|
DE69435044T2
(de)
|
1993-04-23 |
2008-09-18 |
Wyeth |
Rapamycin - Konjugate und Antikörper
|
|
US7279561B1
(en)
*
|
1993-04-23 |
2007-10-09 |
Wyeth |
Anti-rapamycin monoclonal antibodies
|
|
US6187757B1
(en)
*
|
1995-06-07 |
2001-02-13 |
Ariad Pharmaceuticals, Inc. |
Regulation of biological events using novel compounds
|
|
FR2736550B1
(fr)
|
1995-07-14 |
1998-07-24 |
Sandoz Sa |
Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
|
|
GB9606452D0
(en)
*
|
1996-03-27 |
1996-06-05 |
Sandoz Ltd |
Organic compounds
|
|
US6258823B1
(en)
*
|
1996-07-12 |
2001-07-10 |
Ariad Pharmaceuticals, Inc. |
Materials and method for treating or preventing pathogenic fungal infection
|
|
US20050031611A1
(en)
*
|
1998-05-08 |
2005-02-10 |
Beth Israel Deaconess Medical Center |
Transplant tolerance by costimulation blockade and T-cell activation-induced apoptosis
|
|
GB9826882D0
(en)
|
1998-12-07 |
1999-01-27 |
Novartis Ag |
Organic compounds
|
|
US8124630B2
(en)
|
1999-01-13 |
2012-02-28 |
Bayer Healthcare Llc |
ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
|
|
ES2377847T3
(es)
|
1999-01-13 |
2012-04-02 |
Bayer Healthcare Llc |
Difenil ureas sustituidas con omega-carboxi arilo como agentes inhibidores de la cinasa p38
|
|
US6955661B1
(en)
*
|
1999-01-25 |
2005-10-18 |
Atrium Medical Corporation |
Expandable fluoropolymer device for delivery of therapeutic agents and method of making
|
|
US6331547B1
(en)
|
1999-08-18 |
2001-12-18 |
American Home Products Corporation |
Water soluble SDZ RAD esters
|
|
EP1212331B1
(en)
|
1999-08-24 |
2004-04-21 |
Ariad Gene Therapeutics, Inc. |
28-epirapalogs
|
|
US7067526B1
(en)
|
1999-08-24 |
2006-06-27 |
Ariad Gene Therapeutics, Inc. |
28-epirapalogs
|
|
US7807211B2
(en)
|
1999-09-03 |
2010-10-05 |
Advanced Cardiovascular Systems, Inc. |
Thermal treatment of an implantable medical device
|
|
US6790228B2
(en)
|
1999-12-23 |
2004-09-14 |
Advanced Cardiovascular Systems, Inc. |
Coating for implantable devices and a method of forming the same
|
|
US20070032853A1
(en)
*
|
2002-03-27 |
2007-02-08 |
Hossainy Syed F |
40-O-(2-hydroxy)ethyl-rapamycin coated stent
|
|
US6277983B1
(en)
|
2000-09-27 |
2001-08-21 |
American Home Products Corporation |
Regioselective synthesis of rapamycin derivatives
|
|
US7300662B2
(en)
|
2000-05-12 |
2007-11-27 |
Cordis Corporation |
Drug/drug delivery systems for the prevention and treatment of vascular disease
|
|
US6670355B2
(en)
*
|
2000-06-16 |
2003-12-30 |
Wyeth |
Method of treating cardiovascular disease
|
|
US6399626B1
(en)
*
|
2000-10-02 |
2002-06-04 |
Wyeth |
Hydroxyesters of 7-desmethylrapamycin
|
|
US20040018228A1
(en)
*
|
2000-11-06 |
2004-01-29 |
Afmedica, Inc. |
Compositions and methods for reducing scar tissue formation
|
|
US6534693B2
(en)
|
2000-11-06 |
2003-03-18 |
Afmedica, Inc. |
Surgically implanted devices having reduced scar tissue formation
|
|
US20040241211A9
(en)
*
|
2000-11-06 |
2004-12-02 |
Fischell Robert E. |
Devices and methods for reducing scar tissue formation
|
|
HUP0303888A3
(en)
|
2000-11-28 |
2007-05-02 |
Wyeth Corp |
Expression analysis of fkbp nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer
|
|
US7754208B2
(en)
|
2001-01-17 |
2010-07-13 |
Trubion Pharmaceuticals, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
AU2005201004A1
(en)
*
|
2001-02-19 |
2005-03-24 |
Novartis Ag |
Cancer treatment
|
|
LT2269604T
(lt)
|
2001-02-19 |
2016-11-10 |
Novartis Ag |
Inkstų solidinių navikų gydymas rapamicino dariniu
|
|
AU2011226835C1
(en)
*
|
2001-02-19 |
2018-01-04 |
Novartis Ag |
Cancer treatment
|
|
AU2016206379B2
(en)
*
|
2001-02-19 |
2017-09-14 |
Novartis Ag |
Cancer Treatment
|
|
CA2449019A1
(en)
*
|
2001-05-29 |
2002-12-05 |
Guilford Pharmaceuticals Inc. |
Method for treating nerve injury caused by surgery
|
|
DK1285659T3
(da)
*
|
2001-08-13 |
2007-10-29 |
Fond Salvatore Maugeri Clinica |
Anvendelse af clarithromycin til fremstilling af et lægemiddel til behandlingen af arthritis deformans
|
|
US20030054042A1
(en)
*
|
2001-09-14 |
2003-03-20 |
Elaine Liversidge |
Stabilization of chemical compounds using nanoparticulate formulations
|
|
PL216224B1
(pl)
*
|
2002-02-01 |
2014-03-31 |
Ariad Pharmaceuticals |
Pochodne rapamycyny zawierające fosfor, kompozycja je zawierająca oraz ich zastosowanie
|
|
EP1478358B1
(en)
|
2002-02-11 |
2013-07-03 |
Bayer HealthCare LLC |
Sorafenib tosylate for the treatment of diseases characterized by abnormal angiogenesis
|
|
EP1340498A1
(en)
*
|
2002-03-01 |
2003-09-03 |
Schering Aktiengesellschaft |
Use of epothilones in the treatment of brain diseases associated with proliferative processes
|
|
MXPA04011384A
(es)
|
2002-05-16 |
2005-02-14 |
Novartis Ag |
Uso de agentes de union del receptor edg en cancer.
