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AR108411A2 - Inhibidores del virus de la hepatitis c - Google Patents

Inhibidores del virus de la hepatitis c

Info

Publication number
AR108411A2
AR108411A2 ARP170101215A ARP170101215A AR108411A2 AR 108411 A2 AR108411 A2 AR 108411A2 AR P170101215 A ARP170101215 A AR P170101215A AR P170101215 A ARP170101215 A AR P170101215A AR 108411 A2 AR108411 A2 AR 108411A2
Authority
AR
Argentina
Prior art keywords
imidazol
pyrrolidinyl
biphenylyl
methyl
methyl carbamate
Prior art date
Application number
ARP170101215A
Other languages
English (en)
Inventor
Lawrence G Hamann
Gan Wang
David R Langley
Fukang Yang
Laurent Denis R St
Lawrence B Snyder
Edward H Ruediger
Jeffrey Lee Romine
Van N Nguyen
Nicholas A Meanwell
Alain Martel
Omar D Lopez
Rico Lavoie
Clint A James
Jason Goodrich
Andrew C Good
Daniel H Deon
Makonen Belema
Carol Bachand
Original Assignee
Bristol Myers Squibb Holdings Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Holdings Ireland filed Critical Bristol Myers Squibb Holdings Ireland
Publication of AR108411A2 publication Critical patent/AR108411A2/es

Links

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Reivindicación 1: Un compuesto, caracterizado porque se selecciona de: ((1S)-1-(((2S)-2-(5-(4’-(2-((2S)-1-((2S)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1H-imidazol-5-il)-4-bifenilil)-1H-imidazol-2-il)-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metilo; (1R,1’R)-2,2’-(4,4’-bifenildiilbis(1H-imidazol-5,2-diil(2S)-2,1-pirrolidindiil))bis(N,N-dimetil-2-oxo-1-feniletanamina); ((1S)-2-((2S)-2-(5-(4’-(2-((2S)-1-((2R)-2-(dietilamino)-2-fenilacetil)-2-pirrolidinil)-1H-imidazol-5-il)-4-bifenilil)-1H-imidazol-2-il)-1-pirrolidinil)-1-metil-2-oxoetil)carbamato de metilo; ((1S)-1-(((2S)-2-(4-(4’-(2-((2S)-4,4-difluoro-1-((2S)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-pirrolidinil)-1H-imidazol-4-il)-4-bifenilil)-1H-imidazol-2-il)-4,4-difluoro-1-pirrolidinil)carbonil)-2-metilpropil)carbamato de metilo; ((1S)-1-(((1R,3R,5R)-3-(5-(4’-(2-((1R,3R,5R)-2-((2S)-2-((metoxicarbonil)amino)-3-metilbutanoil)-2-azabiciclo[3.1.0]hex-3-il)-1H-imidazol-5-il)-4-bifenilil)-1H-imidazol-2-il)-2-azabiciclo[3.1.0]hex-2-il)carbonil)-2-metilpropil)carbamato de metilo; ((1R)-2-oxo-1-fenil-2-((2S)-2-(5-(4’-(2-((2S)-1-((2R)-tetrahidro-2-furanilcarbonil)-2-pirrolidinil)-1H-imidazol-5-il)-4-bifenilil)-1H-imidazol-2-il)-1-pirrolidinil)etil)carbamato de metilo; ((1S)-2-metil-1-(((2S)-2-(5-(4’-(2-((2S)-1-(N-2-pirimidinil-D-valil)-2-pirrolidinil)-1H-imidazol-5-il)-4-bifenilil)-1H-imidazol-2-il)-1-pirrolidinil)carbonil)propil)carbamato de metilo; ((1R)-2-((2S)-2-(5-(4’-(2-((2S)-1-((2R)-2-(dimetilamino)-2-fenilacetil)-2-pirrolidinil)-1H-imidazol-5-il)-4-bifenilil)-1H-imidazol-2-il)-1-pirrolidinil)-2-oxo-1-feniletil)carbamato de metilo; (4,4’-bifenildiilbis(1H-imidazol-5,2-diil(2S)-2,1-pirrolidindiil((1R)-2-oxo-1-fenil-2,1-etandiil)))biscarbamato de dimetilo; (1R)-N,N-dimetil-2-oxo-1-fenil-2-((2S)-2-(5-(4’-(2-((2S)-1-((2R)-tetrahidro-2-furanilcarbonil)-2-pirrolidinil)-1H-imidazol-5-il)-4-bifenilil)-1H-imidazol-2-il)-1-pirrolidinil)etanamina; ((1S)-2-((2S)-2-(5-(4’-(2-((2S)-1-(N-(metoxicarbonil)-L-alanil)-2-pirrolidinil)-1H-imidazol-5-il)-4-bifenilil)-1H-imidazol-2-il)-1-pirrolidinil)-1-metil-2-oxoetil)carbamato de metilo; y ((1S)-1-(((2S)-2-(5-(4’-(2-((2S)-1-((2S)-2-((metoxicarbonil)amino)-3,3-dimetilbutanoil)-2-pirrolidinil)-1H-imidazol-5-il)-4-bifenilil)-1H-imidazol-2-il)-1-pirrolidinil)carbonil)-2,2-dimetilpropil)carbamato de metilo.
ARP170101215A 2006-08-11 2017-05-09 Inhibidores del virus de la hepatitis c AR108411A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83699606P 2006-08-11 2006-08-11

Publications (1)

Publication Number Publication Date
AR108411A2 true AR108411A2 (es) 2018-08-15

Family

ID=41175598

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP170101215A AR108411A2 (es) 2006-08-11 2017-05-09 Inhibidores del virus de la hepatitis c

Country Status (3)

Country Link
CN (1) CN101558059B (es)
AR (1) AR108411A2 (es)
TW (1) TWI400072B (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110281910A1 (en) * 2009-11-12 2011-11-17 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
EP2550278A1 (en) * 2010-03-24 2013-01-30 Vertex Pharmaceuticals Incorporated Analogues for the treatment or prevention of flavivirus infections
WO2012061552A1 (en) * 2010-11-04 2012-05-10 Theravance, Inc. Novel inhibitors of hepatitis c virus
PT2730564T (pt) * 2010-11-19 2018-07-24 Ligand Pharm Inc Aminas heterocíclicas e suas utilizações
US8552047B2 (en) * 2011-02-07 2013-10-08 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9546160B2 (en) * 2011-05-12 2017-01-17 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US9212168B2 (en) * 2011-11-03 2015-12-15 Theravance Biopharma R&D Ip, Llc Hepatitis C virus inhibitors
CN103304551B (zh) * 2012-03-14 2017-06-13 北京凯因科技股份有限公司 丙肝聚合酶抑制剂
JP6333372B2 (ja) * 2013-07-09 2018-05-30 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ Ｃ型肝炎ウイルス阻害剤の組み合わせ
CN105073740B (zh) * 2014-01-21 2017-06-27 杭州普晒医药科技有限公司 一种化合物的盐及晶型或无定型物、其制备方法、含有它们的药物组合物和用途
CN108084172A (zh) * 2014-02-21 2018-05-29 常州寅盛药业有限公司 抗丙肝病毒化合物
WO2015184644A1 (zh) * 2014-06-06 2015-12-10 爱博新药研发(上海)有限公司 抑制丙肝病毒的化合物、药物组合物及其应用
CN105524049B (zh) * 2014-09-28 2018-11-06 正大天晴药业集团股份有限公司 氘代的丙型肝炎病毒ns5a蛋白抑制剂
CN104546780A (zh) * 2014-12-12 2015-04-29 安徽一灵药业有限公司 一种达卡他韦薄膜包衣片制剂及其制备方法
WO2017076358A1 (zh) * 2015-11-06 2017-05-11 苏州晶云药物科技有限公司 咪唑基联苯基化合物盐的新晶型及其制备方法
CN106496199A (zh) * 2016-10-19 2017-03-15 上海博志研新药物技术有限公司 达卡他韦及其中间体的制备方法
US10766912B2 (en) 2017-03-22 2020-09-08 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Silicon-containing compound for resistance to hepatitis C virus infection
CN115448892B (zh) * 2022-09-19 2023-07-07 郑州铁路职业技术学院 一种苯并噻二唑杂环化合物的合成方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004005264A2 (en) * 2002-07-05 2004-01-15 Axxima Pharmaceuticals Ag Imidazole compounds for the treatment of hepatitis c virus infections

Also Published As

Publication number Publication date
TWI400072B (zh) 2013-07-01
TW200934486A (en) 2009-08-16
CN101558059B (zh) 2014-12-03
CN101558059A (zh) 2009-10-14

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