DD210304A5 - Verfahren zur herstellung eines replikablen vektors - Google Patents

Verfahren zur herstellung eines replikablen vektors Download PDF

Info

Publication number: DD210304A5
Authority: DD; German Democratic Republic
Prior art keywords: leip; interferon; items; fragment; polypeptide
Prior art date: 1980-07-01

Application number

DD81255299A

Other languages

German (de)

English (en)

Inventor

Goeddel David Van Norman

Sidney Pestka

Original Assignee

Hoffmann La Roche

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-07-01

Filing date

1981-07-01

Publication date

1984-06-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DD210304(A5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1981-04-21 Priority claimed from US06/256,204 external-priority patent/US6610830B1/en

1981-07-01 Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche

1984-06-06 Publication of DD210304A5 publication Critical patent/DD210304A5/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
- C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Microbiology (AREA)
Biophysics (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Medicinal Chemistry (AREA)
Crystallography & Structural Chemistry (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DD81255299A 1980-07-01 1981-07-01 Verfahren zur herstellung eines replikablen vektors DD210304A5 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US16498680A	1980-07-01	1980-07-01
US18490980A	1980-09-08	1980-09-08
US20557880A	1980-11-10	1980-11-10
US06/256,204 US6610830B1 (en)	1980-07-01	1981-04-21	Microbial production of mature human leukocyte interferons

Publications (1)

Publication Number	Publication Date
DD210304A5 true DD210304A5 (de)	1984-06-06

Family

ID=27496622

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
DD81231371A DD202307A5 (de)	1980-07-01	1981-07-01	Verfahren zur herstellung eines polypeptids
DD81255300A DD210305A5 (de)	1980-07-01	1981-07-01	Verfahren zur herstellung von mikroorganismen
DD81255299A DD210304A5 (de)	1980-07-01	1981-07-01	Verfahren zur herstellung eines replikablen vektors

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
DD81231371A DD202307A5 (de)	1980-07-01	1981-07-01	Verfahren zur herstellung eines polypeptids
DD81255300A DD210305A5 (de)	1980-07-01	1981-07-01	Verfahren zur herstellung von mikroorganismen

Country Status (36)