|
|
JP4265888B2
(ja)
*
|
2002-06-12 |
2009-05-20 |
株式会社リコー |
画像形成装置
|
|
US7300942B2
(en)
|
2002-07-16 |
2007-11-27 |
Biotica Technology Limited |
Production of polyketides and other natural products
|
|
JP4509028B2
(ja)
|
2002-09-24 |
2010-07-21 |
ノバルティス アーゲー |
有機化合物
|
|
AU2003293529A1
(en)
|
2002-12-16 |
2004-07-29 |
Nitromed, Inc. |
Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use
|
|
JP2006516548A
(ja)
|
2002-12-30 |
2006-07-06 |
アンジオテック インターナショナル アクツィエン ゲゼルシャフト |
迅速ゲル化ポリマー組成物からの薬物送達法
|
|
WO2004089369A2
(en)
*
|
2003-04-11 |
2004-10-21 |
Cambridge University Technical Services Limited |
Methods and means for treating protein conformational disorders
|
|
US7160867B2
(en)
|
2003-05-16 |
2007-01-09 |
Isotechnika, Inc. |
Rapamycin carbohydrate derivatives
|
|
ES2288694T3
(es)
|
2003-05-20 |
2008-01-16 |
Bayer Pharmaceuticals Corporation |
Diaril ureas para enfermedades mediadas por el receptor del factor de crecimiento derivado de plaquetas.
|
|
JP4351474B2
(ja)
*
|
2003-06-05 |
2009-10-28 |
住友金属工業株式会社 |
ゴルフクラブヘッドフェース用板材の製造方法およびゴルフクラブヘッド
|
|
JP4041774B2
(ja)
*
|
2003-06-05 |
2008-01-30 |
住友金属工業株式会社 |
β型チタン合金材の製造方法
|
|
US20050118344A1
(en)
|
2003-12-01 |
2005-06-02 |
Pacetti Stephen D. |
Temperature controlled crimping
|
|
AU2004261163A1
(en)
*
|
2003-07-25 |
2005-02-10 |
Wyeth |
CCI-779 lyophilized formulations
|
|
WO2005023254A1
(en)
*
|
2003-09-03 |
2005-03-17 |
Wyeth |
Amorphous rapamycin 42-ester with 3-hydroxy-2-(hydroxymethyl)-2-methylpropionic acid and its pharmaceutical compositions containing the same
|
|
US8021331B2
(en)
*
|
2003-09-15 |
2011-09-20 |
Atrium Medical Corporation |
Method of coating a folded medical device
|
|
CA2544731A1
(en)
*
|
2003-11-03 |
2005-05-12 |
Altachem Pharma Ltd. |
Rapamycin peptides conjugates: synthesis and uses thereof
|
|
US7220755B2
(en)
*
|
2003-11-12 |
2007-05-22 |
Biosensors International Group, Ltd. |
42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same
|
|
GB0327840D0
(en)
*
|
2003-12-01 |
2003-12-31 |
Novartis Ag |
Organic compounds
|
|
EP1768662A2
(en)
|
2004-06-24 |
2007-04-04 |
Novartis Vaccines and Diagnostics, Inc. |
Small molecule immunopotentiators and assays for their detection
|
|
GB0417852D0
(en)
|
2004-08-11 |
2004-09-15 |
Biotica Tech Ltd |
Production of polyketides and other natural products
|
|
EP1812022B1
(en)
|
2004-09-28 |
2014-01-15 |
Atrium Medical Corporation |
Stand-alone film and methods for making the same
|
|
US9012506B2
(en)
|
2004-09-28 |
2015-04-21 |
Atrium Medical Corporation |
Cross-linked fatty acid-based biomaterials
|
|
US9000040B2
(en)
|
2004-09-28 |
2015-04-07 |
Atrium Medical Corporation |
Cross-linked fatty acid-based biomaterials
|
|
US8021849B2
(en)
*
|
2004-11-05 |
2011-09-20 |
Siemens Healthcare Diagnostics Inc. |
Methods and kits for the determination of sirolimus in a sample
|
|
WO2006053754A1
(en)
*
|
2004-11-19 |
2006-05-26 |
Novartis Ag |
COMBINATIONS OF ANTI-ATHEROSCLEROTIC PEPTIDES AND AN mTOR INHIBITING AGENT AND THEIR METHODS OF USE
|
|
HN2005035605A
(es)
*
|
2004-12-20 |
2010-08-05 |
Wyeth Corp |
Analogos de rapamicina y los usos de los mismos en el tratamiento de trastornos neurologicos, proliferativos e inflamatorios
|
|
GB0504544D0
(en)
|
2005-03-04 |
2005-04-13 |
Novartis Ag |
Organic compounds
|
|
GB0504994D0
(en)
|
2005-03-11 |
2005-04-20 |
Biotica Tech Ltd |
Novel compounds
|
|
CA2599547A1
(en)
|
2005-03-11 |
2006-09-14 |
