DE20104419U1 - Antioxidant preparations - Google Patents
Antioxidant preparationsInfo
- Publication number
- DE20104419U1 DE20104419U1 DE20104419U DE20104419U DE20104419U1 DE 20104419 U1 DE20104419 U1 DE 20104419U1 DE 20104419 U DE20104419 U DE 20104419U DE 20104419 U DE20104419 U DE 20104419U DE 20104419 U1 DE20104419 U1 DE 20104419U1
- Authority
- DE
- Germany
- Prior art keywords
- npg
- vitamin
- preparation
- cysteine
- lipoic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims description 86
- 239000003963 antioxidant agent Substances 0.000 title claims description 30
- 230000003078 antioxidant effect Effects 0.000 title claims description 17
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 claims description 193
- 235000010388 propyl gallate Nutrition 0.000 claims description 101
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 80
- AGBQKNBQESQNJD-UHFFFAOYSA-N alpha-Lipoic acid Natural products OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 claims description 59
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 57
- 235000019154 vitamin C Nutrition 0.000 claims description 43
- 239000011718 vitamin C Substances 0.000 claims description 43
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 40
- 229930003268 Vitamin C Natural products 0.000 claims description 40
- PWKSKIMOESPYIA-BYPYZUCNSA-N L-N-acetyl-Cysteine Chemical compound CC(=O)N[C@@H](CS)C(O)=O PWKSKIMOESPYIA-BYPYZUCNSA-N 0.000 claims description 34
- 229960004308 acetylcysteine Drugs 0.000 claims description 34
- 229940065287 selenium compound Drugs 0.000 claims description 34
- 150000003343 selenium compounds Chemical class 0.000 claims description 34
- 235000018417 cysteine Nutrition 0.000 claims description 33
- 235000019165 vitamin E Nutrition 0.000 claims description 32
- 239000011709 vitamin E Substances 0.000 claims description 32
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 31
- 229930003427 Vitamin E Natural products 0.000 claims description 29
- 229930014669 anthocyanidin Natural products 0.000 claims description 29
- 235000008758 anthocyanidins Nutrition 0.000 claims description 29
- 235000006708 antioxidants Nutrition 0.000 claims description 29
- NWKFECICNXDNOQ-UHFFFAOYSA-N flavylium Chemical compound C1=CC=CC=C1C1=CC=C(C=CC=C2)C2=[O+]1 NWKFECICNXDNOQ-UHFFFAOYSA-N 0.000 claims description 29
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 29
- 229940046009 vitamin E Drugs 0.000 claims description 27
- 235000021466 carotenoid Nutrition 0.000 claims description 24
- 150000001747 carotenoids Chemical class 0.000 claims description 24
- 235000019136 lipoic acid Nutrition 0.000 claims description 17
- 229960002663 thioctic acid Drugs 0.000 claims description 17
- 239000000473 propyl gallate Substances 0.000 claims description 11
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims description 9
- 229960001009 acetylcarnitine Drugs 0.000 claims description 9
- 235000010208 anthocyanin Nutrition 0.000 claims description 8
- 239000004410 anthocyanin Substances 0.000 claims description 8
- 229940087603 grape seed extract Drugs 0.000 claims description 8
- 235000002532 grape seed extract Nutrition 0.000 claims description 8
- 239000001717 vitis vinifera seed extract Substances 0.000 claims description 8
- AGBQKNBQESQNJD-SSDOTTSWSA-N (R)-lipoic acid Chemical compound OC(=O)CCCC[C@@H]1CCSS1 AGBQKNBQESQNJD-SSDOTTSWSA-N 0.000 claims description 7
- 235000015872 dietary supplement Nutrition 0.000 claims description 7
- 150000001746 carotenes Chemical class 0.000 claims description 6
- 235000005473 carotenes Nutrition 0.000 claims description 6
- 229940075579 propyl gallate Drugs 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 229930002877 anthocyanin Natural products 0.000 claims description 4
- 150000004636 anthocyanins Chemical class 0.000 claims description 4
- 229930003799 tocopherol Natural products 0.000 claims description 3
- 239000011732 tocopherol Substances 0.000 claims description 3
- 235000019149 tocopherols Nutrition 0.000 claims description 3
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 claims description 3
- PMYDPQQPEAYXKD-UHFFFAOYSA-N 3-hydroxy-n-naphthalen-2-ylnaphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(NC(=O)C3=CC4=CC=CC=C4C=C3O)=CC=C21 PMYDPQQPEAYXKD-UHFFFAOYSA-N 0.000 claims description 2