Country	Link
EP (2)	EP0211148B2 (sv)
AR (1)	AR242833A1 (sv)
AT (3)	ATE79901T1 (sv)
AU (1)	AU552004B2 (sv)
BG (1)	BG42189A3 (sv)
BR (1)	BR8104189A (sv)
CH (2)	CH651308A5 (sv)
CS (1)	CS273152B2 (sv)
DD (3)	DD202307A5 (sv)
DE (3)	DE3177288T3 (sv)
DK (1)	DK173543B1 (sv)
DZ (1)	DZ312A1 (sv)
ES (1)	ES503528A0 (sv)
FI (1)	FI82712C (sv)
FR (1)	FR2486098B1 (sv)
GB (1)	GB2079291B (sv)
GE (1)	GEP19960519B (sv)
GR (1)	GR75714B (sv)
HK (1)	HK49285A (sv)
HU (1)	HU196457B (sv)
IE (1)	IE49255B1 (sv)
IT (1)	IT1137272B (sv)
KE (1)	KE3534A (sv)
LU (1)	LU83461A1 (sv)
MC (1)	MC1396A1 (sv)
MY (1)	MY8700711A (sv)
NL (1)	NL8103151A (sv)
NO (1)	NO159392C (sv)
NZ (1)	NZ197572A (sv)
PH (1)	PH18036A (sv)
PL (3)	PL148260B1 (sv)
PT (1)	PT73289B (sv)
RO (1)	RO87590A (sv)
SE (2)	SE465223C5 (sv)
SU (1)	SU1414319A3 (sv)
YU (1)	YU47700B (sv)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA811368B (en)	1980-03-24	1982-04-28	Genentech Inc	Bacterial polypedtide expression employing tryptophan promoter-operator
IE57069B1 (en)	1980-04-03	1992-04-22	Biogen Inc	Dna sequences,recombinant dna molecules and processes for producing human fibroblast interferon
DE3176011D1 (en) *	1980-06-12	1987-04-23	Japan Found Cancer	Plasmid
DK489481A (da) *	1980-11-10	1982-05-11	Searle & Co	Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) *	1981-02-25	1985-12-13	Genentech Inc	Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
WO1983000693A1 (en) *	1981-08-14	1983-03-03	Berg, Kurt, Frimann	SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
JPS58110548A (ja) *	1981-12-24	1983-07-01	Asahi Chem Ind Co Ltd	新規な生理活性ペプチド
US4973479A (en) *	1982-01-15	1990-11-27	Cetus Corporation	Interferon-α61
US4975276A (en) *	1982-01-15	1990-12-04	Cetus Corporation	Interferon-alpha 54
US5098703A (en) *	1982-01-15	1992-03-24	Cetus Corporation	Interferon-alpha 76
US5827694A (en) *	1982-03-08	1998-10-27	Genentech, Inc.	DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US6432677B1 (en)	1982-03-08	2002-08-13	Genentech, Inc.	Non-human animal interferons
US4775622A (en) *	1982-03-08	1988-10-04	Genentech, Inc.	Expression, processing and secretion of heterologous protein by yeast
IE54592B1 (en) *	1982-03-08	1989-12-06	Genentech Inc	Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
EP0088994B1 (en) *	1982-03-15	1991-06-19	Schering Corporation	Hybrid dna, binding composition prepared thereby and processes therefor
US4748233A (en) *	1982-03-23	1988-05-31	Bristol-Myers Company	Alpha-interferon Gx-1
CA1210714A (en) *	1982-03-23	1986-09-02	Alan Sloma	.alpha.-INTERFERON GX-1
US4695543A (en) *	1982-03-23	1987-09-22	Bristol-Myers Company	Alpha Interferon GX-1
US6936694B1 (en) *	1982-05-06	2005-08-30	Intermune, Inc.	Manufacture and expression of large structural genes
US5831023A (en) *	1982-11-01	1998-11-03	Genentech, Inc.	Recombinant animal interferon polypeptides
US4751287A (en) *	1983-02-24	1988-06-14	Institut Organicheskogo Sinteza Akademii Nauk Latviiskoi Ssr	Human leukocyte interferon N and a method of producing same in bacterial cells
EP0165942A1 (en) *	1983-12-23	1986-01-02	Monash University	PRODUCTION OF HUMAN INTERFERON-$g(a)
SU1364343A1 (ru) *	1984-07-13	1988-01-07	Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов	Способ получени человеческого лейкоцитарного интерферона альфа-2
WO1986002068A1 (fr) *	1984-09-26	1986-04-10	Takeda Chemical Industries, Ltd.	Separation mutuelle de proteines
IL76360A0 (en)	1984-09-26	1986-01-31	Takeda Chemical Industries Ltd	Mutual separation of proteins
DE3515336C2 (de) *	1985-04-27	1994-01-20	Boehringer Ingelheim Int	Verfahren zur Herstellung und Reinigung von â-Interferon
US5196323A (en) *	1985-04-27	1993-03-23	Boehringer Ingelheim International Gmbh	Process for preparing and purifying alpha-interferon
JP2514950B2 (ja) *	1986-03-10	1996-07-10	エフ・ホフマン―ラロシユアーゲー	化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) *	1987-05-04	1989-03-09	Oncogen	Oncostatin m and novel composition having antitumor activity
CA1309044C (en) *	1987-11-09	1992-10-20	Toshiya Takano	Method of producing foreign gene products
GB8813032D0 (en) *	1988-06-02	1988-07-06	Boehringer Ingelheim Int	Antiviral pharmaceutical composition
WO1991003251A1 (en) *	1989-09-08	1991-03-21	California Institute Of Biological Research	Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) *	1989-09-28	1991-04-11	Boehringer Ingelheim Int	Verfahren zur reinigung von beta-interferon
ES2186714T3 (es) *	1994-03-07	2003-05-16	Imperial College	Uso de sustipo simple alpha 8 en la preparacion de medicamentos para el tratamiento de infecciones virales del higado.
ES2161793T3 (es) *	1994-04-09	2001-12-16	Hoffmann La Roche	Proceso para la produccion de alfa-interferona.
GB9609932D0 (en) *	1996-05-13	1996-07-17	Hoffmann La Roche	Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en)	1996-12-24	2003-10-09	Biogen, Inc.	Stable liquid interferon formulations
ZA9811070B (en)	1997-12-08	2000-07-03	Genentech Inc	Type I interferons.
IL136326A0 (en)	1997-12-08	2001-05-20	Genentech Inc	Human interferon-epsilon: a type i interferon
PT2158923E (pt)	1998-08-06	2013-06-04	Univ Duke	Conjugados de peg-urato oxidase e sua utilização
US6783965B1 (en)	2000-02-10	2004-08-31	Mountain View Pharmaceuticals, Inc.	Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
US6268178B1 (en)	1999-05-25	2001-07-31	Phage Biotechnology Corp.	Phage-dependent super-production of biologically active protein and peptides
WO2002036627A2 (en) *	2000-11-03	2002-05-10	Pbl Biomedical Laboratories	Interferons, uses and compositions related thereto
FR2822845B1 (fr)	2001-03-30	2003-12-12	Genodyssee	Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr)	2001-04-04	2003-12-12	Genodyssee	Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr)	2001-06-11	2004-09-24	Genodyssee	Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
NZ562292A (en)	2005-04-11	2009-11-27	Savient Pharmaceuticals Inc	Variant forms of urate oxidase and use thereof
WO2009090056A2 (en) *	2008-01-18	2009-07-23	F. Hoffmann-La Roche Ag	Purification of not-glycosylated polypeptides
EP2446260B1 (en)	2009-06-25	2018-12-26	Horizon Pharma Rheumatology LLC	Methods and kits for predicting infusion reaction risk and antibody-mediated loss of response by monitoring serum uric acid during pegylated uricase therapy
EP3538135A4 (en)	2016-11-11	2020-07-29	Horizon Pharma Rheumatology LLC	POLYTHERAPIES OF PREDNISONE AND URICASE MOLECULES AND THEIR USES
WO2018087345A1 (en)	2016-11-14	2018-05-17	F. Hoffmann-La Roche Ag	COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
WO2020160325A1 (en)	2019-01-30	2020-08-06	Horizon Pharma Rheumatology Llc	Reducing immunogenicity to pegloticase
US12269875B2 (en)	2023-08-03	2025-04-08	Jeff R. Peterson	Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN150740B (sv) *	1978-11-24	1982-12-04	Hoffmann La Roche
FI77877C (sv) *	1979-04-20	1989-05-10	Technobiotic Ltd	Förfarande för framställning och rening av human Le-formig interferonp rotein.
EP0032134B2 (en) *	1980-01-08	1993-10-13	Biogen, Inc.	Dna sequences, recombinant dna molecules and processes for producing human interferon-alpha like polypeptides
DE3005897A1 (de) *	1980-02-16	1981-09-03	Hoechst Ag, 6000 Frankfurt	Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
DE3176011D1 (en) *	1980-06-12	1987-04-23	Japan Found Cancer	Plasmid
ES506955A0 (es) *	1980-11-10	1983-02-01	Genentech Inc	Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) *	1980-12-31	1984-01-10	Ilkka Antero Palva	Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
EP0062971B1 (en) *	1981-03-27	1990-03-07	Imperial Chemical Industries Plc	Genetically modified microorganisms