Biotica Technology Limited |
Medical uses of 39-desmethoxyrapamycin and analogues thereof
|
|
US7189582B2
(en)
*
|
2005-04-27 |
2007-03-13 |
Dade Behring Inc. |
Compositions and methods for detection of sirolimus
|
|
CA2608879A1
(en)
*
|
2005-05-31 |
2006-12-07 |
Novartis Ag |
Combination of hmg-coa reductase inhibitors amd mtor inhibitors
|
|
WO2007011708A2
(en)
|
2005-07-15 |
2007-01-25 |
Micell Technologies, Inc. |
Stent with polymer coating containing amorphous rapamycin
|
|
US8298565B2
(en)
|
2005-07-15 |
2012-10-30 |
Micell Technologies, Inc. |
Polymer coatings containing drug powder of controlled morphology
|
|
US20080200486A1
(en)
|
2005-07-20 |
2008-08-21 |
Heidi Lane |
Combination Of Organic Compounds
|
|
PT1912675E
(pt)
|
2005-07-25 |
2014-05-09 |
Emergent Product Dev Seattle |
Moléculas de ligaçao especificas para cd37 e especificas para cd20
|
|
CA2621083C
(en)
|
2005-08-30 |
2017-04-11 |
University Of Miami |
Immunomodulating tumor necrosis factor receptor 25 (tnfr25) agonists, antagonists and immunotoxins
|
|
US9278161B2
(en)
|
2005-09-28 |
2016-03-08 |
Atrium Medical Corporation |
Tissue-separating fatty acid adhesion barrier
|
|
US9427423B2
(en)
|
2009-03-10 |
2016-08-30 |
Atrium Medical Corporation |
Fatty-acid based particles
|
|
US20070134739A1
(en)
*
|
2005-12-12 |
2007-06-14 |
Gyros Patent Ab |
Microfluidic assays and microfluidic devices
|
|
GB0601406D0
(en)
*
|
2006-01-24 |
2006-03-08 |
Novartis Ag |
Organic Compounds
|
|
MX339116B
(es)
*
|
2006-02-02 |
2016-05-12 |
Novartis Ag |
Tratamiento de esclerosis tuberosa.
|
|
AU2007243268B2
(en)
|
2006-04-26 |
2013-06-13 |
Micell Technologies, Inc. |
Coatings containing multiple drugs
|
|
AU2007287809A1
(en)
*
|
2006-08-22 |
2008-02-28 |
Novartis Ag |
Rapamycin and its derivatives for the treatment of liver-associated fibrosing disorders
|
|
US8088789B2
(en)
|
2006-09-13 |
2012-01-03 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
|
US10695327B2
(en)
|
2006-09-13 |
2020-06-30 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
|
EP2431036B1
(en)
|
2006-09-13 |
2017-04-12 |
Elixir Medical Corporation |
Macrocyclic lactone compounds and methods for their use
|
|
WO2008065887A1
(en)
*
|
2006-11-27 |
2008-06-05 |
Terumo Kabushiki Kaisha |
Process for producing o-alkylated rapamycin derivative, and o-alkylated rapamycin derivative
|
|
US11426494B2
(en)
|
2007-01-08 |
2022-08-30 |
MT Acquisition Holdings LLC |
Stents having biodegradable layers
|
|
CN101711137B
(zh)
|
2007-01-08 |
2014-10-22 |
米歇尔技术公司 |
具有可生物降解层的支架
|
|
US7938286B2
(en)
*
|
2007-02-13 |
2011-05-10 |
Gateway Plastics, Inc. |
Container system
|
|
US8921642B2
(en)
|
2008-01-11 |
2014-12-30 |
Massachusetts Eye And Ear Infirmary |
Conditional-stop dimerizable caspase transgenic animals
|
|
US20100048524A1
(en)
|
2008-03-14 |
2010-02-25 |
Angela Brodie |
Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens;Synthesis In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
|
|
US20090253733A1
(en)
*
|
2008-04-02 |
2009-10-08 |
Biointeractions, Ltd. |
Rapamycin carbonate esters
|
|
NZ603059A
(en)
|
2008-04-11 |
2014-07-25 |
Emergent Product Dev Seattle |
Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
|
|
BRPI0910969B8
(pt)
|
2008-04-17 |
2021-06-22 |
Micell Technologies Inc |
dispositivo
|
|
MX2010014223A
(es)
|
2008-06-20 |
2011-01-21 |
Novartis Ag |
Composiciones pediatricas para el tratamiento de esclerosis multiple.
