-ORC)R3 ist, worin
    RB Wasserstoffatom, C1-6Alkylgruppe, C1-6Haloalkylgruppe, -C1-6Alkyl-RB1, -C(O)R3, -C(O)N(H)R3 oder -S(O)2R3, -C(O)(CH2)1-4COOR, -C(O)(CH2)1-4(NR)COOR, -C(O)CH(NH2)(RD), -S(O)2OR3, -S(O)2N(R3)2, -CHZ-OP(O)2(OR)2 oder -P(O)(OR3)2 ist,
    worin
    RB1 Cyangruppe, Nitrogruppe, C1-6Alkylgruppe, C1-6Haloalkylgruppe, -OR, -N(R)2, -SR, -C(O)OR, -C(O)N(R)2, -C(O)R, -S(O)R, -S(O)OR, -S(O)N(R)2, -S(O)2R, -S(O)2OR, -S(O)2N(R)2, -OC(O)R, -OC(O)OR, -OC(O)N(R)2, -N(R)C(O)R, -N(R)C(O)OR oder -N(R)C(O)N(R)2 ist;
    RD Wasserstoffatom, Methylgruppe, -CH(CH3)2, -CH2CH(CH3)2, -CH(CH3)(CH2CH3), Benzylgruppe, 4-Hydroxybenzylgruppe, -CH2(3-indolyl), -CH2SH, -CH2CH2SCH3, -CH2OH, -CH(CH3)OH, -(CH2)4-NH2, -(CH2)3-N(H)C(=NH)NH2, -CH2(4-imidazolyl), -CH2COOH, -CH2CH2COOH, -CH2CONH2, -CH2CH2CONH2 ist;
    jeder R3 unabhängig Wasserstoffatom, C1-6Alkyl-, C1-6Haloalkyl-, Aryl-, Heteroaryl-, C3-8Cycloalkyl-, C3-8Cycloalkenyl-, 3-10-gliedrige Heterocyclyl-, ArylC1-6Alkyl--, HeteroarylC1-6Alkyl--, C3-8CycloalkylC1-6Alkyl--, C3-8CycloalkenylC1-6Alkyl--, (3-10-gliedrige Heterocyclyl)C1-6Alkyl-- oder (Heteroaryl)-(3-10-gliedrige Heterocyclyl)--Gruppe ist,
    worin
    die Alkyl-, C3-8Cycloalkyl-, C3-8Cycloalkenyl-, 3-10-gliedrige Heterocyclyl-, C3-8CycloalkylC1-6Alkyl--, C3-8CycloalkenylC1-6Alkyl-, (3-10-gliedrige Heterocyclyl)C1-6Alkyl-- und (Heteroaryl)-(3-10-gliedrige Heterocyclyl)--Gruppen jeweils unabhängig mit einer =R32-Gruppe gegebenenfalls substituiert sind und jeweils unabhängig mit einer, zwei, drei oder vier R31-Gruppen gegebenenfalls substituiert sind;
    die Aryl-, Heteroaryl-, ArylC1-6Alkyl-- und HeteroarylC1-6Alkyl--Gruppen jeweils mit einer, zwei, drei oder vier R31-Gruppen gegebenenfalls substituiert sind;
    worin
    jeder R31 unabhängig Halogenatom, Cyangruppe, Nitrogruppe, C1-6Alkylgruppe, -C1-6Alkyl-R33, C1-6Haloalkylgruppe, -OR, -N(R)2, -SR, -C(O)OR, -C(O)N(R)2, -C(O)N(OH)R, -C(O)R, -C(NR11)R, -C(NR11)N(R11)R, -S(O)R, -S(O)OR, -S(O)N(R)2, -S(O)2R, -S(O)2OR, -S(O)2N(R)2, -OC(O)R, -OC(O)OR, -OC(O)N(R)2, -N(R)C(O)R, -N(R)C(O)OR, -N(R)C(O)N(R)2 ist, worin
    R33 Cyangruppe, -OR, -N(R)2, -SR, -C(O)OR, -C(O)N(R)2, -C(O)R, -S(O)R, -S(O)OR, -S(O)N(R)2, -S(O)2R, -S(O)2OR, -S(O)2N(R)2, -OC(O)R, -OC(O)OR, -OC(O)N(R)2, -N(R)C(O)R, -N(R)C(O)OR oder -N(R)C(O)N(R)2 ist;
    R32 =O, =S, =N(R), =N(OR), =C(R34)2, =(Spiro-C3-8Cycloalkyl) oder =(Spiro-(3-10-gliedrige Heterocyclylgruppe)) ist, worin
    jeder R34 unabhängig Wasserstoffatom, Halogenatom, Cyangruppe, C1-6Alkylgruppe, -C1-6Alkyl-OR, C1-6Haloalkylgruppe, C3-8Cycloalkylgruppe oder 3-10-gliedrige Heterocyclylgruppe ist;
    oder beide R34 mit dem Atom, an das sie beide gebunden sind, zusammengenommen eine monocyclische C3-8Cycloalkyl- oder monocyclische 3-8-gliedrige Heterocyclylgruppe ausbilden;
    RC Wasserstoffatom oder C1-6Alkylgruppe ist;
    und
    jeder R unabhängig Wasserstoffatom oder R10 ist, worin
    R10 C1-6Alkyl-, C1-6Haloalkyl-, Aryl-, Heteroaryl-, C3-8Cycloalkyl-, C3-8Cycloalkenyl-, 3-10-gliedrige Heterocyclyl-, ArylC1-6Alkyl-, HeteroarylC1-6Alkyl--, C3-8CycloalkylC1-6Alkyl--, C3-8CycloalkenylC1-6Alkyl-- oder (3-10-gliedrige Heterocyclyl)C1-6Alkyl-Gruppe ist, jeder R10 mit einer, zwei, drei oder vier Gruppen gegebenenfalls substituiert ist, die jeweils unabhängig Halogenatom, Cyangruppe, Nitrogruppe, C1-6Alkylgruppe, C1-6Haloalkylgruppe, -OR11, -N(R11)2, -SR11, -C(O)OR11, -C(O)N(R11)2, -C(O)R11, -S(O)R11, -S(O)OR11, -S(O)N(R11)2, -S(O)2R11, -S(O)2OR11, -S(O)2N(R11)2, -OC(O)R11, -OC(O)OR11, -OC(O)N(R11)2, -N(R11)C(O)R11, -N(R11)C(O)OR11, -N(R11)C(O)N(R11)2, -N(R11)S(O)2R11 oder -C(O)-(3-10-gliedrige Heterocyclylgruppe) sind, worin jeder R11 unabhängig Wasserstoffatom oder C1-6Alkylgruppe ist.
  8. Verbindung zur Verwendung nach Anspruch 7, die
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)ethanol;
    Ethyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)acetat;
    (E)-5-(2-Bromstyryl)-5H-imidazo[5,1-a]isoindol;
    2-(6-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanol;
    2-(6-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)ethyl-2-(((1R,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetat;
    tert-Butyl-(4-(2-(5H-imidazo[5,1-a]isoindol-5-yl)acetyl)phenyl)carbamat;
    1-(4-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    tert-Butyl-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)phenyl)carbamat;
    1-(4-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(3-nitrophenyl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(3-nitrophenyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(2-nitrophenyl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(2-nitrophenyl)ethanol;
    tert-Butyl-(2-(2-(5H-imidazo[5,1-a]isoindol-5-yl)acetyl)phenyl)carbamat;
    tert-Butyl-(2-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)phenyl)carbamat;
    1-(2-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    1-(2-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(2-Chlorphenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    1-(5H-Imidazo[5,1-a]isoindol-5-yl)-2-methylpropan-2-ol;
