BG108830A - Метод за получаване на 4' - трифлуорометилбифенил-2-карбоксамидо-(1,2,3,4-тетрахидроизохинолин-6-ил) и негови соли - Google Patents
Метод за получаване на 4' - трифлуорометилбифенил-2-карбоксамидо-(1,2,3,4-тетрахидроизохинолин-6-ил) и негови соли Download PDFInfo
- Publication number
- BG108830A BG108830A BG108830A BG10883099A BG108830A BG 108830 A BG108830 A BG 108830A BG 108830 A BG108830 A BG 108830A BG 10883099 A BG10883099 A BG 10883099A BG 108830 A BG108830 A BG 108830A
- Authority
- BG
- Bulgaria
- Prior art keywords
- give
- compound
- added
- structural formula
- mmol
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title claims abstract 6
- -1 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXAMIDO-(1,2,3,4-TETRAHYDROISOQUINOLINE-6-YL) Chemical class 0.000 title claims abstract 4
- 238000000034 method Methods 0.000 title claims abstract 4
- 150000001408 amides Chemical class 0.000 claims abstract 8
- 239000002253 acid Substances 0.000 claims abstract 5
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 claims 2
- 239000012458 free base Substances 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 1
- 238000010511 deprotection reaction Methods 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical class C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000013067 intermediate product Substances 0.000 abstract 1
- 210000001589 microsome Anatomy 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3230796P | 1996-11-27 | 1996-11-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG108830A true BG108830A (bg) | 2005-10-31 |
Family
ID=21864233
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103434A BG103434A (en) | 1996-11-27 | 1999-05-26 | Apo b-secretion/mtp inhibiting amides |
| BG108830A BG108830A (bg) | 1996-11-27 | 1999-05-26 | Метод за получаване на 4' - трифлуорометилбифенил-2-карбоксамидо-(1,2,3,4-тетрахидроизохинолин-6-ил) и негови соли |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103434A BG103434A (en) | 1996-11-27 | 1999-05-26 | Apo b-secretion/mtp inhibiting amides |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US6121283A (is) |
| EP (1) | EP0944602A1 (is) |
| JP (1) | JP3270764B2 (is) |
| KR (1) | KR100334567B1 (is) |
| CN (2) | CN1238764A (is) |
| AP (1) | AP804A (is) |
| AR (1) | AR010309A1 (is) |
| AU (1) | AU716151B2 (is) |
| BG (2) | BG103434A (is) |
| BR (1) | BR9714364A (is) |
| CA (1) | CA2272719C (is) |
| CZ (1) | CZ292160B6 (is) |
| DZ (1) | DZ2358A1 (is) |
| EA (1) | EA001539B1 (is) |
| GT (1) | GT199700122A (is) |
| HN (1) | HN1997000144A (is) |
| HR (1) | HRP970642A2 (is) |
| ID (1) | ID18995A (is) |
| IL (1) | IL129744A0 (is) |
| IS (1) | IS5040A (is) |
| MA (1) | MA26451A1 (is) |
| NO (1) | NO312760B1 (is) |
| NZ (1) | NZ335162A (is) |
| OA (1) | OA11050A (is) |
| PA (1) | PA8441601A1 (is) |
| PE (1) | PE17199A1 (is) |
| SK (1) | SK65499A3 (is) |
| TN (1) | TNSN97193A1 (is) |
| TR (1) | TR199901180T2 (is) |
| TW (1) | TW502023B (is) |
| UY (1) | UY24789A1 (is) |
| WO (1) | WO1998023593A1 (is) |
| YU (1) | YU23499A (is) |