|
|
CA2730995C
(en)
|
2008-07-17 |
2016-11-22 |
Micell Technologies, Inc. |
Drug delivery medical device
|
|
EP2352459A4
(en)
*
|
2008-10-03 |
2013-09-25 |
Elixir Medical Corp |
MACROCYCLIC LACTONE COMPOUNDS AND METHODS OF USE
|
|
ES2645692T3
(es)
|
2008-11-11 |
2017-12-07 |
The Board Of Regents,The University Of Texas System |
Microcápsulas de rapamicina y su uso para el tratamiento del cáncer
|
|
DE102008060549A1
(de)
|
2008-12-04 |
2010-06-10 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Wirkstoff-Peptid-Konstrukt zur extrazellulären Anreicherung
|
|
AU2010210422A1
(en)
|
2009-02-05 |
2011-08-18 |
Tokai Pharmaceuticals, Inc. |
Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens
|
|
EP2413847A4
(en)
|
2009-04-01 |
2013-11-27 |
Micell Technologies Inc |
COATED STENTS
|
|
EP2419058B1
(en)
|
2009-04-17 |
2018-02-28 |
Micell Technologies, Inc. |
Stents having controlled elution
|
|
EP2453834A4
(en)
|
2009-07-16 |
2014-04-16 |
Micell Technologies Inc |
MEDICAL DEVICE DISPENSING MEDICINE
|
|
SG178125A1
(en)
|
2009-08-03 |
2012-03-29 |
Univ Miami |
Method for in vivo expansion of t regulatory cells
|
|
US20110038910A1
(en)
|
2009-08-11 |
2011-02-17 |
Atrium Medical Corporation |
Anti-infective antimicrobial-containing biomaterials
|
|
WO2015103447A1
(en)
|
2013-12-31 |
2015-07-09 |
Rapamycin Holdings, Llc |
Oral rapamycin nanoparticle preparations and use
|
|
US9283211B1
(en)
|
2009-11-11 |
2016-03-15 |
Rapamycin Holdings, Llc |
Oral rapamycin preparation and use for stomatitis
|
|
US20170079962A1
(en)
|
2009-11-11 |
2017-03-23 |
Rapamycin Holdings, Llc |
Oral Rapamycin Preparation and Use for Stomatitus
|
|
WO2011097103A1
(en)
|
2010-02-02 |
2011-08-11 |
Micell Technologies, Inc. |
Stent and stent delivery system with improved deliverability
|
|
ES2689177T3
(es)
|
2010-04-13 |
2018-11-08 |
Novartis Ag |
Combinación que comprende un inhibidor de cinasa 4 dependiente de ciclina o cinasa dependiente de ciclina (CDK4/6) y un inhibidor de mTOR para tratar cáncer
|
|
NZ602807A
(en)
|
2010-04-16 |
2014-02-28 |
Novartis Ag |
4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one and an mtor inhibitor
|
|
CA2797110C
(en)
|
2010-04-22 |
2020-07-21 |
Micell Technologies, Inc. |
Stents and other devices having extracellular matrix coating
|
|
MX342590B
(es)
|
2010-04-27 |
2016-10-05 |
Roche Glycart Ag |
Terapia de combinacion de un anticuerpo cd20 afucosilado con un inhibidor mtor.
|
|
CA2805631C
(en)
|
2010-07-16 |
2018-07-31 |
Micell Technologies, Inc. |
Drug delivery medical device
|
|
EP2593141B1
(en)
|
2010-07-16 |
2018-07-04 |
Atrium Medical Corporation |
Composition and methods for altering the rate of hydrolysis of cured oil-based materials
|
|
MX357939B
(es)
|
2011-02-18 |
2018-07-31 |
Novartis Pharma Ag |
Terapia de combinacion de inhibidor de objetivo de rapamicina en mamifero/janus cinasa (mtor/jak).
|
|
JP2014519813A
(ja)
|
2011-04-25 |
2014-08-21 |
オーエスアイ・ファーマシューティカルズ,エルエルシー |
癌薬剤発見、診断、および治療におけるemt遺伝子シグネチャーの使用
|
|
US20140066474A1
(en)
|
2011-04-25 |
2014-03-06 |
Novartis Ag |
Combination of phosphatidylinositol-3-kinase (pi3k) inhibitor and a mtor inhibitor
|
|
WO2013012689A1
(en)
|
2011-07-15 |
2013-01-24 |
Micell Technologies, Inc. |
Drug delivery medical device
|
|
US10188772B2
(en)
|
2011-10-18 |
2019-01-29 |
Micell Technologies, Inc. |
Drug delivery medical device
|
|
EP2589383A1
(en)
|
2011-11-06 |
2013-05-08 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Berlin |
FKBP subtype-specific rapamycin analogue for use in treatment of diseases
|
|
AU2012338869A1
(en)
|
2011-11-15 |
2014-06-05 |
Novartis Ag |
Combination of a phosphoinositide 3-kinase inhibitor and a modulator of the Janus Kinase 2-Signal Transducer and Activator of Transcription 5 pathway
|
|
GB201122305D0
(en)
|
2011-12-23 |
2012-02-01 |
Biotica Tech Ltd |
Novel compound
|
|
US9867880B2
(en)
|
2012-06-13 |
2018-01-16 |
Atrium Medical Corporation |
Cured oil-hydrogel biomaterial compositions for controlled drug delivery
|
|
WO2013192367A1
(en)
|
2012-06-22 |
2013-12-27 |
Novartis Ag |
Neuroendocrine tumor treatment
|
|
EP2869818A1
(en)
|
2012-07-06 |
2015-05-13 |
Novartis AG |
Combination of a phosphoinositide 3-kinase inhibitor and an inhibitor of the il-8/cxcr interaction
|
|
CA2926747A1
(en)
|
2012-10-12 |
2014-04-17 |
Arlan RICHARDSON |
Use of mtor inhibitors to treat vascular cognitive impairment
|
|
EP2919759A4
(en)
|
2012-11-14 |
2016-07-20 |
Ohio State Innovation Foundation |
MATERIALS AND METHODS FOR THE TREATMENT OF GLIOBLASTOMES
|
|
