EE200300168A - Tripeptidüülpeptidaasi inhibiitorid, nende valmistamine ja kasutamine ravimina ning neid sisaldav farmatseutiline kompositsioon - Google Patents
Tripeptidüülpeptidaasi inhibiitorid, nende valmistamine ja kasutamine ravimina ning neid sisaldav farmatseutiline kompositsioonInfo
- Publication number
- EE200300168A EE200300168A EEP200300168A EEP200300168A EE200300168A EE 200300168 A EE200300168 A EE 200300168A EE P200300168 A EEP200300168 A EE P200300168A EE P200300168 A EEP200300168 A EE P200300168A EE 200300168 A EE200300168 A EE 200300168A
- Authority
- EE
- Estonia
- Prior art keywords
- pharmaceuticals
- preparation
- pharmaceutical composition
- composition containing
- tripeptidyl peptidase
- Prior art date
Links
- 102000003779 Dipeptidyl-peptidases and tripeptidyl-peptidases Human genes 0.000 title abstract 2
- 108090000194 Dipeptidyl-peptidases and tripeptidyl-peptidases Proteins 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 108090000189 Neuropeptides Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Neurology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24422300P | 2000-10-30 | 2000-10-30 | |
| PCT/EP2001/012388 WO2002036116A2 (en) | 2000-10-30 | 2001-10-24 | Tripeptidyl peptidase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE200300168A true EE200300168A (et) | 2003-06-16 |
Family
ID=22921880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP200300168A EE200300168A (et) | 2000-10-30 | 2001-10-24 | Tripeptidüülpeptidaasi inhibiitorid, nende valmistamine ja kasutamine ravimina ning neid sisaldav farmatseutiline kompositsioon |
Country Status (25)
| Country | Link |
|---|---|
| US (4) | US7125891B2 (et) |
| EP (1) | EP1392291B1 (et) |
| JP (1) | JP2004512365A (et) |
| KR (1) | KR100820598B1 (et) |
| CN (2) | CN101307046B (et) |
| AT (1) | ATE363276T1 (et) |
| AU (2) | AU2002224797B2 (et) |
| BG (1) | BG107729A (et) |
| CA (1) | CA2422617C (et) |
| CZ (1) | CZ20031422A3 (et) |
| DE (1) | DE60128731T2 (et) |
| DK (1) | DK1392291T3 (et) |
| EA (1) | EA006443B1 (et) |
| EE (1) | EE200300168A (et) |
| ES (1) | ES2287185T3 (et) |
| HU (1) | HU230376B1 (et) |
| IL (2) | IL155604A0 (et) |
| MX (1) | MXPA03003868A (et) |
| NO (1) | NO324503B1 (et) |
| NZ (1) | NZ525928A (et) |
| PL (1) | PL205536B1 (et) |
| PT (1) | PT1392291E (et) |
| SK (1) | SK6282003A3 (et) |
| WO (1) | WO2002036116A2 (et) |
| ZA (1) | ZA200303302B (et) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101307046B (zh) * | 2000-10-30 | 2012-08-15 | 詹森药业有限公司 | 三肽酶抑制剂 |
| US7041681B2 (en) * | 2002-04-29 | 2006-05-09 | Janssen Pharmaceutica N.V. | Compounds as opioid receptor modulators |
| AU2012268813B2 (en) * | 2002-04-29 | 2015-04-30 | Janssen Pharmaceutica N.V. | Heterocyclic derivatives as opioid modulators |
| AU2003280985A1 (en) * | 2002-07-10 | 2004-02-02 | Bayer Healthcare Ag | Regulation of human tripeptidyl peptidase ii |
| JP2006502134A (ja) | 2002-08-09 | 2006-01-19 | アストラゼネカ アクチボラグ | 代謝調節型グルタミン酸受容体において活性を有する化合物 |
| DE602004022153D1 (de) * | 2003-05-14 | 2009-09-03 | High Point Pharmaceuticals Llc | Verbindungen zur behandlung von obesitas |
| CN102786476B (zh) | 2004-03-15 | 2017-01-18 | 詹森药业有限公司 | 作为阿片受体调节剂的化合物 |
| WO2006028970A1 (en) | 2004-09-02 | 2006-03-16 | Cengent Therapeutics, Inc. | Derivatives of thiazole and thiadiazole inhibitors of tyrosine phosphatases |