    1-(2-Chlorphenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(3-Chlorphenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-phenylethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-phenylethanol;
    1-(2,4-Dimethylfuran-3-yl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(3-Chlorphenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    1-Cyclohexyl-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    1-Cyclohexyl-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(tetrahydro-2H-pyran-4-yl)ethanol;
    2-(7-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanol;
    (Z)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanonoxim;
    1-Cyclopentyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    tert-Butyl-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanamin;
    tert-Butyl-(3-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)phenyl)carbamat;
    1-(3-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    1-Cyclohexyl-2-(9-methoxy-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    5-(2-Cyclohexyl-2-hydroxyethyl)-5H-imidazo[5,1-a]isoindol-9-ol;
    2-(8-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanol;
    1-(Cyclohex-1-en-1-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-(8-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)ethanol;
    4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanon;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-methylencyclohexyl)ethanol;
    1-(Cyclohex-3-en-1-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4-(Hydroxymethyl)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)(thiophen-2-yl)methanon;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-methylencyclohexyl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-methylcyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(thiazol-4-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(thiazol-5-yl)ethanol;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2,2-dimethylpropan-1-on;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(furan-2-yl)ethanol;
    (1S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (1R)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-(iodmethylen)cyclohexyl)ethanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)propan-1-ol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)acetonitril;
    1-Cyclohexyl-3-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)propan-2-ol;
    l-Cyclohexyl-3-(5H-imidazo[5,1-a]isoindol-5-yl)propan-2-ol;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-y1)-2-phenylethanon;
    1-(4,4-Difluorcyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4,4-Difluorcyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-methyl-1H-imidazol-5-yl)ethanol;
    1-(4-(Cyclopropylmethylen)cyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-(propan-2-yliden)cyclohexyl)ethanol;
    (E)-5-(2-Cyclohexylvinyl)-5H-imidazo[5,1-a]isoindol;
    2-(9-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-methylcyclohexyl)ethanol;
    1-(Cyclohex-3-en-1-yl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (S)-1-Cyclohexyl-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (R)-l-Cyclohexyl-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (R)-l-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (S)-1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yliden)ethanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylacetat,
    1-(4-(2-(Benzyloxy)ethy|iden)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(1-(Benzylsulfonyl)piperidin-4-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(pyrimidin-5-yl)ethanon;
    2-(3,4-Difluorphenyl)-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    Cyclohexyl(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)methanon;
    Methyl-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexancarboxylat;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylphenylcarbamat;
    4-(1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethoxy)-4-oxobuttersäure;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylbenzoat;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(2-(methylsulfonamido)ethyl)cyclohexancarboxamid;
    (2S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl-2-amino-3-methylbutanoat;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyldihydrogenphosphat;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexancarbonsäure;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(pyridin-4-yl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(spiro[2.5]octan-6-yl)ethanol;
    2-(4-Fluorphenyl)-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    (2S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl-2-aminopropanoat;
    1-(4-(2-Hydroxyethyliden)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (2S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylpyrrolidin-2-carboxylat;
    (2S)-5-(1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-1-methyl-2-aminopentandioat;
    1-(4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    (3-Fluor-2-hydroxyphenyl)(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)methanon;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    (4-Fluorphenyl)(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)methanon;
