DD207719A5 - Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen - Google Patents

Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen Download PDF

Info

Publication number: DD207719A5
Authority: DD; German Democratic Republic
Prior art keywords: formula; compound; alkyl; pharmaceutically acceptable; guanidino
Prior art date: 1980-10-14

Application number

DD81248821A

Other languages

German (de)

English (en)

Inventor

John L Lamattina

Christopher A Lipinski

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1980-10-14

Filing date

1981-10-14

Publication date

1984-03-14

1981-10-14 Application filed by Pfizer filed Critical Pfizer

1984-03-14 Publication of DD207719A5 publication Critical patent/DD207719A5/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DD81248821A 1980-10-14 1981-10-14 Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen DD207719A5 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US19623180A	1980-10-14	1980-10-14
US06/293,574 US4374843A (en)	1980-10-14	1981-08-20	2-Guanidino-4-heteroarylthiazoles

Publications (1)

Publication Number	Publication Date
DD207719A5 true DD207719A5 (de)	1984-03-14

Family

ID=26891753

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
DD81248822A DD207913A5 (de)	1980-10-14	1981-10-14	Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen
DD81248820A DD207718A5 (de)	1980-10-14	1981-10-14	Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen
DD81234080A DD202293A5 (de)	1980-10-14	1981-10-14	Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen
DD81248821A DD207719A5 (de)	1980-10-14	1981-10-14	Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen

Family Applications Before (3)

Application Number	Title	Priority Date	Filing Date
DD81248822A DD207913A5 (de)	1980-10-14	1981-10-14	Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen
DD81248820A DD207718A5 (de)	1980-10-14	1981-10-14	Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen
DD81234080A DD202293A5 (de)	1980-10-14	1981-10-14	Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen

Country Status (28)

Country	Link
US (1)	US4374843A (es)
EP (1)	EP0050458B1 (es)
KR (1)	KR850001858B1 (es)
AR (3)	AR228675A1 (es)
AT (1)	ATE11048T1 (es)
AU (2)	AU530589B2 (es)
CA (1)	CA1156239A (es)
CS (1)	CS231182B2 (es)
DD (4)	DD207913A5 (es)
DE (1)	DE3168067D1 (es)
DK (1)	DK453181A (es)
ES (4)	ES506216A0 (es)
FI (1)	FI75821C (es)
GR (1)	GR75098B (es)
HK (1)	HK52387A (es)
HU (2)	HU186788B (es)
IE (1)	IE51642B1 (es)
IL (1)	IL64035A (es)
KE (1)	KE3707A (es)
MY (1)	MY8700512A (es)
NO (1)	NO159654C (es)
NZ (1)	NZ198629A (es)
PH (3)	PH17562A (es)
PL (3)	PL134491B1 (es)
PT (1)	PT73817B (es)
SG (1)	SG23487G (es)
SU (1)	SU1153829A3 (es)
YU (4)	YU42434B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4482723A (en) *	1983-04-11	1984-11-13	Pfizer Inc.	Process for preparation of 4-acetyl-2-substituted-imidazoles
US4435396A (en) *	1982-05-10	1984-03-06	Pfizer Inc.	Antiulcer 2-guanidino-4-(2-substituted-amino-4-imidazolyl)thiazoles and process therefor
GB2122988B (en) *	1982-06-17	1986-06-11	Toyama Chemical Co Ltd	Process for producing 2-(2-aminothiazol-4-yl) glyoxylic acid derivative; intermediates
EP0156644A1 (en) *	1984-04-02	1985-10-02	Pfizer Inc.	Process and intermediates for 4-acetylimidazoles
US4560690A (en) *	1984-04-30	1985-12-24	Pfizer Inc.	2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents
US4567179A (en) *	1984-10-11	1986-01-28	Pfizer, Inc.	Antiinflammatory salts of piroxicam
US4632993A (en) *	1984-10-11	1986-12-30	Pfizer Inc.	Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
US4591595A (en) *	1984-10-11	1986-05-27	Pfizer Inc.	2-guanidino-4-(2-methyl-4-imidazolyl)thiazoles in the treatment of rheumatoid arthritis
WO1986003203A1 (fr) *	1984-11-22	1986-06-05	Yoshitomi Pharmaceutical Industries, Ltd.	Derives de thienylthiazole
US4814341A (en) *	1986-08-26	1989-03-21	Reiter Lawrence A	2-guanidino-4-(2-furyl) thiazoles as antiulcer agents
EP0259085B1 (en) *	1986-08-29	1991-08-21	Pfizer Inc.	2-guanidino-4-arylthiazoles for treatment of peptic ulcers
DE3750023T2 (de) *	1986-10-29	1994-09-29	Pfizer, Inc., New York, N.Y.	Verfahren zur Herstellung von 2-(1-Pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)Thiazol und dessen kristallinisches Dihydrochlorid-Trihydrat.
IL95548A0 (en) *	1989-09-15	1991-06-30	Fujisawa Pharmaceutical Co	Thiazole derivatives,processes for the preparation thereof and pharmaceutical composition containing the same
EP0575614A1 (en) *	1991-03-13	1993-12-29	Fujisawa Pharmaceutical Co., Ltd.	Thiazole derivatives
SI0928793T1 (en) *	1998-01-02	2002-10-31	F. Hoffmann-La Roche Ag	Thiazole derivatives
US7858807B2 (en) *	2005-08-23	2010-12-28	Ube Industries, Ltd.	Method for producing 1-substituted-5-acylimidazole compound
US9499533B2 (en)	2012-03-27	2016-11-22	Shionogi & Co., Ltd.	Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity
KR20220119653A (ko)	2019-12-20	2022-08-30	테나야 테라퓨틱스, 인코포레이티드	플루오로알킬-옥사디아졸 및 이의 용도
EP4196793A1 (en)	2020-08-11	2023-06-21	Université de Strasbourg	H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR1516777A (fr) *	1966-08-02	1968-02-05	Innothera Lab Sa	Dérivés du thiazole ainsi que de la thiazolo [4,5-d] pyridazine et leur préparation
US3519637A (en) *	1966-12-06	1970-07-07	Hoffmann La Roche	1-(4-thiazolylmethyl)nitroimidazole derivatives
BE758146A (fr) *	1969-10-29	1971-04-28	Smith Kline French Lab	Derives de l'amidine
US3950353A (en) *	1971-03-09	1976-04-13	Smith Kline & French Laboratories Limited	Pharmacologically active thiourea and urea compounds
HU168776B (es) *	1973-11-09	1976-07-28
DE2614189A1 (de) *	1976-04-02	1977-10-20	Hoechst Ag	Therapeutisch wirksame ureido- und semicarbazido-derivate des tiazols und verfahren zu ihrer herstellung
ZA782129B (en) *	1977-04-20	1979-03-28	Ici Ltd	Hertocyclic derivatives
US4315009A (en) *	1978-01-18	1982-02-09	Imperial Chemical Industries Limited	Antisecretory guanidine derivatives and pharmaceutical compositions containing them
DE3069889D1 (en) *	1979-01-18	1985-02-14	Ici Plc	Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them
US4220654A (en) *	1979-06-04	1980-09-02	Merck & Co., Inc.	Cyclic imidazole cyanoguanidines
AU518569B2 (en) *	1979-08-07	1981-10-08	Farmos-Yhtyma Oy	4-benzyl- and 4-benzoyl imidazole derivatives

1981
- 1981-08-20 US US06/293,574 patent/US4374843A/en not_active Expired - Fee Related
- 1981-10-12 EP EP81304724A patent/EP0050458B1/en not_active Expired
- 1981-10-12 IL IL64035A patent/IL64035A/xx unknown
- 1981-10-12 IE IE2384/81A patent/IE51642B1/en unknown
- 1981-10-12 AT AT81304724T patent/ATE11048T1/de not_active IP Right Cessation
- 1981-10-12 DE DE8181304724T patent/DE3168067D1/de not_active Expired
- 1981-10-13 CS CS817500A patent/CS231182B2/cs unknown
- 1981-10-13 HU HU812951A patent/HU186788B/hu not_active IP Right Cessation
- 1981-10-13 GR GR66268A patent/GR75098B/el unknown
- 1981-10-13 NO NO813442A patent/NO159654C/no unknown
- 1981-10-13 NZ NZ198629A patent/NZ198629A/en unknown
- 1981-10-13 YU YU2464/81A patent/YU42434B/xx unknown
- 1981-10-13 ES ES506216A patent/ES506216A0/es active Granted
- 1981-10-13 SU SU813344744A patent/SU1153829A3/ru active
- 1981-10-13 DK DK453181A patent/DK453181A/da not_active Application Discontinuation
- 1981-10-13 PH PH26341A patent/PH17562A/en unknown
- 1981-10-13 AU AU76287/81A patent/AU530589B2/en not_active Ceased
- 1981-10-13 FI FI813177A patent/FI75821C/fi not_active IP Right Cessation
- 1981-10-13 CA CA000387744A patent/CA1156239A/en not_active Expired
- 1981-10-13 HU HU833918A patent/HU191895B/hu not_active IP Right Cessation
- 1981-10-13 KR KR1019810003857A patent/KR850001858B1/ko not_active Expired
- 1981-10-14 DD DD81248822A patent/DD207913A5/de not_active IP Right Cessation
- 1981-10-14 DD DD81248820A patent/DD207718A5/de not_active IP Right Cessation
- 1981-10-14 DD DD81234080A patent/DD202293A5/de not_active IP Right Cessation
- 1981-10-14 PL PL1981233430A patent/PL134491B1/pl unknown
- 1981-10-14 PL PL1981241644A patent/PL135331B1/pl unknown
- 1981-10-14 PT PT73817A patent/PT73817B/pt unknown
- 1981-10-14 DD DD81248821A patent/DD207719A5/de not_active IP Right Cessation
- 1981-10-14 PL PL1981241643A patent/PL133712B1/pl unknown
1982
- 1982-08-20 ES ES515159A patent/ES8306751A1/es not_active Expired
- 1982-08-20 ES ES515158A patent/ES8306750A1/es not_active Expired
- 1982-08-20 ES ES515157A patent/ES515157A0/es active Granted
- 1982-08-27 AR AR290463A patent/AR228675A1/es active
- 1982-08-27 AR AR290461A patent/AR229703A1/es active
- 1982-08-27 AR AR290462A patent/AR228674A1/es active
1983
- 1983-04-06 PH PH28741A patent/PH17856A/en unknown
- 1983-04-06 PH PH28740A patent/PH18467A/en unknown
- 1983-05-12 YU YU1053/83A patent/YU42078B/xx unknown
- 1983-05-12 YU YU1052/83A patent/YU42077B/xx unknown
- 1983-05-12 YU YU1051/83A patent/YU42076B/xx unknown
1984
- 1984-08-17 AU AU32062/84A patent/AU548992B2/en not_active Ceased
1987
- 1987-03-09 SG SG234/87A patent/SG23487G/en unknown
- 1987-03-20 KE KE3707A patent/KE3707A/xx unknown
- 1987-07-09 HK HK523/87A patent/HK52387A/xx unknown
- 1987-12-30 MY MY512/87A patent/MY8700512A/xx unknown

Also Published As

Publication number	Publication date
KR830007638A (ko)	1983-11-04
ES8306749A1 (es)	1983-06-01
NZ198629A (en)	1985-02-28
FI75821C (fi)	1988-08-08
PL134491B1 (en)	1985-08-31
IE812384L (en)	1982-04-14
ES515158A0 (es)	1983-06-01
NO813442L (no)	1982-04-15
DD202293A5 (de)	1983-09-07
NO159654B (no)	1988-10-17
HU186788B (en)	1985-09-30
AU548992B2 (en)	1986-01-09
PH17856A (en)	1985-01-09
FI813177L (fi)	1982-04-15
ES515159A0 (es)	1983-06-01
IL64035A (en)	1986-01-31
EP0050458B1 (en)	1985-01-02
ES8306751A1 (es)	1983-06-01
YU105283A (en)	1983-10-31
HU191895B (en)	1987-04-28
US4374843A (en)	1983-02-22
PL241643A1 (en)	1983-11-21
DD207718A5 (de)	1984-03-14
PT73817A (en)	1981-11-01
YU105183A (en)	1983-10-31
YU42434B (en)	1988-08-31
YU42076B (en)	1988-04-30
YU42077B (en)	1988-04-30
PT73817B (en)	1983-11-07
ES8301978A1 (es)	1982-12-16
EP0050458A2 (en)	1982-04-28
CS231182B2 (en)	1984-10-15
PH18467A (en)	1985-07-18
YU105383A (en)	1983-10-31
GR75098B (es)	1984-07-13
ATE11048T1 (de)	1985-01-15
AR228674A1 (es)	1983-03-30
AR228675A1 (es)	1983-03-30
KR850001858B1 (ko)	1985-12-28
MY8700512A (en)	1987-12-31
AU7628781A (en)	1982-04-22
ES8306750A1 (es)	1983-06-01
PL133712B1 (en)	1985-06-29
HK52387A (en)	1987-07-17
AU530589B2 (en)	1983-07-21
YU42078B (en)	1988-04-30
SG23487G (en)	1987-07-10
NO159654C (no)	1989-01-25
DK453181A (da)	1982-04-15
FI75821B (fi)	1988-04-29
AR229703A1 (es)	1983-10-31
CA1156239A (en)	1983-11-01
PH17562A (en)	1984-10-01
PL135331B1 (en)	1985-10-31
PL233430A1 (en)	1983-11-21
DE3168067D1 (en)	1985-02-14
IL64035A0 (en)	1982-01-31
YU246481A (en)	1983-10-31
EP0050458A3 (en)	1982-09-01
DD207913A5 (de)	1984-03-21
PL241644A1 (en)	1983-11-21
SU1153829A3 (ru)	1985-04-30
KE3707A (en)	1987-04-03
CS750081A2 (en)	1984-02-13
ES515157A0 (es)	1983-06-01
IE51642B1 (en)	1987-01-21
AU3206284A (en)	1984-11-29
ES506216A0 (es)	1982-12-16

Publication	Publication Date	Title
DD207719A5 (de)	1984-03-14	Verfahren zur herstellung von 2-guanidino-4-heteroarylthiazolen
DE3218584C2 (es)	1989-11-02
DD233374A5 (de)	1986-02-26	Verfahren zur herstellung von 2-(n-subst.-guanidino)-4-heteroarylthiazole
DD202152A5 (de)	1983-08-31	Verfahren zur herstellung von phenylpiperazinderivaten
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Legal Events

Date	Code	Title	Description
1994-03-17	ENJ	Ceased due to non-payment of renewal fee
1994-04-14	NPV	Change in the person, the name or the address of the representative (addendum to changes before extension act)