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HK1060045A1 - Formulations comprising ibuprofen and diphenhydramine and the use thereof for the treatment of sleep disturbances - Google Patents

Formulations comprising ibuprofen and diphenhydramine and the use thereof for the treatment of sleep disturbances Download PDF

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Publication number
HK1060045A1
HK1060045A1 HK04102765A HK04102765A HK1060045A1 HK 1060045 A1 HK1060045 A1 HK 1060045A1 HK 04102765 A HK04102765 A HK 04102765A HK 04102765 A HK04102765 A HK 04102765A HK 1060045 A1 HK1060045 A1 HK 1060045A1
Authority
HK
Hong Kong
Prior art keywords
diphenhydramine
ibuprofen
sleep
composition
pain
Prior art date
Application number
HK04102765A
Other languages
English (en)
French (fr)
Chinese (zh)
Other versions
HK1060045B (en
Inventor
Allen Cooper Stephen
Ann Doyle Geraldine
David Cook Graham
Shawn Koch Todd
Joseph Fort James
Bianco Giustino
Hugh Giamalva David
Original Assignee
Wyeth
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22997281&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1060045(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth filed Critical Wyeth
Publication of HK1060045A1 publication Critical patent/HK1060045A1/en
Publication of HK1060045B publication Critical patent/HK1060045B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4816—Wall or shell material
    • A61K9/4825—Proteins, e.g. gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/485—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Inorganic Chemistry (AREA)
  • Anesthesiology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (14)

  1. Zusammensetzung, umfassend Ibuprofen und Diphenhydramin in Mengen, welche wirksam sind, eine mit Schmerz verbundene Schlafstörung zu behandeln, wobei die Zusammensetzung entweder:
    a) eine Doppelschicht-Tablette oder Doppelschicht-Caplet ist, formuliert, um negative Interaktionen zwischen dem Diphenhydramin und dem Ibuprofen zu verhindern, durch physikalisches Trennen des Ibuprofen und des Diphenhydramins in getrennte Bereiche von besagter Tablette oder Caplet
    oder b) in eine weiche Gelatinekapsel formuliert ist, welche Polyethylenglycol enthält, um Interaktion zwischen dem Ibuprofen und dem Diphenhydramin zu verhindern.
  2. Zusammensetzung wie in Anspruch 1 beansprucht, wobei die Schlafstörung die Schlafdauer beeinträchtigt.
  3. Zusammensetzung wie in Anspruch 1 oder Anspruch 2 beansprucht, worin das Ibuprofen in einer Menge von 50 mg bis 800 mg vorhanden ist.
  4. Zusammensetzung wie in Anspruch 1 oder Anspruch 2 beansprucht, worin das Ibuprofen in einer Menge von 200 mg vorhanden ist.
  5. Zusammensetzung wie in einem der Ansprüche 1 bis 4 beansprucht, worin das Diphenhydramin als Diphenhydramin-HCl oder Diphenhydramincitrat vorhanden ist.
  6. Zusammensetzung wie in Anspruch 5 beansprucht, worin das Diphenhydramin-HCl in einer Menge von 12,5 mg bis 50 mg vorhanden ist.
  7. Zusammensetzung wie in Anspruch 5 beansprucht, worin das Diphenhydramin-HCl in einer Menge von 25 mg vorhanden ist.
  8. Zusammensetzung wie in Anspruch 5 beansprucht, worin das Diphenhydramincitrat in einer Menge von 19 mg bis 38 mg vorhanden ist.
  9. Zusammensetzung wie in Anspruch 5 beansprucht, worin das Diphenhydramincitrat in einer Menge von 38 mg vorhanden ist.
  10. Verwendung einer Zusammensetzung wie in einem der Ansprüche 1 bis 9 definiert bei der Herstellung eines Medikaments zur Behandlung von Schlafstörung.
  11. Verwendung wie in Anspruch 10 beansprucht, zur Herstellung eines Medikaments, wobei in Gebrauch eine Dosis der Zusammensetzung verabreicht wird.
  12. Verwendung wie in Anspruch 10 beansprucht, zur Herstellung eines Medikaments, wobei in Gebrauch zwei Dosen der Zusammensetzung gleichzeitig verabreicht werden.
  13. Verwendung wie in Anspruch 10 beansprucht, zur Herstellung eines Medikaments, wobei in Gebrauch eine Dosis verabreicht wird und eine zweite Dosis optional verabreicht wird.
  14. Verwendung von Ibuprofen oder Diphenhydramin zur Herstellung einer Zusammensetzung wie in einem der Ansprüche 1 bis 11 beansprucht.
HK04102765.5A 2001-01-19 2002-01-18 Formulations comprising ibuprofen and diphenhydramine and the use thereof for the treatment of sleep disturbances HK1060045B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26238701P 2001-01-19 2001-01-19
US60/262,387 2001-01-19
PCT/US2002/003855 WO2002056877A1 (en) 2001-01-19 2002-01-18 Treatment of sleep disturbances

Publications (2)

Publication Number Publication Date
HK1060045A1 true HK1060045A1 (en) 2004-07-30
HK1060045B HK1060045B (en) 2006-02-03

Family

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Also Published As

Publication number Publication date
MXPA03006364A (es) 2003-10-06
US20120308483A1 (en) 2012-12-06
ES2251584T3 (es) 2006-05-01
JP4402882B2 (ja) 2010-01-20
DE60207383T2 (de) 2006-08-03
DK1363608T3 (da) 2006-02-13
CA2434484A1 (en) 2002-07-25
JP2009203243A (ja) 2009-09-10
DE60207383D1 (de) 2005-12-22
ATE309797T1 (de) 2005-12-15
WO2002056877A1 (en) 2002-07-25
CA2434484C (en) 2011-08-09
JP2004521104A (ja) 2004-07-15
US20150018421A1 (en) 2015-01-15
US20090169584A1 (en) 2009-07-02
US8263647B2 (en) 2012-09-11
US8883849B2 (en) 2014-11-11
US20020177626A1 (en) 2002-11-28
US9155718B2 (en) 2015-10-13
EP1363608A1 (de) 2003-11-26
EP1363608B1 (de) 2005-11-16

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Effective date: 20220117