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HK1199039B - Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation - Google Patents

Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation Download PDF

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Publication number
HK1199039B
HK1199039B HK14112411.0A HK14112411A HK1199039B HK 1199039 B HK1199039 B HK 1199039B HK 14112411 A HK14112411 A HK 14112411A HK 1199039 B HK1199039 B HK 1199039B
Authority
HK
Hong Kong
Prior art keywords
fsh
sialylation
rfsh
recombinant
sialyltransferase
Prior art date
Application number
HK14112411.0A
Other languages
German (de)
English (en)
Chinese (zh)
Other versions
HK1199039A1 (en
Inventor
Ian Cottingham
Daniel Plaksin
Richard Boyd White
Original Assignee
Ferring B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring B.V. filed Critical Ferring B.V.
Publication of HK1199039A1 publication Critical patent/HK1199039A1/en
Publication of HK1199039B publication Critical patent/HK1199039B/en

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Claims (7)

  1. FSH recombinante (rFSH) avec sialylation sur α2,3 et α2,6, dans laquelle 80% ou plus de la sialylation totale est une sialylation sur α2,3 et de 5 à 20% de la sialylation totale est une sialylation sur α2,6.
  2. FSH recombinante selon la revendication 1, exprimée dans une lignée de cellules humaines.
  3. Composition pharmaceutique comprenant une rFSH selon la revendication 1 ou la revendication 2.
  4. Composition pharmaceutique selon la revendication 3, comprenant en outre de la hCG et/ou de la LH.
  5. Composition pharmaceutique selon la revendication 3 ou 4, destinée à être utilisée dans le traitement de l'infertilité.
  6. Procédé de production de rFSH selon l'une quelconque des revendications 1 ou 2 comprenant l'étape de production ou d'expression de la rFSH dans une lignée de cellules humaines.
  7. Procédé selon la revendication 6 dans lequel la lignée de cellules a été modifiée par α2,3-sialyltransférase et/ou α2,6-sialytransférase.
HK14112411.0A 2008-04-16 2014-12-10 Recombinant fsh including alpha 2,3- and alpha 2,6-sialylation HK1199039B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US4542408P 2008-04-16 2008-04-16
US61/045,424 2008-04-16
EP08251528 2008-04-25
EP08251528.9 2008-04-25

Publications (2)

Publication Number Publication Date
HK1199039A1 HK1199039A1 (en) 2015-06-19
HK1199039B true HK1199039B (en) 2017-09-15

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