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BR9709074A - Derivados de polihidroxifenol agentes de prevencão e terapéuticos para doencas ósseas e de cartilagem contendo os mesmos - Google Patents

Derivados de polihidroxifenol agentes de prevencão e terapéuticos para doencas ósseas e de cartilagem contendo os mesmos

Info

Publication number
BR9709074A
BR9709074A BR9709074A BR9709074A BR9709074A BR 9709074 A BR9709074 A BR 9709074A BR 9709074 A BR9709074 A BR 9709074A BR 9709074 A BR9709074 A BR 9709074A BR 9709074 A BR9709074 A BR 9709074A
Authority
BR
Brazil
Prior art keywords
optionally substituted
alkyl
bone
preventive
therapeutic agents
Prior art date
Application number
BR9709074A
Other languages
English (en)
Inventor
Kunikazau Sakai
Yusuke Satoh
Kazuyuki Doi
Kazuyuki Kitamura
Original Assignee
Hoechst Marion Roussel Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Ltd filed Critical Hoechst Marion Roussel Ltd
Publication of BR9709074A publication Critical patent/BR9709074A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46Friedel-Crafts reactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/512Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being a free hydroxyl group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/825Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups all hydroxy groups bound to the ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
BR9709074A 1996-05-14 1997-05-14 Derivados de polihidroxifenol agentes de prevencão e terapéuticos para doencas ósseas e de cartilagem contendo os mesmos BR9709074A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP8154710A JPH09301916A (ja) 1996-05-14 1996-05-14 ポリヒドロキシフェノール誘導体およびそれらからなる骨・軟骨疾患予防・治療剤
PCT/JP1997/001625 WO1997043235A1 (en) 1996-05-14 1997-05-14 Polyhydroxyphenol derivatives and preventive and therapeutic agents for bone and cartilage diseases containing the same

Publications (1)

Publication Number Publication Date
BR9709074A true BR9709074A (pt) 1999-08-03

Family

ID=15590273

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9709074A BR9709074A (pt) 1996-05-14 1997-05-14 Derivados de polihidroxifenol agentes de prevencão e terapéuticos para doencas ósseas e de cartilagem contendo os mesmos

Country Status (21)

Country Link
US (1) US6177474B1 (pt)
EP (1) EP0994093B1 (pt)
JP (1) JPH09301916A (pt)
CN (1) CN1178889C (pt)
AT (1) ATE314339T1 (pt)
AU (1) AU737890B2 (pt)
BR (1) BR9709074A (pt)
CA (1) CA2255589A1 (pt)
CZ (1) CZ355498A3 (pt)
DE (1) DE69735008D1 (pt)
EA (1) EA001172B1 (pt)
HU (1) HUP9904402A3 (pt)
IL (1) IL126797A (pt)
NO (1) NO312892B1 (pt)
NZ (1) NZ332722A (pt)
PL (1) PL188398B1 (pt)
SK (1) SK283956B6 (pt)
TR (1) TR199802290T2 (pt)
UA (1) UA66759C2 (pt)
WO (1) WO1997043235A1 (pt)
YU (1) YU51398A (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3942759B2 (ja) 1999-01-25 2007-07-11 興和株式会社 電子透かしの埋め込み方法,復号方法およびその装置
US20110275721A1 (en) * 2008-12-10 2011-11-10 Metaproteomics, Llc Method for the purification of substituted cyclopent-2-en-1-one congeners and substituted 1,3-cyclopentadione congeners from a complex mixture using countercurrent separation
BR112023026922A2 (pt) * 2021-06-28 2024-03-05 Firmenich Incorporated Sais policatiônicos de compostos fenólicos e usos dos mesmos
EP4556004A1 (en) 2023-11-17 2025-05-21 Centre National de la Recherche Scientifique Hop derived compounds for use in the treatment of diseases caused by coronaviruses

