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HK1048949A1 - Method and composition for the treatment of scars - Google Patents

Method and composition for the treatment of scars Download PDF

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Publication number
HK1048949A1
HK1048949A1 HK03101230.5A HK03101230A HK1048949A1 HK 1048949 A1 HK1048949 A1 HK 1048949A1 HK 03101230 A HK03101230 A HK 03101230A HK 1048949 A1 HK1048949 A1 HK 1048949A1
Authority
HK
Hong Kong
Prior art keywords
composition
active ingredient
scar
collodion
silicone gel
Prior art date
Application number
HK03101230.5A
Other languages
English (en)
French (fr)
Chinese (zh)
Other versions
HK1048949B (en
Inventor
Joel R. Studin
Original Assignee
The Sg Licensing Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Sg Licensing Corporation filed Critical The Sg Licensing Corporation
Publication of HK1048949A1 publication Critical patent/HK1048949A1/en
Publication of HK1048949B publication Critical patent/HK1048949B/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/695—Silicon compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/22—Lipids, fatty acids, e.g. prostaglandins, oils, fats, waxes
    • A61L2300/222—Steroids, e.g. corticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/402—Anaestetics, analgesics, e.g. lidocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/428—Vitamins, e.g. tocopherol, riboflavin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/43—Hormones, e.g. dexamethasone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Surgery (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)

Claims (16)

  1. Verwendung einer Zusammensetzung bei der Herstellung eines Medikaments zur Behandlung von hypertrophen Narben zum Vermindern von deren Größe und/oder Verbessern von deren Aussehen, wobei die Zusammensetzung einen Collodion-filmbildenden Träger umfasst, in dem ein Wirkstoff enthalten ist, der dazu fähig ist, die Größe der Narbe zu vermindern oder deren Aussehen zu verbessern, wobei der Wirkstoff wenigstens ein topisches Steroid, Silikongel oder Vitamin umfasst.
  2. Verwendung einer Zusammensetzung nach Anspruch 1, wobei der Wirkstoff eine Kombination eines topischen Steroids mit Silikongel umfasst.
  3. Verwendung einer Zusammensetzung nach Anspruch 1 oder 2, wobei der Wirkstoff Hydrocortison oder ein pharmazeutisch unbedenkliches Salz davon umfasst.
  4. Verwendung einer Zusammensetzung nach Anspruch 1, wobei der Wirkstoff das Silikongel Phenyltrimethicon umfasst.
  5. Verwendung einer Zusammensetzung nach Anspruch 1 oder 2, wobei der Wirkstoff Vitamin E umfasst.
  6. Verwendung einer Zusammensetzung nach einem der Ansprüche 1 bis 5, wobei der filmbildende Träger Collodion oder flexibles Collodion umfasst.
  7. Verwendung einer Zusammensetzung nach einem der Ansprüche 1 bis 6, wobei die Zusammensetzung durch Aufstreichen, Aufrollen oder das Aufbringen von Tropfen der Zusammensetzung auf die Narbe auf die Narbe aufgebracht wird.
  8. Zusammensetzung zur Verwendung bei der Behandlung von abträglichen Hautleiden, wobei die Zusammensetzung einen Collodion-filmbildenden Träger und einen Wirkstoff, welcher ein topisch wirksames Steroid, Silikongel, Vitamine oder Mischungen dieser Wirkstoffe umfasst, umfasst, wobei das abträgliche Hautleiden aus einer hypertrophen Narbe, Ekzem, Psoriasis, atopischer Dermatitis und anderen immunologischen Hauterkrankungen ausgewählt ist.
  9. Zusammensetzung nach Anspruch 8, wobei es sich bei dem Wirkstoff um ein topisch wirksames Steroid handelt, welches Hydrocortison oder ein pharmazeutisch unbedenkliches Salz davon umfasst.
  10. Zusammensetzung nach Anspruch 8, wobei der Wirkstoff Vitamin E umfasst.
  11. Zusammensetzung nach Anspruch 8, wobei der Wirkstoff das Silikongel Phenyltrimethicon umfasst.
  12. Zusammensetzung nach Anspruch 8, wobei der Wirkstoff eine Mischung eines topischen Steroids, eines Silikongels und gegebenenfalls Vitamin E umfasst.
  13. Zusammensetzung nach Anspruch 12, wobei es sich bei dem topischen Steroid um Hydrocortison oder ein pharmazeutisch unbedenkliches Salz davon handelt und das Silikongel bei 25°C eine Viskosität von 0,1-30 Ns/m2 (100-30.000 Centipoises) aufweist.
  14. Zusammensetzung nach Anspruch 13, wobei das Silikongel Phenyltrimethicon umfasst.
  15. Zusammensetzung nach einem der Ansprüche 8 bis 14, wobei es sich bei dem filmbildenden Träger um Collodion oder flexibles Collodion handelt.
  16. Zusammensetzung nach einem der Ansprüche 8 bis 15, wobei es sich bei dem abträglichen Hautleiden um eine hypertrophe Narbe handelt.
HK03101230.5A 1999-11-17 2000-11-13 Method and composition for the treatment of scars HK1048949B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/441,138 US6337076B1 (en) 1999-11-17 1999-11-17 Method and composition for the treatment of scars
US441138 1999-11-17
PCT/US2000/042077 WO2001037782A2 (en) 1999-11-17 2000-11-13 Method and composition for the treatment of scars

Publications (2)

Publication Number Publication Date
HK1048949A1 true HK1048949A1 (en) 2003-04-25
HK1048949B HK1048949B (en) 2013-09-27

Family

ID=23751700

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03101230.5A HK1048949B (en) 1999-11-17 2000-11-13 Method and composition for the treatment of scars

Country Status (13)

Country Link
US (7) US6337076B1 (de)
EP (2) EP1231887B1 (de)
JP (1) JP4759902B2 (de)
CN (1) CN1221237C (de)
AU (1) AU779062B2 (de)
BR (1) BR0015604A (de)
CA (1) CA2391310C (de)
CY (2) CY1113841T1 (de)
DK (2) DK1231887T3 (de)
ES (2) ES2399738T3 (de)
HK (1) HK1048949B (de)
PT (2) PT2412368E (de)
WO (1) WO2001037782A2 (de)

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US20020054896A1 (en) 2002-05-09
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