GR1009789B - Ointment for burns - Google Patents

Abstract

The invention relates to an ointment destined for the treatment of burns and skin lesions in general. It is the product of intense mixing and mild heat treatment of the following ingredients: olive oil, petroleum jelly, goose fat, sulfanilamide powder, rapeseed oil, vitamins A, and D. This preparation has the form of an ointment resulting from vigorous mixing and gentle heating for a period of 20-30 minutes. The mixing sequence, the active ingredient’s granulation, the combination of the active ingredient with natural ingredients, the use of vitamins and oils and the mild heat treatment have beneficial effects and reduce the healing time. This final product is used for external use-application on the burn area of the skin for scarless radical, painless and rapid healing.

Description

DESCRIPTION

Ointment for the treatment of burns

The invention refers to an ointment for the treatment of burns and is the product of intense mixing and mild heat treatment of the following ingredients: olive oil, vaseline, goose fat, sulfanilamide powder, rapeseed oil, vitamins A, D and E.

This ointment has the advantage of other products which are not therapeutic but conservative. This treatment can mainly heal skin tissues that have been damaged by first (1<th>), second (2<th>) but also third (3<th>) degree burns as well as wounds that have come from lying down.

The estimated healing period for third (3rd) degree burns is from ten (10) to twenty one (21) days, with the most common onset of healing at fourteen (14) days. Using this ointment halves the healing time compared to other methods and products, but its main feature is that it leaves no marks after healing. A prerequisite for this to happen, however, is its application from the first day of the burn, as well as the method of application, which is as follows: a sufficient amount of the ointment is applied to a sterile cotton cloth, which is applied to the wound in order to healing so that no eschar (scar tissue-cakado) appears on the wound. This is also how we achieve the protection of the wound from exogenous infection factors. This cloth is changed every 48 hours, and the sterile cloth is taped to the healthy areas of the skin in the other way so that the skin can breathe.

Indicative other similar techniques are based on patents such as RU2452475C2, CN102349920B, US3761590, which generally refer to the use of sulfanilamide and other active compounds belonging to the group of sulfonamides, such as sulfadiazine, which have antibiotic and antibacterial properties. action, but not in the form of a powder with a specific particle size and not in combination with the use of olive oil, vaseline, goose fat, rapeseed oil and vitamins A, D and E.

This preparation is in the form of an ointment, which results from intense mixing and gentle heating, for a period of twenty (20) to thirty (30) minutes of the first hour, and then it is kept in a shady and cool place with a temperature of four (4 ° C) to twenty-five (25° C) degrees Celsius, and the exact method of its preparation is as follows:

1. The mixing of the ingredients takes place in a double-walled container and in

constant temperature for the first twenty (20) to thirty (30) minutes of it

hour with a constant mixing rate.

2. The mixing should create a completely homogeneous mixture and to achieve the desired result, a stirrer-mixer or vacuum and pressure homogenizer-mixer stirrer assemblies are used, which are designed to provide high-quality production of pharmaceutical preparations and cosmetic creams, suspensions, gels , toothpastes, mascaras, hair care products, etc.

3. The mixing temperature should remain constant throughout mixing as deviations adversely affect the result and the optimal temperature range is from twenty (20) to forty (40) degrees Celsius (°C), preferably from twenty five (25) to thirty-five (35) degrees Celsius (°C), ideally twenty-seven (27) to thirty-two (32) degrees Celsius (°C).

4. The rotation speed during homogenization may be from 2800 rpm to 3100 rpm, preferably from 2850 rpm to 3050 rpm, ideally from 2900 rpm to 3000 rpm.

5. To avoid the creation of air bubbles in the final product and prolong the storage time, it is recommended to use a vacuum pump with an applied vacuum pressure of the container -0.08Mpa.

6. The ingredients used and the quantities by weight and percentage (%) are listed in table 1 :

TABLE 1

7. The mixing order is as follows: first the first component (1°) is mixed with the second (2°) and then the third (3°) component is added to the resulting mixture and then the fifth (5) is added to the resulting mixture °) component and then the fourth component (4°) is added to the resulting mixture.

8. Goose fat should be golden in color without foreign bodies and be homogeneous, with a characteristic goose smell. Processing of goose fat should be gentle and have a maximum processing temperature of eighty (80) degrees Celsius (°C).

9. The sulfanilamide should be fine-grained, in case it does not have the necessary granulometry characteristics, we convert the component by friction into a finer-grained powder, specifically in a granulometry smaller than thirty (30) microns (μm), preferably smaller than twenty-two (22) microns (μm), ideally the grain size should be from sixteen (16) to twenty two (22) microns (μm).

10. The olive oil is preferably olive oil with low acids of 2-3% and even better Virgin Olive Oil, which is virgin olive oil, i.e. olive oil that has been produced only by natural and mechanical processes, with good organoleptic characteristics, with a free acidity no greater than 2.0%, and even better Extra Virgin Olive Oil, which is virgin olive oil, which has been produced only by natural and mechanical processes, with a perfect aroma and taste, with a free acidity of no more than 0.8%.

11. The final moisture content of the ointment should be from 10% to 20% by weight, preferably from 12.5% to 17.5% by weight.

12. After mixing the above materials and in the quantities mentioned, place them in a container or package and this final product is ready for external dermatological use.