| NZ590570A (en) * | 2005-03-14 | 2012-06-29 | Janssen Pharmaceutica Nv | Process for the preparation of opioid modulators |
| KR20080067697A (ko) * | 2005-11-11 | 2008-07-21 | 에프. 호프만-라 로슈 아게 | 응고 인자 ｘａ의 억제제로서 카보사이클릭 융합된사이클릭 아민 |
| US9101160B2 (en) | 2005-11-23 | 2015-08-11 | The Coca-Cola Company | Condiments with high-potency sweetener |
| JP2009536953A (ja) | 2006-05-11 | 2009-10-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｃｅｔｐ阻害剤としての１，２，３，４−テトラヒドロ−キノリン誘導体 |
| JP2009536954A (ja) | 2006-05-11 | 2009-10-22 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｃｅｔｐ阻害剤としての３，４−ジヒドロ−２ｈ−ベンゾ［１，４］オキサジンおよびチアジン誘導体 |
| US8017168B2 (en) | 2006-11-02 | 2011-09-13 | The Coca-Cola Company | High-potency sweetener composition with rubisco protein, rubiscolin, rubiscolin derivatives, ace inhibitory peptides, and combinations thereof, and compositions sweetened therewith |
| GB0709031D0 (en) * | 2007-05-10 | 2007-06-20 | Sareum Ltd | Pharmaceutical compounds |
| GB201202027D0 (en) | 2012-02-06 | 2012-03-21 | Sareum Ltd | Pharmaceutical compounds |
| US20130231340A1 (en) | 2012-03-02 | 2013-09-05 | Sareum Limited | Pharmaceutical compounds |
| EP2708535A1 (en) | 2012-05-11 | 2014-03-19 | Les Laboratoires Servier | Agents for treating disorders involving modulation of ryanodine receptors |
| EP2961403A4 (en) | 2013-03-01 | 2016-11-30 | Zalicus Pharmaceuticals Ltd | HETEROCYCLIC INHIBITORS OF SODIUM CHANNEL |
| US9675587B2 (en) | 2013-03-14 | 2017-06-13 | Allergan Holdings Unlimited Company | Opioid receptor modulator dosage formulations |
| GB201617871D0 (en) | 2016-10-21 | 2016-12-07 | Sareum Limited | Pharmaceutical compounds |
| WO2018084141A1 (ja) * | 2016-11-01 | 2018-05-11 | 日本農薬株式会社 | Ｎ‐アルキルスルホニルインドリン化合物及び該化合物を含有する農園芸用殺虫剤並びにその使用方法 |
| GB201816369D0 (en) | 2018-10-08 | 2018-11-28 | Sareum Ltd | Pharmaceutical compounds |
| JP7778688B2 (ja) | 2019-10-17 | 2025-12-02 | ジボダン エス エー | Ｔｒｍｐ８モジュレーターとしての置換アザシル |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE584914A (et) * | 1958-11-24 | |||
| JPS50439B1 (et) * | 1970-04-27 | 1975-01-09 | ||
| CH543479A (de) * | 1970-05-06 | 1973-10-31 | Hoffmann La Roche | Verfahren zur Herstellung von Phenyläthylaminderivaten |
| GB2146026A (en) * | 1983-09-07 | 1985-04-11 | Tanabe Seiyaku Co | Peptides and process for preparing the same |
| JPS61227506A (ja) | 1985-04-01 | 1986-10-09 | Nippon Tokushu Noyaku Seizo Kk | カルバモイルイミダゾ−ル類、その中間体、それらの製法並びに除草剤又は農園芸用殺菌剤 |
| US5159081A (en) | 1991-03-29 | 1992-10-27 | Eli Lilly And Company | Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists |
| US5338135A (en) | 1991-04-11 | 1994-08-16 | Sumitomo Electric Industries, Ltd. | Drill and lock screw employed for fastening the same |
| FR2678938B1 (fr) * | 1991-07-10 | 1993-10-08 | Rhone Poulenc Rorer Sa | Derives de pyrrolidine, leur preparation et les medicaments les contenant. |
| JPH05339240A (ja) | 1992-06-04 | 1993-12-21 | Yamanouchi Pharmaceut Co Ltd | テトラヒドロイソキノリンアミド誘導体 |
| SE9402880D0 (sv) | 1994-08-30 | 1994-08-30 | Astra Ab | New peptide derivatives |
| FR2733995B1 (fr) | 1995-05-09 | 1997-07-25 | Inst Nat Sante Rech Med | Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments |
| FR2735776B1 (fr) * | 1995-06-22 | 1997-07-18 | Synthelabo | Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique |
| JP2001505585A (ja) * | 1996-12-16 | 2001-04-24 | 藤沢薬品工業株式会社 | 新規アミド化合物およびそれらの一酸化窒素シンターゼ阻害剤としての用途 |