- ZKZBPNGNEQAJSX-REOHCLBHSA-N L-selenocysteine Chemical compound [SeH]C[C@H](N)C(O)=O ZKZBPNGNEQAJSX-REOHCLBHSA-N 0.000 claims description 2
- 229930182853 L-selenocysteine Natural products 0.000 claims description 2
- RJFAYQIBOAGBLC-BYPYZUCNSA-N Selenium-L-methionine Chemical compound C[Se]CC[C@H](N)C(O)=O RJFAYQIBOAGBLC-BYPYZUCNSA-N 0.000 claims description 2
- 150000001945 cysteines Chemical class 0.000 claims description 2
- 229960001881 sodium selenate Drugs 0.000 claims description 2
- 235000018716 sodium selenate Nutrition 0.000 claims description 2
- 239000011655 sodium selenate Substances 0.000 claims description 2
- 229960001471 sodium selenite Drugs 0.000 claims description 2
- 235000015921 sodium selenite Nutrition 0.000 claims description 2
- 239000011781 sodium selenite Substances 0.000 claims description 2
- 235000013343 vitamin Nutrition 0.000 claims description 2
- 229940088594 vitamin Drugs 0.000 claims description 2
- 229930003231 vitamin Natural products 0.000 claims description 2
- 239000011782 vitamin Substances 0.000 claims description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 28
- 229960002433 cysteine Drugs 0.000 description 28
- MEFKEPWMEQBLKI-AIRLBKTGSA-O S-adenosyl-L-methionine Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H]([NH3+])C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-O 0.000 description 18
- 239000000654 additive Substances 0.000 description 8
- 239000000203 mixture Substances 0.000 description 7
- 125000002252 acyl group Chemical group 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 210000003470 mitochondria Anatomy 0.000 description 4
- 230000008901 benefit Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000014113 dietary fatty acids Nutrition 0.000 description 3
- 239000000284 extract Substances 0.000 description 3
- 229930195729 fatty acid Natural products 0.000 description 3
- 239000000194 fatty acid Substances 0.000 description 3
- 150000004665 fatty acids Chemical class 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical class OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 3
- 239000005445 natural material Substances 0.000 description 3
- 230000001590 oxidative effect Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 description 2
- 241000219095 Vitis Species 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 244000309464 bull Species 0.000 description 2
- 229960004203 carnitine Drugs 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 210000001700 mitochondrial membrane Anatomy 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- 239000003755 preservative agent Substances 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- UQDJGEHQDNVPGU-UHFFFAOYSA-N serine phosphoethanolamine Chemical compound [NH3+]CCOP([O-])(=O)OCC([NH3+])C([O-])=O UQDJGEHQDNVPGU-UHFFFAOYSA-N 0.000 description 2
- 230000002459 sustained effect Effects 0.000 description 2
- SNRUBQQJIBEYMU-UHFFFAOYSA-N Dodecane Natural products CCCCCCCCCCCC SNRUBQQJIBEYMU-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 208000019926 Keshan disease Diseases 0.000 description 1
- 206010027439 Metal poisoning Diseases 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 230000002292 Radical scavenging effect Effects 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- -1 aliphatic alcohols Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 238000006701 autoxidation reaction Methods 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 1
- 239000000555 dodecyl gallate Substances 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- FCZCIXQGZOUIDN-UHFFFAOYSA-N ethyl 2-diethoxyphosphinothioyloxyacetate Chemical compound CCOC(=O)COP(=S)(OCC)OCC FCZCIXQGZOUIDN-UHFFFAOYSA-N 0.000 description 1
- 239000003172 expectorant agent Substances 0.000 description 1
- 230000004129 fatty acid metabolism Effects 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 229940087559 grape seed Drugs 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- 208000010501 heavy metal poisoning Diseases 0.000 description 1
