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HK1085663B - Mutated neublastin - Google Patents

Mutated neublastin Download PDF

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Publication number
HK1085663B
HK1085663B HK06105655.9A HK06105655A HK1085663B HK 1085663 B HK1085663 B HK 1085663B HK 06105655 A HK06105655 A HK 06105655A HK 1085663 B HK1085663 B HK 1085663B
Authority
HK
Hong Kong
Prior art keywords
neublastin
polypeptide
polymer
seq
mutated
Prior art date
Application number
HK06105655.9A
Other languages
English (en)
French (fr)
Chinese (zh)
Other versions
HK1085663A1 (en
Inventor
Dinah Wen-Yee Sah
R. Blake Pepinsky
Paula Ann Boriack-Sjodin
Stephan S. Miller
Anthony Rossomando
Laura Silvian
Original Assignee
Biogen Ma Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/356,264 external-priority patent/US7442370B2/en
Application filed by Biogen Ma Inc. filed Critical Biogen Ma Inc.
Publication of HK1085663A1 publication Critical patent/HK1085663A1/en
Publication of HK1085663B publication Critical patent/HK1085663B/en

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Claims (4)

  1. Neublastin-Polypeptid, das zu mindestens 80 % identisch ist mit den Aminosäuren 8-113 der SEQ ID NO:1, und das eine Substitution eines oder mehrerer des Arginins an Position 48, des Arginins an Position 49 oder des Arginins an Position 51 durch einen Glutaminsäurerest enthält.
  2. Polypeptid nach Anspruch 1, wobei der Argininrest an Position 48 durch Glutaminsäure substituiert ist.
  3. Polypeptid nach Anspruch 1, wobei der Argininrest an Position 49 durch Glutaminsäure substituiert ist.
  4. Polypeptid nach Anspruch 1, wobei der Argininrest an Position 51 durch Glutaminsäure substituiert ist.
HK06105655.9A 2003-01-31 2004-02-02 Mutated neublastin HK1085663B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/356,264 US7442370B2 (en) 2001-02-01 2003-01-31 Polymer conjugates of mutated neublastin
US10/356,264 2003-01-31
PCT/US2004/002763 WO2004069176A2 (en) 2001-02-01 2004-02-02 Polymer conjugates of mutated neublastin

Publications (2)

Publication Number Publication Date
HK1085663A1 HK1085663A1 (en) 2006-09-01
HK1085663B true HK1085663B (en) 2010-12-03

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