    (2S)-2-Amino-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-3-phenylpropan-1-on;
    (4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)((S)-pyrrolidin-2-yl)methanon;
    (1R,4s)-4-(2-((S)-6-Fluor-SH-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)-cyclohexylbenzoat;
    (1R,4s)-4-(2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)-cyclohexanol;
    1-(3-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)azetidin-1-yl)-2-phenylethanon;
    3-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylazetidin-1-carboxamid;
    tert-Butyl-3-(1-hydroxy-2-(5H-imidazo[5,1-a]isomdol-5-yl)ethyl)azetidin-1-carboxylat;
    1-(Azetidin-3-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    tert-Butyl-4-((S)-1-hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    tert-Butyl-4-((R)-1-hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    tert-Butyl-4-((R)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    tert-Butyl-4-((S)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    1-((1s,4s)-4-(Benzyloxy)cyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(pyridin-3-yl)ethanol;
    (1r,4r)-4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    4-((S)-1-Hydroxy-2-((R)-SH-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    4-((R)-1-Hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    1-(4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    (1R,4s)-4-((S)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4s)-4-((R)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4s)-4-((R)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1R,4s)-4-((S)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4r)-4-((S)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4r)-4-((S)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1R,4r)-4-((R)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1R,4r)-4-((R)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    1-(4-((S)-1-Hydroxy-2-((S)-SH-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethanon;
    1-(4-((R)-1-Hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    N-((1s,4s)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)benzamid;
    1-(4-((S)-1-Hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1-(phenylcarbamoyl)piperidin-4-yl)ethylphenylcarbamat;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isomdol-5-yl)ethyl)-N-((1r,4R)-4-hydroxycyclohexyl)piperidin-1-carboxamid;
    4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-1-carboxamid;
    4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-((1r,4S)-4-hydroxycyclohexyl)piperidin-1-carboxamid;
    1-((1r,4r)-4-(Benzyloxy)cyclohexyl)-2-(SH-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-(Benzyloxy)cyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(pyridin-4-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(pyridin-2-yl)ethanol;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-1-carboxamid;
    N-Cyclohexyl-4-((R)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    N-((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)benzamid;
    N-Cyclopentyl-4-((R)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin- 1-carboxamid;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-(trifluormethyl)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(trifluormethyl)cyclohexyl)ethanol;
    1-(4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(4-(trifluormethyl)phenyl)ethanon;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(4-(trifluormethyl)phenyl)piperidin-1-carboxamid;
    (4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)(1H-imidazol-1-yl)methanon;
    1-(5H-Imidazo[5,1-a]isoindol-5-yl)-3-methylbutan-2-ol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(tetrahydro-2H-pyran-3-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(piperidin-3-yl)ethanol;
    1-Cyclohexyl-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-3-(5H-imidazo[5,1-a]isoindol-5-yl)propan-1-ol;
    1-Cyclohexyl-2-(9-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)phenyl)-2-(tetrahydro-2H-pyran-4-yl)acetamid;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1H-imidazol-2-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1H-imidazol-4-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(thiazol-2-yl)ethanol;
    (5S)-5-(2-Cyclohexyl-2-hydroxyethyl)-5H-imidazo[5,1-a]isoindol-6-ol;
    1-(2-Aminocyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-(1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)acetamid;
    N-(2-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)acetamid;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)-N-methylethanamin;
    2-((1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)amino)ethansulfonamid;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-methylpiperidin-4-yl)ethanol;
    1-(4-Aminocyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)acetamid;
    1-(4-(Aminomethyl)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexancarboxamid;