- 125000001072 heteroaryl group Chemical group 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000002075 main ingredient Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000574 octyl gallate Substances 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000010627 oxidative phosphorylation Effects 0.000 description 1
- 150000002927 oxygen compounds Chemical class 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229930182852 proteinogenic amino acid Natural products 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 210000003699 striated muscle Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Antioxidantien-Präparate BeschreibungAntioxidant preparations Description
Die Erfindung betrifft Antioxidantien-Präparate, die ausschließlich aus Naturstoffen bestehen und frei verkäuflich sind, also keine Medikamente darstellen. Es handelt sich bei diesen Präparaten um die Mischungen verschiedener Antioxidantien, von denen das E 310 (Propylgallat) im Zentrum steht und gegebenenfalls Zusatzstoffen. N-Propylgallat wird - mitThe invention relates to antioxidant preparations that consist exclusively of natural substances and are freely available, i.e. do not constitute medicines. These preparations are mixtures of various antioxidants, of which E 310 (propyl gallate) is the main ingredient, and possibly additives. N-propyl gallate is - with
&iacgr;&ogr; Zusätzen als Wirkstoff allein oder gemeinsam mit anderen Anti-Oxidantien - eingesetzt, um eine sich erhaltende bzw. ergänzende Wirkungskaskade gegenüber oxidativen Stressoren in den Zellen und im Organismus verfügbar zu halten.&iacgr;&ogr; additives as an active ingredient alone or together with other antioxidants - used to maintain a sustained or complementary cascade of effects against oxidative stressors in the cells and in the organism.
Unter den Gallussäureestern (Gallaten) werden die Ester der Gallussäure mit aliphatischen Alkoholen als Antioxidantien in Kosmetika eingesetzt, einige von ihnen - so Dodecyl-, Octyl- und Propylester (E 312, E 311, E310: http://www.elc-eu.org/enumber.htm) - auch als Zusatzstoffe in Lebensmitteln (RÖMPP: CHEMIE LEXIKON, 9. Auflage, Georg Thieme Verlag Stuttgart - New York, 1995).Among the gallic acid esters (gallates), the esters of gallic acid with aliphatic alcohols are used as antioxidants in cosmetics, some of them - such as dodecyl, octyl and propyl esters (E 312, E 311, E310: http://www.elc-eu.org/enumber.htm) - also as additives in foodstuffs (RÖMPP: CHEMIE LEXIKON, 9th edition, Georg Thieme Verlag Stuttgart - New York, 1995).
Die Wirkung von Antioxidantien besteht meist darin, dass sie als Radikalfanger für die bei der Autoxidation auftretenden freien Radikale wirken (RÖMPP: a.a.O.). Den freien Radikalen wird auch eine signifikante Rolle im Prozess des Alterns und bei altersbedingten Erkrankungen zugeschrieben (LucY et al. 1999: Mutat. Res. 423, 11-21; Sastre J et al. 2000: Free Radic. Res. 32, 189-198; B. Villeponteau et al. 2000: Experimental Gerontology 35, 1405-1417).
N-Propyl-Gallat (NPG) ist in Deutschland bisher nicht als Nahrungsergänzungsmittel auf dem Markt. Es ist allerdings seit Jahren als Konservierungsmittel in der Lebensmittelindustrie bestens eingeführt und auch mit einer E-Nummer - E 310 (http://www.elceu.org/enumber.htm) - versehen.The effect of antioxidants usually consists in their function as radical scavengers for the free radicals that occur during autoxidation (RÖMPP: aaO). Free radicals are also believed to play a significant role in the process of aging and in age-related diseases (LucY et al. 1999: Mutat. Res. 423, 11-21; Sastre J et al. 2000: Free Radic. Res. 32, 189-198; B. Villeponteau et al. 2000: Experimental Gerontology 35, 1405-1417).
N-propyl gallate (NPG) is not yet available on the German market as a food supplement. However, it has been well established as a preservative in the food industry for years and is also given an E number - E 310 (http://www.elceu.org/enumber.htm).
Der Erfindung liegt die Aufgabe zugrunde, Nahrungsergänzungsmittel zu entwickeln, die als gesundheitsfördernde Zusammensetzungen gegenüber oxidativen Stressoren in den Zellen und im Organismus wirken.The invention is based on the object of developing dietary supplements which act as health-promoting compositions against oxidative stressors in the cells and in the organism.
