BRPI9903436A - methylphenidate synthesis process. - Google Patents
methylphenidate synthesis process.Info
- Publication number
- BRPI9903436A BRPI9903436A BRPI9903436A BRPI9903436A BRPI9903436A BR PI9903436 A BRPI9903436 A BR PI9903436A BR PI9903436 A BRPI9903436 A BR PI9903436A BR PI9903436 A BRPI9903436 A BR PI9903436A BR PI9903436 A BRPI9903436 A BR PI9903436A
- Authority
- BR
- Brazil
- Prior art keywords
- methylphenidate
- synthesis process
- threo
- nitro
- chlorine
- Prior art date
Links
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001344 methylphenidate Drugs 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
Abstract
''processo de síntese de metilfenidato'', que pode ser utilizado para a obtenção dos isômeros treo e eritro de metilfenidato <b>(7a)<d> bem como de seus derivados metóxi <b>(7b)<d>, cloro <b>(7c)<d> e nitro <b>(7d)<d>.''methylphenidate synthesis process'', which can be used to obtain the threo and erythro isomers of methylphenidate <b>(7a)<d> as well as its methoxy derivatives <b>(7b)<d>, chlorine <b>(7c)<d> and nitro <b>(7d)<d>.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI9903436-0A BRPI9903436B1 (en) | 1999-08-02 | 1999-08-02 | methylphenidate synthesis process. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BRPI9903436-0A BRPI9903436B1 (en) | 1999-08-02 | 1999-08-02 | methylphenidate synthesis process. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BRPI9903436A true BRPI9903436A (en) | 2001-03-13 |
| BRPI9903436B1 BRPI9903436B1 (en) | 2011-10-04 |
Family
ID=77351464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9903436-0A BRPI9903436B1 (en) | 1999-08-02 | 1999-08-02 | methylphenidate synthesis process. |
Country Status (1)
| Country | Link |
|---|---|
| BR (1) | BRPI9903436B1 (en) |
-
1999
- 1999-08-02 BR BRPI9903436-0A patent/BRPI9903436B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI9903436B1 (en) | 2011-10-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 04/10/2011, OBSERVADAS AS CONDICOES LEGAIS. NA FOLHA 08 (PAGINA 1, LINHAS 1-2 DO RELATORIO DESCRITIVO) ONDE SE LE: "PROCESSO DE SINTESE DE METILFENIDATO" LEIA-SE: "PROCESSO DE SINTESE DE METILFENIDATO E SEUS DERIVADOS" |
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| B22L | Other matters related to patents and certificates of addition of invention: notification of licence offer (art 64 par 1 of lpi) |
Free format text: CONDICOES CONTRATUAIS: 1) ROYALTIES: R$ 7.000,00 EM ATE 10 DIAS APOS A ASSINATURA DO CONTRATO DE LICENCA, REFERENTES A DESPESAS DE PROTECAO E MANUTENCAO REALIZADAS PELO TITULAR; 2) PRAZO: SERA ATE O TERMINO DE VIGENCIA DA PATENTE, EM 02.08.2019; 3) CONDICOES DE PAGAMENTO: APOS EFETIVA EXPLORACAO OU COLOCACAO NO MERCADO, PAGAMENTO DE ROYALTIES: R$ 5.700,60 QUE PODERA SER PARCELADO MEDIANTE PROPOSTA DO INTERESSADO NA LICENCA, ALEM DE ROYALTIES DE 2% SOBRE O FATURAMENTO LIQUIDO; 4) DISPONIBILIDADE DE "KNOW-HOW": SIM. |
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| B22L | Other matters related to patents and certificates of addition of invention: notification of licence offer (art 64 par 1 of lpi) |
Free format text: CONDICOES CONTRATUAIS: 1) ROYALTIES: R$ 7.000,00 EM ATE 10 DIAS APOS A ASSINATURA DO CONTRATO DE LICENCA, REFERENTES A DESPESAS DE PROTECAO E MANUTENCAO REALIZADAS PELO TITULAR; 2) PRAZO: SERA ATE O TERMINO DA VIGENCIA DA PATENTE, EM 02.08.2019; 3) CONDICOES DE PAGAMENTO: APOS EFETIVA EXPLORACAO OU COLOCACAO NO MERCADO, PAGAMENTO DE ROYALTIES: R$ 5.700,60 QUE PODERA SER PARCELADO MEDIANTE PROPOSTA DO INTERESSADO NA LICENCA, ALEM DE ROYALTIES DE 2% SOBRE O FATURAMENTO LIQUIDO; 4) DISPONIBILIDADE DE KNOW-HOW: SIM |
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| B22L | Other matters related to patents and certificates of addition of invention: notification of licence offer (art 64 par 1 of lpi) |
Free format text: CONDICOES CONTRATUAIS: 1) ROYALTIES: R$ 7.000,00 EM ATE 10 DIAS APOS A ASSINATURA DO CONTRATO DE LICENCA, REFERENTES A DESPESAS DE PROTECAO E MANUTENCAO REALIZADAS PELO TITULAR; 2) PRAZO: SERA ATE O TERMINO DA VIGENCIA DA PATENTE, EM 02.08.2019; 3) CONDICOES DE PAGAMENTO: APOS EFETIVA EXPLORACAO OU COLOCACAO NO MERCADO, PAGAMENTO DE ROYALTIES DE R$ 5.700,60, QUE PODERA SER PARCELADO MEDIANTE PROPOSTA DO INTERESSADO NA LICENCA, ALEM DE ROYALTIES DE 2%, SOBRE O FATURAMENTO LIQUIDO; 4) DISPONIBILIDADE DE "KNOW-HOW": SIM |
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| B22L | Other matters related to patents and certificates of addition of invention: notification of licence offer (art 64 par 1 of lpi) |
Free format text: CONDICOES CONTRATUAIS: 1) ROYALTIES: R$ 7.000,00 EM ATE 10 DIAS APOS A ASSINATURA DO CONTRATO DE LICENCA, REFERENTES A DESPESAS DE PROTECAO E MANUTENCAO REALIZADAS PELO TITULAR; 2) PRAZO: SERA ATE O TERMINO DA VIGENCIA DA PATENTE, EM 02.08.2019; 3) CONDICOES DE PAGAMENTO: APOS EFETIVA EXPLORACAO OU COLOCACAO NO MERCADO, PAGAMENTO DE ROYALTIES DE R$ 5.700,60, QUE PODERA SER PARCELADO MEDIANTE PROPOSTA DO INTERESSADO NA LICENCA, ALEM DE ROYALTIES DE 2%, SOBRE O FATURAMENTO LIQUIDO; 4) DISPONIBILIDADE DE "KNOW-HOW": SIM |
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| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/08/99, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO |
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| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
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