CA2897826C
(en)
|
2013-01-09 |
2022-09-27 |
Taylor H. Schreiber |
Compositions and methods for the regulation of t regulatory cells using tl1a-ig fusion protein
|
|
WO2014165264A1
(en)
|
2013-03-12 |
2014-10-09 |
Micell Technologies, Inc. |
Bioabsorbable biomedical implants
|
|
DK2968281T3
(da)
|
2013-03-13 |
2020-11-02 |
Univ Texas |
Mtor-hæmmere til forebyggelse af vækst af tarmpolyp
|
|
BR112015023098A2
(pt)
|
2013-03-14 |
2017-07-18 |
Univ Jefferson |
agentes de infrarregulação do receptor de andrógeno e usos dos mesmos
|
|
US10274503B2
(en)
|
2013-05-08 |
2019-04-30 |
Vegenics Pty Limited |
Methods of using VEGF-C biomarkers for age-related macular degeneration (AMD) diagnosis
|
|
JP2016519965A
(ja)
|
2013-05-15 |
2016-07-11 |
マイセル・テクノロジーズ,インコーポレイテッド |
生体吸収性バイオメディカルインプラント
|
|
CA2905229C
(en)
|
2013-06-11 |
2023-10-10 |
Clontech Laboratories, Inc. |
Protein enriched microvesicles and methods of making and using the same
|
|
EP3010926B1
(en)
*
|
2013-06-20 |
2019-11-20 |
Novartis AG |
Alkylation with an alkyl fluoroalkyl sulfonate
|
|
US9808472B2
(en)
|
2013-08-12 |
2017-11-07 |
Tokai Pharmaceuticals, Inc. |
Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
|
|
US9580758B2
(en)
|
2013-11-12 |
2017-02-28 |
Luc Montagnier |
System and method for the detection and treatment of infection by a microbial agent associated with HIV infection
|
|
JP2016537345A
(ja)
|
2013-11-13 |
2016-12-01 |
ノバルティス アーゲー |
免疫応答を増強するためのmTOR阻害剤
|
|
SG11201604815RA
(en)
|
2013-12-19 |
2016-07-28 |
Novartis Ag |
Human mesothelin chimeric antigen receptors and uses thereof
|
|
WO2015090229A1
(en)
|
2013-12-20 |
2015-06-25 |
Novartis Ag |
Regulatable chimeric antigen receptor
|
|
CN103739616B
(zh)
*
|
2013-12-27 |
2015-12-30 |
福建省微生物研究所 |
含噻唑基雷帕霉素类衍生物及其应用
|
|
US9700544B2
(en)
|
2013-12-31 |
2017-07-11 |
Neal K Vail |
Oral rapamycin nanoparticle preparations
|
|
RU2016135413A
(ru)
|
2014-02-11 |
2018-03-14 |
Новартис Аг |
Фармацевтические комбинации, включающие ингибитор pi3k, для лечения рака
|
|
WO2015142675A2
(en)
|
2014-03-15 |
2015-09-24 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor
|
|
US20170081411A1
(en)
|
2014-03-15 |
2017-03-23 |
Novartis Ag |
Regulatable chimeric antigen receptor
|
|
CA2943609A1
(en)
|
2014-03-27 |
2015-10-01 |
The Brigham And Women's Hospital, Inc. |
Metabolically-activated drug conjugates to overcome resistance in cancer therapy
|
|
SG11201606909RA
(en)
|
2014-04-07 |
2016-10-28 |
Novartis Ag |
Treatment of cancer using anti-cd19 chimeric antigen receptor
|
|
WO2015171723A1
(en)
|
2014-05-06 |
2015-11-12 |
Research Development Foundation |
Methods for treating insulin resistance and for sensitizing patients to glp1 agonist therapy
|
|
KR20170031668A
(ko)
|
2014-06-02 |
2017-03-21 |
칠드런'즈 메디컬 센터 코포레이션 |
면역 조절을 위한 방법 및 조성물
|
|
WO2016014530A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Combinations of low, immune enhancing. doses of mtor inhibitors and cars
|
|
US9777061B2
(en)
|
2014-07-21 |
2017-10-03 |
Novartis Ag |
Treatment of cancer using a CD33 chimeric antigen receptor
|
|
WO2016014553A1
(en)
|
2014-07-21 |
2016-01-28 |
Novartis Ag |
Sortase synthesized chimeric antigen receptors
|
|
EP4205749A1
(en)
|
2014-07-31 |
2023-07-05 |
Novartis AG |
Subset-optimized chimeric antigen receptor-containing cells
|
|
AU2015301460B2
(en)
|
2014-08-14 |
2021-04-08 |
Novartis Ag |
Treatment of cancer using GFR alpha-4 chimeric antigen receptor
|
|
WO2016028896A1
(en)
|
2014-08-19 |
2016-02-25 |
Novartis Ag |
Anti-cd123 chimeric antigen receptor (car) for use in cancer treatment
|
|
CN107073066B
(zh)
|
2014-09-11 |
2021-09-17 |
加利福尼亚大学董事会 |
mTORC1抑制剂
|
|
AU2015317608B2
(en)
|
2014-09-17 |
2021-03-11 |
Novartis Ag |
Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
|
|
IL279420B2
(en)
|
2014-10-08 |
2024-09-01 |
Novartis Ag |
Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof
|
|
WO2016066608A1
(en)
|
2014-10-28 |
2016-05-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for treatment of pulmonary cell senescence and peripheral aging
|
|
EP3280795B1
(en)
|
2015-04-07 |
2021-03-24 |
Novartis AG |
Combination of chimeric antigen receptor therapy and amino pyrimidine derivatives
|
|
CN118726268A
(zh)
|
2015-04-17 |
2024-10-01 |
诺华股份有限公司 |
改善嵌合抗原受体表达细胞的功效和扩增的方法
|
|
WO2016172583A1
(en)
|
2015-04-23 |
2016-10-27 |
Novartis Ag |
Treatment of cancer using chimeric antigen receptor and protein kinase a blocker
|
|
MX2017014776A
(es)
|
2015-05-20 |
2018-02-15 |
Novartis Ag |
Combinacion farmaceutica de everolimus con dactolisib.