1981
- 1981-06-26 CH CH4244/81A patent/CH651308A5/de not_active IP Right Cessation
- 1981-06-26 CH CH1475/85A patent/CH657141A5/de not_active IP Right Cessation
- 1981-06-29 FR FR8112724A patent/FR2486098B1/fr not_active Expired
- 1981-06-29 MC MC811525A patent/MC1396A1/fr unknown
- 1981-06-29 HU HU811882A patent/HU196457B/hu unknown
- 1981-06-29 DZ DZ816241A patent/DZ312A1/fr active
- 1981-06-29 BG BG052673A patent/BG42189A3/xx unknown
- 1981-06-30 SU SU813302642A patent/SU1414319A3/ru active
- 1981-06-30 LU LU83461A patent/LU83461A1/de unknown
- 1981-06-30 GR GR65379A patent/GR75714B/el unknown
- 1981-06-30 YU YU162281A patent/YU47700B/sh unknown
- 1981-06-30 PT PT73289A patent/PT73289B/pt unknown
- 1981-06-30 AT AT86105365T patent/ATE79901T1/de not_active IP Right Cessation
- 1981-06-30 SE SE8104093A patent/SE465223C5/sv not_active IP Right Cessation
- 1981-06-30 NL NL8103151A patent/NL8103151A/nl not_active Application Discontinuation
- 1981-06-30 AT AT0290981A patent/AT380272B/de not_active IP Right Cessation
- 1981-06-30 AR AR81285934A patent/AR242833A1/es active
- 1981-06-30 EP EP86105365A patent/EP0211148B2/en not_active Expired - Lifetime
- 1981-06-30 DK DK198102910A patent/DK173543B1/da not_active IP Right Cessation
- 1981-06-30 PL PL1981231940A patent/PL148260B1/pl unknown
- 1981-06-30 PL PL1981255774A patent/PL148276B1/pl unknown
- 1981-06-30 DE DE3177288T patent/DE3177288T3/de not_active Expired - Lifetime
- 1981-06-30 SE SE8104093D patent/SE8104093L/sv not_active Application Discontinuation
- 1981-06-30 DE DE8181105067T patent/DE3176448D1/de not_active Expired
- 1981-06-30 PL PL1981255773A patent/PL148261B1/pl unknown
- 1981-06-30 NO NO812247A patent/NO159392C/no not_active IP Right Cessation
- 1981-06-30 AT AT81105067T patent/ATE29727T1/de not_active IP Right Cessation
- 1981-06-30 EP EP81105067A patent/EP0043980B1/en not_active Expired
- 1981-06-30 DE DE3125706A patent/DE3125706C2/de not_active Expired - Lifetime
- 1981-06-30 IE IE1463/81A patent/IE49255B1/en not_active IP Right Cessation
- 1981-06-30 ES ES503528A patent/ES503528A0/es active Granted
- 1981-06-30 NZ NZ197572A patent/NZ197572A/en unknown
- 1981-06-30 RO RO81104732A patent/RO87590A/ro unknown
- 1981-06-30 CS CS503781A patent/CS273152B2/cs unknown
- 1981-07-01 DD DD81231371A patent/DD202307A5/de not_active IP Right Cessation
- 1981-07-01 DD DD81255300A patent/DD210305A5/de not_active IP Right Cessation
- 1981-07-01 GB GB8120279A patent/GB2079291B/en not_active Expired
- 1981-07-01 BR BR8104189A patent/BR8104189A/pt unknown
- 1981-07-01 DD DD81255299A patent/DD210304A5/de not_active IP Right Cessation
- 1981-07-01 IT IT22682/81A patent/IT1137272B/it active Protection Beyond IP Right Term
- 1981-07-01 PH PH25843A patent/PH18036A/en unknown
- 1981-07-01 AU AU72462/81A patent/AU552004B2/en not_active Expired
- 1981-07-01 FI FI812067A patent/FI82712C/sv not_active IP Right Cessation
1985
- 1985-05-21 KE KE3534A patent/KE3534A/xx unknown
- 1985-06-27 HK HK492/85A patent/HK49285A/xx not_active IP Right Cessation
1987
- 1987-12-30 MY MY711/87A patent/MY8700711A/xx unknown
1993
- 1993-07-12 GE GEAP1993999A patent/GEP19960519B/en unknown

