[go: up one dir, main page]

BR9913948A - Composição farmacêutica para o tratamento de dor aguda por administração sublingual, uso de fentanila ou um sal farmaceuticamente aceitável da mesma, e processo para o tratamento de dor aguda - Google Patents

Composição farmacêutica para o tratamento de dor aguda por administração sublingual, uso de fentanila ou um sal farmaceuticamente aceitável da mesma, e processo para o tratamento de dor aguda

Info

Publication number
BR9913948A
BR9913948A BR9913948-0A BR9913948A BR9913948A BR 9913948 A BR9913948 A BR 9913948A BR 9913948 A BR9913948 A BR 9913948A BR 9913948 A BR9913948 A BR 9913948A
Authority
BR
Brazil
Prior art keywords
treatment
acute pain
fentanyl
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
BR9913948-0A
Other languages
English (en)
Other versions
BR9913948B1 (pt
Inventor
Anders Pettersson
Nyrstroem Christer
Hans Lennernos
Bo Lennernos
Thomas Hedner
Original Assignee
Diabact Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20412701&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9913948(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Diabact Ab filed Critical Diabact Ab
Publication of BR9913948A publication Critical patent/BR9913948A/pt
Publication of BR9913948B1 publication Critical patent/BR9913948B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Physiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

"COMPOSIçãO FARMACêUTICA PARA O TRATAMENTO DE DOR AGUDA POR ADMINISTRAçãO SUBLINGUAL, USO DE FENTANILA OU UM SAL FARMACEUTICAMENTE ACEITáVEL DA MESMA, E PROCESSO PARA O TRATAMENTO DE DOR AGUDA" Uma composição farmacêutica para o tratamento de dor aguda por administração sublingual é descrita. A composição compreende uma mistura ordenada, essencialmente isenta de água, de fentanila ou um sal farmaceuticamente aceitável da mesma, na forma de micro partículas que são aderidas à superfície das partículas portadoras que são substancialmente maiores do que as partículas de fentanila, e são essencialmente solúveis em água em água. Em uma forma de realização preferida, a composição também contém um agente promotor de bioadesão e/ou mucoadesão. A invenção também se refere à preparação da composição, e ao uso de composição para o tratamento de dor aguda.
BRPI9913948-0A 1998-09-24 1999-09-24 composição farmacêutica para o tratamento de dor aguda por administração sublingual, uso de fentanila ou um sal farmaceuticamente aceitável da mesma, e, uso de uma composição farmacêutica essencialmente isenta de água. BR9913948B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9803239A SE9803239D0 (sv) 1998-09-24 1998-09-24 Composition for the treatment of acute pain
SE9803239-4 1998-09-24
PCT/SE1999/001688 WO2000016751A1 (en) 1998-09-24 1999-09-24 Fentanyl composition for the treatment of acute pain

Publications (2)

Publication Number Publication Date
BR9913948A true BR9913948A (pt) 2001-06-12
BR9913948B1 BR9913948B1 (pt) 2011-02-08

Family

ID=20412701

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9913948-0A BR9913948B1 (pt) 1998-09-24 1999-09-24 composição farmacêutica para o tratamento de dor aguda por administração sublingual, uso de fentanila ou um sal farmaceuticamente aceitável da mesma, e, uso de uma composição farmacêutica essencialmente isenta de água.

Country Status (26)

Country Link
US (1) US6759059B1 (pt)
EP (1) EP1115384B1 (pt)
JP (2) JP2002526440A (pt)
KR (1) KR100760531B1 (pt)
CN (1) CN1170524C (pt)
AT (1) ATE247950T1 (pt)
AU (1) AU764473B2 (pt)
BG (1) BG65363B1 (pt)
BR (1) BR9913948B1 (pt)
CA (1) CA2345064C (pt)
CZ (1) CZ301562B6 (pt)
DE (1) DE69910803T2 (pt)
DK (1) DK1115384T3 (pt)
EE (1) EE200100176A (pt)
ES (1) ES2207295T3 (pt)
HU (2) HU228992B1 (pt)
IL (2) IL142126A0 (pt)
NO (1) NO332228B1 (pt)
NZ (1) NZ510646A (pt)
PL (1) PL197078B1 (pt)
PT (1) PT1115384E (pt)
RU (1) RU2232580C2 (pt)
SE (1) SE9803239D0 (pt)
SK (1) SK283503B6 (pt)
TR (1) TR200100812T2 (pt)
WO (1) WO2000016751A1 (pt)

