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HK1051693B - Process for preparing adefovir dipivoxil - Google Patents

Process for preparing adefovir dipivoxil Download PDF

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Publication number
HK1051693B
HK1051693B HK03102359.8A HK03102359A HK1051693B HK 1051693 B HK1051693 B HK 1051693B HK 03102359 A HK03102359 A HK 03102359A HK 1051693 B HK1051693 B HK 1051693B
Authority
HK
Hong Kong
Prior art keywords
crystals
xrd
solution
mixture
crystallization
Prior art date
Application number
HK03102359.8A
Other languages
English (en)
French (fr)
Chinese (zh)
Other versions
HK1051693A1 (en
Inventor
N Arimilli Murty
T.K Lee Thomas
V Manes Lawrence
D. Munger John Jr.
J Prisbe Ernest
M Schultze Lisa
E Kelly Daphne
Original Assignee
Gilead Sciences, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences, Inc. filed Critical Gilead Sciences, Inc.
Publication of HK1051693A1 publication Critical patent/HK1051693A1/en
Publication of HK1051693B publication Critical patent/HK1051693B/en

Links

Claims (4)

  1. Verfahren zur Herstellung von Adefovir Dipivoxil, welches das in Kontakt Bringen von 9-[2-(Phosphonomethoxy)ethyl]adenin mit Chlormethylpivalat in 1-Methyl-2-pyrrolidinon und einem Trialkylamin und die Gewinnung des Adevovir Dipivoxils umfasst.
  2. Verfahren nach Anspruch 1, wobei es sich bei dem Trialkylamin um Triethylamin handelt.
  3. Verfahren nach Anspruch 2, wobei man 1 Moläquivalent 9-[2-(Phosphonomethoxy)ethyl]adenin und etwa 5,6 - 56,8 Moläquivalente 1-Methyl-2-pyrrolidinon in Kontakt bringt.
  4. Verfahren nach Anspruch 1, wobei man 1 Moläquivalent 9-[2-(Phosphonomethoxy)ethyl]adenin und etwa 2 - 5 Moläquivalente Triethylamin in Kontakt bringt.
HK03102359.8A 1997-07-25 2003-04-02 Process for preparing adefovir dipivoxil HK1051693B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5377197P 1997-07-25 1997-07-25
US90074597A 1997-07-25 1997-07-25
US900745 1997-07-25
US53771P 1997-07-25

Publications (2)

Publication Number Publication Date
HK1051693A1 HK1051693A1 (en) 2003-08-15
HK1051693B true HK1051693B (en) 2005-05-20

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