Die Aufgabe wurde durch die Bereitstellung von Antioxidantien-Präparaten als Nahrungsergänzungsmittel gelöst, deren wesentlicher Bestandteile N-Propyl-Gallat (NPG, EThe task was solved by providing antioxidant preparations as food supplements, the essential components of which are N-propyl gallate (NPG, E
310) darstellt - allein oder in Kombination mit anderen Antioxidantien - und die gegebenenfalls weitere gesundheitsfördernde Zusätze enthalten. Als weitere Antioxidantien310) - alone or in combination with other antioxidants - and which may contain other health-promoting additives. Other antioxidants
kommen Tocopherole (Vitamin E) und /oder Vitamin C, Carotinoide, a-Liponsäure, Cystein bzw. N-Acetyl-Cystein, Selenverbindungen und /oder Anthocyanidine in Betracht. Als Zusätze werden Acyl-Carnitine eingesetzt.
Die erfindungsgemäßen Zusammensetzungen enthalten Verbindungen, die bereits eingeführt sind und die weithin mit E-Nummern - EG-Nummern - versehen sind, so das NPG (E 310) selbst, Carotine (E 160a), Carotinoide (E 160b-g) sowie die Anthocyanine (E 163). Liponsäure [(R)-5-(l,2-Dithiolan-3-yl)-pentansäure, Thioctsäure] wird verwendet bei Schwermetallvergiftungen und bei Leberaffektionen. Unter den Selenverbindungen kommen Natriumselenit - verwendet bei der Keshan-Krankheit und als Futtermittelzusatz - auchTocopherols (vitamin E) and/or vitamin C, carotenoids, a-lipoic acid, cysteine or N-acetyl-cysteine, selenium compounds and/or anthocyanidins are considered. Acyl-carnitines are used as additives.
The compositions according to the invention contain compounds that are already introduced and that are widely provided with E numbers - EC numbers - such as the NPG (E 310) itself, carotenes (E 160a), carotenoids (E 160b-g) and anthocyanins (E 163). Lipoic acid [(R)-5-(l,2-dithiolan-3-yl)-pentanoic acid, thioctic acid] is used in heavy metal poisoning and in liver disorders. Among the selenium compounds, sodium selenite - used in Keshan disease and as a feed additive - also comes
&iacgr;&ogr; Natriumselenat oder die in der Natur vorkommenden Aminosäuren Seleno-L-methionin oder L-Selenocystein (L-Form: See) in Betracht. Cystein als proteinogene Aminosäure ist in den meisten Proteinen enthalten und - aufgrund seiner Radikalfängereigenschaften - in Enzymen oft am Katalysemechanismus beteiligt. N-Acetyl-Cystein (NAC) findet als Mycolytikum Verwendung (RÖMPP: a.a.O.).&iacgr;&ogr; Sodium selenate or the naturally occurring amino acids seleno-L-methionine or L-selenocysteine (L-form: See) come into consideration. Cysteine is a proteinogenic amino acid found in most proteins and - due to its radical-scavenging properties - is often involved in the catalysis mechanism in enzymes. N-acetyl-cysteine (NAC) is used as a mycolytic agent (RÖMPP: ibid.).
N-Propyl-Gallat (NPG) wird erfindungsgemäß als Nahrungsergänzungsmittel eingesetzt, das als Antioxidantien-Präparat wirkt. In Kombination mit anderen Antioxidantien lassen sich spezifische Wirkungen und ein breiteres Anwendungsspektrum erreichen.
NPG hat wesentliche Vorteile gegenüber den derzeit verfügbaren Antioxidantien. Er wirkt überraschenderweise ungleich effektiver und besitzt keine potenziell schädigenden Wirkanteile, wie z.B. die Gefahr der umgekehrten Pro-Oxidation bei hoher Konzentration.According to the invention, N-propyl gallate (NPG) is used as a dietary supplement that acts as an antioxidant preparation. In combination with other antioxidants, specific effects and a broader range of applications can be achieved.
NPG has significant advantages over currently available antioxidants. Surprisingly, it is much more effective and does not contain any potentially harmful active components, such as the risk of reverse pro-oxidation at high concentrations.