Families Citing this family (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030091629A1 (en) * 1998-03-27 2003-05-15 Cima Labs Inc. Sublingual buccal effervescent
US20030118645A1 (en) * 1998-04-29 2003-06-26 Pather S. Indiran Pharmaceutical compositions for rectal and vaginal administration
US6974590B2 (en) 1998-03-27 2005-12-13 Cima Labs Inc. Sublingual buccal effervescent
SE9803240D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
KR101197919B1 (ko) 1999-10-29 2012-11-29 유로-셀티크 소시에떼 아노뉨 서방성 하이드로코돈 제형
IT1318618B1 (it) * 2000-07-10 2003-08-27 A C R Applied Coating Res S A Microsfere bioadesive a rilascio rapido per la somministrazionesublinguale di principi attivi.
CN100346788C (zh) 2000-07-31 2007-11-07 尼科梅德丹麦有限公司 用于鼻内给药的芬太尼组合物
US6733783B2 (en) 2000-10-30 2004-05-11 Euro-Celtique S.A. Controlled release hydrocodone formulations
US20030003113A1 (en) * 2001-06-29 2003-01-02 Lewandowski Leon J. Individualized addiction cessation therapy
FR2827517B1 (fr) 2001-07-23 2003-10-24 Bioalliance Pharma Systemes therapeutiques bioadhesifs a liberation prolongee
ES2284783T3 (es) * 2001-11-16 2007-11-16 Randox Laboratories Ltd. Metodo y estuche para detectar, o determinar la cantidad de,metabolitos de fentanilo y metabolitos de analogos de fentanilo.
GB0217056D0 (en) * 2002-07-23 2002-08-28 Ass Octel Use
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
ES2270335T7 (es) * 2003-01-31 2012-03-16 Orexo Ab Composicion farmaceuta de efecto.
CA2516338A1 (en) * 2003-03-11 2004-09-23 Arakis Ltd. Novel compositions containing fentanyl
JP5137286B2 (ja) 2003-06-10 2013-02-06 帝國製薬株式会社 フェンタニル含有口腔粘膜貼付剤
GB0315632D0 (en) 2003-07-04 2003-08-13 West Pharm Serv Drug Res Ltd Pharmaceutical formulations
US7201920B2 (en) 2003-11-26 2007-04-10 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse of opioid containing dosage forms
WO2005065317A2 (en) 2003-12-31 2005-07-21 Cima Labs Inc. Effervescent oral fentanyl dosage form
JP5244318B2 (ja) 2003-12-31 2013-07-24 シーマ・ラブス、インコーポレイテッド 発泡性経口アヘン薬投薬形態およびアヘン薬の投与方法
BRPI0418228B8 (pt) * 2003-12-31 2021-05-25 Cima Labs Inc forma de dosagem, e, método de preparação de um tablete para administração bucal, gengival ou sublingual de fentanil
JP5179757B2 (ja) * 2004-02-17 2013-04-10 トランセプト ファーマシューティカルズ， インコーポレイティド 口腔粘膜を介して催眠剤をデリバリーするための組成物及びその使用方法
GB0423800D0 (en) 2004-10-27 2004-12-01 Orexo Ab New pharmaceutical formulations
FR2883179B1 (fr) 2005-03-18 2009-04-17 Ethypharm Sa Comprime enrobe
EP1863456A1 (en) * 2005-03-28 2007-12-12 Orexo AB New pharmaceutical compositions useful in the treatment of pain
US20070287740A1 (en) * 2005-05-25 2007-12-13 Transcept Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
US20070225322A1 (en) * 2005-05-25 2007-09-27 Transoral Pharmaceuticals, Inc. Compositions and methods for treating middle-of-the night insomnia
US20060281783A1 (en) * 2005-05-25 2006-12-14 Transoral Pharmaceuticals, Inc. Compositions and methods of treating middle-of-the night insomnia
JP5586151B2 (ja) * 2005-12-13 2014-09-10 バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド 乱用抵抗性経粘膜薬剤送達デバイス
US8252329B2 (en) * 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8252328B2 (en) * 2006-01-06 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US9066847B2 (en) * 2007-01-05 2015-06-30 Aceirx Pharmaceuticals, Inc. Storage and dispensing devices for administration of oral transmucosal dosage forms
US9289583B2 (en) 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
CN101394863B (zh) * 2006-01-06 2016-12-21 阿塞尔Rx制药有限公司 小体积口腔经粘膜剂型
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8357114B2 (en) 2006-01-06 2013-01-22 Acelrx Pharmaceuticals, Inc. Drug dispensing device with flexible push rod
EP1976521B1 (en) * 2006-01-25 2015-03-11 Insys Therapeutics, Inc. Sublingual fentanyl spray
EP1837020A1 (en) 2006-03-24 2007-09-26 Bioalliance Pharma Mucosal bioadhesive slow release carrier for delivering active principles
