FI83644B - Foerfarande foer framstaellning av optiskt aktiva 2-klor-12-(3-dimetylamino-2-metylpropyl)-12h-dibenzo-/d,g//1,3,6/ dioxazociner, som aer verksamma mot parkinsons sjukdom. - Google Patents
Foerfarande foer framstaellning av optiskt aktiva 2-klor-12-(3-dimetylamino-2-metylpropyl)-12h-dibenzo-/d,g//1,3,6/ dioxazociner, som aer verksamma mot parkinsons sjukdom. Download PDFInfo
- Publication number
- FI83644B FI83644B FI865244A FI865244A FI83644B FI 83644 B FI83644 B FI 83644B FI 865244 A FI865244 A FI 865244A FI 865244 A FI865244 A FI 865244A FI 83644 B FI83644 B FI 83644B
- Authority
- FI
- Finland
- Prior art keywords
- chloro
- dimethylamino
- methylpropyl
- dibenzo
- optically active
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02T—CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO TRANSPORTATION
- Y02T50/00—Aeronautics or air transport
- Y02T50/10—Drag reduction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Luminescent Compositions (AREA)
Claims (3)
1. Förfarande för framställning av en optiskt aktiv 2-klor-12-(3-d imetylamino-2-metylpropyl)-12H-d ibenso[d,g][l,3,6]-dioxazocin, som Sr verksam mot Parkinsons sjukdom, och farmaceutiskt godtagbara syraadditionssalter därav, kännetecknat av att man a) uppdelar racemisk 2-klor-12-(3-dimetylamino-2-metyl-propyl)-12H-dibenso[d,g][l,3,6]dioxazocin med en optiskt aktiv organisk syra och separerar enantiomererna eller b) löser racemisk 2-klor-l2-(3-dimetylamino-2-metylpropyl)-12H-dibenso[d,g][l,3,6]dioxazocin i ett organiskt lösnings-medel och kristalliserar samt isolerar en av enantiomererna, varvid man godtyckligt löser en ytterligare mängd av racemisk 2-klor-12-(3-dimetylamino-2-metylpropyl)-12H-dibenso[d,g]- [1,3,6]-dioxazocin i den erhällna moderluten och kristalliserar samt isolerar den andra enantiomeren och, om sä öns-kas, upprepar hela förfarandet och, om sä önskas, omvandlar en erhällen enantiomer till ett syraadditionssalt med en oorganisk eller organisk syra.
2. Förfarande enligt patentkrav la), känneteck- n a t av att den optiskt aktiva organiska syran är optiskt aktiv vinsyra.
3. Förfarande enligt patentkrav ib), känneteck-n a t av att det organiska lösningsmedlet Mr isopropanol. li
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU854881A HU195491B (en) | 1985-12-20 | 1985-12-20 | Process for production of optically active 2-chlor-12-/3-/dimethil-amin/-2-methil-prophil/-12h-dibenzol /d,g/ /1,3,6/-diaxazocine and medical compositions containing such compounds |
| HU488185 | 1985-12-20 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI865244A0 FI865244A0 (fi) | 1986-12-19 |
| FI865244A7 FI865244A7 (fi) | 1987-06-21 |
| FI83644B true FI83644B (fi) | 1991-04-30 |
| FI83644C FI83644C (sv) | 1991-08-12 |
Family
ID=10969129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI865244A FI83644C (sv) | 1985-12-20 | 1986-12-19 | Förfarande för framställning av optiskt aktiva 2-klor-12-(3-dimetylami no-2-metylpropyl)-12H-dibenzo-/d,g//1,3,6/dioxazociner, som är verksam ma mot Parkinsons sjukdom |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US4906622A (sv) |
| JP (1) | JPS62158265A (sv) |
| CN (1) | CN86108260A (sv) |
| AT (1) | AT394366B (sv) |
| AU (1) | AU589725B2 (sv) |
| BE (1) | BE905907A (sv) |
| BG (1) | BG46004A3 (sv) |
| CA (1) | CA1291133C (sv) |
| CH (1) | CH670638A5 (sv) |
| CS (1) | CS262681B2 (sv) |
| DD (1) | DD256695A5 (sv) |
| DE (1) | DE3643991A1 (sv) |
| DK (1) | DK616886A (sv) |
| ES (1) | ES2003994A6 (sv) |
| FI (1) | FI83644C (sv) |
| FR (1) | FR2592043B1 (sv) |
| GB (1) | GB2184445B (sv) |
| HU (1) | HU195491B (sv) |
| IT (1) | IT1199821B (sv) |
| NL (1) | NL8603236A (sv) |
| NO (1) | NO865179L (sv) |
| PH (1) | PH24385A (sv) |
| PL (1) | PL263134A1 (sv) |
| PT (1) | PT83979B (sv) |