Anthocyanidine werden in Gestalt von Traubenkern- oder Pinienextrakt eingesetzt. Es handelt sich hierbei um den chemisch definierten Anteil eines Naturstoffextraktes, und zwar dem Extrakt aus Traubenkernen (Weintrauben). Dieser Stoff hat wesentliche Vorteile gegenüber den derzeit verfügbaren Antioxidantien, er wirkt sehr effektiv und birgt bei hohen Konzentrationen ebenfalls nicht die Gefahr der umgekehrten Pro-Oxidation in sich.Anthocyanidins are used in the form of grape seed or pine extract. This is the chemically defined portion of a natural substance extract, namely the extract from grape seeds (grapes). This substance has significant advantages over the antioxidants currently available; it is very effective and, at high concentrations, does not pose the risk of reverse pro-oxidation.
Das erfindungsgemäß eingesetzte NPG kann aus Traubenkernen stammen, wird jedoch auch in gereinigter Form eingesetzt. Zusätzliche Verwendung findet Traubenkernextrakt, der chemisch nicht weiter aufgearbeitet wurde und als Quelle weiterer Antioxidantien, u.a. der Anthocyanidine, dient.The NPG used according to the invention can come from grape seeds, but is also used in purified form. Grape seed extract, which has not been further chemically processed, is also used and serves as a source of other antioxidants, including anthocyanidins.
Auch bei den Zusatzstoffen handelt es sich um Naturstoffe. Die L-Form des Carnitins ist ein charakteristischer Bestandteil der gestreiften Muskulatur. Es dient vor allem im Fettsäure-Stoffwechsel als Überträger für Acyl-Gruppen durch die Mitochondrien-Membran hindurch (RÖMPP: ibid.).The additives are also natural substances. The L-form of carnitine is a characteristic component of striated muscles. It serves primarily in fatty acid metabolism as a carrier for acyl groups through the mitochondrial membrane (RÖMPP: ibid.).
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NPG ist bisher nur als Konservierungsmittel für Lebensmittel im Einsatz und nicht als Antioxidans zur Einnahme bei Menschen. Das heißt, NPG wirkt gemäß dieser Erfindung nicht als Schutzstoff für die zu verzehrenden Lebensmittel, sondern als Schutzstoff für den Organismus des Verzehrenden.NPG has so far only been used as a preservative for food and not as an antioxidant for human consumption. This means that according to this invention, NPG does not act as a protective substance for the food being consumed, but rather as a protective substance for the organism of the person consuming it.
Erfindungsgemäße typische Zusammensetzungen der Antioxidantien-Präparate als Nahrungsergänzungsmittel enthalten:Typical compositions of antioxidant preparations as dietary supplements according to the invention contain:
·- neben E 310 - Vitamin E und /oder Vitamin C und /oder E 160a-g und /oder Thioctsäure und /oder Selenverbindung und /oder Cystein und /oder NAC und /oder E 163 und /oder Acyl-Carnitine ·- in addition to E 310 - vitamin E and/or vitamin C and/or E 160a-g and/or thioctic acid and/or selenium compound and/or cysteine and/or NAC and/or E 163 and/or acyl-carnitine
·- neben Propyl-Gallat -die wirksamen Bestandteile Tocopherole und /oder Vitamin C und /oder Carotine und /oder Carotinoide und /oder Liponsäure und /oder Cystein und /oder N-Acetyl-Cystein (NAC) und /oder Selenverbindungen und /oder Anthocyanine (Anthocyanine heißen sie als E 163) und /oder Anthocyanidine·- in addition to propyl gallate - the active ingredients tocopherols and/or vitamin C and/or carotenes and/or carotenoids and/or lipoic acid and/or cysteine and/or N-acetyl-cysteine (NAC) and/or selenium compounds and/or anthocyanins (anthocyanins are called E 163) and/or anthocyanidins
·- neben N-Propyl-Gallat (NPG) -die wirksamen Bestandteile Vitamin E und /oder Vitamin C und /oder Carotine und /oder Carotinoide und /oder &agr;-Liponsäure sowie Acyl-Carnitine und /oder Cystein und /oder NAC und /oder Selenverbindungen und /oder Anthocyanidine.·- in addition to N-propyl gallate (NPG) - the active ingredients vitamin E and/or vitamin C and/or carotenes and/or carotenoids and/or α-lipoic acid as well as acyl carnitines and/or cysteine and/or NAC and/or selenium compounds and/or anthocyanidins.