|
|
JP2018537447A
(ja)
|
2015-11-11 |
2018-12-20 |
ノバルティス アーゲー |
ミオスタチンアンタゴニストの使用、それを含有する組合せ物およびその使用
|
|
CN109640959B
(zh)
|
2016-04-29 |
2023-03-17 |
西奈山伊坎医学院 |
靶向先天免疫系统以诱导长期耐受性及解决动脉粥样硬化中的巨噬细胞累积
|
|
CN116769050A
(zh)
|
2016-07-20 |
2023-09-19 |
犹他大学研究基金会 |
Cd229 car t细胞及其使用方法
|
|
WO2018067992A1
(en)
|
2016-10-07 |
2018-04-12 |
Novartis Ag |
Chimeric antigen receptors for the treatment of cancer
|
|
JP2020500930A
(ja)
|
2016-11-23 |
2020-01-16 |
ノバルティス アーゲー |
エベロリムス、ダクトリシブまたは両方で免疫応答を増強する方法
|
|
WO2018100190A1
(en)
|
2016-12-02 |
2018-06-07 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and compositions for diagnosing renal cell carcinoma
|
|
CN110366550A
(zh)
|
2016-12-22 |
2019-10-22 |
美国安进公司 |
作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物
|
|
SG11201908226XA
(en)
|
2017-02-10 |
2019-10-30 |
Mount Tam Therapeutics Inc |
Rapamycin analog
|
|
WO2018201056A1
(en)
|
2017-04-28 |
2018-11-01 |
Novartis Ag |
Cells expressing a bcma-targeting chimeric antigen receptor, and combination therapy with a gamma secretase inhibitor
|
|
ES2871499T3
(es)
|
2017-05-15 |
2021-10-29 |
Bard Inc C R |
Dispositivo médico con recubrimiento de elución de fármaco y capa intermedia
|
|
JOP20190272A1
(ar)
|
2017-05-22 |
2019-11-21 |
Amgen Inc |
مثبطات kras g12c وطرق لاستخدامها
|
|
EP3679040B1
(en)
|
2017-09-08 |
2022-08-03 |
Amgen Inc. |
Inhibitors of kras g12c and methods of using the same
|
|
UY37900A
(es)
*
|
2017-09-26 |
2019-04-30 |
Novartis Ag |
Nuevos derivados de rapamicina
|
|
US10596165B2
(en)
|
2018-02-12 |
2020-03-24 |
resTORbio, Inc. |
Combination therapies
|
|
EP3784351A1
(en)
|
2018-04-27 |
2021-03-03 |
Novartis AG |
Car t cell therapies with enhanced efficacy
|
|
EP3788050B1
(en)
|
2018-05-01 |
2024-08-28 |
Revolution Medicines, Inc. |
C26-linked rapamycin analogs as mtor inhibitors
|
|
CR20240382A
(es)
|
2018-05-01 |
2025-08-29 |
Revolution Medicines Inc |
ANÁLOGOS DE RAPAMICINA A C40, C28 Y C32 COMO INHIBIDORES DE MTOR (Divisional 2020-578)
|
|
EP3788369A1
(en)
|
2018-05-01 |
2021-03-10 |
Novartis Ag |
Biomarkers for evaluating car-t cells to predict clinical outcome
|
|
US11090304B2
(en)
|
2018-05-04 |
2021-08-17 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
MA52496A
(fr)
|
2018-05-04 |
2021-03-10 |
Amgen Inc |
Inhibiteurs de kras g12c et leurs procédés d'utilisation
|
|
WO2019217691A1
(en)
|
2018-05-10 |
2019-11-14 |
Amgen Inc. |
Kras g12c inhibitors for the treatment of cancer
|
|
US11096939B2
(en)
|
2018-06-01 |
2021-08-24 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
JP7357644B2
(ja)
|
2018-06-11 |
2023-10-06 |
アムジエン・インコーポレーテツド |
がんを処置するためのkras g12c阻害剤
|
|
EP3807276B1
(en)
|
2018-06-12 |
2025-12-10 |
Amgen Inc. |
Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer
|
|
EP4302827A3
(en)
|
2018-06-15 |
2024-03-13 |
JANSSEN Pharmaceutica NV |
Rapamycin analogs and uses thereof
|
|
WO2020101675A1
(en)
|
2018-11-14 |
2020-05-22 |
Lutonix, Inc. |
Medical device with drug-eluting coating on modified device surface
|
|
JP7516029B2
(ja)
|
2018-11-16 |
2024-07-16 |
アムジエン・インコーポレーテツド |
Kras g12c阻害剤化合物の重要な中間体の改良合成法
|
|
JP7377679B2
(ja)
|
2018-11-19 |
2023-11-10 |
アムジエン・インコーポレーテツド |
がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法
|
|
AU2019384118B2
(en)
|
2018-11-19 |
2025-06-12 |
Amgen Inc. |
KRAS G12C inhibitors and methods of using the same
|
|
AU2019409366B2
(en)
|
2018-12-18 |
2022-10-27 |
Novartis Ag |
Rapamycin derivatives
|
|
EP3898616B1
(en)
|
2018-12-20 |
2024-10-02 |
Amgen Inc. |
Heteroaryl amides useful as kif18a inhibitors
|
|
US12459932B2
(en)
|
2018-12-20 |
2025-11-04 |
Amgen Inc. |
KIF18A inhibitors
|
|
IL283639B2
(en)
|
2018-12-20 |
2024-06-01 |
Amgen Inc |
Kif18a inhibitors
|
|
ES2997190T3
(en)
|
2018-12-20 |
2025-02-14 |
Amgen Inc |
Heteroaryl amides useful as kif18a inhibitors
|
|
AU2020232616A1
(en)
|
2019-03-01 |
2021-09-09 |
Revolution Medicines, Inc. |
Bicyclic heterocyclyl compounds and uses thereof
|
|
WO2020180768A1
(en)
|
2019-03-01 |
2020-09-10 |
Revolution Medicines, Inc. |
Bicyclic heteroaryl compounds and uses thereof
|
|
WO2020209828A1
(en)
|
2019-04-08 |
2020-10-15 |
Bard Peripheral Vascular, Inc. |
Medical device with drug-eluting coating on modified device surface
|
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
|
JP7092935B2
(ja)
|
2019-05-21 |
2022-06-28 |
アムジエン・インコーポレーテツド |
固体形態
|
|
JP2021008453A
(ja)
|
2019-07-02 |
2021-01-28 |
エフェクター・セラピューティクス,インコーポレーテッド |
翻訳阻害剤およびその使用
|
|
CA3147276A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
CA3147451A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
CA3146693A1
(en)
|
2019-08-02 |
2021-02-11 |
Amgen Inc. |
Kif18a inhibitors
|
|
EP4007753B1
(en)
|
2019-08-02 |
2025-09-24 |
Amgen Inc. |
Kif18a inhibitors
|
|
KR20220054347A
(ko)
|
2019-08-26 |
2022-05-02 |
아비나스 오퍼레이션스, 인코포레이티드 |
에스트로겐 수용체 분해제로서의 테트라히드로나프탈렌 유도체로 유방암을 치료하는 방법
|
|
WO2021055728A1
(en)
|
2019-09-18 |
2021-03-25 |
Merck Sharp & Dohme Corp. |
Small molecule inhibitors of kras g12c mutant
|
|
TW202126323A
(zh)
*
|
2019-10-01 |
2021-07-16 |
約翰斯赫普金斯大學 |
雷帕弗辛(Rapafucin)衍生化合物及其使用方法
|
|
AU2020369569A1
(en)
|
2019-10-24 |
2022-04-14 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as KRAS G12C and KRAS G12D inhibitors in the treatment of cancer
|
|
CA3158793A1
(en)
|
2019-10-28 |
2021-05-06 |
Merck Sharp & Dohme Corp. |
Small molecule inhibitors of kras g12c mutant
|
|
CN115551500A
(zh)
|
2019-10-31 |
2022-12-30 |
大鹏药品工业株式会社 |
4-氨基丁-2-烯酰胺衍生物及其盐
|
|
US11608346B2
(en)
|
2019-11-04 |
2023-03-21 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
IL320513A
(en)
|
2019-11-04 |
2025-06-01 |
Revolution Medicines Inc |
RAS inhibitors
|
|
CR20220240A
(es)
|
2019-11-04 |
2022-08-03 |
Revolution Medicines Inc |
Inhibidores de ras
|
|
CN114901662A
(zh)
|
2019-11-08 |
2022-08-12 |
锐新医药公司 |
双环杂芳基化合物及其用途
|
|
BR112022009390A2
(pt)
|
2019-11-14 |
2022-08-09 |
Amgen Inc |
Síntese melhorada de composto inibidor de kras g12c
|
|
TW202132271A
(zh)
|
2019-11-14 |
2021-09-01 |
美商安進公司 |
Kras g12c抑制劑化合物之改善的合成
|
|
CN114980976A
(zh)
|
2019-11-27 |
2022-08-30 |
锐新医药公司 |
共价ras抑制剂及其用途
|
|
WO2021106231A1
(en)
|
2019-11-29 |
2021-06-03 |
Taiho Pharmaceutical Co., Ltd. |
A compound having inhibitory activity against kras g12d mutation
|
|
MX2022006807A
(es)
|
2019-12-05 |
2022-09-12 |
Anakuria Therapeutics Inc |
Análogos de rapamicina y usos de estos.