Also Published As

Publication number	Publication date
EP0211148A1 (en)	1987-02-25
EP0043980A2 (en)	1982-01-20
CS503781A2 (en)	1990-07-12
MC1396A1 (fr)	1982-04-27
LU83461A1 (de)	1983-04-06
ES8207514A1 (es)	1982-10-01
PL148260B1 (en)	1989-09-30
PL231940A1 (en)	1983-07-18
EP0211148B2 (en)	1999-11-24
KE3534A (en)	1985-06-07
DE3125706C2 (de)	1995-05-24
DE3177288T2 (de)	1992-12-10
NO812247L (no)	1982-01-04
SE8104093L (sv)	1982-01-02
DK291081A (da)	1982-01-02
HU196457B (en)	1988-11-28
IE811463L (en)	1982-01-01
NO159392B (no)	1988-09-12
CS273152B2 (en)	1991-03-12
SE465223B (sv)	1991-08-12
DE3176448D1 (en)	1987-10-22
EP0043980B1 (en)	1987-09-16
DE3125706A1 (de)	1982-04-15
AR242833A1 (es)	1993-05-31
CH657141A5 (de)	1986-08-15
EP0211148B1 (en)	1992-08-26
FR2486098B1 (fr)	1985-12-27
NO159392C (no)	1988-12-21
AT380272B (de)	1986-05-12
AU552004B2 (en)	1986-05-22
ATE79901T1 (de)	1992-09-15
SU1414319A3 (ru)	1988-07-30
AU7246281A (en)	1982-01-07
FR2486098A1 (fr)	1982-01-08
BR8104189A (pt)	1982-03-16
IE49255B1 (en)	1985-09-04
GB2079291A (en)	1982-01-20
PT73289B (en)	1983-05-11
IT1137272B (it)	1986-09-03
DE3177288D1 (de)	1992-10-01
DE3177288T3 (de)	2000-03-16
RO87590A (ro)	1986-07-30
PT73289A (en)	1981-07-01
ATA290981A (de)	1985-09-15
FI82712C (sv)	1991-04-10
DD210305A5 (de)	1984-06-06
SE465223C5 (sv)	1998-02-10
HK49285A (en)	1985-07-05
GEP19960519B (en)	1996-07-02
MY8700711A (en)	1987-12-31
PL148276B1 (en)	1989-09-30
CH651308A5 (de)	1985-09-13
PL148261B1 (en)	1989-09-30
FI82712B (fi)	1990-12-31
DZ312A1 (fr)	2004-09-13
FI812067L (fi)	1982-01-02
DD202307A5 (de)	1983-09-07
ES503528A0 (es)	1982-10-01
NZ197572A (en)	1985-07-31
DK173543B1 (da)	2001-02-05
IT8122682A0 (it)	1981-07-01
EP0043980A3 (en)	1982-09-15
YU162281A (en)	1984-02-29
GR75714B (sv)	1984-08-02
NL8103151A (nl)	1982-02-01
ATE29727T1 (de)	1987-10-15
BG42189A3 (en)	1987-10-15
YU47700B (sh)	1996-01-08
GB2079291B (en)	1984-06-13
PH18036A (en)	1985-03-06