    1-(3-Aminocyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyridin-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyridin-3-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyridin-4-ylmethoxy)cyclohexyl)ethanol;
    1-((1r,4r)-4-((2-Aminopyridin-4-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyrazin-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyrimidin-5-ylmethoxy)cyclohexyl)ethanol;
    1-((1r,4r)-4-((6-Aminopyridin-2-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((6-Aminopyridm-3-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((3-Aminopyridin-2-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((2-Ammopyrimidin-5-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((4-Aminopyrimidin-5-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((5-Aminopyridin-2-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    4-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)-N,N-dimethylbenzamid;
    3-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)-N,N-dimethylbenzamid;
    2-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)-N,N-dimethylbenzamid;
    4-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    3-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    2-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    4-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzamid;
    3-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzamid;
    2-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzamid;
    Methyl-4-((((1r,4r)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzoat;
    Methyl-3-((((1r,4r)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzoat;
    Methyl-2-((((1r,4r)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzoat;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-methoxycyclohexyl)ethanol;
    1-((1r,4r)-4-Ethoxycyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-isopropoxycyclohexyl)ethanol;
    1-((1r,4r)-4-(Cyclopropylmethoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-(Cyclopentylmethoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(thiophen-2-ylmethoxy)cyclohexyl)ethanol;
    1-((1r,4r)-4-((1H-Indol-3-yl)oxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((1H-Indol-5-yl)oxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-((tetrahydro-2H-pyran-4-yl)methoxy)cyclohexyl)ethanol;
    4-(((4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(oxazol-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(thiazol-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1-(1-imino-2-phenylethyl)piperidin-4-yl)ethanol;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboximidamid;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(pyridin-4-yl)piperidin-1-carboximidamid;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-1-carboximidamid;
    N-(4-Cyanphenyl)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    N-(tert-Butyl)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    N-(tert-Butyl)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-sulfonamid;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(3-hydroxyphenyl)ethanon;
    2-(1-(Azetidin-1-carbonyl)piperidin-4-yl)-2-hydroxy-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    2-Cyclopentyl-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    1 -(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(2-methylthiazol-5-yl)ethanon;
    N-Cyclohexyl-N-hydroxy-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1 -carboxamid;
    N-(4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)phenyl)methansulfonamid;
    N-Cyclopropyl-N-hydroxy-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    3,3-Difluor-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)butan-1-on;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(p-tolyl)ethanon;
    1-(1-(4-Aminopyrimidin-2-yl)piperidin-4-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(1-(2-Aminopyrimidin-4-yl)piperidin-4-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-Cyclopropyl-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    2-Cyclopropyl-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyliden)acetonitril;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(4-(trifluormethyl)thiazol-2-yl)piperidin-1-carboxamid;
    4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzamid;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(4-(methylsulfonyl)phenyl)ethanon;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-((1r,4r)-4-methylcyclohexyl)piperidin-1-carboxamid;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-3,3-dimethylbutan-1-on;
    4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzolsulfonamid;
    N-(tert-Butyl)-4-(2-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzolsulfonamid;
    4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzoesäure;
    1-(4-(Difluormethylen)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(2,2,2-trifluorethyliden)cyclohexyl)ethanol;
    N-Benzyl-4-(2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexancarboxamid;
    4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)-N-phenylcyclohexancarboxamid;
    N-(4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexyl)benzamid;
    1-(4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexyl)-3-phenylharnstoff;
    N-(4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexyl)-2-phenylacetamid;
    oder ein pharmazeutisch verträgliches Salz davon ist.
  9. Verbindung zur Verwendung nach Anspruch 7, die
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid,
    1-(4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon,
    1-(4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon,
    (S)-1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol,
    (1R,4r)-4-((R)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol oder ein pharmazeutisch verträgliches Salz davon ist.
  10. Verbindung der Formel oder ein pharmazeutisch verträgliches Salz davon zur Verwendung bei der Behandlung von Indolamin-2,3-dioxygenase (IDO)-vermittelter Immunsuppression, worin Bindung α eine Einfach- oder Doppelbindung ist;
    n 0, 1, 2, 3 oder 4 ist;
    jeder R1 unabhängig Halogenatom, Cyangruppe, Nitrogruppe, C1-6Alkylruppe, C1-6Haloalkylgruppe, -OR, -N(R)2, -SR, -C(O)OR, -C(O)N(R)2, -C(O)R, -S(O)R, -S(O)OR, -S(O)N(R)2, -S(O)2R, -S(O)2OR, -S(O)2N(R)2, -OC(O)R, -OC(O)OR, -OC(O)N(R)2, -N(R)C(O)R, -N(R)C(O)OR oder -N(R)C(O)N(R)2 ist;
    R2 -C1-4Alkyl-RA oder -C2-4Alkenyl-R3 ist, wenn Bindung α eine Einfachbindung ist; und
    R2 =C(H)RA ist, wenn Bindung α eine Doppelbindung ist;
    worin
    RA-CN, -C(O)R3, -C(O)OR3, -C(O)N(R3)(RC), -C(ORB)(R3)(RC), -C(NHRB)(R3)(RC) oder -C(=N-ORC)R3 ist, worin
    RB Wasserstoffatom, C1-6Alkylgruppe, C1-6Haloalkylgruppe, -C1-6Alkyl-RB1, -C(O)R3, -C(O)N(H)R3 oder -S(O)2R3, -C(O)(CH2)1-4COOR, -C(O)(CH2)1-4(NR)COOR, -C(O)CH(NH2)(RD), -S(O)2OR3, -S(O)2N(R3)2, -CH2-OP(O)2(OR)2 oder -P(O)(OR3)2 ist,
    worin
    RB1 Cyangruppe, Nitrogruppe, C1-6Alkylgruppe, C1-6Haloalkylgruppe, -OR, -N(R)2, -SR, -C(O)OR, -C(O)N(R)2, -C(O)R, -S(O)R, -S(O)OR, -S(O)N(R)2, -S(O)2R, -S(O)2OR, -S(O)2N(R)2, -OC(O)R, -OC(O)OR, -OC(O)N(R)2, -N(R)C(O)R, -N(R)C(O)OR oder -N(R)C(O)N(R)2 ist;
    RD Wasserstoffatom, Methylgruppe, -CH(CH3)2, -CH2CH(CH3)2, -CH(CH3)(CH2CH3), Benzylgruppe, 4-Hydroxybenzylgruppe, -CH2(3-indolyl), -CH2SH, -CH2CH2SCH3, -CH2OH, -CH(CH3)OH, -(CH2)4-NH2, -(CH2)3-N(H)C(=NH)NH2, -CH2(4-imidazolyl), -CH2COOH, -CH2CH2COOH, -CH2CONH2, -CH2CH2CONH2 ist;
    jeder R3 unabhängig Wasserstoffatom, C1-6Alkyl-, C1-6Haloalkyl-, Aryl-, Heteroaryl-, C3-8Cycloalkyl-, C3-8Cycloalkenyl-, 3-10-gliedrige Heterocyclyl-, ArylC1-6Alkyl--, HeteroarylC1-6Alkyl--, C3-8CycloalkylC1-6Alkyl--, C3-8Cycloalkeny1C1-6Alkyl--, (3-10-gliedrige Heterocyclyl)C1-6Alkyl-- oder (Heteroaryl)-(3-10-gliedrige Heterocyclyl)--Gruppe ist,
    worin
    die Alkyl-, C3-8Cycloalkyl-, C3-8Cycloalkenyl-, 3-10-gliedrige Heterocyclyl-, C3-8CycloalkylC1-6Alkyl--, C3-8CycloalkenylC1-6Alkyl--, (3-10-gliedrige Heterocyclyl)C1-6Alkyl-- und (Heteroaryl)-(3-10-gliedrige Heterocyclyl)--Gruppen jeweils unabhängig mit einer =R32-Gruppe gegebenenfalls substituiert sind und jeweils unabhängig mit einer, zwei, drei oder vier R31-Gruppen gegebenenfalls substituiert sind;
    die Aryl-, Heteroaryl-, ArylC1-6Alkyl-- und HeteroarylC1-6Alkyl--Gruppen jeweils mit einer, zwei, drei oder vier R31-Gruppen gegebenenfalls substituiert sind;
    worin
    jeder R31 unabhängig Halogenatom, Cyangruppe, Nitrogruppe, C1-6Alkylgruppe, -C1-6Alkyl-R33, C1-6Haloalkylgruppe, -OR, -N(R)2, -SR, -C(O)OR, -C(O)N(R)2, -C(O)N(OH)R, -C(O)R, -C(NR11)R, -C(NR11)N(R11)R, -S(O)R, -S(O)OR, -S(O)N(R)2, -S(O)2R, -S(O)2OR, -S(O)2N(R)2, -OC(O)R, -OC(O)OR, -OC(O)N(R)2, -N(R)C(O)R, -N(R)C(O)OR, -N(R)C(O)N(R)2 ist, worin
    R33 Cyangruppe, -OR, -N(R)2, -SR, -C(O)OR, -C(O)N(R)2, -C(O)R, -S(O)R, -S(O)OR, -S(O)N(R)2, -S(O)2R, -S(O)2OR, -S(O)2N(R)2, -OC(O)R, -OC(O)OR, -OC(O)N(R)2, -N(R)C(O)R, -N(R)C(O)OR oder -N(R)C(O)N(R)2 ist;
    R32 =O, =S, =N(R), =N(OR), =C(R34)2, =(Spiro-C3-8Cycloalkyl) oder =(Spiro-(3-10-gliedrige Heterocyclylgruppe)) ist, worin
    jeder R34 unabhängig Wasserstoffatom, Halogenatom, Cyangruppe, C1-6Alkylgruppe, -C1-6Alkyl-OR, C1-6Haloalkylgruppe, C3-sCycloalkylgruppe oder 3-10-gliedrige Heterocyclylgruppe ist;
    oder beide R34 mit dem Atom, an das sie beide gebunden sind, zusammengenommen eine monocyclische C3-8Cycloalkyl- oder monocyclische 3-8-gliedrige Heterocyclylgruppe ausbilden;
    RC Wasserstoffatom oder C1-6Alkylgruppe ist;
    und
    jeder R unabhängig Wasserstoffatom oder R10 ist, worin
    R10 C1-6Alkyl-, C1-6Haloalkyl-, Aryl-, Heteroaryl-, C3-8Cycloalkyl-, C3-8Cycloalkenyl-, 3-10-gliedrige Heterocyclyl-, ArylC1-6Alkyl-, HeteroarylC1-6Alkyl--, C3-8CycloalkylC1-6Alkyl--, C3-8CycloalkenylC1-6Alkyl- oder (3-10-gliedrige Heterocyclyl)C1-6Alkyl-Gruppe ist, jeder R10 mit einer, zwei, drei oder vier Gruppen gegebenenfalls substituiert ist, die jeweils unabhängig Halogenatom, Cyangruppe, Nitrogruppe, C1-6Alkylgruppe, C1-6Haloalkylgruppe, -OR11, -N(R11)2, -SR11, -C(O)OR11, -C(O)N(R11)2, -C(O)R11, -S(O)R11, -S(O)OR11, -S(O)N(R11)2, -S(O)2R11, -S(O)2OR11, -S(O)2N(R11)2, -OC(O)R11, -OC(O)OR11, -OC(O)N(R11)2, -N(R11)C(O)R11, -N(R11)C(O)OR11, -N(R11)C(O)N(R11)2, -N(R11)S(O)2R11 oder -C(O)-(3-10-gliedrige Heterocyclylgruppe) sind, worin jeder R11 unabhängig Wasserstoffatom oder C1-6Alkylgruppe ist.