| US5965537A (en) * | 1997-03-10 | 1999-10-12 | Basf Aktiengesellschaft | Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus |
| WO1999033801A1 (en) * | 1997-12-23 | 1999-07-08 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Tripeptidyl peptidase inhibitors |
| AU3768799A (en) * | 1998-04-28 | 1999-11-16 | Trega Biosciences, Inc. | Isoquinoline compound melanocortin receptor ligands and methods of using same |
| AU1620499A (en) * | 1998-06-03 | 1999-12-20 | Amgen, Inc. | Ureas and carbamates of n-heterocyclic carboxylic acids and carboxylic acid isosteres |
| US6916905B2 (en) * | 2000-03-24 | 2005-07-12 | The United States Of America As Represented By The Department Of Health And Human Services | Dmt-Tic di-and tri-peptidic derivatives and related compositions and methods of use |
| CN101307046B (zh) | 2000-10-30 | 2012-08-15 | 詹森药业有限公司 | 三肽酶抑制剂 |
| FR2816207B1 (fr) | 2000-11-08 | 2003-01-03 | Oreal | Composition de teinture d'oxydation pour fibres keratiniques comprenant un polyurethane associatif cationique |
| US6755387B2 (en) | 2001-02-08 | 2004-06-29 | Symons Corporation | Transition strip for disparate concrete forms |
-
2001
- 2001-10-24 CN CN2008101078402A patent/CN101307046B/zh not_active Expired - Lifetime
- 2001-10-24 AU AU2002224797A patent/AU2002224797B2/en not_active Expired
- 2001-10-24 NZ NZ525928A patent/NZ525928A/en not_active IP Right Cessation
- 2001-10-24 PT PT01992570T patent/PT1392291E/pt unknown
- 2001-10-24 EA EA200300523A patent/EA006443B1/ru not_active IP Right Cessation
- 2001-10-24 DK DK01992570T patent/DK1392291T3/da active
- 2001-10-24 ES ES01992570T patent/ES2287185T3/es not_active Expired - Lifetime
- 2001-10-24 MX MXPA03003868A patent/MXPA03003868A/es active IP Right Grant
- 2001-10-24 WO PCT/EP2001/012388 patent/WO2002036116A2/en not_active Ceased
- 2001-10-24 IL IL15560401A patent/IL155604A0/xx unknown
- 2001-10-24 AT AT01992570T patent/ATE363276T1/de active
- 2001-10-24 CZ CZ20031422A patent/CZ20031422A3/cs unknown
- 2001-10-24 AU AU2479702A patent/AU2479702A/xx active Pending
- 2001-10-24 CN CNB018181015A patent/CN100400040C/zh not_active Expired - Lifetime
- 2001-10-24 JP JP2002538928A patent/JP2004512365A/ja active Pending
- 2001-10-24 DE DE60128731T patent/DE60128731T2/de not_active Expired - Lifetime
- 2001-10-24 PL PL361064A patent/PL205536B1/pl unknown
- 2001-10-24 CA CA2422617A patent/CA2422617C/en not_active Expired - Lifetime
- 2001-10-24 KR KR1020037004180A patent/KR100820598B1/ko not_active Expired - Lifetime
- 2001-10-24 EE EEP200300168A patent/EE200300168A/et unknown
- 2001-10-24 HU HU0302770A patent/HU230376B1/hu unknown
- 2001-10-24 EP EP01992570A patent/EP1392291B1/en not_active Expired - Lifetime
- 2001-10-24 US US10/415,623 patent/US7125891B2/en not_active Expired - Lifetime
- 2001-10-24 SK SK628-2003A patent/SK6282003A3/sk unknown
-
2003
- 2003-04-16 BG BG107729A patent/BG107729A/bg unknown
- 2003-04-28 IL IL155604A patent/IL155604A/en unknown
- 2003-04-29 ZA ZA200303302A patent/ZA200303302B/en unknown
- 2003-04-29 NO NO20031930A patent/NO324503B1/no not_active IP Right Cessation
-
2006
- 2006-08-07 US US11/499,937 patent/US20060276509A1/en not_active Abandoned
-
2007
- 2007-10-30 US US11/928,273 patent/US7947713B2/en not_active Expired - Fee Related
-
2011
- 2011-05-19 US US13/111,010 patent/US8247432B2/en not_active Expired - Fee Related
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