Publication	Publication Date	Title
DD210304A5 (de)	1984-06-06	Verfahren zur herstellung eines replikablen vektors
DE3238554C2 (sv)	1989-11-23
DE3685996T2 (de)	1993-01-14	Hybrid-interferone.
DE3043981C2 (sv)	1989-11-30
DD203330A5 (de)	1983-10-19	Verfahren zur herstellung hybrider human-leukozyten-interferone
CH663032A5 (de)	1987-11-13	Doppelstraengige dna, replizierbare plasmidische expressionstraeger zur mikrobiellen herstellung von hybrid human-leukozyten-interferon und transformierte mikroorganismen.
LU83648A1 (de)	1983-06-08	Human-fibroblasten-interferon und dessen herstellung
DD160280A5 (de)	1983-05-25	Verfahren zur herstellung eines eine immunologische oder biologische aktivitaet von humanfibroblast-interferon aufweisenden polypeptids
DE3382575T2 (de)	1993-02-11	Dna-sequenzen, rekombinante dna-molekuele und verfahren zur herstellung von schweinewachstumshormonaehnlichen polypeptiden.
DE3650625T2 (de)	1997-10-02	AraB-Promoter und Verfahren zur Herstellung von Polypeptiden einschliesslich Cecropinen mittels mikrobiologischer Verfahren
DD159782A5 (de)	1983-04-06	Verfahren zur herstellung eines eine immunologische oder biologische aktivitaet von humanleukozyten-interferon aufweisendes polypeptids
DD204494A5 (de)	1983-11-30	Verfahren zum schneiden doppelstraengiger dns
EP0099084A2 (de)	1984-01-25	Verfahren zur Herstellung von Interferon und Expressionsvektoren dafür
DD216044A5 (de)	1984-11-28	Verfahren zur herstellung eines rekombinierenden dna-klonierungsvektors
DD219212A5 (de)	1985-02-27	Verfahren zur herstellung eines rekombinanten dna-klonierungsvektors
AT394209B (de)	1992-02-25	Verfahren zur herstellung neuer mikroorganismen zur produktion von hybriden human-leukozyten-interferonen
AT394208B (de)	1992-02-25	Verfahren zur herstelluung von vektoren
AT394207B (de)	1992-02-25	Verfahren zur herstellung von human-leukozyteninterferonen
AT394210B (de)	1992-02-25	Verfahren zur herstellung von doppelstraengiger dna kodierend fuer hybride human-leukozyten-interferone
FI82713B (fi)	1990-12-31	Plasmid, som foermaor expressera humant moget leukocytinterferon, foerfarande foer dess framstaellning samt dess anvaendning vid framstaellning av humant leukocytinterferon.
EP0379506A1 (de)	1990-08-01	Rekombinante plasmide zur produktion von humanem adrenocorticotropen hormon (acth)
DD259419A5 (de)	1988-08-24	Verfahren zur Herstellung von neuen Expressionsplasmiden
DE3347772A1 (de)	1985-07-25	Verfahren zur herstellung eines polypeptids

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