GB1388198A - Antibiotic fr-1923 and a process for the preparation thereof - Google Patents
Antibiotic fr-1923 and a process for the preparation thereofInfo
- Publication number
- GB1388198A GB1388198A GB3858672A GB3858672A GB1388198A GB 1388198 A GB1388198 A GB 1388198A GB 3858672 A GB3858672 A GB 3858672A GB 3858672 A GB3858672 A GB 3858672A GB 1388198 A GB1388198 A GB 1388198A
- Authority
- GB
- United Kingdom
- Prior art keywords
- antibiotic
- aug
- organism
- forms
- pharmaceutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- CTNZOGJNVIFEBA-UPSUJEDGSA-N nocardicin A Chemical compound C1=CC(OCC[C@@H](N)C(O)=O)=CC=C1C(=N\O)\C(=O)N[C@@H]1C(=O)N([C@@H](C(O)=O)C=2C=CC(O)=CC=2)C1 CTNZOGJNVIFEBA-UPSUJEDGSA-N 0.000 title abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 241000520858 Nocardia uniformis Species 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012059 conventional drug carrier Substances 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 159000000000 sodium salts Chemical class 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
1388198 Antibiotic FR-1923 FUJISAWA PHARMACEUTICAL CO Ltd 18 Aug 1972 [31 Aug 1971] 38586/72 Heading C2A A new antibiotic designated "FR-1923" is isolated as a white, crystalline, amphoteric solid from aerobic cultures of an organism of the species Nocardia uniformis in a nutrient medium containing sources of assimilable carbon, nitrogen and inorganic salts. The preferred organism is Nocardia uniformis var. tsuyamanensis ATCC 21806. Isolation is by conventional procedures from the filtered broth. The antibiotic forms a sodium salt (also claimed) which may readily be converted to the free compound, e.g. by treatment with an acid. Pharmaceutical compositions in conventional forms for oral, parenteral and local application may be produced comprising the antibiotic and/or its salts and conventional pharmaceutical carriers and excipients.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6731271A JPS5417028B2 (en) | 1971-08-31 | 1971-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1388198A true GB1388198A (en) | 1975-03-26 |
Family
ID=13341360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3858672A Expired GB1388198A (en) | 1971-08-31 | 1972-08-18 | Antibiotic fr-1923 and a process for the preparation thereof |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS5417028B2 (en) |
| AU (1) | AU468413B2 (en) |
| BE (1) | BE788099A (en) |
| CA (1) | CA994268A (en) |
| CH (1) | CH572979A5 (en) |
| DE (1) | DE2242699A1 (en) |
| DK (1) | DK130423B (en) |
| ES (1) | ES406202A1 (en) |
| FR (1) | FR2150984B1 (en) |
| GB (1) | GB1388198A (en) |
| IT (1) | IT1047896B (en) |
| NL (1) | NL7211870A (en) |
| NO (1) | NO139093C (en) |
| SE (1) | SE385128B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0051312A1 (en) * | 1980-11-03 | 1982-05-12 | Bristol-Myers Company | Fermentation process |
-
0
- BE BE788099D patent/BE788099A/en not_active IP Right Cessation
-
1971
- 1971-08-31 JP JP6731271A patent/JPS5417028B2/ja not_active Expired
-
1972
- 1972-08-18 GB GB3858672A patent/GB1388198A/en not_active Expired
- 1972-08-28 DK DK425572AA patent/DK130423B/en not_active IP Right Cessation
- 1972-08-29 SE SE7211183A patent/SE385128B/en unknown
- 1972-08-29 AU AU46083/72A patent/AU468413B2/en not_active Expired
- 1972-08-30 ES ES406202A patent/ES406202A1/en not_active Expired
- 1972-08-30 NO NO3080/72A patent/NO139093C/en unknown
- 1972-08-30 FR FR7230796A patent/FR2150984B1/fr not_active Expired
- 1972-08-30 IT IT28658/72A patent/IT1047896B/en active
- 1972-08-30 CA CA150,731A patent/CA994268A/en not_active Expired
- 1972-08-30 DE DE2242699A patent/DE2242699A1/en not_active Withdrawn
- 1972-08-31 CH CH1286172A patent/CH572979A5/xx not_active IP Right Cessation
- 1972-08-31 NL NL7211870A patent/NL7211870A/xx not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0051312A1 (en) * | 1980-11-03 | 1982-05-12 | Bristol-Myers Company | Fermentation process |
Also Published As
| Publication number | Publication date |
|---|---|
| BE788099A (en) | 1973-02-28 |
| CA994268A (en) | 1976-08-03 |
| ES406202A1 (en) | 1975-07-01 |
| CH572979A5 (en) | 1976-02-27 |
| NO139093B (en) | 1978-09-25 |
| AU4608372A (en) | 1974-03-07 |
| JPS4833094A (en) | 1973-05-07 |
| FR2150984B1 (en) | 1976-04-23 |
| JPS5417028B2 (en) | 1979-06-27 |
| AU468413B2 (en) | 1976-01-15 |
| DE2242699A1 (en) | 1973-03-08 |
| DK130423C (en) | 1975-09-01 |
| FR2150984A1 (en) | 1973-04-13 |
| NO139093C (en) | 1979-01-03 |
| SE385128B (en) | 1976-06-08 |
| IT1047896B (en) | 1980-10-20 |
| DK130423B (en) | 1975-02-17 |
| NL7211870A (en) | 1973-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |