AR100428A1 - Derivados antibacterianos quinazolina-4(3h)-ona - Google Patents
Derivados antibacterianos quinazolina-4(3h)-onaInfo
- Publication number
- AR100428A1 AR100428A1 ARP150101482A ARP150101482A AR100428A1 AR 100428 A1 AR100428 A1 AR 100428A1 AR P150101482 A ARP150101482 A AR P150101482A AR P150101482 A ARP150101482 A AR P150101482A AR 100428 A1 AR100428 A1 AR 100428A1
- Authority
- AR
- Argentina
- Prior art keywords
- cycloprop
- hydroxymethyl
- trans
- halogen
- methyl
- Prior art date
Links
- 230000000844 anti-bacterial effect Effects 0.000 title 1
- -1 1,2-dihydroxyethyl Chemical group 0.000 abstract 15
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000004477 1-amino-cycloprop-1-yl group Chemical group NC1(CC1)* 0.000 abstract 1
- 125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000005113 hydroxyalkoxy group Chemical group 0.000 abstract 1
- 125000006299 oxetan-3-yl group Chemical group [H]C1([H])OC([H])([H])C1([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto de fórmula (1) donde R¹ es H o halógeno; R² es el grupo M; R³ es H o halógeno; M es uno de los grupos MA y MB representados por las fórmulas (2) y (3), donde A representa un enlace o CºC; R¹A es H o halógeno; R²A es H, alcoxi C₁₋₃ o halógeno; R³A es H, alcoxi C₁₋₃, hidroxialcoxi C₂₋₄, hidroxialquilo C₁₋₄, 1,2-dihidroxietilo, dialquilamino C₁₋₃, 1-hidroximetil-cicloprop-1-ilo, 1-((dimetilglicil)oxi)metil-cicloprop-1-ilo, 3-hidroxioxetan-3-ilo, morfolin-4-il-alquilo C₁₋₂ o morfolin-4-il alcoxi C₂₋₃; y R¹B es hidroxialquilo C₁₋₃, aminoalquilo C₁₋₃, [dialquilamino C₁₋₃]-alquilo C₁₋₃, 1,2-dihidroxiprop-3-ilo, 1-amino-cicloprop-1-ilo, 1-hidroximetil-cicloprop-1-ilo, 1-((fosfonooxi)metil)cicloprop-1-ilo, trans-2-hidroximetil-cicloprop-1-ilo, trans-2-aminometil-cicloprop-1-ilo, 1-fluoro-2-hidroximetil-cicloprop-1-ilo, trans-2-hidroximetil-1-metil-cicloprop-1-ilo, 2-fluoro-2-hidroximetil-cicloprop-1-ilo, trans-2-hidroximetil-2-metil-cicloprop-1-ilo, 1-(1,2-dihidroxietil)-cicloprop-1-ilo, trans-2-(1,2-dihidroxietil-)-cicloprop-1-ilo, 1-(hidroximetil)ciclobut-1-ilo, 3-hidroxioxetan-3-ilo, 3-(hidroxialquil C₁₋₃)oxetan-3-ilo, 3-hidroxitietan-3-ilo, trans-(cis-3,4-dihidroxi)-ciclopent-1-ilo, 3-(2-aminoacetamido)ciclopentil, 3 hidroximetilbiciclo[1,1,1]pentan-1-ilo o 3-hidroxioxetan-3-ilmetilo; o una sal de este compuesto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14168718 | 2014-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR100428A1 true AR100428A1 (es) | 2016-10-05 |
Family
ID=50731968
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP150101482A AR100428A1 (es) | 2014-05-16 | 2015-05-13 | Derivados antibacterianos quinazolina-4(3h)-ona |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US9796686B2 (es) |
| EP (1) | EP3143007B1 (es) |
| JP (1) | JP2017515906A (es) |
| KR (1) | KR20170005105A (es) |
| CN (1) | CN106458931A (es) |
| AR (1) | AR100428A1 (es) |
| AU (1) | AU2015261540A1 (es) |
| BR (1) | BR112016026787A8 (es) |
| CA (1) | CA2948077A1 (es) |
| CL (1) | CL2016002918A1 (es) |
| EA (1) | EA201692305A1 (es) |
| ES (1) | ES2687040T3 (es) |
| IL (1) | IL248922A0 (es) |
| MX (1) | MX2016014989A (es) |
| PH (1) | PH12016502253A1 (es) |
| SG (1) | SG11201609286VA (es) |
| TW (1) | TW201625559A (es) |
| WO (1) | WO2015173329A1 (es) |
| ZA (1) | ZA201608680B (es) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| US9624206B2 (en) | 2013-12-19 | 2017-04-18 | Actelion Pharmaceuticals Ltd | Antibacterial 1H-indazole and 1H-indole derivatives |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
| AR105646A1 (es) | 2015-08-11 | 2017-10-25 | Actelion Pharmaceuticals Ltd | Agentes antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituida |
| US20190031676A1 (en) * | 2015-08-28 | 2019-01-31 | Idorsia Pharmaceuticals Ltd | Antibacterial annulated pyrrolidin-2-one derivatives |
| AR105889A1 (es) | 2015-09-03 | 2017-11-22 | Actelion Pharmaceuticals Ltd | Compuestos antibacterianos 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona sustituidos |
| US10781184B2 (en) | 2015-12-08 | 2020-09-22 | Glaxosmithkline Intellectual Property Development Limited | Substituted benzazinones as antibacterial compounds |
| CA3017388C (en) | 2016-04-01 | 2024-03-12 | Zeno Royalties & Milestones, LLC | Estrogen receptor modulators |
| CN110088087B (zh) * | 2016-09-28 | 2022-08-09 | 东亚St株式会社 | 四氢吡啶衍生物及其作为抗菌剂的用途 |
| EP3993787A4 (en) | 2019-08-06 | 2023-07-12 | Recurium IP Holdings, LLC | Estrogen receptor modulators for treating mutants |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE263554T1 (de) | 1997-02-27 | 2004-04-15 | Wyeth Corp | N-hydroxy-2-(alkyl, aryl oder heteroaryl sulfanyl,sulfinyl oder sulfonyl)-3-substituierte alkyl-, aryl- oder heteroarylamide als matrixmetalloproteinaseinhibitoren |
| WO2003077914A1 (en) | 2002-03-13 | 2003-09-25 | Array Biopharma, Inc | N3 alkylated benzimidazole derivatives as mek inhibitors |
| CA2691987C (en) * | 2007-06-12 | 2016-08-16 | Achaogen, Inc. | Antibacterial agents |
| WO2010024356A1 (ja) | 2008-08-27 | 2010-03-04 | 大正製薬株式会社 | ナフチリジン－ｎ－オキシドを有する新規ヒドロキサム酸誘導体 |
| EP2350039A4 (en) | 2008-10-03 | 2012-10-10 | Boehringer Ingelheim Int | INHIBITORS OF VIRAL POLYMERASE |
| DE102008044132A1 (de) | 2008-11-27 | 2010-06-02 | BSH Bosch und Siemens Hausgeräte GmbH | Kältegerät mit zweiseitig anschlagbarer Tür |
| EP2432468A2 (en) | 2009-05-20 | 2012-03-28 | Ardea Biosciences, Inc. | Methods of modulating uric acid levels |
| EP2488489A2 (en) | 2009-10-13 | 2012-08-22 | Pfizer Inc. | C-linked hydroxamic acid derivatives useful as antibacterial agents |
| US8664401B2 (en) * | 2009-12-16 | 2014-03-04 | Pfizer Inc. | N-linked hydroxamic acid derivatives useful as antibacterial agents |
| WO2012054332A1 (en) | 2010-10-18 | 2012-04-26 | Millennium Pharmaceuticals, Inc. | Substituted hydroxamic acids and uses thereof |
| EP2638006A1 (en) | 2010-11-10 | 2013-09-18 | Achaogen, Inc. | Hydroxamic acid derivatives and their use in the treatment of bacterial infections |
| EP2661438A4 (en) | 2011-01-03 | 2014-06-11 | Hanmi Pharm Ind Co Ltd | NEW BICYCLIC COMPOUND FOR MODULATING G-PROTEIN-COUPLED RECEPTORS |
| MA34963B1 (fr) * | 2011-03-07 | 2014-03-01 | Pfizer | Derives de fluoro-pyridinone utiles en tant qu'agents antibacteriens |
| CA2830866A1 (en) | 2011-04-08 | 2012-10-11 | Pfizer Inc. | Imidazole, pyrazole, and triazole derivatives useful as antibacterial agents |
| JP2014510132A (ja) | 2011-04-08 | 2014-04-24 | ファイザー・インク | 抗菌剤として有用なイソオキサゾール誘導体 |
| AU2012267622B2 (en) | 2011-06-08 | 2017-06-22 | Sunovion Pharmaceuticals, Inc. | Metabotropic glutamate receptor 5 modulators and methods of use thereof |
| EP2847162A1 (en) | 2012-05-09 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| EP2847168A1 (en) * | 2012-05-10 | 2015-03-18 | Achaogen, Inc. | Antibacterial agents |
| WO2015024010A2 (en) | 2013-08-16 | 2015-02-19 | Duke University | Substituted hydroxamic acid compounds |
| AR097617A1 (es) | 2013-09-13 | 2016-04-06 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos del 2h-indazol |
| US9624206B2 (en) | 2013-12-19 | 2017-04-18 | Actelion Pharmaceuticals Ltd | Antibacterial 1H-indazole and 1H-indole derivatives |
| AR099612A1 (es) | 2014-03-04 | 2016-08-03 | Actelion Pharmaceuticals Ltd | Derivados antibacterianos de 1,2-dihidro-3h-pirrolo[1,2-c]imidazol-3-ona |
-
2015
- 2015-05-13 US US15/311,758 patent/US9796686B2/en not_active Expired - Fee Related
- 2015-05-13 ES ES15722212.6T patent/ES2687040T3/es active Active
- 2015-05-13 CN CN201580024307.8A patent/CN106458931A/zh active Pending
- 2015-05-13 KR KR1020167035088A patent/KR20170005105A/ko not_active Withdrawn
- 2015-05-13 CA CA2948077A patent/CA2948077A1/en not_active Abandoned
- 2015-05-13 SG SG11201609286VA patent/SG11201609286VA/en unknown
- 2015-05-13 AU AU2015261540A patent/AU2015261540A1/en not_active Abandoned
- 2015-05-13 EP EP15722212.6A patent/EP3143007B1/en not_active Not-in-force
- 2015-05-13 BR BR112016026787A patent/BR112016026787A8/pt not_active Application Discontinuation
- 2015-05-13 MX MX2016014989A patent/MX2016014989A/es unknown
- 2015-05-13 JP JP2017512426A patent/JP2017515906A/ja not_active Ceased
- 2015-05-13 EA EA201692305A patent/EA201692305A1/ru unknown
- 2015-05-13 AR ARP150101482A patent/AR100428A1/es unknown
- 2015-05-13 WO PCT/EP2015/060653 patent/WO2015173329A1/en not_active Ceased
- 2015-05-15 TW TW104115665A patent/TW201625559A/zh unknown
-
2016
- 2016-11-11 PH PH12016502253A patent/PH12016502253A1/en unknown
- 2016-11-13 IL IL248922A patent/IL248922A0/en unknown
- 2016-11-16 CL CL2016002918A patent/CL2016002918A1/es unknown
- 2016-12-15 ZA ZA2016/08680A patent/ZA201608680B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW201625559A (zh) | 2016-07-16 |
| MX2016014989A (es) | 2017-03-31 |
| KR20170005105A (ko) | 2017-01-11 |
| US9796686B2 (en) | 2017-10-24 |
| BR112016026787A8 (pt) | 2017-12-26 |
| EP3143007B1 (en) | 2018-07-11 |
| SG11201609286VA (en) | 2016-12-29 |
| PH12016502253A1 (en) | 2017-01-16 |
| EA201692305A1 (ru) | 2017-05-31 |
| CN106458931A (zh) | 2017-02-22 |
| AU2015261540A1 (en) | 2017-01-12 |
| CL2016002918A1 (es) | 2017-04-07 |
| ZA201608680B (en) | 2018-11-28 |
| BR112016026787A2 (es) | 2017-08-15 |
| EP3143007A1 (en) | 2017-03-22 |
| JP2017515906A (ja) | 2017-06-15 |
| US20170081292A1 (en) | 2017-03-23 |
| CA2948077A1 (en) | 2015-11-19 |
| ES2687040T3 (es) | 2018-10-23 |
| IL248922A0 (en) | 2017-01-31 |
| WO2015173329A1 (en) | 2015-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |