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BRPI0409166A - processo para preparação de ferutinina a partir de plantas do gênero ferula - Google Patents

processo para preparação de ferutinina a partir de plantas do gênero ferula

Info

Publication number
BRPI0409166A
BRPI0409166A BRPI0409166-3A BRPI0409166A BRPI0409166A BR PI0409166 A BRPI0409166 A BR PI0409166A BR PI0409166 A BRPI0409166 A BR PI0409166A BR PI0409166 A BRPI0409166 A BR PI0409166A
Authority
BR
Brazil
Prior art keywords
ferutinin
plants
preparing
ferula
genus
Prior art date
Application number
BRPI0409166-3A
Other languages
English (en)
Inventor
Ezio Bombardelli
Gabriele Fontana
Aldo Cristoni
Enrico Mercalli
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of BRPI0409166A publication Critical patent/BRPI0409166A/pt
Publication of BRPI0409166B1 publication Critical patent/BRPI0409166B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
    • C07C2602/30—Azulenes; Hydrogenated azulenes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Emergency Medicine (AREA)
  • Toxicology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"PROCESSO PARA PREPARAçãO DE FERUTININA A PARTIR DE PLANTAS DO GêNERO FERULA". A presente invenção refere-se a um processo para preparação de ferutinina, de fórmula (Ia) a partir de extratos de Ferula spp, compreendendo a hidrólise básica dos extratos e tratamento com o ácido p-pivaloilóxi-benzóico. A invenção referese também ao uso dos extratos e de ferutinina no campo cosmético e dermatológico.
BRPI0409166-3A 2003-04-04 2004-03-23 Processo para preparação de ferutinina a partir de plantas do gênero ferula e uso de p-pivaloilóxi-ferutina BRPI0409166B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2003A000661 2003-04-04
IT000661A ITMI20030661A1 (it) 2003-04-04 2003-04-04 Processo per la preparazione della ferutinina da piante del genere ferula
PCT/EP2004/003055 WO2004087179A1 (en) 2003-04-04 2004-03-23 A process for the preparation of ferutinine from ferula genus plants

Publications (2)

Publication Number Publication Date
BRPI0409166A true BRPI0409166A (pt) 2006-04-11
BRPI0409166B1 BRPI0409166B1 (pt) 2015-09-01

Family

ID=33105046

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0409166-3A BRPI0409166B1 (pt) 2003-04-04 2004-03-23 Processo para preparação de ferutinina a partir de plantas do gênero ferula e uso de p-pivaloilóxi-ferutina

Country Status (19)

Country Link
US (4) US7371886B2 (pt)
EP (1) EP1615651B1 (pt)
JP (2) JP4648305B2 (pt)
KR (2) KR101132526B1 (pt)
CN (2) CN100518732C (pt)
AT (1) ATE517631T1 (pt)
AU (1) AU2004226853B2 (pt)
BR (1) BRPI0409166B1 (pt)
CA (2) CA2766702C (pt)
DK (1) DK1615651T3 (pt)
ES (1) ES2367361T3 (pt)
IL (1) IL171230A (pt)
IT (1) ITMI20030661A1 (pt)
NO (1) NO333671B1 (pt)
PL (1) PL1615651T3 (pt)
PT (1) PT1615651E (pt)
RU (2) RU2342153C2 (pt)
SI (1) SI1615651T1 (pt)
WO (1) WO2004087179A1 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20032286A1 (it) * 2003-11-24 2005-05-25 Indena Spa Composizioni per il trattamento di dermatiti atopiche di stati allergici cutanei e dell'acne
US8536584B2 (en) 2007-11-14 2013-09-17 Cree, Inc. High voltage wire bond free LEDS
US20100260695A1 (en) * 2009-04-09 2010-10-14 Mary Kay Inc. Combination of plant extracts to improve skin tone
CN103025387B (zh) * 2010-05-24 2016-06-01 因德纳有限公司 用于治疗炎性疾病的罗望子种子多糖
EP2706995B1 (en) * 2011-05-12 2016-11-30 B.R.A.I.N. Biotechnology Research and Information Network AG Small molecule inhibitors of trpa1
US9913799B2 (en) 2014-07-11 2018-03-13 Mary Kay Inc. Cosmetic compositions and methods of their use
CN105820146A (zh) * 2015-01-08 2016-08-03 辽宁医联新药研究所 一种阿魏内酯及其提取纯化的方法
GB2570508A (en) * 2018-01-30 2019-07-31 Saeed Mohammad Sultan Alaryani Humaid Preparation for treatment of wounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1604225A (en) * 1978-05-15 1981-12-02 Skourides A A Extract of ambelferae for pharmacological use
CH672251A5 (pt) * 1987-05-29 1989-11-15 Inst Khim Rastitelnykh Vesches
RU2090198C1 (ru) * 1991-03-12 1997-09-20 Иван Иванович Уваров Способ получения биологически активных веществ, обладающих противогрибковой активностью
DE4444238A1 (de) * 1994-12-13 1996-06-20 Beiersdorf Ag Kosmetische oder dermatologische Wirkstoffkombinationen aus Zimtsäurederivaten und Flavonglycosiden
JP4244093B2 (ja) * 2000-01-24 2009-03-25 三省製薬株式会社 美白化粧料
ES2291333T3 (es) * 2000-06-27 2008-03-01 Qualilife Pharmaceuticals Inc. Composiciones y metodos para el tratamiento de la respuesta sexual de las mujeres.
US6623768B1 (en) * 2002-04-16 2003-09-23 Yousry M. A. Naguib Pharmaceutically active composition extracted from Ferula hermonis and process of its extraction

Also Published As

Publication number Publication date
CA2521100C (en) 2012-05-01
US20120095094A1 (en) 2012-04-19
JP2006522043A (ja) 2006-09-28
CN101371818A (zh) 2009-02-25
AU2004226853A1 (en) 2004-10-14
US20080248139A1 (en) 2008-10-09
RU2342153C2 (ru) 2008-12-27
NO333671B1 (no) 2013-08-05
US8247005B2 (en) 2012-08-21
EP1615651A1 (en) 2006-01-18
SI1615651T1 (sl) 2011-11-30
US20100255125A1 (en) 2010-10-07
AU2004226853B2 (en) 2009-06-04
CA2766702A1 (en) 2004-10-14
NO20054545L (no) 2005-10-06
PL1615651T3 (pl) 2011-12-30
US20060275246A1 (en) 2006-12-07
BRPI0409166B1 (pt) 2015-09-01
RU2469733C2 (ru) 2012-12-20
WO2004087179A1 (en) 2004-10-14
JP2010209099A (ja) 2010-09-24
KR20060008307A (ko) 2006-01-26
JP4648305B2 (ja) 2011-03-09
ES2367361T3 (es) 2011-11-02
CA2521100A1 (en) 2004-10-14
CA2766702C (en) 2015-09-29
JP5409505B2 (ja) 2014-02-05
EP1615651B1 (en) 2011-07-27
ATE517631T1 (de) 2011-08-15
DK1615651T3 (da) 2011-10-24
PT1615651E (pt) 2011-09-02
US7371886B2 (en) 2008-05-13
CN100518732C (zh) 2009-07-29
CN1767841A (zh) 2006-05-03
IL171230A (en) 2014-02-27
HK1087618A1 (zh) 2006-10-20
ITMI20030661A1 (it) 2004-10-05
KR20110082091A (ko) 2011-07-15
KR101132526B1 (ko) 2012-04-03
NO20054545D0 (no) 2005-10-03
RU2008122295A (ru) 2009-12-10
US8101215B2 (en) 2012-01-24
KR101169893B1 (ko) 2012-07-31
RU2005130639A (ru) 2006-04-27

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B15K Others concerning applications: alteration of classification

Free format text: A CLASSIFICACAO ANTERIOR ERA: A61K 35/78

Ipc: C07C 67/31 (2006.01), C07C 69/84 (2006.01), A61K 8

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 01/09/2015, OBSERVADAS AS CONDICOES LEGAIS.

B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 15A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2507 DE 22-01-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.