Die Acyl-Carnitine sind für sich genommen keine Antioxidantien, aber zusammen mit Antioxidantien - wie insbesondere der a-Liponsäure - stellen sie hervorragende Additiva dar.The acyl carnitines are not antioxidants in themselves, but together with antioxidants - especially a-lipoic acid - they are excellent additives.
Acetyl-Carnitin z.B. hat in vivo die Aufgabe, Fettsäuren zur Energiegewinnung in die Mitochondrien zu schaffen. Es wirkt also quasi als Fettsäure-Pumpe in der Mitochondrien-Membran. &agr;-Liponsäure ist chemisch fettsäureartig strukturiert und wird von Acetyl-Carnitin aktiv in die Mitochondrien gepumpt. Hierdurch verstärkt sich die antioxidative Wirkung von &agr;-Liponsäure um das Mehrfache gerade dort, wo sie am meisten gebraucht wird, nämlich in den Mitochondrien (Ames, BN et al. 1995, Biochem. Biophys. Acta [27], 165-170). In den Mitochondrien findet im Rahmen der oxidativen Phosphorylierung physiologischerweise die größte Freisetzung an reaktiven Sauerstoffverbindungen statt, die durch Antioxidantien vor Ort neutralisiert werden sollen. Speziell die Zusammensetzungen Acyl-Carnitine und a-Liponsäure stellen interessante und hoch potente antioxidative Kombinationen dar.Acetyl-carnitine, for example, has the task in vivo of bringing fatty acids into the mitochondria for energy production. It thus acts as a kind of fatty acid pump in the mitochondrial membrane. α-lipoic acid is chemically structured like a fatty acid and is actively pumped into the mitochondria by acetyl-carnitine. This increases the antioxidant effect of α-lipoic acid several times over precisely where it is needed most, namely in the mitochondria (Ames, BN et al. 1995, Biochem. Biophys. Acta [27], 165-170). In the mitochondria, the greatest release of reactive oxygen compounds occurs physiologically as part of oxidative phosphorylation, and these are to be neutralized locally by antioxidants. Especially the compositions acyl-carnitine and a-lipoic acid represent interesting and highly potent antioxidant combinations.
Unter Acyl-Gruppen des Carnitins werden Säurereste der Atomgruppierung -CO-R mit R = Alkyl, Aryl oder Hetaryl verstanden, insbesondere kommt dem Acetylrest eine besondere Bedeutung zu.Acyl groups of carnitine are understood to be acid residues of the atom group -CO-R with R = alkyl, aryl or hetaryl, in particular the acetyl residue is of particular importance.
Ein wesentliches Merkmal der Erfindung besteht darin, dass die Präparate - neben Propyl-Gallat, Vitaminen, Carotinen, Liponsäure, Cysteinen, Selenverbindungen und /oder Anthocyanidinen - zusätzlich Acyl-Carnitine, insbesondere Acetyl-Carnitin, enthalten.
Alpha-Liponsäure kann auch in Gestalt von Traubenkernextrakt-Äquivalent eingesetzt werden, vorzugsweise in Dosierungen von 50 - 250 mg.An essential feature of the invention is that the preparations - in addition to propyl gallate, vitamins, carotenes, lipoic acid, cysteines, selenium compounds and/or anthocyanidins - additionally contain acyl carnitines, in particular acetyl carnitine.
Alpha-lipoic acid can also be used in the form of grape seed extract equivalent, preferably in doses of 50 - 250 mg.
Die Merkmale der Erfindung gehen außer aus den Ansprüchen auch aus der Beschreibung hervor, wobei die einzelnen Merkmale jeweils für sich allein oder zu mehreren in Form von Kombinationen vorteilhafte Ausführungen darstellen, für die mit dieser Schrift Schutz beantragt wird. Die Kombination besteht aus bekannten Verbindungen, die in ihrer neuenThe features of the invention are not only evident from the claims but also from the description, whereby the individual features, either individually or in combination, represent advantageous embodiments for which protection is sought with this document. The combination consists of known compounds which, in their new form,
&iacgr;&ogr; Gesamtwirkung einen Gebrauchsvorteil und den erstrebten Erfolg ergeben, der darin liegt, dass Antioxidantien-Präparate als Nahrungsergänzungsmittel zur Gesundheitspflege sowie zur Prophylaxe bereitgestellt werden, um eine sich erhaltende bzw. ergänzende Wirkungskaskade gegenüber oxidativen Stressoren in den Zellen und im Organismus verfügbar zu halten.