US20070260491A1 (en) * 2006-05-08 2007-11-08 Pamela Palmer System for delivery and monitoring of administration of controlled substances
US20070286900A1 (en) * 2006-06-09 2007-12-13 Catherine Herry Low dose tablets of opioid analgesics and preparation process
US20080069891A1 (en) * 2006-09-15 2008-03-20 Cima Labs, Inc. Abuse resistant drug formulation
US20070299687A1 (en) * 2006-06-23 2007-12-27 Pamela Palmer Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed
DK2054031T3 (en) 2006-07-21 2016-05-17 Biodelivery Sciences Int Inc Transmucosal delivery devices with improved uptake
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
US20080090874A1 (en) * 2006-09-20 2008-04-17 Messina John C Jr Treatment of breakthrough pain in patients suffering from chronic low back pain
FR2907680B1 (fr) * 2006-10-27 2012-12-28 Scras Utilisation therapeutique d'au moins une neurotoxine botulique dans le traitement de la douleur induite par au moins un agent anti-cancereux
JP5484062B2 (ja) * 2006-12-04 2014-05-07 オレクソ・アクチエボラゲット オピオイドを含む新規の非−乱用性医薬組成物
WO2008100434A1 (en) * 2007-02-09 2008-08-21 Durect Corporation Transoral dosage forms comprising sufentanil and naloxone
US8173666B2 (en) 2007-03-12 2012-05-08 Nektar Therapeutics Oligomer-opioid agonist conjugates
US10512644B2 (en) 2007-03-12 2019-12-24 Inheris Pharmaceuticals, Inc. Oligomer-opioid agonist conjugates
WO2008133952A2 (en) * 2007-04-24 2008-11-06 Cephalon, Inc. Transmucosal treatment with fentanyl in patients with mucositis
JP2010529073A (ja) * 2007-06-06 2010-08-26 ビーエーエスエフ ソシエタス・ヨーロピア チュアブル錠及びトローチ剤製造のための医薬製剤
PL2180844T3 (pl) 2007-08-02 2018-07-31 Insys Development Company, Inc. Rozpylacz podjęzykowy z fentanylem
US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
EP2295046B1 (de) * 2009-09-14 2012-12-19 Acino AG Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff davon
WO2011041414A1 (en) 2009-09-30 2011-04-07 Acura Pharmaceuticals, Inc. Methods and compositions for deterring abuse
US10744086B2 (en) 2009-10-30 2020-08-18 Ix Biopharma Ltd. Fast dissolving solid dosage form
US12186426B2 (en) 2009-10-30 2025-01-07 Ix Biopharma Ltd. Solid dosage form
MX2012012991A (es) 2010-05-11 2012-11-30 Cima Labs Inc Formas de dosificacion oral de liberacion prolongada resistentes al alcohol y que contienen metoprolol.
US20120183580A1 (en) * 2011-01-13 2012-07-19 Theralpha Analgesic Composition for Transbuccal Administration
US8703177B2 (en) 2011-08-18 2014-04-22 Biodelivery Sciences International, Inc. Abuse-resistant mucoadhesive devices for delivery of buprenorphine
HUE056309T2 (hu) 2011-09-19 2022-02-28 Orexo Ab Buprenorfint és naloxont tartalmazó szublingvális, abúzus-rezisztens tabletták
US9901539B2 (en) 2011-12-21 2018-02-27 Biodelivery Sciences International, Inc. Transmucosal drug delivery devices for use in chronic pain relief
DE102012006396A1 (de) 2012-03-29 2013-10-02 Willy Rüsch GmbH Tracheostomietubus
AU2013255640B2 (en) 2012-05-02 2017-06-15 Orexo Ab New alfentanil composition for the treatment of acute pain
MX392839B (es) 2012-11-30 2025-03-24 Acura Pharmaceuticals Inc Liberacion autorregulada de ingrediente farmaceutico activo.
US20150118300A1 (en) 2013-10-31 2015-04-30 Cima Labs Inc. Immediate Release Abuse-Deterrent Granulated Dosage Forms
IL276030B (en) * 2014-02-07 2022-09-01 Sentar Pharmaceuticals Inc Non-toxic systems, from natural materials, for administering medicine under the tongue
WO2016086095A1 (en) 2014-11-25 2016-06-02 Biodelivery Sciences International, Inc. Patches, methods for forming and testing pharmaceutical agent delivery patches
US11103581B2 (en) 2015-08-31 2021-08-31 Acura Pharmaceuticals, Inc. Methods and compositions for self-regulated release of active pharmaceutical ingredient
US11324707B2 (en) 2019-05-07 2022-05-10 Clexio Biosciences Ltd. Abuse-deterrent dosage forms containing esketamine
US20220062200A1 (en) 2019-05-07 2022-03-03 Clexio Biosciences Ltd. Abuse-deterrent dosage forms containing esketamine