  11. Verbindung zur Verwendung nach Anspruch 10, die
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)ethanol;
    Ethyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)acetat;
    (E)-5-(2-Bromstyryl)-5H-imidazo[5,1-a]isoindol;
    2-(6-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanol;
    2-(6-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)ethyl-2-(((1R,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetat;
    tert-Butyl-(4-(2-(5H-imidazo[5,1-a]isoindol-5-yl)acetyl)phenyl)carbamat;
    1-(4-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    tert-Butyl-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)phenyl)carbamat;
    1-(4-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(3-nitrophenyl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(3-nitrophenyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(2-nitrophenyl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(2-nitrophenyl)ethanol;
    tert-Butyl-(2-(2-(5H-imidazo[5,1-a]isoindol-5-yl)acetyl)phenyl)carbamat;
    tert-Butyl-(2-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)phenyl)carbamat;
    1-(2-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    1-(2-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(2-Chlorphenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    1-(5H-Imidazo[5,1-a]isoindol-5-yl)-2-methylpropan-2-ol;
    1-(2-Chlorphenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(3-Chlorphenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-phenylethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-phenylethanol;
    1-(2,4-Dimethylfuran-3-yl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(3-Chlorphenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    1-Cyclohexyl-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanon;
    1-Cyclohexyl-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(tetrahydro-2H-pyran-4-yl)ethanol;
    2-(7-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanol;
    (Z)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanonoxim;
    1-Cyclopentyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    tert-Butyl-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanamin;
    tert-Butyl-(3-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)phenyl)carbamat;
    1-(3-Aminophenyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    1-Cyclohexyl-2-(9-methoxy-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    5-(2-Cyclohexyl-2-hydroxyethyl)-5H-imidazo[5,1-a]isoindol-9-ol;
    2-(8-Chlor-5H-imidazo[5,1-a]isoindol-5-yl)-1-cyclohexylethanol;
    1-(Cyclohex-1-en-1-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-(8-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(1,4-dioxaspiro[4.5]decan-8-yl)ethanol;
    4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanon;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-methylencyclohexyl)ethanol;
    1-(Cyclohex-3-en-1-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4-(Hydroxymethyl)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidm-1-yl)(thiophen-2-yl)methanon;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-methylencyclohexyl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-methylcyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(thiazol-4-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(thiazol-5-yl)ethanol;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2,2-dimethylpropan-1-on;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(furan-2-yl)ethanol;
    (1S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (1R)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-(iodmethylen)cyclohexyl)ethanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)propan-1-ol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)acetonitril;
    1-Cyclohexyl-3-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)propan-2-ol;
    1-Cyclohexyl-3-(5H-imidazo[5,1-a]isoindol-5-yl)propan-2-ol;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    1-(4,4-Difluorcyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4,4-Difluorcyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-methyl-1H-imidazol-5-yl)ethanol;
    1-(4-(Cyclopropylmethylen)cyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-(propan-2-yliden)cyclohexyl)ethanol;
    (E)-5-(2-Cyclohexylvinyl)-5H-imidazo[5,1-a]isoindol;
    2-(9-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-methylcyclohexyl)ethanol;
    1-(Cyclohex-3-en-l-yl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (S)-1-Cyclohexyl-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (R)-1-Cyclohexyl-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (R)-1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (S)-1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yliden)ethanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylacetat;
    1-(4-(2-(Benzyloxy)ethyliden)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(1-(Benzylsulfonyl)piperidin-4-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(pyrimidin-5-yl)ethanon;
    2-(3,4-Difluorphenyl)-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    Cyclohexyl(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)methanon;
    Methyl-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexancarboxylat;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylphenylcarbamat;
    4-(1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethoxy)-4-oxobuttersäure;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexanol;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylbenzoat;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(2-(methylsulfonamido)ethyl)cyclohexancarboxamid;
    (2S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl-2-amino-3-methylbutanoat;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyldihydrogenphosphat;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexancarbonsäure;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-alisoindol-5-yl)ethyl)piperidin-1-yl)-2-(pyridin-4-yl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(spiro[2.5]octan-6-yl)ethanol;
    2-(4-Fluorphenyl)-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    (2S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl-2-aminopropanoat;
    1-(4-(2-Hydroxyethyliden)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    (2S)-1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethylpyrrolidin-2-carboxylat;