| ZA (1) | ZA9710641B (is) |
Families Citing this family (98)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| MX9709914A (es) * | 1995-06-07 | 1998-03-31 | Pfizer | Derivados de acido bifenil-2-carboxilico-tetrahidro-isoquinolin-6-ilo, su preparacion y el uso de los mismos. |
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| US5968950A (en) * | 1997-06-23 | 1999-10-19 | Pfizer Inc | Apo B-secretion/MTP inhibitor hydrochloride salt |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| AU4543899A (en) | 1998-06-08 | 1999-12-30 | Advanced Medicine, Inc. | Multibinding inhibitors of microsomal triglyceride transferase protein |
| PL347237A1 (en) | 1998-10-08 | 2002-03-25 | Smithkline Beecham Plc | Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors (antipsychotic agents) |
| GB9826412D0 (en) | 1998-12-03 | 1999-01-27 | Glaxo Group Ltd | Chemical compounds |
| EP1354604A1 (en) * | 1998-12-23 | 2003-10-22 | G.D. Searle LLC. | Combinations for cardiovascular indications |
| DE69908643T2 (de) | 1998-12-23 | 2004-05-13 | G.D. Searle Llc, Chicago | Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen |
| EA005815B1 (ru) * | 1998-12-23 | 2005-06-30 | Джи.Ди.Сирл Ллс | Комбинация ингибиторов транспорта желчных кислот в подвздошной кишке и ингибиторов белка, переносящего эфиры холестерина, для сердечно-сосудистых показаний |
| DE19929012A1 (de) * | 1999-06-25 | 2000-12-28 | Bayer Ag | Kombination von MTP-Inhibitoren und stoffwechselbeeinflussenden Wirkstoffen und ihre Verwendung in Arzneimitteln |
| DE19929031A1 (de) * | 1999-06-25 | 2000-12-28 | Bayer Ag | Kombination von MTP-Inhibitoren und Lipidsenkern und ihre Verwendung in Arzneimitteln |
| DE19929065A1 (de) * | 1999-06-25 | 2000-12-28 | Bayer Ag | Kombination von MTP-Inhibitoren und HMG-CoA-Reduktase-Inhibitoren und ihre Verwendung in Arzneimitteln |
| WO2001005767A1 (en) * | 1999-07-20 | 2001-01-25 | Novartis Ag | Organic compounds |
| CA2324800A1 (en) * | 1999-11-10 | 2001-05-10 | Mary Anne Hickman | Use of apo b secretion/mtp inhibitors |
| IL139450A0 (en) * | 1999-11-10 | 2001-11-25 | Pfizer Prod Inc | Methods of administering apo b-secretion/mtp inhibitors |
| CA2324801A1 (en) * | 1999-11-10 | 2001-05-10 | Andrew Gordon Swick | Use of apo b secretion/mtp inhibitors and anti-obesity agents |
| CO5271688A1 (es) * | 1999-11-10 | 2003-04-30 | Pfizer Prod Inc | Uso de inhibidor de secrecion de apoliproteinas b y/o de proteina de transferencia de trigliceridos microsmales |
| ATE295836T1 (de) * | 2000-01-18 | 2005-06-15 | Novartis Pharma Gmbh | Carboxamide und ihre verwendung als inhibitoren des mikrosomalen triglycerid-transfer-proteins und der apolipoprotein b (apo b) sekretion |
| ATE286500T1 (de) * | 2000-03-14 | 2005-01-15 | Actelion Pharmaceuticals Ltd | 1,2,3,4-tetrahydroisochinolin-derivate |
| AU2001262185A1 (en) * | 2000-04-10 | 2001-10-23 | Novartis Ag | Substituted (hetero)aryl carboxamide derivatives as microsomal triglyceride transfer protein (mtp) and apolipoprotein b (apo b) secretion |
| GB0013383D0 (en) * | 2000-06-01 | 2000-07-26 | Glaxo Group Ltd | Therapeutic benzamide derivatives |
| GB0013346D0 (en) * | 2000-06-01 | 2000-07-26 | Glaxo Group Ltd | Therapeutic benzamide derivatives |
| WO2002014277A1 (en) * | 2000-08-10 | 2002-02-21 | Tanabe Seiyaku Co., Ltd. | Biphenylcarboxamidoisoindoline compounds, processes for the preparation of the same and intermediates for the synthesis thereof |
| AU2001277727A1 (en) * | 2000-08-10 | 2002-02-25 | Tanabe Seiyaku Co., Ltd. | Benzoylaminoisoindoline compounds, processes for the preparation of the same andintermediates for the synthesis thereof |
| PL362244A1 (en) * | 2000-09-01 | 2004-10-18 | Sankyo Company, Limited | Medicinal compositions |
| JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
| CA2425097A1 (en) * | 2000-10-05 | 2002-04-11 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide compounds as apo b secretion inhibitors |
| JO2409B1 (en) | 2000-11-21 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Second-phenyl carboxy amides are useful as lipid-lowering agents |
| WO2002090347A1 (en) * | 2001-04-30 | 2002-11-14 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds |
| CA2450957A1 (en) * | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Pharmaceutical compositions of dispersions of drugs and neutral polymers |
| HU229551B1 (hu) * | 2001-06-28 | 2014-01-28 | Zoetis P Llc | Mikroszóma triglicerid transzfer protein (MTP) és/vagy apolipoprotein B(APO B) kiválasztás inhibitorokként alkalmazható triamiddal helyettesített indol-, benzofurán- és benzotiofén-származékok |
| US20030144350A1 (en) * | 2001-07-20 | 2003-07-31 | Adipogenix, Inc. | Fat accumulation-modulation compounds |
| WO2003013516A1 (en) * | 2001-08-10 | 2003-02-20 | Adipogenix, Inc. | Fat accumulation-modulating compounds |
| JP2005510564A (ja) * | 2001-11-28 | 2005-04-21 | 藤沢薬品工業株式会社 | アポリポタンパク質ｂ阻害剤としての複素環式アミド化合物 |
| JP2005521653A (ja) | 2002-01-17 | 2005-07-21 | ファルマシア コーポレイション | 先端ナトリウム同時依存性胆汁酸輸送（ａｓｂｔ）およびタウロコール酸塩取込みの阻害剤としての新規アルキル／アリールヒドロキシまたはケトチエピン化合物 |
| EP1469833B1 (en) | 2002-02-01 | 2021-05-19 | Bend Research, Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus |
| NZ531890A (en) * | 2002-02-28 | 2006-02-24 | Japan Tobacco Inc | Ester compound and medicinal use thereof |
| NZ535366A (en) * | 2002-03-13 | 2007-07-27 | Univ Tennessee Res Foundation | Substituted tetrahydroisoquinoline compounds, methods of making, and their use |
| WO2004039795A2 (en) * | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds for the treatment of hyperlipidemia |
| MXPA05006679A (es) * | 2002-12-20 | 2005-08-16 | Pfizer Prod Inc | Inhibidores de la proteina de transferencia de trigliceridos microsomales. |
| JP2006514032A (ja) * | 2002-12-20 | 2006-04-27 | ファイザー・プロダクツ・インク | ミクロソームトリグリセリド転送タンパク質阻害剤 |
| US7276536B2 (en) | 2003-03-17 | 2007-10-02 | Japan Tobacco Inc. | Method for increasing the bioavailability of the active form of S-[2-([[1-(2-ethylbutyl)cyclohexyl]carbonyl]amino) phenyl] 2-methylpropanethioate |
| JP4832897B2 (ja) | 2003-08-29 | 2011-12-07 | 日本たばこ産業株式会社 | エステル誘導体及びその医薬用途 |
| RU2378257C2 (ru) | 2004-03-01 | 2010-01-10 | Актелион Фармасьютиклз Лтд | Замещенные производные 1,2,3,4-тетрагидроизохинолина |
| CA2910191C (en) | 2004-03-05 | 2022-03-08 | The Trustees Of The Univeristy Of Pennsylvania | The use of mtp inhibitors for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects |
| US7262318B2 (en) * | 2004-03-10 | 2007-08-28 | Pfizer, Inc. | Substituted heteroaryl- and phenylsulfamoyl compounds |
| US20050288340A1 (en) * | 2004-06-29 | 2005-12-29 | Pfizer Inc | Substituted heteroaryl- and phenylsulfamoyl compounds |
| US20060030623A1 (en) * | 2004-07-16 | 2006-02-09 | Noboru Furukawa | Agent for the treatment or prevention of diabetes, obesity or arteriosclerosis |
| US8101774B2 (en) | 2004-10-18 | 2012-01-24 | Japan Tobacco Inc. | Ester derivatives and medicinal use thereof |
| AU2005297923B2 (en) * | 2004-10-25 | 2010-12-23 | Japan Tobacco Inc. | Solid medicinal preparation improved in solubility and stability and process for producing the same |
| WO2006050999A2 (en) * | 2004-11-15 | 2006-05-18 | Obe Therapy Biotechnology S.A.S | Methods of reducing body fat |
| CA2590533C (en) | 2004-11-23 | 2010-09-07 | Warner-Lambert Company Llc | 7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia |
| JP2006249022A (ja) | 2005-03-11 | 2006-09-21 | Sumitomo Chemical Co Ltd | ４−（２−メチルフェニル）ベンゾトリフルオライドの製造方法 |
| CA2605510C (en) | 2005-04-19 | 2013-12-24 | Surface Logix, Inc. | Inhibitors of microsomal triglyceride transfer protein and apo-b secretion |
| JP2008542255A (ja) * | 2005-05-27 | 2008-11-27 | ファイザー・プロダクツ・インク | 肥満症の治療または体重減量の維持のためのカンナビノイド−１受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用 |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US8383660B2 (en) | 2006-03-10 | 2013-02-26 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| KR20080109841A (ko) * | 2006-03-10 | 2008-12-17 | 뉴로젠 코포레이션 | 피페라지닐 옥소알킬 테트라히드로이소퀴놀린 및 관련유사체 |
| US7919506B2 (en) | 2006-03-10 | 2011-04-05 | Pfizer Inc. | Dibenzyl amine compounds and derivatives |
| SG10201406016SA (en) * | 2006-04-03 | 2014-11-27 | Stella Aps | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| CA3024953A1 (en) | 2006-04-03 | 2007-10-11 | Roche Innovation Center Copenhagen A/S | Pharmaceutical composition comprising anti-mirna antisense oligonucleotides |
| US20090042835A1 (en) * | 2006-06-02 | 2009-02-12 | Davis Roger A | Compositions and methods for ameliorating hyperlipidemia |
| AU2007254827A1 (en) * | 2006-06-02 | 2007-12-13 | San Diego State University Research Foundation | Compositions and methods for ameliorating hyperlipidemia |
| AU2007306361A1 (en) * | 2006-10-09 | 2008-04-17 | Santaris Pharma A/S | RNA antagonist compounds for the modulation of PCSK9 |
| CL2007002958A1 (es) * | 2006-10-12 | 2008-05-09 | Epix Delaware Inc | Compuestos derivados de heteroaril-carboxamida, antagonistas del receptor de quimioquina; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades tales como rechazo de transplante de organos, artritis reumatoidea, lupus, entr |
| JO2653B1 (en) | 2006-10-24 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Tetrahydroflavin 1-carboxylic acid substituted with pyridine or pyrazine inhibit MTB |
| ATE469122T1 (de) * | 2006-10-24 | 2010-06-15 | Janssen Pharmaceutica Nv | Mtp-inhibierende tetrahydronaphthalin-1- carbonsäurederivate |
| ATE547394T1 (de) | 2006-12-01 | 2012-03-15 | Bristol Myers Squibb Co | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen |
| WO2008075949A1 (en) * | 2006-12-20 | 2008-06-26 | Friesland Brands B.V. | Modulation of human microsomal triglyceride transfer protein (mtp or mttp) gene expression by food-grade/ingested dietary microorganisms |
| WO2008079398A1 (en) * | 2006-12-21 | 2008-07-03 | Aegerion Pharmaceuticals, Inc. | Methods for treating obesity with a combination comprising a mtp inhibitor and a cholesterol absorption inhibitor |
| WO2008113832A2 (en) * | 2007-03-22 | 2008-09-25 | Santaris Pharma A/S | SHORT RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF TARGET mRNA |
| CA2681406A1 (en) * | 2007-03-22 | 2008-09-25 | Santaris Pharma A/S | Rna antagonist compounds for the inhibition of apo-b100 expression |
| KR20100040872A (ko) * | 2007-06-25 | 2010-04-21 | 뉴로젠 코포레이션 | 피페라지닐 옥소알킬 테트라하이드로-베타-카르볼린 및 이의 관련 유사체 |
| WO2009027527A2 (en) * | 2007-08-30 | 2009-03-05 | Santaris Pharma A/S | Rna antagonist compounds for the modulation of fabp4/ap2 |
| CA2701547C (en) * | 2007-10-04 | 2020-03-10 | Santaris Pharma A/S | Oligonucleotides which target and inhibit micrornas |
| ES2575131T3 (es) | 2007-12-03 | 2016-06-24 | Obe Therapy Biotechnology | Inhibidores boropéptidos de enteropeptidasa y sus usos en tratamientos de obesidad, sobrepeso y/o enfermedades asociadas con un metabolismo anormal de la grasa |
| JP2011506466A (ja) | 2007-12-11 | 2011-03-03 | 株式会社サイトパスファインダー | カルボキサミド化合物ならびにケモカイン受容体アゴニストとしてのそれらの使用 |
| US20090197947A1 (en) * | 2008-02-01 | 2009-08-06 | The Research Foundation Of State University Of New York | Medicaments and methods for lowering plasma lipid levels and screening drugs |
| EP2268811A1 (en) * | 2008-03-07 | 2011-01-05 | Santaris Pharma A/S | Pharmaceutical compositions for treatment of microrna related diseases |
| ES2541442T3 (es) | 2008-08-01 | 2015-07-20 | Roche Innovation Center Copenhagen A/S | Modulación mediada por microARN de factores estimulantes de colonias |
| US9034837B2 (en) * | 2009-04-24 | 2015-05-19 | Roche Innovation Center Copenhagen A/S | Pharmaceutical compositions for treatment of HCV patients that are poor-responders to interferon |
| US8563528B2 (en) | 2009-07-21 | 2013-10-22 | Santaris Pharma A/S | Antisense oligomers targeting PCSK9 |
| CA2909442A1 (en) | 2013-04-17 | 2014-10-23 | Pfizer Inc. | N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases |
| SG11201510656PA (en) | 2013-06-27 | 2016-01-28 | Roche Innovation Ct Copenhagen As | Antisense oligomers and conjugates targeting pcsk9 |
| WO2015065595A1 (en) | 2013-10-30 | 2015-05-07 | Trustees Of Dartmouth College | Method for selectively inhibiting acat1 in the treatment of obesity, metabolic syndrome, and atherosclerosis |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| JP2018502900A (ja) * | 2014-10-22 | 2018-02-01 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | ジスコイジンドメイン受容体１を標的化する小分子阻害剤およびその使用 |
| HUE069590T2 (hu) | 2019-01-18 | 2025-03-28 | Astrazeneca Ab | PCSK9-gátló 6'-[[(1s,3s)-3-[[5-(difluormetoxi)-2-pirimidinil]amino]ciklopentil]amino][1(2h ),3'-bipiridin]-2-on és alkalmazására szolgáló eljárások |
| AU2021316011A1 (en) | 2020-07-29 | 2023-02-09 | Amryt Pharmaceuticals Inc. | Lomitapide for use in methods of treating hyperlipidemia and hypercholesterolemia in pediatric patients |
| BR112023019288A2 (pt) * | 2021-03-26 | 2023-10-24 | Chiesi Farm Spa | Derivados de indolina como inibidores de ddrs |
| JP2024513180A (ja) * | 2021-03-26 | 2024-03-22 | キエシ・フアルマチエウテイチ・ソチエタ・ペル・アチオニ | Ｄｄｒ阻害物質としてのインドリン誘導体 |
| CN113292493A (zh) * | 2021-06-23 | 2021-08-24 | 上海立科化学科技有限公司 | 5,7-二氯-1,2,3,4-四氢异喹啉的制备方法 |
| WO2024216197A2 (en) * | 2023-04-13 | 2024-10-17 | Acelot, Inc. | Compounds and methods for treating protein aggregation diseases |
| US12453728B1 (en) | 2024-08-08 | 2025-10-28 | Redux Therapeutics, Llc | Compositions comprising inhibitors of microsomal triglyceride transfer protein and Apo-B secretion |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022900A (en) * | 1970-09-09 | 1977-05-10 | Marion Laboratories, Inc. | Compositions containing 1,2,3,4-tetrahydroisoquinolines used as hypotensive agents |
| US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
| US5739135A (en) * | 1993-09-03 | 1998-04-14 | Bristol-Myers Squibb Company | Inhibitors of microsomal triglyceride transfer protein and method |
| WO1996040640A1 (en) * | 1995-06-07 | 1996-12-19 | Pfizer Inc. | BIPHENYL-2-CARBOXYLIC ACID-TETRAHYDRO-ISOQUINOLIN-6-YL AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN AND/OR APOLIPOPROTEIN B (Apo B) SECRETION |
-
1997
- 1997-11-03 EP EP97945048A patent/EP0944602A1/en not_active Withdrawn
- 1997-11-03 BR BR9714364A patent/BR9714364A/pt not_active Application Discontinuation
- 1997-11-03 EA EA199900416A patent/EA001539B1/ru not_active IP Right Cessation
- 1997-11-03 JP JP52446498A patent/JP3270764B2/ja not_active Expired - Fee Related
- 1997-11-03 WO PCT/IB1997/001368 patent/WO1998023593A1/en not_active Ceased
- 1997-11-03 SK SK654-99A patent/SK65499A3/sk unknown
- 1997-11-03 US US09/284,466 patent/US6121283A/en not_active Expired - Fee Related
- 1997-11-03 AU AU46347/97A patent/AU716151B2/en not_active Ceased
- 1997-11-03 NZ NZ335162A patent/NZ335162A/xx unknown
- 1997-11-03 TR TR1999/01180T patent/TR199901180T2/xx unknown
- 1997-11-03 KR KR1019997004662A patent/KR100334567B1/ko not_active Expired - Fee Related
- 1997-11-03 CA CA002272719A patent/CA2272719C/en not_active Expired - Fee Related
- 1997-11-03 CN CN97180033A patent/CN1238764A/zh active Pending
- 1997-11-03 YU YU23499A patent/YU23499A/sh unknown
- 1997-11-03 IL IL12974497A patent/IL129744A0/xx unknown
- 1997-11-04 HN HN1997000144A patent/HN1997000144A/es unknown
- 1997-11-05 TW TW086116476A patent/TW502023B/zh not_active IP Right Cessation
- 1997-11-14 PA PA84416A patent/PA8441601A1/es unknown