| SE (1) | SE466399B (sv) |
| SU (1) | SU1470187A3 (sv) |
| YU (1) | YU45814B (sv) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU198194B (en) * | 1986-12-30 | 1989-08-28 | Egyt Gyogyszervegyeszeti Gyar | Process for production of new derivatives of dioxazocin and medical compositions containing them |
| HU201318B (en) * | 1987-12-31 | 1990-10-28 | Egyt Gyogyszervegyeszeti Gyar | Process for producing dioxazoline derivatives and pharmaceutical compositions comprising same |
| ATE91487T1 (de) * | 1989-10-20 | 1993-07-15 | Akzo Nv | Dibenzodioxazecin- und dibenzodioxaazacycloundecin-derivate. |
| WO1997011071A1 (en) * | 1995-09-19 | 1997-03-27 | Novo Nordisk A/S | Novel heterocyclic compounds |
| RU2436782C1 (ru) * | 2010-06-10 | 2011-12-20 | Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | 2-МЕТОКСИ-4[(3aR,7aS)-3,3,6-ТРИМЕТИЛ-1,3,3a,4,5,7a-ГЕКСАГИДРО-2-БЕНЗОФУРАН-1-ИЛ]ФЕНОЛ - НОВОЕ СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ БОЛЕЗНИ ПАРКИНСОНА |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2705M (fr) * | 1963-04-18 | 1964-08-03 | Rhone Poulenc Sa | Nouvelles compositions anti-émétiques. |
| NL7202963A (sv) * | 1972-03-07 | 1973-09-11 | ||
| NL176458C (nl) * | 1972-09-23 | 1985-04-16 | Akzo Nv | Werkwijze ter bereiding van een farmaceutisch preparaat en werkwijze voor de bereiding van daartoe geschikte actieve stoffen. |
| HU174126B (hu) * | 1977-08-02 | 1979-11-28 | Egyt Gyogyszervegyeszeti Gyar | Sposob poluchenija novykh proizvodnykh dibenzo-kvadratnaja skobka-d,g-kvadratnaja skobka zakryta-kvadratnaja skobka-1,3,6-kvadratnaja skobka zakryta-dioksazocina |
| DE3426720A1 (de) * | 1984-07-20 | 1986-01-23 | Hoechst Ag, 6230 Frankfurt | Benzthiazepinon- und benzthiazocinon-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung, sowie zwischenprodukte bei ihrer herstellung |
-
1985
- 1985-12-20 HU HU854881A patent/HU195491B/hu not_active IP Right Cessation
-
1986
- 1986-12-10 AT AT0326986A patent/AT394366B/de not_active IP Right Cessation
- 1986-12-12 BE BE1/011589A patent/BE905907A/fr not_active IP Right Cessation
- 1986-12-17 CN CN198686108260A patent/CN86108260A/zh active Pending
- 1986-12-18 CH CH5108/86A patent/CH670638A5/de not_active IP Right Cessation
- 1986-12-18 PH PH34611A patent/PH24385A/en unknown
- 1986-12-18 SE SE8605457A patent/SE466399B/sv not_active IP Right Cessation
- 1986-12-19 YU YU218886A patent/YU45814B/sh unknown
- 1986-12-19 PT PT83979A patent/PT83979B/pt not_active IP Right Cessation
- 1986-12-19 GB GB8630431A patent/GB2184445B/en not_active Expired
- 1986-12-19 NO NO865179A patent/NO865179L/no unknown
- 1986-12-19 CA CA000525829A patent/CA1291133C/en not_active Expired - Lifetime
- 1986-12-19 CS CS869606A patent/CS262681B2/cs unknown
- 1986-12-19 PL PL1986263134A patent/PL263134A1/xx unknown
- 1986-12-19 ES ES8603527A patent/ES2003994A6/es not_active Expired
- 1986-12-19 FR FR868617825A patent/FR2592043B1/fr not_active Expired - Lifetime
- 1986-12-19 FI FI865244A patent/FI83644C/sv not_active IP Right Cessation
- 1986-12-19 DK DK616886A patent/DK616886A/da not_active Application Discontinuation
- 1986-12-19 DD DD86298019A patent/DD256695A5/de not_active IP Right Cessation
- 1986-12-19 AU AU66765/86A patent/AU589725B2/en not_active Ceased
- 1986-12-19 BG BG077613A patent/BG46004A3/xx unknown
- 1986-12-19 IT IT22780/86A patent/IT1199821B/it active
- 1986-12-19 NL NL8603236A patent/NL8603236A/nl not_active Application Discontinuation
- 1986-12-19 SU SU864028671A patent/SU1470187A3/ru active
- 1986-12-20 JP JP61302884A patent/JPS62158265A/ja active Pending
- 1986-12-22 DE DE19863643991 patent/DE3643991A1/de active Granted
-
1988
- 1988-05-18 US US07/195,691 patent/US4906622A/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: EGIS GYOGYSZERGYAR |