    (2S)-5-(1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-1-methyl-2-aminopentandioat;
    1-(4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    (3-Fluor-2-hydroxyphenyl)(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1- yl)methanon;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    (4-Fluorphenyl)(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)methanon;
    (2S)-2-Amino-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-3-phenylpropan-1-on;
    (4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)((S)-pyrrolidin-2-yl)methanon;
    (1R,4s)-4-(2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)-cyclohexylbenzoat;
    (1R,4s)-4-(2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)-cyclohexanol;
    1-(3-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)azetidin-1-yl)-2-phenylethanon;
    3-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylazetidin-1-carboxamid;
    tert-Butyl-3-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)azetidin-1-carboxylat;
    1-(Azetidin-3-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    tert-Butyl-4-((S)-1-hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    tert-Butyl-4-((R)-1-hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    tert-Butyl-4-((R)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    tert-Butyl-4-((S)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxylat;
    1-((1s,4s)-4-(Benzyloxy)cyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a] isoindol-5-yl)-1-(pyridin-3 -yl)ethanol;
    (1r,4r)-4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    4-((S)-1-Hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    4-((R)-1-Hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid;
    1-(4-((R)-1-Hydroxy-2-(S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    (1R,4s)-4-((S)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4s)-4-((R)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4s)-4-((R)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1R,4s)-4-((S)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4r)-4-((S)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1S,4r)-4-((S)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1R,4r)-4-((R)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    (1R,4r)-4-((R)-2-((R)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol;
    1-(4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethanon;
    1-(4-((R)-1-Hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    N-((1s,4s)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a] isoindol-5-yl)ethyl)cyclohexyl)benzamid;
    1-(4-((S)-1-Hydroxy-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1-(phenylcarbamoyl)piperidin-4-yl)ethylphenylcarbamat;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-((1r,4R)-4-hydroxycyclohexyl)piperidin-1-carboxamid;
    4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-1-carboxamid;
    4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-((1r,4S)-4-hydroxycyclohexyl)piperidin-1-carboxamid;
    1-((1r,4r)-4-(Benzyloxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-(Benzyloxy)cyclohexyl)-2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethanon;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(pyridin-4-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(pyridin-2-yl)ethanol;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-1-carboxamid;
    N-Cyclohexyl-4-((R)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    N-((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)benzamid;
    N-Cyclopentyl-4-((R)-1-hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(4-(trifluormethyl)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(trifluormethyl)cyclohexyl)ethanol;
    1-(4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(4-(trifluormethyl)phenyl)ethanon;
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(4-(trifluormethyl)phenyl)piperidin-1-carboxamid;
    (4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)(1H-imidazol-1 -yl)methanon;
    1-(5H-Imidazo[5,1-a]isoindol-5-yl)-3-methylbutan-2-ol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(tetrahydro-2H-pyran-3-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(piperidin-3-yl)ethanol;
    1-Cyclohexyl-2-((R)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-Cyclohexyl-3-(5H-imidazo[5,1-a]isoindol-5-yl)propan-1-ol;
    1-Cyclohexyl-2-(9-fluor-5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)phenyl)-2-(tetrahydro-2H-pyran-4-yl)acetamid;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1H-imidazol-2-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1H-imidazol-4-yl)ethanol;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(thiazol-2-yl)ethanol;
    (5S)-5-(2-Cyclohexyl-2-hydroxyethyl)-5H-imidazo[5,1-a]isoindol-6-ol;
    1-(2-Aminocyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-(1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)acetamid;
    N-(2-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)acetamid;
    1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)-N-methylethanamin;
    2-((1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)amino)ethansulfonamid;
    2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-(1-methylpiperidin-4-yl)ethanol;
    1-(4-Aminocyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)acetamid;
    1-(4-(Aminomethyl)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexancarboxamid;
    1-(3-Aminocyclohexyl)-2-(5H-imidazo[5,l-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyridin-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyridin-3-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyridin-4-ylmethoxy)cyclohexyl)ethanol;
    1-((1r,4r)-4-((2-Aminopyridin-4-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a] isoindol-5-yl)-1-((1r,4r)-4-(pyrazin-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(pyrimidin-5-ylmethoxy)cyclohexyl)ethanol;
    1-((1r,4r)-4-((6-Aminopyridin-2-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((6-Aminopyridin-3-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a] isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((3-Aminopyridin-2-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((2-Ammopyrimidm-5-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((4-Aminopyrimidin-5-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a] isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((5-Aminopyridin-2-yl)methoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    4-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)-N,N-dimethylbenzamid;
    3-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a] isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)-N,N-dimethylbenzamid;
    2-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)-N,N-dimethylbenzamid;
    4-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    3-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    2-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    4-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzamid;
    3-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzamid;
    2-((((1r,4r)-4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzamid;
    Methyl-4-((((1r,4r)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzoat;
    Methyl-3-((((1r,4r)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzoat;
    Methyl-2-((((1r,4r)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzoat;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-methoxycyclohexyl)ethanol;
    1-((1r,4r)-4-Ethoxycyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-isopropoxycyclohexyl)ethanol;
    1-((1r,4r)-4-(Cyclopropylmethoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-(Cyclopentylmethoxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-((1r,4r)-4-(thiophen-2-ylmethoxy)cyclohexyl)ethanol;
    1-((1r,4r)-4-((1H-Indol-3-yl)oxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-((1r,4r)-4-((1H-Indol-5-yl)oxy)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-((tetrahydro-2H-pyran-4-yl)methoxy)cyclohexyl)ethanol;
    4-(((4-(1-Hydroxy-2-(5H-imidazo[5,1-a] isoindol-5-yl)ethyl)cyclohexyl)oxy)methyl)benzolsulfonamid;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(oxazol-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(thiazol-2-ylmethoxy)cyclohexyl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(1-(1-imino-2-phenylethyl)piperidin-4-yl)ethanol;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboximidamid;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(pyridin-4-yl)piperidin-1-carboximidamid;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(tetrahydro-2H-pyran-4-yl)piperidin-1-carboximidamid;
    N-(4-Cyanphenyl)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    N-(tert-Butyl)-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    N-(tert-Butyl)-4-(1-hydroxy-2-(5H-imidazo[5,1-alisoindol-5-yl)ethyl)piperidin-1-sulfonamid;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(3-hydroxyphenyl)ethanon;
    2-(1-(Azetidin-1-carbonyl)piperidin-4-yl)-2-hydroxy-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    2-Cyclopentyl-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(2-methylthiazol-5-yl)ethanon;
    N-Cyclohexyl-N-hydroxy-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    N-(4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)phenyl)methansulfonamid;
    N-Cyclopropyl-N-hydroxy-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    3,3 -Difluor-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)butan-1-on;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-alisoindol-5-yl)ethyl)piperidin-1-yl)-2-(p-tolyl)ethanon;
    1-(1-(4-Aminopyrimidin-2-yl)piperidin-4-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    1-(1-(2-Aminopyrimidin-4-yl)piperidin-4-yl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    N-Cyclopropyl-4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-carboxamid;
    2-Cyclopropyl-1-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)ethanon;
    2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)cyclohexyliden)acetonitril;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-(4-(trifluormethyl)thiazol-2-yl)piperidin-1-carboxamid;
    4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzamid;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-(4-(methylsulfonyl)phenyl)ethanon;
    4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-((1r,4r)-4-methylcyclohexyl)piperidin-1-carboxamid;
    1-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-3,3-dimethylbutan-1-on;
    4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzolsulfonamid;
    N-(tert-Butyl)-4-(2-(4-(1-hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzolsulfonamid;
    4-(2-(4-(1-Hydroxy-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-oxoethyl)benzoesäure;
    1-(4-(Difluormethylen)cyclohexyl)-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol;
    2-(5H-Imidazo[5,1-a]isoindol-5-yl)-1-(4-(2,2,2-trifluorethyliden)cyclohexyl)ethanol;
    N-Benzyl-4-(2-(6-fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexancarboxamid;
    4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)-N-phenylcyclohexancarboxamid;
    N-(4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexyl)benzamid;
    1-(4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexyl)-3-phenylharnstoff;
    N-(4-(2-(6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexyl)-2-phenylacetamid;
    oder ein pharmazeutisch verträgliches Salz davon ist.
  12. Verbindung zur Verwendung nach Anspruch 10, die
    4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)-N-phenylpiperidin-1-carboxamid,
    1-(4-((R)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1 -yl)-2-phenylethanon,
    1-(4-((S)-1-Hydroxy-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethyl)piperidin-1-yl)-2-phenylethanon,
    (S)-1-Cyclohexyl-2-((S)-5H-imidazo[5,1-a]isoindol-5-yl)ethanol,
    (1R,4r)-4-((R)-2-((S)-6-Fluor-5H-imidazo[5,1-a]isoindol-5-yl)-1-hydroxyethyl)cyclohexanol oder ein pharmazeutisch verträgliches Salz davon ist.
  13. Verbindung zur Verwendung nach einem der Ansprüche 10-12, wobei die Immunsuppression mit Krebs assoziiert ist.
  14. Verbindung zur Verwendung nach Anspruch 13, wobei der Krebs Colon-, Pankreas-, Brust-, Prostata-, Lungen-, Gehirn-, Ovarial-, Cervix-, Hoden-, Nieren-, Kopf- oder Halskrebs, oder Lymphom, Leukämie oder Melanom ist.
HK16111731.3A 2011-04-15 2016-10-11 Fused imidazole derivatives useful as ido inhibitors HK1223371B (en)

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US201161475788P 2011-04-15 2011-04-15
US201161475788P 2011-04-15

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HK1223371A1 HK1223371A1 (en) 2017-07-28
HK1223371B true HK1223371B (en) 2018-10-12

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