13. The above product, after being stored in the refrigerator, takes the form of an aqueous ointment with a pale yellow color and a characteristic smell of goose and its butter.

14. The above product after its airtight packaging remains active, in a refrigerator from four (4) degrees Celsius (°C) to a temperature of up to twenty-five (25) degrees Celsius (°C), in a shady and cool place for twelve (12 months.

15. The preservative used is potassium sorbate in a proportion of from 0.1% to 0.3% by weight, preferably from 0.1% to 0.2% by weight. 16. With the final product as described above and in an amount of approximately one (1) gram per 5 square centimeters (cm<2>) smear on a suitable sterile cloth, preferably hypoallergenic cotton and place it on the affected area from the first day to the wound healing every 48 hours and in a period of seven (7) to twenty one (21) days results become apparent even in third (3rd) degree burns. After healing unlike the other methods the burn scar is no longer visible.

17. The ointment is suitable for burns of all three degrees, as defined below based on the depth of the damage. In addition to burns, it is also suitable for the healing of other skin damage such as from openings in the skin caused by lying down.

The ointment is suitable and indicated for:

-First degree burns, where the damage is located in the most superficial layers of the skin, i.e. in the superficial layers of the skin (epithelium). It manifests itself with signs of slight inflammation, due to local vasodilatation and characterized by redness, swelling of the area and sensitivity. They are particularly painful and subside automatically in 2-3 days, so peeling of the skin is also observed. Usually these heal within one to two weeks, with apoptosis of the outer layers of the skin leaving a visible scar. By using the ointment the healing time is reduced by 30-40% and without leaving a visible scar.

-Second degree burns, where the damage affects the skin deeper, epithelium and a small or large part of the dermis. The irritation of the nerve endings creates intense pain, while at the same time subcutaneous swelling develops and bubbles containing serous fluid are formed. The skin may be pink and moist or a mixture of red and whitish. Healing of these burns takes two or three weeks if treated properly and scar formation depends on the depth of the skin damage. By using the ointment the healing time is reduced by 35-45% and without leaving a visible scar.

-Third degree burns in which the damage concerns the entire thickness of the skin (epidermis, dermis and subcutaneous tissue). Sensation (pain) is almost abolished, due to destruction of the nerve endings, and the burned surface appears dry, pale or even charred. Healing is very slow, a scar is always formed (hard ptosis) and skin grafting may be required. By using the ointment the healing time is reduced by 40-50% and without leaving a visible scar.

Claims (8)

CLAIMS 1. Ointment for the treatment of burns, which is produced by intense mixing and mild heat treatment of a mixture of fatty acids consisting of vegetable oils in a percentage by weight of 40% preferably rapeseed oil, water, vegetable fats in a percentage by weight of 20% consisting of palm oil and palm kernel oil , milk butter, salt in a percentage by weight of 0.3%, emulsifiers, vitamins A, D, E, preservative preferably potassium sorbate, aromatic substances, dyes, citric acid, olive oil, preferably extra virgin olive oil, which is virgin olive oil , which has been produced only by natural and mechanical processes, with a free acidity of not more than 0.8%, medicated petrolatum, goose fat with salt and sulfanilamide, for the treatment of burns, in which it is formed from specific quantities of the above materials, i.e. : 2. To obtain the product according to claim 1, this mixture is subjected to vigorous mixing and mild heat treatment for the first twenty (20) to thirty (30) minutes of the hour with a constant mixing rate and after cooling the formed aqueous ointment is ready to packaging and use. 3. Product obtained according to claim 1 with specific characteristics of its ingredients and on the basis that the olive oil will preferably be olive oil with low acids of 2-3% and even better virgin olive oil, i.e. olive oil that has been produced only by natural and mechanical processes, with good organoleptic properties characteristics, with free acidity not greater than 2.0%, and even better extra virgin olive oil, which is virgin olive oil, which has been produced only by natural and mechanical processes, with perfect aroma and taste, with free acidity not greater than 0 .8%. 4. Product obtained according to claim 1 with specific characteristics of its components and on the basis that the active substance sulfanilamide should have a particle size of less than 30 microns (μm) preferably less than 22 microns (μm), ideally the particle size should be from 16 to 22 microns (µm). 5. Product obtained according to claim 1 for use for the rapid, painless and radical treatment of burns with the particularity of using goose fat, an ingredient which, together and in combination with sulfanilamide, has a beneficial effect on burns and other skin damage, the combination not of sulfanilamide with goose fat has a healing effect and the effectiveness of the product is multiplied by the above synergy. 6. Product obtained according to claim 1 for use in the rapid, painless and radical treatment of burns and with the ability to rapidly heal burns or other damage from pathophysiological reactions of skin tissues - from exogenous effects of high temperature, chemical substance, radiation and electric power. 7. Product obtained according to claim 1 with the combined action of its ingredients, which are olive oil, petroleum jelly, goose fat, sulfanilamide, rapeseed oil, vitamins A, D and E. 8. Product obtained according to claim 1 and with a specific mixing order which is as follows: initially the first component (1°) is mixed with the second (2°) and then the third (3°) component is added to the resulting mixture and then the fifth (5°) component is added to the resulting mixture and then the fourth component (4°) is added to the resulting mixture.