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU168744B (pt) * 1971-12-02 1976-07-28
JPS5515443A (en) 1978-07-19 1980-02-02 Kirin Brewery Co Ltd Antibacterial agent
JPS5581814A (en) 1978-12-15 1980-06-20 Kirin Brewery Co Ltd Antifungal agent
JPS56140943A (en) * 1980-04-07 1981-11-04 Takeda Chem Ind Ltd Preparation of organic compound
JPS59175448A (ja) * 1983-03-25 1984-10-04 Sanko Kaihatsu Kagaku Kenkyusho:Kk フエノ−ル系化合物
JPS60155111A (ja) * 1983-10-20 1985-08-15 Hisamitsu Pharmaceut Co Inc 安定なケトプロフェン含有外用経皮製剤
JPS6176433A (ja) * 1984-09-21 1986-04-18 Toyobo Co Ltd 新規なカルコン誘導体
JPS61176548A (ja) * 1985-01-31 1986-08-08 Nippon Zeon Co Ltd アルキル(ジヒドロキシフエニル)ケトンの製造法
JPS61180738A (ja) * 1985-02-06 1986-08-13 Nippon Zeon Co Ltd アルキル(ジヒドロキシフエニル)ケトンの製造法
JPS61293945A (ja) * 1985-06-05 1986-12-24 Sumitomo Chem Co Ltd ポリヒドロキシベンゾフェノンの製造方法
JPH0629182B2 (ja) 1986-12-20 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPH0629184B2 (ja) 1986-12-22 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPH0629185B2 (ja) 1986-12-22 1994-04-20 キツセイ薬品工業株式会社 骨粗鬆症治療剤
JPS63264543A (ja) * 1987-04-17 1988-11-01 Toyo Gosei Kogyo Kk ポリヒドロキシベンゾフエノン類の製造方法
JPH01242540A (ja) 1988-03-22 1989-09-27 Tsumura & Co 新規カルコン誘導体および該誘導体を有効成分とする抗潰瘍剤
DE3936592A1 (de) * 1989-11-03 1991-05-08 Basf Ag Verfahren zur herstellung und reinigung von 2-hydroxy-4-(2'-hydroxy-ethoxy)phenylarylketonen
JP2627349B2 (ja) 1989-11-13 1997-07-02 株式会社大塚製薬工場 3―アルキルフラボン誘導体及び5―リポキシゲナーゼ阻害剤
DE69227515T2 (de) 1991-07-15 1999-06-02 S.S. Steiner, Inc., New York, N.Y. Schaum stabilisierende agentien und bittermacher aus hopfen
JPH0625081A (ja) 1992-02-27 1994-02-01 Asahi Breweries Ltd 抗酸化作用を有するβ酸(ルプロン類)アシル誘導体
JPH06312924A (ja) * 1993-04-28 1994-11-08 Asahi Breweries Ltd 抗酸化作用を有するフムロン類の利用
JP3814309B2 (ja) * 1994-04-12 2006-08-30 リポプロテイン・テクノロジーズ・インコーポレイテッド 骨粗鬆症治療剤
JP3525267B2 (ja) 1994-07-19 2004-05-10 アサヒビール株式会社 抗酸化作用を有するマロフェノンの利用およびその製造方法
JPH0827057A (ja) 1994-07-19 1996-01-30 Asahi Breweries Ltd 抗酸化作用を有する新規物質およびその製造方法
FR2729387B1 (fr) * 1995-01-13 1997-03-21 Great Lakes Chemical France Procede pour la fabrication d'hydroxy-alcoxy-benzophenones
JPH08277241A (ja) * 1995-04-04 1996-10-22 Nippon Kayaku Co Ltd ヒドロキシフェニルベンジルケトン類の製造方法と結晶変態

Also Published As

Publication number Publication date
SK283956B6 (sk) 2004-06-08
JPH09301916A (ja) 1997-11-25
NZ332722A (en) 2001-07-27
PL188398B1 (pl) 2005-01-31
US6177474B1 (en) 2001-01-23
IL126797A0 (en) 1999-08-17
EA001172B1 (ru) 2000-10-30
NO312892B1 (no) 2002-07-15
CZ355498A3 (cs) 1999-04-14
TR199802290T2 (xx) 2001-09-21
DE69735008D1 (de) 2006-02-02
EP0994093A1 (en) 2000-04-19
PL329885A1 (en) 1999-04-12
WO1997043235A1 (en) 1997-11-20
NO985298D0 (no) 1998-11-13
CN1225082A (zh) 1999-08-04
CN1178889C (zh) 2004-12-08
AU737890B2 (en) 2001-09-06
SK153198A3 (en) 1999-06-11
IL126797A (en) 2004-06-20
AU2788797A (en) 1997-12-05
UA66759C2 (en) 2004-06-15
NO985298L (no) 1999-01-13
ATE314339T1 (de) 2006-01-15
YU51398A (sh) 2000-03-21
EP0994093B1 (en) 2005-12-28
HUP9904402A2 (hu) 2000-09-28
EP0994093A4 (en) 2000-05-17
HUP9904402A3 (en) 2002-07-29
CA2255589A1 (en) 1997-11-20
EA199801012A1 (ru) 1999-06-24

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DE INT.CL.8: C07C 49/713, C07C 49/743, C07C 49/747 ,C07C 49/825, C07C 49/835, C07C 49/84 , C07C 45/00, C07C 45/62, A61K 31/12, A61P 3/00, A61P 19/00, A61P 19/02, A61P 19/08, A61P 19/10

Ipc: C07C 49/713, C07C 49/743, C07C 49/747, C07C 49/825

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 36O DA LPI