Die erfindungsgemäßen Zusammensetzungen bestehen aus den genannten Verbindungen und&iacgr;&ogr; Overall effect results in a benefit in use and the desired success, which lies in the fact that antioxidant preparations are provided as dietary supplements for health care and prophylaxis in order to maintain a sustained or complementary cascade of effects against oxidative stressors in the cells and in the organism.
The compositions according to the invention consist of the compounds mentioned and
is ihren Kombinationen untereinander.is their combinations with each other.
Die folgende Tabelle zeigt Beispiele von Kombinationen der Antioxidantien und Zusätze untereinander, ohne dass die Erfindung auf diese Beispiele beschränkt wäre.The following table shows examples of combinations of antioxidants and additives with each other, without the invention being limited to these examples.
Vitamin ENPG
Vitamin E
CarotinoideNPG
Carotenoids
a-LiponsäureNPG
a-lipoic acid
Vitamin CNPG
vitamin C
CysteinNPG
Cysteine
N-Acetyl-CysteinNPG
N-Acetyl-Cysteine
AnthocyanidineNPG
Anthocyanidins
SelenverbindungNPG
Selenium compound
Vitamin C
CarotinoideNPG
vitamin C
Carotenoids
Vitamin C
a-LiponsäureNPG
vitamin C
a-lipoic acid
Vitamin C
SelenverbindungNPG
vitamin C
Selenium compound
Vitamin C
Vitamin ENPG
vitamin C
Vitamin E
Vitamin C
N-Acetyl-CysteinNPG
vitamin C
N-Acetyl-Cysteine
Vitamin C
AnthocyanidineNPG
vitamin C
Anthocyanidins
a-Liponsäure
Acyl-CarnitinNPG
a-lipoic acid
Acyl-carnitine
Vitamin C
CysteinNPG
vitamin C
Cysteine
Vitamin E
a-LiponsäureNPG
Vitamin E
a-lipoic acid
Vitamin E
SelenverbindungNPG
Vitamin E
Selenium compound
Vitamin E
CysteinNPG
Vitamin E
Cysteine
Vitamin E
CarotinoideNPG
Vitamin E
Carotenoids
Vitamin E
AnthocyanidineNPG
Vitamin E
Anthocyanidins
Carotinoide
a-LiponsäureNPG
Carotenoids
a-lipoic acid
Carotinoide
SelenverbindungNPG
Carotenoids
Selenium compound
Vitamin E
N-Acetyl-CysteinNPG
Vitamin E
N-Acetyl-Cysteine
Carotinoide
N-Acetyl-CysteinNPG
Carotenoids
N-Acetyl-Cysteine
Carotinoide
AnthocyanidineNPG
Carotenoids
Anthocyanidins
a-Liponsäure
SelenverbindungNPG
a-lipoic acid
Selenium compound
Carotinoide
CysteinNPG
Carotenoids
Cysteine
a-Liponsäure
N-Acetyl-CysteinNPG
a-lipoic acid
N-Acetyl-Cysteine
a-Liponsäure
AnthocyanidineNPG
a-lipoic acid
Anthocyanidins
Vitamin C
a-Liponsäure
Acyl-CarnitinNPG
vitamin C
a-lipoic acid
Acyl-carnitine
a-Liponsäure
CysteinNPG
a-lipoic acid
Cysteine
Carotinoide
a-Liponsäure
Acyl-CarnitinNPG
Carotenoids
a-lipoic acid
Acyl-carnitine
a-Liponsäure
Selenverbindung
Acyl-CarnitinNPG
a-lipoic acid
Selenium compound
Acyl-carnitine
a-Liponsäure
Cystein
Acyl-CarnitinNPG
a-lipoic acid
Cysteine
Acyl-carnitine
Vitamin E
a-Liponsäure
Acyl-CarnitinNPG
Vitamin E
a-lipoic acid
Acyl-carnitine
a-Liponsäure
Anthocyanidine
Acyl-CarnitinNPG
a-lipoic acid
Anthocyanidins
Acyl-carnitine
Selenverbindung
CysteinNPG
Selenium compound
Cysteine
Selenverbindung
N-Acetyl-CysteinNPG
Selenium compound
N-Acetyl-Cysteine
a-Liponsäure
N-Acetyl-Cystein
Acyl-CarnitinNPG
a-lipoic acid
N-Acetyl-Cysteine
Acyl-carnitine
CysteinNPG
Cysteine
CysteinNPG
Cysteine
N-Acetyl-CysteinNPG
N-Acetyl-Cysteine
SelenverbindungNPG
Selenium compound
Typische Ausgestaltungen der erfindungsgemäßen Zusammensetzungen bestehen ausTypical embodiments of the compositions according to the invention consist of
sowie Cystein bzw. N-Acetyl-Cystein.as well as cysteine or N-acetyl-cysteine.