|
|
EP4073102A4
(en)
|
2019-12-12 |
2024-05-08 |
Ting Therapeutics LLC |
Compositions and methods for the prevention and treatment of hearing loss
|
|
WO2021142026A1
(en)
|
2020-01-07 |
2021-07-15 |
Revolution Medicines, Inc. |
Shp2 inhibitor dosing and methods of treating cancer
|
|
EP4139299B1
(en)
|
2020-04-24 |
2025-12-17 |
Taiho Pharmaceutical Co., Ltd. |
Kras g12d protein inhibitors
|
|
US20230181536A1
(en)
|
2020-04-24 |
2023-06-15 |
Taiho Pharmaceutical Co., Ltd. |
Anticancer combination therapy with n-(1-acryloyl-azetidin-3-yl)-2-((1h-indazol-3-yl)amino)methyl)-1h-imidazole-5-carboxamide inhibitor of kras-g12c
|
|
KR20230031926A
(ko)
|
2020-07-15 |
2023-03-07 |
다이호야쿠힌고교 가부시키가이샤 |
종양의 치료에 사용되는 피리미딘 화합물을 포함하는 조합
|
|
CA3187757A1
(en)
|
2020-09-03 |
2022-03-24 |
Ethan AHLER |
Use of sos1 inhibitors to treat malignancies with shp2 mutations
|
|
US11690915B2
(en)
|
2020-09-15 |
2023-07-04 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
US20240051956A1
(en)
|
2020-12-22 |
2024-02-15 |
Qilu Regor Therapeutics Inc. |
Sos1 inhibitors and uses thereof
|
|
KR20230171435A
(ko)
|
2021-03-19 |
2023-12-20 |
트레인드 테라퓨틱스 디스커버리, 아이엔씨. |
훈련된 면역을 조절하기 위한 화합물 및 이의 사용 방법
|
|
CN118561952A
(zh)
|
2021-05-05 |
2024-08-30 |
锐新医药公司 |
Ras抑制剂
|
|
CN117500811A
(zh)
|
2021-05-05 |
2024-02-02 |
锐新医药公司 |
共价ras抑制剂及其用途
|
|
CR20230558A
(es)
|
2021-05-05 |
2024-01-24 |
Revolution Medicines Inc |
Inhibidores de ras para el tratamiento del cáncer
|
|
EP4347041A1
(en)
|
2021-05-28 |
2024-04-10 |
Taiho Pharmaceutical Co., Ltd. |
Small molecule inhibitors of kras mutated proteins
|
|
JP2024529341A
(ja)
|
2021-07-15 |
2024-08-06 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
粒子が付着している細胞に関連する組成物および方法
|
|
AR127308A1
(es)
|
2021-10-08 |
2024-01-10 |
Revolution Medicines Inc |
Inhibidores ras
|
|
WO2023064058A1
(en)
|
2021-10-12 |
2023-04-20 |
Peloton Therapeutics Inc. |
Tricyclic sultams and sulfamides as antitumor agents
|
|
US20250282782A1
(en)
|
2021-12-17 |
2025-09-11 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
EP4227307A1
(en)
|
2022-02-11 |
2023-08-16 |
Genzyme Corporation |
Pyrazolopyrazine compounds as shp2 inhibitors
|
|
AU2023230882A1
(en)
|
2022-03-07 |
2024-08-22 |
Amgen Inc. |
A process for preparing 4-methyl-2-propan-2-yl-pyridine-3-carbonitrile.
|
|
CN119136806A
(zh)
|
2022-03-08 |
2024-12-13 |
锐新医药公司 |
用于治疗免疫难治性肺癌的方法
|
|
AU2023275778A1
(en)
|
2022-05-25 |
2024-12-12 |
Revolution Medicines, Inc. |
Methods of treating cancer with an mtor inhibitor
|
|
EP4536364A1
(en)
|
2022-06-10 |
2025-04-16 |
Revolution Medicines, Inc. |
Macrocyclic ras inhibitors
|
|
EP4601644A1
(en)
|
2022-10-14 |
2025-08-20 |
Black Diamond Therapeutics, Inc. |
Methods of treating cancers using isoquinoline or 6-aza-quinoline derivatives
|
|
WO2024167904A1
(en)
|
2023-02-07 |
2024-08-15 |
Arvinas Operations, Inc. |
Dosage regimens of estrogen receptor degraders in combination with an mtor inhibitor
|
|
CR20250458A
(es)
|
2023-03-30 |
2025-11-21 |
Revolution Medicines Inc |
Composiciones para inducir la hidrólisis de ras gtp y sus usos
|
|
US20240360153A1
(en)
|
2023-04-07 |
2024-10-31 |
Regeneron Pharmaceuticals, Inc. |
Selective rapamycin analogs and uses thereof
|
|
KR20260005904A
(ko)
|
2023-04-07 |
2026-01-12 |
레볼루션 메디슨즈, 인크. |
매크로사이클릭 ras 억제제
|
|
WO2024211712A1
(en)
|
2023-04-07 |
2024-10-10 |
Revolution Medicines, Inc. |
Condensed macrocyclic compounds as ras inhibitors
|
|
AU2024252105A1
(en)
|
2023-04-14 |
2025-10-16 |
Revolution Medicines, Inc. |
Crystalline forms of ras inhibitors, compositions containing the same, and methods of use thereof
|
|
AU2024251341A1
(en)
|
2023-04-14 |
2025-10-16 |
Revolution Medicines, Inc. |
Crystalline forms of a ras inhibitor
|
|
AU2024265078A1
(en)
|
2023-05-04 |
2025-12-11 |
Revolution Medicines, Inc. |
Combination therapy for a ras related disease or disorder
|
|
US20250049810A1
(en)
|
2023-08-07 |
2025-02-13 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
TW202515582A
(zh)
|
2023-08-24 |
2025-04-16 |
日商大塚製藥股份有限公司 |
西區嘧啶(cedazuridine)之固定劑量組合
|
|
US20250154171A1
(en)
|
2023-10-12 |
2025-05-15 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
US12466840B2
(en)
|
2023-10-20 |
2025-11-11 |
Merck Sharp & Dohme Llc |
Small molecule inhibitors of KRAS proteins
|
|
WO2025137507A1
(en)
|
2023-12-22 |
2025-06-26 |
Regor Pharmaceuticals, Inc. |
Sos1 inhibitors and uses thereof
|
|
WO2025171296A1
(en)
|
2024-02-09 |
2025-08-14 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025240847A1
(en)
|
2024-05-17 |
2025-11-20 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2025255438A1
(en)
|
2024-06-07 |
2025-12-11 |
Revolution Medicines, Inc. |
Methods of treating a ras protein-related disease or disorder
|
|
WO2025265060A1
(en)
|
2024-06-21 |
2025-12-26 |
Revolution Medicines, Inc. |
Therapeutic compositions and methods for managing treatment-related effects
|
|
WO2026006747A1
(en)
|
2024-06-28 |
2026-01-02 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
WO2026015825A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Use of ras inhibitor for treating pancreatic cancer
|
|
WO2026015796A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015801A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|
|
WO2026015790A1
(en)
|
2024-07-12 |
2026-01-15 |
Revolution Medicines, Inc. |
Methods of treating a ras related disease or disorder
|