- 1997-11-20 AP APAP/P/1997/001145A patent/AP804A/en active
- 1997-11-24 PE PE1997001062A patent/PE17199A1/es not_active Application Discontinuation
- 1997-11-25 UY UY24789A patent/UY24789A1/es not_active Application Discontinuation
- 1997-11-25 GT GT199700122A patent/GT199700122A/es unknown
- 1997-11-25 ID IDP973763A patent/ID18995A/id unknown
- 1997-11-26 DZ DZ970208A patent/DZ2358A1/xx active
- 1997-11-26 TN TNTNSN97193A patent/TNSN97193A1/fr unknown
- 1997-11-26 MA MA24877A patent/MA26451A1/fr unknown
- 1997-11-26 AR ARP970105560A patent/AR010309A1/es unknown
- 1997-11-26 ZA ZA9710641A patent/ZA9710641B/xx unknown
- 1997-11-26 HR HR60/032,307A patent/HRP970642A2/hr not_active Application Discontinuation
-
1999
- 1999-04-30 IS IS5040A patent/IS5040A/is unknown
- 1999-05-19 OA OA9900106A patent/OA11050A/en unknown
- 1999-05-26 BG BG103434A patent/BG103434A/xx unknown
- 1999-05-26 BG BG108830A patent/BG108830A/bg unknown
- 1999-05-26 NO NO19992525A patent/NO312760B1/no unknown
-
2002
- 2002-02-19 CN CN02105189A patent/CN1380289A/zh active Pending
- 2002-09-17 CZ CZ20023137A patent/CZ292160B6/cs not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG108830A (bg) | Метод за получаване на 4' - трифлуорометилбифенил-2-карбоксамидо-(1,2,3,4-тетрахидроизохинолин-6-ил) и негови соли | |
| JP2006501236A (ja) | ムスカリン性レセプター拮抗薬としてのフルオロおよびスルホニルアミノ含有３，６−二置換アザビシクロ（３．１．０）ヘキサン誘導体 | |
| WO2005095343A1 (en) | Dpp-iv inhibitors | |
| JP2008545688A (ja) | 置換３−シアノキノリン並びにその中間体を合成する方法 | |
| WO2005056013A1 (en) | Dpp-iv inhibitors | |
| EP1828138A1 (en) | Dpp-iv inhibitors | |
| JP2524489B2 (ja) | Ｎ−アルキル化α−アミノ酸ベンジルエステルのマレイン酸塩 | |
| RS52465B (sr) | Postupak za pripremanje visoko čistog perindoprila i intermedijera korisnih u sintezama | |
| KR910007887B1 (ko) | 1,4-디아자비사이클로[3.2.2]노난의 제조방법 | |
| CA2222687A1 (en) | Novel naphthyridine derivatives | |
| Itoh et al. | A general method for the asymmetric synthesis of both enantiomers of 1-substituted 1, 2, 3, 4-tetrahydro-β-carbolines employing pyroglutamic acid derivatives as chiral auxiliaries | |
| EP0987250A1 (en) | Indole dicarboxylic acid derivatives | |
| WO2006018309A1 (en) | 5-ht7 receptor antagonists | |
| TW202140423A (zh) | 製備(r)-4-(1-(6-(4-(三氟甲基)芐基)-6-氮雜螺[2.5]辛烷-5-甲醯胺基)-環丙基)苯甲酸或其鹽之方法 | |
| EP0279937B1 (en) | 2-aminoacetamide derivatives | |
| JP2002540108A (ja) | ［Ｓ−（Ｒ＊，Ｓ＊）］−β−［［［１−［１−オキソ−３−（４−ピペリジニル）プロピル］−３−ピペリジニル］カルボニル］アミノ］−３−ピリジンプロパン酸及び誘導体を製造する方法 | |
| US5252747A (en) | Chiral quinolone intermediates | |
| WO2007025481A1 (fr) | Procede de preparation de carbamate (s)-n-ethyl-n-methyl-s-[1(dimethylamino) ethyl]-phenyle et de son tartrate | |
| CN114591299A (zh) | 一种帕罗韦德中间体及其制备和应用 | |
| US7884243B2 (en) | Process for the synthesis of eneamide derivatives | |
| JP3204368B2 (ja) | 光学活性アミド類の製法 | |
| JPH0912547A (ja) | ニューキノロン系化合物中間体の製造方法 | |
| JP2024511422A (ja) | ５－｛５－クロロ－２－［（３ｓ）－３－［（モルホリン－４－イル）メチル］－３，４－ジヒドロイソキノリン－２（１ｈ）－カルボニル］フェニル｝－１，２－ジメチル－１ｈ－ピロール－３－カルボン酸誘導体を合成するための新規な製造方法及び医薬化合物を製造するためのその適用 | |
| JPH10291979A (ja) | １，２，３，４−テトラヒドロイソキノリン−３−カルボン酸ターシャリーブチルアミドの製造方法 | |
| JPH0912546A (ja) | アザビシクロ環化合物および製造方法 |