sowie Cystein bzw. N-Acetyl-Cystein.as well as cysteine or N-acetyl-cysteine.
• .:. ..· · ·• .:. ..· · ·
:*·. : 1 - 60 mg and/or
:*·. :
:··*:... .:.. *..: .·. ·..: "i •&Ggr; · · · · ·· · · ■
: ··*:... .:.. *.. : .·. ·..: "i
Carotinoide 1 - 20 mg und /oderCarotenoids 1 - 20 mg and/or
Alpha-Liponsäure 10-400 mgAlpha-lipoic acid 10-400 mg
und /oder Traubenkernextrakt-Äquivalent und /oder Selenverbindung 20 - 100 &mgr;g und /oderand/or grape seed extract equivalent and/or selenium compound 20 - 100 μg and/or
Anthocyanidine 10 - 100 mg als Traubenkemextrakt und /oderAnthocyanidins 10 - 100 mg as grape seed extract and/or
Acetyl-Carnitin 10 -100 mg und /oderAcetyl-Carnitine 10 -100 mg and/or
Cystein und /oder N-Acetyl-Cystein.Cysteine and/or N-acetyl-cysteine.
Claims (6)
NPG 1-10 mg
Vitamin C 1-500 mg und/oder
Vitamin E 1-60 mg und/oder
Carotinoide 1-20 mg und/oder
Alpha-Liponsäure 10-400 mg und/oder Traubenkernextrakt-Äquivalent und/oder
Selenverbindung 20-100 mg und/oder
Anthocyanidine 10-100 mg und/oder
Acetyl-Carnitin 10-100 mg und/oder
Cystein und/oder N-Acetyl-Cystein. 5. Antioxidant preparations according to claims 1 to 4, characterized in that they contain
NPG 1-10 mg
Vitamin C 1-500 mg and/or
Vitamin E 1-60 mg and/or
Carotenoids 1-20 mg and/or
Alpha-lipoic acid 10-400 mg and/or grape seed extract equivalent and/or
Selenium compound 20-100 mg and/or
Anthocyanidins 10-100 mg and/or
Acetyl-carnitine 10-100 mg and/or
Cysteine and/or N-acetyl-cysteine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE20104419U DE20104419U1 (en) | 2001-03-08 | 2001-03-08 | Antioxidant preparations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE20104419U DE20104419U1 (en) | 2001-03-08 | 2001-03-08 | Antioxidant preparations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE20104419U1 true DE20104419U1 (en) | 2001-08-16 |
Family
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| DE20104419U Expired - Lifetime DE20104419U1 (en) | 2001-03-08 | 2001-03-08 | Antioxidant preparations |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060083796A1 (en) * | 2002-09-09 | 2006-04-20 | Sylvie Pridmore-Merten | Orally administrable composition for improving hair and coat quality |
| WO2009063333A3 (en) * | 2007-11-14 | 2009-09-24 | Omnica Gmbh | Compositions and methods to increase bioavailability of carotenoids |
-
2001
- 2001-03-08 DE DE20104419U patent/DE20104419U1/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060083796A1 (en) * | 2002-09-09 | 2006-04-20 | Sylvie Pridmore-Merten | Orally administrable composition for improving hair and coat quality |
| WO2009063333A3 (en) * | 2007-11-14 | 2009-09-24 | Omnica Gmbh | Compositions and methods to increase bioavailability of carotenoids |
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