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8332556D0 (en) * 1983-12-06 1984-01-11 Reckitt & Colmann Prod Ltd Analgesic compositions
US5288497A (en) * 1985-05-01 1994-02-22 The University Of Utah Compositions of oral dissolvable medicaments
SE8800080L (sv) * 1988-01-13 1989-07-14 Kabivitrum Ab Laekemedelskomposition
SE8904298D0 (sv) * 1989-12-21 1989-12-21 Astra Ab New compounds
JP3836566B2 (ja) * 1996-05-13 2006-10-25 久光製薬株式会社 フェンタニル含有経皮投与テープ製剤
JP3943724B2 (ja) * 1998-07-31 2007-07-11 東光薬品工業株式会社 フェンタニル含有経皮投与マトリックス型貼付剤
SE9803240D0 (sv) * 1998-09-24 1998-09-24 Diabact Ab A pharmaceutical composition having a rapid action

Also Published As

Publication number Publication date
AU6492899A (en) 2000-04-10
CZ20011030A3 (cs) 2001-09-12
CA2345064A1 (en) 2000-03-30
JP4478512B2 (ja) 2010-06-09
HUP0103621A3 (en) 2005-05-30
DK1115384T3 (da) 2003-12-22
BG105380A (en) 2001-12-29
ATE247950T1 (de) 2003-09-15
KR100760531B1 (ko) 2007-10-04
BG65363B1 (bg) 2008-04-30
NO20011502D0 (no) 2001-03-23
HUP0103621A2 (hu) 2002-02-28
WO2000016751A1 (en) 2000-03-30
EE200100176A (et) 2002-08-15
US6759059B1 (en) 2004-07-06
IL142126A (en) 2006-04-10
NO332228B1 (no) 2012-07-30
PT1115384E (pt) 2004-01-30
AU764473B2 (en) 2003-08-21
SK283503B6 (sk) 2003-08-05
CN1328448A (zh) 2001-12-26
JP2004269545A (ja) 2004-09-30
CZ301562B6 (cs) 2010-04-14
DE69910803T2 (de) 2004-06-17
PL347467A1 (en) 2002-04-08
CN1170524C (zh) 2004-10-13
EP1115384A1 (en) 2001-07-18
SE9803239D0 (sv) 1998-09-24
BR9913948B1 (pt) 2011-02-08
HU230688B1 (hu) 2017-09-28
ES2207295T3 (es) 2004-05-16
HU228992B1 (en) 2013-07-29
CA2345064C (en) 2008-05-27
RU2232580C2 (ru) 2004-07-20
NO20011502L (no) 2001-03-23
EP1115384B1 (en) 2003-08-27
TR200100812T2 (tr) 2001-07-23
SK4012001A3 (en) 2001-10-08
IL142126A0 (en) 2002-03-10
NZ510646A (en) 2004-04-30
KR20010075314A (ko) 2001-08-09
JP2002526440A (ja) 2002-08-20
PL197078B1 (pl) 2008-02-29
DE69910803D1 (de) 2003-10-02

Similar Documents

Publication Publication Date Title
BR9913948A (pt) Composição farmacêutica para o tratamento de dor aguda por administração sublingual, uso de fentanila ou um sal farmaceuticamente aceitável da mesma, e processo para o tratamento de dor aguda
BR9913945A (pt) Composição farmacêutica para o tratamento de distúrbios agudos por meio de administração sublingual, e, processo para o tratamento de distúrbios agudos
BR0107147A (pt) Composições farmacêuticas de drogas anti-tuberculosas e processo para as suas preparações
EE04463B1 (et) 3-arüülpropaanhappe derivaadid ja nende analoogid, nende valmistamise meetod, neid sisaldavad ravimkoostised ja ühendid kasutamiseks ravis
BR0014384A (pt) Compostos para o tratamento da isquémia
BR9808812A (pt) Composição compreendendo partìculas cristalinas, finamente divididas de budesonida
BR9714082A (pt) Composto, uso do mesmo, composição farmacêutica, e, processos para tratamento ou profilaxia de doenças inflamatórias, e para a preparação de um composto.
ES2178430T3 (es) Utilizacion de composiciones farmaceuticas gelificables en parodontologia.
PT949925E (pt) Preparacao medicinal chato para a aplicacao e a libertacao de buprenorfina ou de uma substancia farmacologicamente comparavel na cavidade bucal e processo para a sua producao
BR0016504A (pt) Preparação farmacêutica plana, uso de uma preparação farmacêutica, método para o tratamento de estados de dor e método para o tratamento de dependencia de opiáceo ou cocaìna dentro da estrutura de terapia de substituição ou de alcance de abstinência
BR0108600A (pt) Composto, processo para a preparação do mesmo, composição farmacêutica, processo para a preparação da mesma, uso de um composto, e, métodos para tratamento de uma doença mediada por quimiocina e para tratamento de uma doença inflamatória
IT1309427B1 (it) Composizione dietetica o farmaceutica utile per la prevenzione o iltrattamento dell'iperossaluria e suo uso
BR0111913A (pt) Análogos de gabapentina para distúrbios do sono
BR0008509A (pt) Composição farmacêutica oral estabilizada contendo iodeto e iodato e método
EE04997B1 (et) Loteprednooli ja antihistamiinseid aineid sisaldav farmatseutiline kompositsioon, neid aineid sisaldav ravim, meetod selle ravimi valmistamiseks ja nende ainete kombinatsiooni kasutamine
DK0680326T3 (da) Farmaceutisk formulering af nikotinafhængighed.
BR0103169A (pt) Composição farmacêutica para o tratamento do distúrbio de hiperatividade de déficit de atenção (adhd)
BR9908510A (pt) Uso de um composto, composto, processo para a preparação de um composto, composição farmacêutica, e, processo de tratar um paciente que sofre de, ou em risco de, uma doença micobacteriana
BR9813514A (pt) Agente para tratamento de fibras queratìnicas
PE20020387A1 (es) Uso de una combinacion de salmeterol y fluticasona
BR0311747A (pt) Composição farmacêutica, forma de dose simples ou de múltiplas doses da composição, kit, e, método para tratar doença
AR011437A1 (es) Composicion farmaceutica para el tratamiento de la migrana y el uso de la misma en la preparacion de un medicamento.
NO983177L (no) Anvendelse av 1-enantiomeren av centkroman til fremstilling av et farmasaytisk preparat for behandling eller profylakse av brystkreft
BR0212249A (pt) Composto, composição farmacêutica, método de tratamento ou profilaxia de doenças, e, uso de um composto
AR047480A1 (es) Composicion para la prevencion y/o tratamiento de enfermedades metabolicas oseas; proceso de preparacion y uso de esta composicion

Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 08/02/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 21A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2599 DE 27-10-2020 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.